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Widespread selection against deleterious mutations in the Drosophila genome

https://doi.org/10.1101/2020.02.12.946392

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-0-387-21822-9openalex-snapshot

Mathematical Population Genetics : I. Theoretical Introduction

inferredcites →https://doi.org/10.1007/978-1-4613-0931-4_4openalex-snapshot

Historical Biogeography of the Drosophila melanogaster Species Subgroup

inferredcites →https://doi.org/10.1007/bf00275839openalex-snapshot

Frequency spectra of neutral and deleterious alleles in a finite population

inferredcites →https://doi.org/10.1007/bf02459575openalex-snapshot

Evolution in mendelian populations

inferredcites →https://doi.org/10.1016/0040-5809(72)90035-4openalex-snapshot

The sampling theory of selectively neutral alleles

inferredcites →https://doi.org/10.1016/0040-5809(75)90020-9openalex-snapshot

On the number of segregating sites in genetical models without recombination

inferredcites →https://doi.org/10.1016/j.tig.2011.06.003openalex-snapshot

Weighing the evidence for adaptation at the molecular level

inferredcites →https://doi.org/10.1016/j.tree.2010.04.001openalex-snapshot

Approximate Bayesian Computation (ABC) in practice

inferredcites →https://doi.org/10.1016/s0040-5809(02)00050-3openalex-snapshot

Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data

inferredcites →https://doi.org/10.1017/cbo9780511623486openalex-snapshot

The Neutral Theory of Molecular Evolution

inferredcites →https://doi.org/10.1017/s0016672300014634openalex-snapshot

The hitch-hiking effect of a favourable gene

inferredcites →https://doi.org/10.1017/s0016672300033619openalex-snapshot

The effect of recombination on background selection

inferredcites →https://doi.org/10.1017/s0305004100033193openalex-snapshot

Random processes in genetics

inferredcites →https://doi.org/10.1038/246096a0openalex-snapshot

Slightly Deleterious Mutant Substitutions in Evolution

inferredcites →https://doi.org/10.1038/nature04107openalex-snapshot

Adaptive evolution of non-coding DNA in Drosophila

inferredcites →https://doi.org/10.1038/nrg2146openalex-snapshot

The distribution of fitness effects of new mutations

inferredcites →https://doi.org/10.1038/nrg3454openalex-snapshot

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

inferredcites →https://doi.org/10.1038/scientificamerican1179-98openalex-snapshot

The Neutral Theory of Molecular Evolution

inferredcites →https://doi.org/10.1093/bfgp/elu038openalex-snapshot

Functional roles of nucleosome stability and dynamics

inferredcites →https://doi.org/10.1093/genetics/105.2.437openalex-snapshot

EVOLUTIONARY RELATIONSHIP OF DNA SEQUENCES IN FINITE POPULATIONS

inferredcites →https://doi.org/10.1093/genetics/114.2.525openalex-snapshot

THE ORGANIZATION OF GENETIC VARIATION FOR RECOMBINATION IN DROSOPHILA MELANOGASTER

inferredcites →https://doi.org/10.1093/genetics/123.4.887openalex-snapshot

The "hitchhiking effect" revisited.

inferredcites →https://doi.org/10.1093/genetics/132.4.1161openalex-snapshot

Population genetics of polymorphism and divergence.

inferredcites →https://doi.org/10.1093/genetics/138.1.227openalex-snapshot

Selection intensity for codon bias.

inferredcites →https://doi.org/10.1093/genetics/141.4.1605openalex-snapshot

Deleterious background selection with recombination.

