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Model-based identification of the crosstalks and feedbacks that determine the doxorubicin response dynamics of the JNK-p38-p53 network

https://doi.org/10.1101/2020.03.10.985994

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/emmm.201302732openalex-snapshot

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin‐induced apoptosis mediated by reactive oxygen species and JNK

inferredcites →https://doi.org/10.1006/bbrc.1999.1454openalex-snapshot

Pyridinylimidazole Compound SB 203580 Inhibits the Activity but Not the Activation of p38 Mitogen-Activated Protein Kinase

inferredcites →https://doi.org/10.1007/978-1-4939-2694-7_23openalex-snapshot

Multistrip Western Blotting: A Tool for Comparative Quantitative Analysis of Multiple Proteins

inferredcites →https://doi.org/10.1016/0014-5793(95)00357-fopenalex-snapshot

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

inferredcites →https://doi.org/10.1016/j.canlet.2016.10.008openalex-snapshot

Targeting p38 MAP kinase signaling in cancer through post-translational modifications

inferredcites →https://doi.org/10.1016/j.cell.2016.03.025openalex-snapshot

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

inferredcites →https://doi.org/10.1016/j.celrep.2018.08.020openalex-snapshot

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death

inferredcites →https://doi.org/10.1016/j.cels.2018.10.013openalex-snapshot

Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model

inferredcites →https://doi.org/10.1016/j.jtbi.2004.08.022openalex-snapshot

Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy

inferredcites →https://doi.org/10.1016/j.molmet.2016.12.001openalex-snapshot

JNK at the crossroad of obesity, insulin resistance, and cell stress response

inferredcites →https://doi.org/10.1016/j.yexcr.2009.09.007openalex-snapshot

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin

inferredcites →https://doi.org/10.1016/s0021-9258(17)37680-9openalex-snapshot

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

inferredcites →https://doi.org/10.1016/s0960-9822(01)00330-xopenalex-snapshot

Bistability in the JNK cascade

inferredcites →https://doi.org/10.1038/cdd.2011.113openalex-snapshot

A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila

inferredcites →https://doi.org/10.1038/embor.2008.149openalex-snapshot

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin‐induced liver failure

inferredcites →https://doi.org/10.1038/nbt.3185openalex-snapshot

Silence on the relevant literature and errors in implementation

inferredcites →https://doi.org/10.1038/ng2033openalex-snapshot

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot

NIH Image to ImageJ: 25 years of image analysis

inferredcites →https://doi.org/10.1038/nrc3983openalex-snapshot

The dynamic control of signal transduction networks in cancer cells

inferredcites →https://doi.org/10.1038/nrn3729openalex-snapshot

Nuclear and cytosolic JNK signalling in neurons

inferredcites →https://doi.org/10.1038/s41540-017-0023-2openalex-snapshot

Performance of objective functions and optimisation procedures for parameter estimation in system biology models

inferredcites →https://doi.org/10.1038/s41540-019-0096-1openalex-snapshot

Mapping connections in signaling networks with ambiguous modularity

inferredcites →https://doi.org/10.1038/s41580-019-0110-xopenalex-snapshot

The multiple mechanisms that regulate p53 activity and cell fate

inferredcites →https://doi.org/10.1038/s41598-018-34353-3openalex-snapshot

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

inferredcites →https://doi.org/10.1038/s41598-020-59636-6openalex-snapshot

trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

inferredcites →https://doi.org/10.1038/sj.onc.1205239openalex-snapshot

Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20

inferredcites →https://doi.org/10.1042/ebc20180012openalex-snapshot

Reverse engineering gene regulatory networks by modular response analysis – a benchmark

inferredcites →https://doi.org/10.1073/pnas.0703423105openalex-snapshot

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

inferredcites →https://doi.org/10.1073/pnas.1100600108openalex-snapshot

Two-phase dynamics of p53 in the DNA damage response

inferredcites →https://doi.org/10.1073/pnas.192442699openalex-snapshot

Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

inferredcites →https://doi.org/10.1073/pnas.251194298openalex-snapshot

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

inferredcites →https://doi.org/10.1074/jbc.c000781200openalex-snapshot

Stabilization of the MDM2 Oncoprotein by Mutant p53

inferredcites →https://doi.org/10.1074/jbc.m105134200openalex-snapshot

Osmotic Shock Induces G1 Arrest through p53 Phosphorylation at Ser33 by Activated p38MAPK without Phosphorylation at Ser15 and Ser20

