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Repurposing Pyramax® for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate

https://doi.org/10.1101/2020.04.25.061333

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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High Throughput and Computational Repurposing for Neglected Diseases

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Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 to Treat Pitt Hopkins Syndrome

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Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond

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Comparison of the predicted and observed secondary structure of T4 phage lysozyme

inferredcites →https://doi.org/10.1016/j.antiviral.2016.11.017openalex-snapshot

Synergistic drug combination effectively blocks Ebola virus infection

inferredcites →https://doi.org/10.1016/j.antiviral.2020.104863openalex-snapshot

Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig

inferredcites →https://doi.org/10.1016/j.chom.2018.12.005openalex-snapshot

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

inferredcites →https://doi.org/10.1016/j.drudis.2018.01.018openalex-snapshot

A bibliometric review of drug repurposing

inferredcites →https://doi.org/10.1016/j.tiv.2010.12.010openalex-snapshot

A high content screening assay for identifying lysosomotropic compounds

inferredcites →https://doi.org/10.1016/j.toxrep.2014.10.019openalex-snapshot

Chloroquine and hydroxychloroquine binding to melanin: Some possible consequences for pathologies

inferredcites →https://doi.org/10.1016/s1473-3099(18)30397-9openalex-snapshot

Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study

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Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

inferredcites →https://doi.org/10.1021/acs.jcim.5b00144openalex-snapshot

Open Source Bayesian Models. 2. Mining a “Big Dataset” To Create and Validate Models with ChEMBL

inferredcites →https://doi.org/10.1021/acs.molpharmaceut.8b00083openalex-snapshot

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

inferredcites →https://doi.org/10.1021/acs.molpharmaceut.8b00546openalex-snapshot

Comparing Multiple Machine Learning Algorithms and Metrics for Estrogen Receptor Binding Prediction

inferredcites →https://doi.org/10.1021/acs.molpharmaceut.8b01214openalex-snapshot

Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches

inferredcites →https://doi.org/10.1021/acs.molpharmaceut.8b01297openalex-snapshot

Multiple Machine Learning Comparisons of HIV Cell-based and Reverse Transcriptase Data Sets

inferredcites →https://doi.org/10.1021/acsinfecdis.5b00030openalex-snapshot

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

inferredcites →https://doi.org/10.1021/acsomega.8b02948openalex-snapshot

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

inferredcites →https://doi.org/10.1021/js960001iopenalex-snapshot

Transport of Artemisinin and Sodium Artesunate in Caco-2 Intestinal Epithelial Cells

inferredcites →https://doi.org/10.1038/d41586-019-02415-9openalex-snapshot

Pandemic bonds: designed to fail in Ebola

inferredcites →https://doi.org/10.1038/nature13777openalex-snapshot

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

inferredcites →https://doi.org/10.1038/s41421-020-0156-0openalex-snapshot

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

inferredcites →https://doi.org/10.1038/s41422-020-0282-0openalex-snapshot

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

inferredcites →https://doi.org/10.1038/s41563-019-0338-zopenalex-snapshot

Exploiting machine learning for end-to-end drug discovery and development

inferredcites →https://doi.org/10.1038/srep25523openalex-snapshot

BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action

inferredcites →https://doi.org/10.1039/c8mt00342dopenalex-snapshot

High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of Staphylococcus aureus

inferredcites →https://doi.org/10.1056/nejmoa1910993openalex-snapshot

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

inferredcites →https://doi.org/10.1056/nejmsr1904253openalex-snapshot

The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019

inferredcites →https://doi.org/10.1078/0940-2993-00338openalex-snapshot

Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential

inferredcites →https://doi.org/10.1093/infdis/jiy304openalex-snapshot

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

inferredcites →https://doi.org/10.1093/infdis/jiy345openalex-snapshot

In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

inferredcites →https://doi.org/10.1093/nar/gkaa216openalex-snapshot

SynergyFinder 2.0: visual analytics of multi-drug combination synergies

inferredcites →https://doi.org/10.1099/0022-1317-43-1-247openalex-snapshot

Regulation of the Interferon System: Evidence that Vero Cells have a Genetic Defect in Interferon Production

