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Testing an alternative explanation for relatively greater base-sharing between Neanderthals and non-African humans

https://doi.org/10.1101/133306
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Heterozygosity and mutation rate: evidence for an interaction and its implications
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Gene conversion as a focusing mechanism for correlated mutations: a hypothesis
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Determinants of rate variation in mammalian DNA sequence evolution
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Unexpected Conservation of the X-Linked Color Vision Gene in Nocturnal Prosimians: Evidence from Two Bush Babies
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Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences
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Population-Specific Links Between Heterozygosity and the Rate Human Microsatellite Evolution
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Meiosis-specific formation of joint DNA molecules containing sequences from homologous chromosomes
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Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania
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A Haplotype at STAT2 Introgressed from Neanderthals and Serves as a Candidate of Positive Selection in Papua New Guinea
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Small Amounts of Archaic Admixture Provide Big Insights into Human History
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Geography predicts neutral genetic diversity of human populations
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Pervasive Multinucleotide Mutational Events in Eukaryotes
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The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans
inferredcites →https://doi.org/10.1016/s0168-9525(02)02669-0openalex-snapshot
Human SNP variability and mutation rate are higher in regions of high recombination
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The effect of ancient population bottlenecks on human phenotypic variation
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A map of human genome variation from population-scale sequencing
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The genomic landscape of Neanderthal ancestry in present-day humans
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Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
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An early modern human from Romania with a recent Neanderthal ancestor
inferredcites →https://doi.org/10.1038/nature14649openalex-snapshot
Parent–progeny sequencing indicates higher mutation rates in heterozygotes
inferredcites →https://doi.org/10.1038/nature16544openalex-snapshot
Ancient gene flow from early modern humans into Eastern Neanderthals
inferredcites →https://doi.org/10.1038/nature18964openalex-snapshot
The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
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Genomic insights into the peopling of the Southwest Pacific
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Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptation
inferredcites →https://doi.org/10.1038/ng.658openalex-snapshot
PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
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Microsatellites show mutational bias and heterozygote instability
inferredcites →https://doi.org/10.1038/ng1565openalex-snapshot
Human recombination hot spots hidden in regions of strong marker association
inferredcites →https://doi.org/10.1073/pnas.1418652112openalex-snapshot
Evidence for recent, population-specific evolution of the human mutation rate
inferredcites →https://doi.org/10.1073/pnas.1600374113openalex-snapshot
Variation in the molecular clock of primates
inferredcites →https://doi.org/10.1080/10409230701495631openalex-snapshot
Too Many Mutants with Multiple Mutations
inferredcites →https://doi.org/10.1093/genetics/123.1.69openalex-snapshot
Length and distribution of meiotic gene conversion tracts and crossovers in Saccharomyces cerevisiae.
inferredcites →https://doi.org/10.1093/molbev/msr048openalex-snapshot
Testing for Ancient Admixture between Closely Related Populations
inferredcites →https://doi.org/10.1093/molbev/msu269openalex-snapshot
Evaluating the Use of ABBA–BABA Statistics to Locate Introgressed Loci
inferredcites →https://doi.org/10.1098/rsbl.2015.0929openalex-snapshot
Heterozygosity increases microsatellite mutation rate
inferredcites →https://doi.org/10.1098/rspb.2009.1757openalex-snapshot
Even small SNP clusters are non-randomly distributed: is this evidence of mutational non-independence?
inferredcites →https://doi.org/10.1098/rspb.2010.2056openalex-snapshot
Using human demographic history to infer natural selection reveals contrasting patterns on different families of immune genes
inferredcites →https://doi.org/10.1098/rstb.2011.0014openalex-snapshot
The genome as a life-history character: why rate of molecular evolution varies between mammal species
inferredcites →https://doi.org/10.1111/mec.13556openalex-snapshot
Detecting hybridization using ancient DNA
inferredcites →https://doi.org/10.1126/science.1105322openalex-snapshot
Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees
inferredcites →https://doi.org/10.1126/science.1188021openalex-snapshot
A Draft Sequence of the Neandertal Genome
inferredcites →https://doi.org/10.1126/science.1224344openalex-snapshot
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
inferredcites →https://doi.org/10.1126/science.aaa0114openalex-snapshot
Genomic structure in Europeans dating back at least 36,200 years
inferredcites →https://doi.org/10.1126/science.aad2149openalex-snapshot
The phenotypic legacy of admixture between modern humans and Neandertals
inferredcites →https://doi.org/10.1126/science.aad9416openalex-snapshot
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
inferredcites →https://doi.org/10.1146/annurev-genom-031714-125740openalex-snapshot
Determinants of Mutation Rate Variation in the Human Germline
inferredcites →https://doi.org/10.1146/annurev.genom.1.1.361openalex-snapshot
Genetic Perspectives on Human Origins and Differentiation
inferredcites →https://doi.org/10.1371/journal.pbio.0020199openalex-snapshot
Evidence for Widespread Convergent Evolution around Human Microsatellites
inferredcites →https://doi.org/10.1371/journal.pgen.0020148openalex-snapshot
The Influence of Recombination on Human Genetic Diversity
inferredcites →https://doi.org/10.1371/journal.pgen.1000471openalex-snapshot
Widespread Genomic Signatures of Natural Selection in Hominid Evolution
inferredcites →https://doi.org/10.1371/journal.pgen.1002905openalex-snapshot
The Many Landscapes of Recombination in Drosophila melanogaster
inferredcites →https://doi.org/10.1371/journal.pgen.1002947openalex-snapshot
The Date of Interbreeding between Neandertals and Modern Humans
inferredcites →https://doi.org/10.1371/journal.pgen.1004528openalex-snapshot
Demography and the Age of Rare Variants
inferredcites →https://doi.org/10.1371/journal.pgen.1006315openalex-snapshot
Multi-nucleotide de novo Mutations in Humans
inferredcites →https://doi.org/10.1371/journal.pgen.1006340openalex-snapshot
The Strength of Selection against Neanderthal Introgression
inferredcites →https://doi.org/10.1371/journal.pone.0063048openalex-snapshot
Variation in Heterozygosity Predicts Variation in Human Substitution Rates between Populations, Individuals and Genomic Regions
inferredcites →https://doi.org/10.1534/genetics.112.145037openalex-snapshot
Ancient Admixture in Human History
inferredcites →https://doi.org/10.7554/elife.24284openalex-snapshot
Rapid evolution of the human mutation spectrum

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.gde.2017.08.007openalex-snapshot
Interpreting the genomic landscape of introgression
inferred← citeshttps://doi.org/10.1101/101410openalex-snapshot
Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA
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