inferredcites →https://doi.org/10.1074/jbc.m110.117911openalex-snapshot

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

inferredcites →https://doi.org/10.1074/jbc.m110299200openalex-snapshot

Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation

inferredcites →https://doi.org/10.1074/jbc.m113.452029openalex-snapshot

Tuning of Protein Kinase Circuitry by p38α Is Vital for Epithelial Tissue Homeostasis

inferredcites →https://doi.org/10.1074/jbc.m200453200openalex-snapshot

The Dual Specificity JKAP Specifically Activates the c-Jun N-terminal Kinase Pathway

inferredcites →https://doi.org/10.1074/jbc.m207396200openalex-snapshot

The Cytoprotective Aminothiol WR1065 Activates p53 through a Non-genotoxic Signaling Pathway Involving c-Jun N-terminal Kinase

inferredcites →https://doi.org/10.1074/jbc.m603324200openalex-snapshot

Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains

inferredcites →https://doi.org/10.1093/bioinformatics/bty473openalex-snapshot

Modelling signalling networks from perturbation data

inferredcites →https://doi.org/10.1093/emboj/18.23.6845openalex-snapshot

Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

inferredcites →https://doi.org/10.1093/emboj/19.23.6517openalex-snapshot

p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

inferredcites →https://doi.org/10.1093/emboj/cdg552openalex-snapshot

Feedback control of the protein kinase TAK1 by SAPK2a/p38α

inferredcites →https://doi.org/10.1097/cad.0000000000000572openalex-snapshot

Autophagy and doxorubicin resistance in cancer

inferredcites →https://doi.org/10.1101/cshperspect.a000968openalex-snapshot

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4

inferredcites →https://doi.org/10.1126/science.aac5610openalex-snapshot

Schedule-dependent interaction between anticancer treatments

inferredcites →https://doi.org/10.1126/scisignal.aab0990openalex-snapshot

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

inferredcites →https://doi.org/10.1126/scisignal.aah6671openalex-snapshot

p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

inferredcites →https://doi.org/10.1128/mcb.21.8.2743-2754.2001openalex-snapshot

Jun NH 2 -Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

inferredcites →https://doi.org/10.1128/mmbr.00043-14openalex-snapshot

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

inferredcites →https://doi.org/10.1158/0008-5472.can-18-2738openalex-snapshot

AKT as a Therapeutic Target for Cancer

inferredcites →https://doi.org/10.1186/1752-0509-7-57openalex-snapshot

Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology

inferredcites →https://doi.org/10.1242/jcs.179127openalex-snapshot

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

inferredcites →https://doi.org/10.1371/journal.pone.0087293openalex-snapshot

Evaluating Strategies to Normalise Biological Replicates of Western Blot Data

inferredcites →https://doi.org/10.15252/msb.20166982openalex-snapshot

Erratum To: Frequency modulation of ERK activation dynamics rewires cell fate

inferredcites →https://doi.org/10.15252/msb.20167258openalex-snapshot

Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation

inferredcites →https://doi.org/10.18632/oncotarget.1559openalex-snapshot

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

inferredcites →https://doi.org/10.3389/fphys.2012.00355openalex-snapshot

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

inferredcites →https://doi.org/10.3390/cancers10050131openalex-snapshot

Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

inferredcites →https://doi.org/10.4103/0973-1482.139267openalex-snapshot

An overview of doxorubicin formulations in cancer therapy

inferredcites →https://doi.org/10.5306/wjco.v7.i5.352openalex-snapshot

Role of Akt signaling in resistance to DNA-targeted therapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41598-025-89884-3openalex-snapshot

PHD-2/HIF-1α axis mediates doxorubicin-induced angiogenesis in SH-SY5Y neuroblastoma microenvironment: a potential survival mechanism

inferred← citeshttps://doi.org/10.3390/ijms231810895openalex-snapshot

Doxorubicin-Induced TrkAIII Activation: A Selection Mechanism for Resistant Dormant Neuroblastoma Cells

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