inferredcites →https://doi.org/10.1099/jgv.0.000309openalex-snapshot

Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model

inferredcites →https://doi.org/10.1124/dmd.112.050054openalex-snapshot

Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)

inferredcites →https://doi.org/10.1124/mol.117.111443openalex-snapshot

Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates

inferredcites →https://doi.org/10.1126/science.aad5224openalex-snapshot

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

inferredcites →https://doi.org/10.1126/scitranslmed.3005471openalex-snapshot

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

inferredcites →https://doi.org/10.1128/aac.00440-20openalex-snapshot

Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses

inferredcites →https://doi.org/10.1128/aac.00819-20openalex-snapshot

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs

inferredcites →https://doi.org/10.1128/aac.01142-19openalex-snapshot

Repurposing Quinacrine against Ebola Virus Infection In Vivo

inferredcites →https://doi.org/10.1128/aac.01711-17openalex-snapshot

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

inferredcites →https://doi.org/10.1128/jvi.2.10.955-961.1968openalex-snapshot

Defectiveness of Interferon Production and of Rubella Virus Interference in a Line of African Green Monkey Kidney Cells (Vero)

inferredcites →https://doi.org/10.1162/089120104773633402openalex-snapshot

The Kappa Statistic: A Second Look

inferredcites →https://doi.org/10.1172/jci89857openalex-snapshot

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

inferredcites →https://doi.org/10.1177/001316446002000104openalex-snapshot

A Coefficient of Agreement for Nominal Scales

inferredcites →https://doi.org/10.1186/1475-2875-11-270openalex-snapshot

Review of pyronaridine anti-malarial properties and product characteristics

inferredcites →https://doi.org/10.12688/f1000research.6181.1openalex-snapshot

Finding small molecules for the ‘next Ebola’

inferredcites →https://doi.org/10.12688/f1000research.7217.1openalex-snapshot

Machine learning models identify molecules active against the Ebola virus in vitro [version 1; referees: 2 approved]

inferredcites →https://doi.org/10.12688/f1000research.7217.3openalex-snapshot

Machine learning models identify molecules active against the Ebola virus in vitro

inferredcites →https://doi.org/10.1371/journal.pcbi.1007604openalex-snapshot

SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy

inferredcites →https://doi.org/10.1371/journal.pntd.0004364openalex-snapshot

A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus

inferredcites →https://doi.org/10.1371/journal.pntd.0007890openalex-snapshot

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection

inferredcites →https://doi.org/10.1371/journal.pone.0060579openalex-snapshot

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

inferredcites →https://doi.org/10.1371/journal.pone.0166318openalex-snapshot

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

inferredcites →https://doi.org/10.3390/v8110277openalex-snapshot

Antiviral Screening of Multiple Compounds against Ebola Virus

inferredcites →https://doi.org/10.48550/arxiv.cmp-lg/9602004openalex-snapshot

Assessing agreement on classification tasks: the kappa statistic

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00091openalex-snapshot

Pyronaridine Protects against SARS-CoV-2 Infection in Mouse

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.0c00298openalex-snapshot

Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein

inferred← citeshttps://doi.org/10.1101/2020.07.28.225102openalex-snapshot

Pyronaridine and artesunate are potential antiviral drugs against COVID-19 and influenza

inferred← citeshttps://doi.org/10.1101/2021.09.30.462449openalex-snapshot

Pyronaridine Protects Against SARS-CoV-2 in Mouse

inferred← citeshttps://doi.org/10.3390/ijms25136998openalex-snapshot

Inter-Species Pharmacokinetic Modeling and Scaling for Drug Repurposing of Pyronaridine and Artesunate

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