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EGLN Inhibition Reduces Gastrointestinal Radiation Toxicity and Improves Survival in a Murine Model of Locally Advanced Pancreatic Cancer

https://doi.org/10.1101/195610

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1 of the 49 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.18632/oncotarget.10212 (notice 2024-02-08).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2016.4324openalex-snapshot

Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib

inferredcites →https://doi.org/10.1002/cncr.28144openalex-snapshot

Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma

inferredcites →https://doi.org/10.1002/cncr.29161openalex-snapshot

Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma

inferredcites →https://doi.org/10.1016/j.adro.2017.02.004openalex-snapshot

Dose escalation with an IMRT technique in 15 to 28 fractions is better tolerated than standard doses of 3DCRT for LAPC

inferredcites →https://doi.org/10.1016/j.adro.2017.05.006openalex-snapshot

Two-and-a-half-year clinical experience with the world's first magnetic resonance image guided radiation therapy system

inferredcites →https://doi.org/10.1016/j.canlet.2015.12.006openalex-snapshot

Toward stratification of patients with pancreatic cancer: Past lessons from traditional approaches and future applications with physical biomarkers

inferredcites →https://doi.org/10.1016/j.ccr.2005.04.023openalex-snapshot

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

inferredcites →https://doi.org/10.1016/j.cell.2011.11.025openalex-snapshot

EMT and Dissemination Precede Pancreatic Tumor Formation

inferredcites →https://doi.org/10.1016/j.cell.2012.01.058openalex-snapshot

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

inferredcites →https://doi.org/10.1016/j.ijrobp.2008.01.051openalex-snapshot

Gemcitabine Chemotherapy and Single-Fraction Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer

inferredcites →https://doi.org/10.1016/j.ijrobp.2009.05.071openalex-snapshot

Radiation Dose–Volume Effects in the Stomach and Small Bowel

inferredcites →https://doi.org/10.1016/j.ijrobp.2013.06.803openalex-snapshot

The Influence of Radiation Therapy Dose Escalation on Overall Survival in Unresectable Pancreatic Adenocarcinoma

inferredcites →https://doi.org/10.1016/j.ijrobp.2014.11.004openalex-snapshot

High Nuclear Hypoxia-Inducible Factor 1 Alpha Expression Is a Predictor of Distant Recurrence in Patients With Resected Pancreatic Adenocarcinoma

inferredcites →https://doi.org/10.1016/j.ijrobp.2015.12.003openalex-snapshot

Focal Radiation Therapy Dose Escalation Improves Overall Survival in Locally Advanced Pancreatic Cancer Patients Receiving Induction Chemotherapy and Consolidative Chemoradiation

inferredcites →https://doi.org/10.1016/j.ijrobp.2016.09.005openalex-snapshot

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

inferredcites →https://doi.org/10.1016/j.molcel.2008.04.009openalex-snapshot

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

inferredcites →https://doi.org/10.1016/j.stem.2008.03.009openalex-snapshot

PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

inferredcites →https://doi.org/10.1016/s0360-3016(00)00803-8openalex-snapshot

Pancreatic tumors show high levels of hypoxia

inferredcites →https://doi.org/10.1016/s0360-3016(99)00134-0openalex-snapshot

Maximizing therapeutic gain with gemcitabine and fractionated radiation

inferredcites →https://doi.org/10.1016/s1470-2045(14)70412-7openalex-snapshot

Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience

inferredcites →https://doi.org/10.1021/jm201542dopenalex-snapshot

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

inferredcites →https://doi.org/10.1038/ncomms10539openalex-snapshot

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

inferredcites →https://doi.org/10.1038/onc.2013.488openalex-snapshot

Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer

inferredcites →https://doi.org/10.1038/sj.bjc.6690404openalex-snapshot

The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects

inferredcites →https://doi.org/10.1053/j.gastro.2016.02.070openalex-snapshot

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

inferredcites →https://doi.org/10.1056/nejmc1107627openalex-snapshot

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

inferredcites →https://doi.org/10.1056/nejmcibr1610065openalex-snapshot

The Hypoxia Response Pathways — Hats Off!

inferredcites →https://doi.org/10.1056/nejmoa1011923openalex-snapshot

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

inferredcites →https://doi.org/10.1056/nejmoa1304369openalex-snapshot

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

inferredcites →https://doi.org/10.1073/pnas.0601273103openalex-snapshot

Both p16 Ink4a and the p19 Arf -p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

inferredcites →https://doi.org/10.1073/pnas.0908428107openalex-snapshot

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

inferredcites →https://doi.org/10.1073/pnas.1001296107openalex-snapshot

HIF-2α deletion promotes Kras-driven lung tumor development

inferredcites →https://doi.org/10.1093/annonc/mdn281openalex-snapshot

Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000–01 FFCD/SFRO study

inferredcites →https://doi.org/10.1093/ndt/gfv302openalex-snapshot

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients

inferredcites →https://doi.org/10.1097/igc.0b013e318286aa68openalex-snapshot

Tolerance of the Small Bowel to Therapeutic Irradiation

inferredcites →https://doi.org/10.1101/gad.1415606openalex-snapshot

Genetics and biology of pancreatic ductal adenocarcinoma

inferredcites →https://doi.org/10.1101/gad.275776.115openalex-snapshot

Genetics and biology of pancreatic ductal adenocarcinoma

inferredcites →https://doi.org/10.1118/1.4842415openalex-snapshot

Modality comparison for small animal radiotherapy: A simulation study

inferredcites →https://doi.org/10.1126/science.1166202openalex-snapshot

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

inferredcites →https://doi.org/10.1126/scitranslmed.3008523openalex-snapshot

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

inferredcites →https://doi.org/10.1158/0008-5472.can-13-1996openalex-snapshot

CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

inferredcites →https://doi.org/10.1158/0008-5472.can-14-0155openalex-snapshot

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

inferredcites →https://doi.org/10.1200/jco.2008.17.7188openalex-snapshot

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

inferredcites →https://doi.org/10.1371/journal.pone.0026064openalex-snapshot

Activation of Hif1α by the Prolylhydroxylase Inhibitor Dimethyoxalyglycine Decreases Radiosensitivity

inferredcites →https://doi.org/10.18632/oncotarget.10212openalex-snapshot

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

inferredcites →https://doi.org/10.18632/oncotarget.14901openalex-snapshot

The DPC4/SMAD4 genetic status determines recurrence patterns and treatment outcomes in resected pancreatic ductal adenocarcinoma: A prospective cohort study

inferredcites →https://doi.org/10.2215/cjn.06890615openalex-snapshot

Oral Hypoxia–Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD

inferredcites →https://doi.org/10.3389/fonc.2012.00094openalex-snapshot

Mouse genetic approaches applied to the normal tissue radiation response

inferredcites →https://doi.org/10.4251/wjgo.v8.i4.358openalex-snapshot

Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.cej.2021.131725openalex-snapshot

Fullerenol@nano-montmorillonite nanocomposite as an efficient radioprotective agent for ameliorating radioactive duodenal injury

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