inferredcites →https://doi.org/10.1093/genetics/155.3.1405openalex-snapshot

Hitchhiking Under Positive Darwinian Selection

inferredcites →https://doi.org/10.1093/genetics/159.4.1779openalex-snapshot

Directional Selection and the Site-Frequency Spectrum

inferredcites →https://doi.org/10.1093/genetics/162.1.203openalex-snapshot

Testing Models of Selection and Demography in Drosophila simulans

inferredcites →https://doi.org/10.1093/genetics/162.4.2025openalex-snapshot

Approximate Bayesian Computation in Population Genetics

inferredcites →https://doi.org/10.1093/genetics/69.1.71openalex-snapshot

MODIFICATION OF RECOMBINATION FREQUENCY IN DROSOPHILA. I. SELECTION FOR INCREASED AND DECREASED CROSSING OVER

inferredcites →https://doi.org/10.1093/genetics/69.1.85openalex-snapshot

MODIFICATION OF RECOMBINATION FREQUENCY IN DROSOPHILA. II. THE POLYGENIC CONTROL OF CROSSING OVER

inferredcites →https://doi.org/10.1093/genetics/76.3.447openalex-snapshot

SELECTION FOR REDUCED CROSSING OVER IN DROSOPHILA MELANOGASTER

inferredcites →https://doi.org/10.1093/molbev/msw195openalex-snapshot

A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus

inferredcites →https://doi.org/10.1093/nar/gky1003openalex-snapshot

FlyBase 2.0: the next generation

inferredcites →https://doi.org/10.1098/rstb.2009.0278openalex-snapshot

Genetic hitchhiking versus background selection: the controversy and its implications

inferredcites →https://doi.org/10.1098/rstb.2010.0106openalex-snapshot

Genetic linkage and natural selection

inferredcites →https://doi.org/10.1111/j.0014-3820.2002.tb00188.xopenalex-snapshot

THE ECOLOGY AND GENETICS OF FITNESS IN CHLAMYDOMONAS. XII. REPEATED SEXUAL EPISODES INCREASE RATES OF ADAPTATION TO NOVEL ENVIRONMENTS

inferredcites →https://doi.org/10.1146/annurev.genom.1.1.539openalex-snapshot

Methods to Detect Selection in Populations with Applications to the Human

inferredcites →https://doi.org/10.1371/journal.pcbi.1002803openalex-snapshot

Approximate Bayesian Computation

inferredcites →https://doi.org/10.1371/journal.pcbi.1004845openalex-snapshot

Deep Learning for Population Genetic Inference

inferredcites →https://doi.org/10.1371/journal.pgen.1000495openalex-snapshot

Pervasive Natural Selection in the Drosophila Genome?

inferredcites →https://doi.org/10.1371/journal.pgen.1002905openalex-snapshot

The Many Landscapes of Recombination in Drosophila melanogaster

inferredcites →https://doi.org/10.1371/journal.pgen.1003090openalex-snapshot

Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

inferredcites →https://doi.org/10.1371/journal.pgen.1003527openalex-snapshot

Strong Purifying Selection at Synonymous Sites in D. melanogaster

inferredcites →https://doi.org/10.1371/journal.pgen.1004434openalex-snapshot

Background Selection as Baseline for Nucleotide Variation across the Drosophila Genome

inferredcites →https://doi.org/10.1371/journal.pone.0190186openalex-snapshot

Generalization of the Ewens sampling formula to arbitrary fitness landscapes

inferredcites →https://doi.org/10.1534/genetics.105.048223openalex-snapshot

Approximate Bayesian Inference Reveals Evidence for a Recent, Severe Bottleneck in a Netherlands Population of Drosophila melanogaster

inferredcites →https://doi.org/10.1534/genetics.111.134288openalex-snapshot

The Effects of Deleterious Mutations on Evolution at Linked Sites

inferredcites →https://doi.org/10.1534/genetics.113.151670openalex-snapshot

Rates and Genomic Consequences of Spontaneous Mutational Events in Drosophila melanogaster

inferredcites →https://doi.org/10.1534/genetics.113.158758openalex-snapshot

Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family

inferredcites →https://doi.org/10.1534/genetics.115.174664openalex-snapshot

The Drosophila Genome Nexus: A Population Genomic Resource of 623 Drosophila melanogaster Genomes, Including 197 from a Single Ancestral Range Population

inferredcites →https://doi.org/10.4171/owr/2005/40openalex-snapshot

Mathematical Population Genetics

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