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Improving on a modal-based estimation method: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-0258(19991030)18:20<2693::aid-sim235>3.0.co;2-vopenalex-snapshot
Explaining heterogeneity in meta-analysis: a comparison of methods
inferredcites →https://doi.org/10.1002/gepi.21758openalex-snapshot
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1002/sim.5871openalex-snapshot
Identifying the odds ratio estimated by a two‐stage instrumental variable analysis with a logistic regression model
inferredcites →https://doi.org/10.1002/sim.6835openalex-snapshot
Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
inferredcites →https://doi.org/10.1002/sim.7221openalex-snapshot
A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
inferredcites →https://doi.org/10.1007/s10654-015-0011-zopenalex-snapshot
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot
Discovery and refinement of loci associated with lipid levels
inferredcites →https://doi.org/10.1038/ng.3396openalex-snapshot
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
inferredcites →https://doi.org/10.1038/ng.784openalex-snapshot
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
inferredcites →https://doi.org/10.1080/0094965031000097809openalex-snapshot
Robust and efficient estimation of the mode of continuous data: the mode as a viable measure of central tendency
inferredcites →https://doi.org/10.1080/01621459.2014.994705openalex-snapshot
Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization
inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/ije/dyx102openalex-snapshot
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1101/126102openalex-snapshot
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1136/bmj.d548openalex-snapshot
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
inferredcites →https://doi.org/10.1161/circulationaha.110.948570openalex-snapshot
Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
inferredcites →https://doi.org/10.1177/0962280206077743openalex-snapshot
Mendelian randomization as an instrumental variable approach to causal inference
inferredcites →https://doi.org/10.1214/11-sts360openalex-snapshot
On Instrumental Variables Estimation of Causal Odds Ratios

What points at this work

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inferred← citeshttps://doi.org/10.1038/s41467-019-09432-2openalex-snapshot
Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
inferred← citeshttps://doi.org/10.1038/s41576-018-0020-3openalex-snapshot
Using genetic data to strengthen causal inference in observational research
inferred← citeshttps://doi.org/10.1101/288050openalex-snapshot
The median and the mode as robust meta-analysis methods in the presence of small study effects
inferred← citeshttps://doi.org/10.1101/702787openalex-snapshot
A Comprehensive Evaluation of Methods for Mendelian Randomization Using Realistic Simulations and an Analysis of 38 Biomarkers for Risk of Type-2 Diabetes
inferred← citeshttps://doi.org/10.1146/annurev-genom-083117-021731openalex-snapshot
Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data
inferred← citeshttps://doi.org/10.1186/s12916-018-1065-zopenalex-snapshot
Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study
inferred← citeshttps://doi.org/10.3389/fendo.2019.00564openalex-snapshot
Association of Cortisol Levels With Neuropsychiatric Functions: A Mendelian Randomization Analysis
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