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Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gepi.21758openalex-snapshot

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

inferredcites →https://doi.org/10.1002/sim.5659openalex-snapshot

Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies

inferredcites →https://doi.org/10.1002/sim.6522openalex-snapshot

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

inferredcites →https://doi.org/10.1002/sim.7221openalex-snapshot

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

inferredcites →https://doi.org/10.1007/978-1-4899-3324-9openalex-snapshot

Density Estimation for Statistics and Data Analysis

inferredcites →https://doi.org/10.1007/s10654-015-0011-zopenalex-snapshot

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

inferredcites →https://doi.org/10.1016/j.annepidem.2006.12.005openalex-snapshot

Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al.

inferredcites →https://doi.org/10.1016/j.csda.2005.07.011openalex-snapshot

On a fast, robust estimator of the mode: Comparisons to other robust estimators with applications

inferredcites →https://doi.org/10.1016/s2213-8587(15)00386-1openalex-snapshot

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

inferredcites →https://doi.org/10.1038/ng.2480openalex-snapshot

Large-scale association analysis identifies new risk loci for coronary artery disease

inferredcites →https://doi.org/10.1038/ng.2795openalex-snapshot

Common variants associated with plasma triglycerides and risk for coronary artery disease

inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot

Discovery and refinement of loci associated with lipid levels

inferredcites →https://doi.org/10.1080/0094965031000097809openalex-snapshot

Robust and efficient estimation of the mode of continuous data: the mode as a viable measure of central tendency

inferredcites →https://doi.org/10.1080/01621459.2014.994705openalex-snapshot

Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization

inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

inferredcites →https://doi.org/10.1093/ije/dyh048openalex-snapshot

Commentary: The concept of 'Mendelian Randomization'

inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

inferredcites →https://doi.org/10.1093/ije/dyv108openalex-snapshot

Mendelian randomization: where are we now and where are we going?

inferredcites →https://doi.org/10.1093/ije/dyw220openalex-snapshot

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

inferredcites →https://doi.org/10.1093/ije/dyx028openalex-snapshot

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique

inferredcites →https://doi.org/10.1214/aoms/1177700277openalex-snapshot

Some Direct Estimates of the Mode

inferredcites →https://doi.org/10.1371/journal.pmed.0040352openalex-snapshot

Clustered Environments and Randomized Genes: A Fundamental Distinction between Conventional and Genetic Epidemiology

inferredcites →https://doi.org/10.3945/ajcn.115.118216openalex-snapshot

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s40471-017-0128-6openalex-snapshot

Recent Developments in Mendelian Randomization Studies

inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104503openalex-snapshot

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study

inferred← citeshttps://doi.org/10.1017/s0033291720003402openalex-snapshot

Does smoking cause lower educational attainment and general cognitive ability? Triangulation of causal evidence using multiple study designs

inferred← citeshttps://doi.org/10.1038/s41588-018-0079-yopenalex-snapshot

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

inferred← citeshttps://doi.org/10.1038/s41593-018-0206-1openalex-snapshot

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

inferred← citeshttps://doi.org/10.1073/pnas.2106858119openalex-snapshot

Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

inferred← citeshttps://doi.org/10.1093/hmg/ddy210openalex-snapshot

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

inferred← citeshttps://doi.org/10.1093/ije/dyab084openalex-snapshot

The use of two-sample methods for Mendelian randomization analyses on single large datasets

inferred← citeshttps://doi.org/10.1093/ije/dyab203openalex-snapshot

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

inferred← citeshttps://doi.org/10.1093/ije/dyy131openalex-snapshot

Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study

inferred← citeshttps://doi.org/10.1101/155739openalex-snapshot

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

inferred← citeshttps://doi.org/10.1101/173682openalex-snapshot

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

inferred← citeshttps://doi.org/10.1101/175372openalex-snapshot

Improving on a modal-based estimation method: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid

inferred← citeshttps://doi.org/10.1101/2020.06.29.133702openalex-snapshot

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

inferred← citeshttps://doi.org/10.1101/2022.03.22.22272772openalex-snapshot

Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

inferred← citeshttps://doi.org/10.1101/234294openalex-snapshot

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

inferred← citeshttps://doi.org/10.1101/250068openalex-snapshot

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

inferred← citeshttps://doi.org/10.1101/281436openalex-snapshot

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

inferred← citeshttps://doi.org/10.1101/288241openalex-snapshot

Tendency towards being a “Morning person” increases risk of Parkinson’s disease: evidence from Mendelian randomisation

inferred← citeshttps://doi.org/10.1111/add.15673openalex-snapshot

Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes

inferred← citeshttps://doi.org/10.1192/bjp.2020.68openalex-snapshot

Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches

inferred← citeshttps://doi.org/10.12688/wellcomeopenres.12288.1openalex-snapshot

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study

inferred← citeshttps://doi.org/10.1371/journal.pgen.1007501openalex-snapshot

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

inferred← citeshttps://doi.org/10.1371/journal.pone.0212464openalex-snapshot

The analysis of causal relationships between blood lipid levels and BMD

inferred← citeshttps://doi.org/10.2337/dc17-1642openalex-snapshot

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation

inferred← citeshttps://doi.org/10.3389/fimmu.2022.918749openalex-snapshot

Causal Relationship Between Sleep Traits and Risk of Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

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