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Gene size matters: What determines gene length in the human genome?

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Outgoing claims: the papers this work cites, builds on, or argues with.

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3′UTRs take a long shot in the brain
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A Rising Titan:TTNReview and Mutation Update
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Dilated Cardiomyopathy
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Hypertrophic Cardiomyopathy
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The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis
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Gap junctions in the brain: where, what type, how many and why?
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ECM receptors in neuronal structure, synaptic plasticity, and behavior
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Chondroitin sulfate: A key molecule in the brain matrix
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Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain
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The Molecular Signatures Database Hallmark Gene Set Collection
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The evolution of the human genome
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Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells
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Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy
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STING-dependent cytosolic DNA sensing pathways
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Gangliosides of the Vertebrate Nervous System
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Human GRIN2B variants in neurodevelopmental disorders
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Steroidogenesis in the skin: Implications for local immune functions
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Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
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Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
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FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
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Gene Length Matters in Neurons
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Disruption of GRIN2B Impairs Differentiation in Human Neurons
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Arachidonic acid metabolism in skin health and disease
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Dilated cardiomyopathy
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Hypertrophic cardiomyopathy
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Human housekeeping genes are compact
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Initial sequencing and analysis of the human genome
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FLRT2 and FLRT3 act as repulsive guidance cues for Unc5‐positive neurons
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Finishing the euchromatic sequence of the human genome
inferredcites →https://doi.org/10.1038/ni.f.220openalex-snapshot
Calcium signaling in immune cells
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Sphingolipid metabolism in cancer signalling and therapy
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inferredcites →https://doi.org/10.1038/onc.2016.304openalex-snapshot
Wnt signaling in cancer
inferredcites →https://doi.org/10.1038/s41598-017-00424-0openalex-snapshot
Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells
inferredcites →https://doi.org/10.1038/s43587-022-00317-6openalex-snapshot
Aging is associated with a systemic length-associated transcriptome imbalance
inferredcites →https://doi.org/10.1038/sj.cr.7310107openalex-snapshot
ABC transporters, neural stem cells and neurogenesis – a different perspective
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Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
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Arrhythmogenic Right Ventricular Cardiomyopathy
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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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The universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages
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Keratan Sulfate Biosynthesis
inferredcites →https://doi.org/10.1080/15384101.2016.1234550openalex-snapshot
Gene length as a biological timer to establish temporal transcriptional regulation
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Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer
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The role of adherens junctions in the developing neocortex
inferredcites →https://doi.org/10.1093/ajcn/71.1.361sopenalex-snapshot
Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites
inferredcites →https://doi.org/10.1093/aje/kww224openalex-snapshot
Human Genome Sequencing at the Population Scale: A Primer on High-Throughput DNA Sequencing and Analysis
inferredcites →https://doi.org/10.1093/bib/bbw139openalex-snapshot
Gene co-expression analysis for functional classification and gene–disease predictions
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Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
inferredcites →https://doi.org/10.1093/bioinformatics/btr260openalex-snapshot
Molecular signatures database (MSigDB) 3.0
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/gkh103openalex-snapshot
The UCSC Table Browser data retrieval tool
inferredcites →https://doi.org/10.1093/nar/gkj109openalex-snapshot
BioGRID: a general repository for interaction datasets
inferredcites →https://doi.org/10.1093/nar/gkn923openalex-snapshot
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
inferredcites →https://doi.org/10.1093/nar/gku1042openalex-snapshot
GeneFriends: a human RNA-seq-based gene and transcript co-expression database
inferredcites →https://doi.org/10.1093/nar/gkw1092openalex-snapshot
KEGG: new perspectives on genomes, pathways, diseases and drugs
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Human Ageing Genomic Resources: new and updated databases
inferredcites →https://doi.org/10.1093/nar/gkx1098openalex-snapshot
Ensembl 2018
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New approach for understanding genome variations in KEGG
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WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs
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Molecular mechanisms of retinoid actions in skin
inferredcites →https://doi.org/10.1096/fj.14-257352openalex-snapshot
MUC16: molecular analysis and its functional implications in benign and malignant conditions
inferredcites →https://doi.org/10.1101/cshperspect.a001925openalex-snapshot
Initiating and Growing an Axon
inferredcites →https://doi.org/10.1101/cshperspect.a006023openalex-snapshot
Signaling in Muscle Contraction
inferredcites →https://doi.org/10.1101/gr.109595.110openalex-snapshot
Young proteins experience more variable selection pressures than old proteins
inferredcites →https://doi.org/10.1101/gr.146886.112openalex-snapshot
Widespread and extensive lengthening of 3′ UTRs in the mammalian brain
inferredcites →https://doi.org/10.1101/gr.169722.113openalex-snapshot
Gene length and expression level shape genomic novelties
inferredcites →https://doi.org/10.1101/gr.641103openalex-snapshot
The Signature of Selection Mediated by Expression on Human Genes
inferredcites →https://doi.org/10.1111/imr.12295openalex-snapshot
Drivers of age‐related inflammation and strategies for healthspan extension
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Genomics and the immune system
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Alternative splicing of SMADs in differentiation and tissue homeostasis
inferredcites →https://doi.org/10.1126/science.1058040openalex-snapshot
The Sequence of the Human Genome
inferredcites →https://doi.org/10.1146/annurev-med-051010-162644openalex-snapshot
Human Genome Sequencing in Health and Disease
inferredcites →https://doi.org/10.1158/0008-5472.can-15-1050openalex-snapshot
Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy
inferredcites →https://doi.org/10.1159/000330193openalex-snapshot
Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory
inferredcites →https://doi.org/10.1177/1073858416667270openalex-snapshot
How Wnt Signaling Builds the Brain: Bridging Development and Disease
inferredcites →https://doi.org/10.1186/1471-2148-14-50openalex-snapshot
Genes with a large intronic burden show greater evolutionary conservation on the protein level
inferredcites →https://doi.org/10.1186/1476-4598-13-129openalex-snapshot
MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress
inferredcites →https://doi.org/10.1186/s12864-016-2582-9openalex-snapshot
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases
inferredcites →https://doi.org/10.1186/s12964-017-0177-yopenalex-snapshot
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
inferredcites →https://doi.org/10.1186/s13227-018-0111-4openalex-snapshot
A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development
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Notch Signaling, Brain Development, and Human Disease
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Glycerolipid Metabolism and Signaling in Health and Disease
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Recent advances in understanding phosphoinositide signaling in the nervous system
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TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis
inferredcites →https://doi.org/10.1371/journal.pbio.2006643openalex-snapshot
Large-scale investigation of the reasons why potentially important genes are ignored
inferredcites →https://doi.org/10.1371/journal.pone.0021800openalex-snapshot
REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
inferredcites →https://doi.org/10.1371/journal.pone.0049093openalex-snapshot
Gene Size Matters
inferredcites →https://doi.org/10.15252/embj.201797674openalex-snapshot
Glycosphingolipid metabolic reprogramming drives neural differentiation
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The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases
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Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues
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Increasing Role of Titin Mutations in Neuromuscular Disorders
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The Role of Glycosphingolipids in Immune Cell Functions
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“You Shall Not Pass”—tight junctions of the blood brain barrier
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Roles of the ubiquitin proteasome system in the effects of drugs of abuse
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Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters
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