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Recapitulating evolutionary divergence in a single cis -regulatory element is sufficient to cause expression changes of the lens gene Tdrd7
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Visual system of a naturally microphthalmic mammal: The blind mole rat, Spalax ehrenbergi
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Bacterial Artificial Chromosome Transgenesis Through Pronuclear Injection of Fertilized Mouse Oocytes
inferredcites →https://doi.org/10.1007/s00359-004-0584-6openalex-snapshot
Features of visual function in the naked mole-rat Heterocephalus glaber
inferredcites →https://doi.org/10.1007/s003590050396openalex-snapshot
A nose that looks like a hand and acts like an eye: the unusual mechanosensory system of the star-nosed mole
inferredcites →https://doi.org/10.1016/c2009-0-56108-9openalex-snapshot
Clinical Anatomy and Physiology of the Visual System
inferredcites →https://doi.org/10.1016/j.ajo.2013.10.021openalex-snapshot
Cone Abnormalities in Fundus Albipunctatus Associated With RDH5 Mutations Assessed Using Adaptive Optics Scanning Laser Ophthalmoscopy
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The visual system in subterranean African mole-rats (Rodentia, Bathyergidae): Retina, subcortical visual nuclei and primary visual cortex
inferredcites →https://doi.org/10.1016/j.cell.2008.06.030openalex-snapshot
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
inferredcites →https://doi.org/10.1016/j.cell.2016.09.028openalex-snapshot
Progressive Loss of Function in a Limb Enhancer during Snake Evolution
inferredcites →https://doi.org/10.1016/j.celrep.2014.07.030openalex-snapshot
Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes
inferredcites →https://doi.org/10.1016/j.pep.2005.01.016openalex-snapshot
Protein production by auto-induction in high-density shaking cultures
inferredcites →https://doi.org/10.1016/j.tibtech.2018.12.002openalex-snapshot
The Ultimate qPCR Experiment: Producing Publication Quality, Reproducible Data the First Time
inferredcites →https://doi.org/10.1016/j.ydbio.2006.10.046openalex-snapshot
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: Domain composition, intracellular localization, and function in male germ cells in mice
inferredcites →https://doi.org/10.1016/j.ympev.2014.05.016openalex-snapshot
Eyes underground: Regression of visual protein networks in subterranean mammals
inferredcites →https://doi.org/10.1038/361156a0openalex-snapshot
Ocular regression conceals adaptive progression of the visual system in a blind subterranean mammal
inferredcites →https://doi.org/10.1038/gim.2017.130openalex-snapshot
Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans
inferredcites →https://doi.org/10.1038/msb.2012.40openalex-snapshot
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Phenotypic robustness conferred by apparently redundant transcriptional enhancers
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Genome sequencing reveals insights into physiology and longevity of the naked mole rat
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An integrated encyclopedia of DNA elements in the human genome
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The genetic architecture of type 2 diabetes
inferredcites →https://doi.org/10.1038/nature25461openalex-snapshot
Enhancer redundancy provides phenotypic robustness in mammalian development
inferredcites →https://doi.org/10.1038/ncomms4966openalex-snapshot
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
inferredcites →https://doi.org/10.1038/ng.241openalex-snapshot
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa
inferredcites →https://doi.org/10.1038/ng.3911openalex-snapshot
Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
inferredcites →https://doi.org/10.1038/ng.608openalex-snapshot
Common SNPs explain a large proportion of the heritability for human height
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/nrg2063openalex-snapshot
The evolutionary significance of cis-regulatory mutations
inferredcites →https://doi.org/10.1038/s41467-018-03667-1openalex-snapshot
A genomics approach reveals insights into the importance of gene losses for mammalian adaptations
inferredcites →https://doi.org/10.1038/s41467-018-07122-zopenalex-snapshot
Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution
inferredcites →https://doi.org/10.1038/s41586-019-0875-2openalex-snapshot
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline
inferredcites →https://doi.org/10.1038/s41588-019-0538-0openalex-snapshot
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
inferredcites →https://doi.org/10.1038/s42003-018-0226-0openalex-snapshot
Identification of genes required for eye development by high-throughput screening of mouse knockouts
inferredcites →https://doi.org/10.1073/pnas.1015447108openalex-snapshot
Tudor domain containing 7 ( Tdrd7 ) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis
inferredcites →https://doi.org/10.1073/pnas.1818504116openalex-snapshot
Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores
inferredcites →https://doi.org/10.1074/mcp.o117.067082openalex-snapshot
MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting
inferredcites →https://doi.org/10.1093/bioinformatics/14.1.48openalex-snapshot
Combining evidence using p-values: application to sequence homology searches.
