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The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States
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Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
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Host Factors in Coronavirus Replication
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Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo
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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
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Protease inhibitors targeting coronavirus and filovirus entry
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Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus
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Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment
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The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression
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Everolimus delayed and suppressed cytomegalovirus DNA synthesis, spread of the infection, and alleviated cytomegalovirus infection
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Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells
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Free fatty acids or high-concentration glucose enhances hepatitis A virus replication in association with a reduction in glucose-regulated protein 78 expression
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Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells
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Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
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Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy
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A modular master regulator landscape controls cancer transcriptional identity
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The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1016/j.celrep.2017.07.052openalex-snapshot
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis
inferredcites →https://doi.org/10.1016/j.cels.2015.12.004openalex-snapshot
The Molecular Signatures Database Hallmark Gene Set Collection
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Induction and function of type I and III interferon in response to viral infection
inferredcites →https://doi.org/10.1016/j.coviro.2014.06.002openalex-snapshot
Antiviral drugs specific for coronaviruses in preclinical development
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New drug-strategies to tackle viral-host interactions for the treatment of influenza virus infections
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Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor
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Lung pathology of fatal severe acute respiratory syndrome
inferredcites →https://doi.org/10.1016/s0955-0674(00)00280-5openalex-snapshot
Mammalian G1- and S-phase checkpoints in response to DNA damage
inferredcites →https://doi.org/10.1038/d41573-020-00016-0openalex-snapshot
Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
inferredcites →https://doi.org/10.1038/msb.2010.31openalex-snapshot
A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
inferredcites →https://doi.org/10.1038/nature08712openalex-snapshot
The transcriptional network for mesenchymal transformation of brain tumours
inferredcites →https://doi.org/10.1038/ng.3593openalex-snapshot
Functional characterization of somatic mutations in cancer using network-based inference of protein activity
inferredcites →https://doi.org/10.1038/ng1532openalex-snapshot
Reverse engineering of regulatory networks in human B cells
inferredcites →https://doi.org/10.1038/nm.4184openalex-snapshot
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
inferredcites →https://doi.org/10.1038/nn.4070openalex-snapshot
Identification of neurodegenerative factors using translatome–regulatory network analysis
inferredcites →https://doi.org/10.1038/nrc.2016.124openalex-snapshot
The recurrent architecture of tumour initiation, progression and drug sensitivity
inferredcites →https://doi.org/10.1038/nrc2248openalex-snapshot
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
inferredcites →https://doi.org/10.1038/nrd.2015.37openalex-snapshot
Coronaviruses — drug discovery and therapeutic options
inferredcites →https://doi.org/10.1038/nrm3629openalex-snapshot
Control of cell cycle transcription during G1 and S phases
inferredcites →https://doi.org/10.1038/nrm831openalex-snapshot
Cellular roles of DNA topoisomerases: a molecular perspective
inferredcites →https://doi.org/10.1038/s41421-020-0153-3openalex-snapshot
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
inferredcites →https://doi.org/10.1038/s41467-017-00136-zopenalex-snapshot
PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens
inferredcites →https://doi.org/10.1038/s41467-018-03843-3openalex-snapshot
Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
inferredcites →https://doi.org/10.1038/s41586-020-2286-9openalex-snapshot
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
inferredcites →https://doi.org/10.1038/s41588-018-0138-4openalex-snapshot
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
inferredcites →https://doi.org/10.1038/s41598-018-32523-xopenalex-snapshot
Medium throughput breathing human primary cell alveolus-on-chip model
inferredcites →https://doi.org/10.1038/sj.emboj.7600640openalex-snapshot
Receptor and viral determinants of SARS‐coronavirus adaptation to human ACE2
inferredcites →https://doi.org/10.1056/nejmoa1903455openalex-snapshot
Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma
inferredcites →https://doi.org/10.1056/nejmoa2001017openalex-snapshot
A Novel Coronavirus from Patients with Pneumonia in China, 2019
inferredcites →https://doi.org/10.1056/nejmra032498openalex-snapshot
The Severe Acute Respiratory Syndrome
inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
inferredcites →https://doi.org/10.1074/jbc.m110.112045openalex-snapshot
Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR
inferredcites →https://doi.org/10.1074/jbc.m509233200openalex-snapshot
The Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus Inhibits the Activity of Cyclin-Cyclin-dependent Kinase Complex and Blocks S Phase Progression in Mammalian Cells
inferredcites →https://doi.org/10.1093/bioinformatics/bts635openalex-snapshot
STAR: ultrafast universal RNA-seq aligner
inferredcites →https://doi.org/10.1097/qco.0000000000000498openalex-snapshot
Neuraminidase inhibitor resistance in influenza: a clinical perspective
inferredcites →https://doi.org/10.1099/vir.0.82483-0openalex-snapshot
Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation
inferredcites →https://doi.org/10.1101/677435openalex-snapshot
Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis
inferredcites →https://doi.org/10.1111/cei.12720openalex-snapshot
Respiratory syncytial virus induces phosphorylation of mTOR at ser2448 in CD8 T cells from nasal washes of infected infants
inferredcites →https://doi.org/10.1126/scitranslmed.3005471openalex-snapshot
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection
inferredcites →https://doi.org/10.1128/aac.03011-14openalex-snapshot
Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture
inferredcites →https://doi.org/10.1128/aac.03036-14openalex-snapshot
Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection
inferredcites →https://doi.org/10.1128/aac.03659-14openalex-snapshot
Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis
inferredcites →https://doi.org/10.1128/jvi.01323-14openalex-snapshot
West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression
inferredcites →https://doi.org/10.1128/jvi.01415-17openalex-snapshot
The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
inferredcites →https://doi.org/10.1128/jvi.01579-15openalex-snapshot
Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization
inferredcites →https://doi.org/10.1128/jvi.02705-14openalex-snapshot
AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets
inferredcites →https://doi.org/10.1128/jvi.07012-11openalex-snapshot
The Coronavirus Endoribonuclease Nsp15 Interacts with Retinoblastoma Tumor Suppressor Protein
inferredcites →https://doi.org/10.1128/jvi.79.13.8388-8399.2005openalex-snapshot
Flavivirus Activates Phosphatidylinositol 3-Kinase Signaling To Block Caspase-Dependent Apoptotic Cell Death at the Early Stage of Virus Infection
inferredcites →https://doi.org/10.1146/annurev-micro-020518-115759openalex-snapshot
Human Coronavirus: Host-Pathogen Interaction
inferredcites →https://doi.org/10.1158/0008-5472.can-15-0828openalex-snapshot
Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression
inferredcites →https://doi.org/10.1158/2159-8290.cd-16-0861openalex-snapshot
Cross-Cohort Analysis Identifies a TEAD4–MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma
inferredcites →https://doi.org/10.1172/jci153876openalex-snapshot
BACH2 inhibition reverses β cell failure in type 2 diabetes models
inferredcites →https://doi.org/10.1172/jci89857openalex-snapshot
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1186/s13059-015-0593-5openalex-snapshot
Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks
inferredcites →https://doi.org/10.1371/journal.pone.0008729openalex-snapshot
Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection
inferredcites →https://doi.org/10.1371/journal.pone.0069374openalex-snapshot
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
inferredcites →https://doi.org/10.1371/journal.ppat.1002331openalex-snapshot
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
inferredcites →https://doi.org/10.2202/1544-6115.1027openalex-snapshot
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
inferredcites →https://doi.org/10.3390/v8060152openalex-snapshot
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
inferredcites →https://doi.org/10.6002/ect.2015.0292openalex-snapshot
Use of Everolimus-based Immunosuppression to Decrease Cytomegalovirus Infection After Kidney Transplant.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/rmv.2500openalex-snapshot
Targeting epidermal growth factor receptor signalling pathway: A promising therapeutic option for COVID‐19
inferred← citeshttps://doi.org/10.1007/7355_2021_121openalex-snapshot
Machine Learning Methods in Antiviral Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-3-031-68419-7_13openalex-snapshot
Drug Repositioning as an Antiviral Strategy Against Emerging Viruses
inferred← citeshttps://doi.org/10.1007/s11095-021-03112-xopenalex-snapshot
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections
inferred← citeshttps://doi.org/10.1016/j.antiviral.2021.105115openalex-snapshot
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.07.016openalex-snapshot
Niclosamide: A career builder
inferred← citeshttps://doi.org/10.1093/bib/bbaa328openalex-snapshot
A review of COVID-19 biomarkers and drug targets: resources and tools
inferred← citeshttps://doi.org/10.1093/nar/gkab1226openalex-snapshot
Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p
inferred← citeshttps://doi.org/10.1101/2021.06.08.447491openalex-snapshot
ROS/RNS balancing, aerobic fermentation regulation and cell cycle control – a complex early trait (‘CoV-MAC-TED’) for combating SARS-CoV-2-induced cell reprogramming
inferred← citeshttps://doi.org/10.1101/2021.09.14.21263603openalex-snapshot
Predominance of Distinct Autoantibodies in Response to SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.1101/2021.10.18.464828openalex-snapshot
Transcriptome data from human nasal epithelial cells infected by H3N2 influenza virus indicate early unbalanced ROS/RNA levels, temporarily increased aerobic fermentation linked to enhanced α-tubulin and rapid energy-dependent IRF9-marked immunization
inferred← citeshttps://doi.org/10.1101/2023.10.08.561457openalex-snapshot
Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis
inferred← citeshttps://doi.org/10.1177/2472555220973597openalex-snapshot
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target
inferred← citeshttps://doi.org/10.1186/s41120-023-00072-xopenalex-snapshot
Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1010021openalex-snapshot
Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity
inferred← citeshttps://doi.org/10.3389/fimmu.2021.673692openalex-snapshot
ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell Reprogramming
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