inferredcites →https://doi.org/10.1093/bioinformatics/btq033openalex-snapshot
BEDTools: a flexible suite of utilities for comparing genomic features
inferredcites →https://doi.org/10.1093/bioinformatics/btq054openalex-snapshot
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
inferredcites →https://doi.org/10.1093/gbe/evy243openalex-snapshot
Loss of Enzymes in the Bile Acid Synthesis Pathway Explains Differences in Bile Composition among Mammals
inferredcites →https://doi.org/10.1093/hmg/ddv259openalex-snapshot
Non-coding genetic variants in human disease: Figure 1.
inferredcites →https://doi.org/10.1093/molbev/msw098openalex-snapshot
Controlling for Phylogenetic Relatedness and Evolutionary Rates Improves the Discovery of Associations Between Species’ Phenotypic and Genomic Differences
inferredcites →https://doi.org/10.1093/molbev/msy187openalex-snapshot
REforge associates transcription factor binding site divergence in regulatory elements with phenotypic differences between species
inferredcites →https://doi.org/10.1093/nar/gky1200openalex-snapshot
TFforge utilizes large-scale binding site divergence to identify transcriptional regulators involved in phenotypic differences
inferredcites →https://doi.org/10.1093/nargab/lqz012openalex-snapshot
Losses of human disease-associated genes in placental mammals
inferredcites →https://doi.org/10.1101/gad.1620408openalex-snapshot
Regulatory divergence modifies limb length between mammals
inferredcites →https://doi.org/10.1101/gr.109405.110openalex-snapshot
CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors
inferredcites →https://doi.org/10.1101/gr.3715005openalex-snapshot
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
inferredcites →https://doi.org/10.1126/sciadv.1602878openalex-snapshot
Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades
inferredcites →https://doi.org/10.1126/sciadv.aaw6671openalex-snapshot
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
inferredcites →https://doi.org/10.1126/science.1182213openalex-snapshot
Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer
inferredcites →https://doi.org/10.1126/science.1195970openalex-snapshot
Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma
inferredcites →https://doi.org/10.1126/science.aap7714openalex-snapshot
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals
inferredcites →https://doi.org/10.1126/science.aas9408openalex-snapshot
Sex reversal following deletion of a single distal enhancer of Sox9
inferredcites →https://doi.org/10.1136/jmedgenet-2017-104837openalex-snapshot
Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci
inferredcites →https://doi.org/10.1167/iovs.07-0013openalex-snapshot
Genetic Heterogeneity in Microcornea-Cataract: Five Novel Mutations in CRYAA , CRYGD , and GJA8
inferredcites →https://doi.org/10.1167/iovs.12-9662openalex-snapshot
The Rd8 Mutation of the Crb1 Gene Is Present in Vendor Lines of C57BL/6N Mice and Embryonic Stem Cells, and Confounds Ocular Induced Mutant Phenotypes
inferredcites →https://doi.org/10.1186/s13072-019-0272-yopenalex-snapshot
Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways
inferredcites →https://doi.org/10.1242/dev.158550openalex-snapshot
Disrupting the three-dimensional regulatory topology of the Pitx1 locus results in overtly normal development
inferredcites →https://doi.org/10.1242/jcs.s2-53.210.327openalex-snapshot
The Eyes of Chrysochloris hottentota and C. asiatica
inferredcites →https://doi.org/10.1371/journal.pbio.0050234openalex-snapshot
Deletion of Ultraconserved Elements Yields Viable Mice
inferredcites →https://doi.org/10.1371/journal.pbio.2005293openalex-snapshot
Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals
inferredcites →https://doi.org/10.1371/journal.pcbi.1001025openalex-snapshot
Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
inferredcites →https://doi.org/10.1371/journal.pgen.1000634openalex-snapshot
Molecular Decay of the Tooth Gene Enamelin (ENAM) Mirrors the Loss of Enamel in the Fossil Record of Placental Mammals
inferredcites →https://doi.org/10.1371/journal.pgen.1002649openalex-snapshot
Transcriptional Regulation of Rod Photoreceptor Homeostasis Revealed by In Vivo NRL Targetome Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0089110openalex-snapshot
Otx2 ChIP-seq Reveals Unique and Redundant Functions in the Mature Mouse Retina
inferredcites →https://doi.org/10.3390/ijms161226120openalex-snapshot
Parallel Reaction Monitoring: A Targeted Experiment Performed Using High Resolution and High Mass Accuracy Mass Spectrometry
inferredcites →https://doi.org/10.7554/elife.11613openalex-snapshot
Epigenomic landscapes of retinal rods and cones
inferredcites →https://doi.org/10.7554/elife.25884openalex-snapshot
Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling
inferredcites →https://doi.org/10.7554/elife.27240openalex-snapshot
A tunable refractive index matching medium for live imaging cells, tissues and model organisms
inferredcites →https://doi.org/10.7554/elife.29329openalex-snapshot
Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height
inferredcites →https://doi.org/10.7554/elife.38555openalex-snapshot
A novel enhancer near the Pitx1 gene influences development and evolution of pelvic appendages in vertebrates
inferredcites →https://doi.org/10.7554/elife.42014openalex-snapshot
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
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