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POMC-specific knockdown of Tril reduces body adiposity and increases hypothalamic leptin responsiveness

https://doi.org/10.1101/2020.06.25.172379

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2018.3060openalex-snapshot

Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007-2008 to 2015-2016

inferredcites →https://doi.org/10.1016/j.bbrc.2017.03.066openalex-snapshot

Puromycin-resistant lentiviral control shRNA vector, pLKO.1 induces unexpected cellular differentiation of P19 embryonic stem cells

inferredcites →https://doi.org/10.1016/j.cell.2008.07.043openalex-snapshot

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

inferredcites →https://doi.org/10.1016/j.cell.2013.09.003openalex-snapshot

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

inferredcites →https://doi.org/10.1016/j.cell.2015.03.008openalex-snapshot

The Hunger Genes: Pathways to Obesity

inferredcites →https://doi.org/10.1016/j.cell.2016.05.019openalex-snapshot

Near-Perfect Synaptic Integration by Na v 1.7 in Hypothalamic Neurons Regulates Body Weight

inferredcites →https://doi.org/10.1016/j.cmet.2008.12.004openalex-snapshot

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

inferredcites →https://doi.org/10.1016/j.cmet.2009.08.013openalex-snapshot

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

inferredcites →https://doi.org/10.1016/j.cmet.2019.05.021openalex-snapshot

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

inferredcites →https://doi.org/10.1016/j.cmet.2019.08.010openalex-snapshot

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

inferredcites →https://doi.org/10.1016/j.mce.2017.07.029openalex-snapshot

Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity

inferredcites →https://doi.org/10.1016/j.mce.2019.110574openalex-snapshot

Growth hormone/STAT5 signaling in proopiomelanocortin neurons regulates glucoprivic hyperphagia

inferredcites →https://doi.org/10.1016/j.molmet.2016.07.012openalex-snapshot

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

inferredcites →https://doi.org/10.1016/j.neuron.2004.06.004openalex-snapshot

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

inferredcites →https://doi.org/10.1016/s2213-8587(16)30273-xopenalex-snapshot

Association between excessive BMI increase during puberty and risk of cardiovascular mortality in adult men: a population-based cohort study

inferredcites →https://doi.org/10.1038/ijo.2011.56openalex-snapshot

Altered hypothalamic function in diet-induced obesity

inferredcites →https://doi.org/10.1038/ncomms15143openalex-snapshot

TNFα drives mitochondrial stress in POMC neurons in obesity

inferredcites →https://doi.org/10.1038/nm.2372openalex-snapshot

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

inferredcites →https://doi.org/10.1038/nm.3616openalex-snapshot

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

inferredcites →https://doi.org/10.1038/nm.3673openalex-snapshot

Atypical transforming growth factor–β signaling in the hypothalamus is linked to diabetes

inferredcites →https://doi.org/10.1038/nn.4495openalex-snapshot

A molecular census of arcuate hypothalamus and median eminence cell types

inferredcites →https://doi.org/10.1038/nrendo.2016.107openalex-snapshot

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

inferredcites →https://doi.org/10.1038/s41576-019-0150-2openalex-snapshot

RNA sequencing: the teenage years

inferredcites →https://doi.org/10.1056/nejmoa1512693openalex-snapshot

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

inferredcites →https://doi.org/10.1089/hgtb.2011.034openalex-snapshot

Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences

inferredcites →https://doi.org/10.1093/jnen/nly126openalex-snapshot

Downregulation of LncRNATUG1Inhibited TLR4 Signaling Pathway-Mediated Inflammatory Damage After Spinal Cord Ischemia Reperfusion in Rats via Suppressing TRIL Expression

inferredcites →https://doi.org/10.1152/ajpendo.00249.2011openalex-snapshot

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

inferredcites →https://doi.org/10.1172/jci36714openalex-snapshot

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

inferredcites →https://doi.org/10.1172/jci59660openalex-snapshot

Obesity is associated with hypothalamic injury in rodents and humans

inferredcites →https://doi.org/10.1172/jci62543openalex-snapshot

Obesity-programmed mice are rescued by early genetic intervention

inferredcites →https://doi.org/10.1172/jci88878openalex-snapshot

Hypothalamic inflammation in obesity and metabolic disease

inferredcites →https://doi.org/10.1172/jci9397openalex-snapshot

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

inferredcites →https://doi.org/10.1210/en.2004-1520openalex-snapshot

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

inferredcites →https://doi.org/10.1210/en.2014-1090openalex-snapshot

Defective Regulation of the Ubiquitin/Proteasome System in the Hypothalamus of Obese Male Mice

inferredcites →https://doi.org/10.1210/en.2014-1373openalex-snapshot

Conditional Expression ofPomcin theLepr-Positive Subpopulation of POMC Neurons Is Sufficient for Normal Energy Homeostasis and Metabolism

inferredcites →https://doi.org/10.1371/journal.pbio.1001112openalex-snapshot

Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation

inferredcites →https://doi.org/10.1371/journal.pone.0005045openalex-snapshot

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

inferredcites →https://doi.org/10.1523/jneurosci.2760-08.2009openalex-snapshot

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

inferredcites →https://doi.org/10.1530/ey.17.15.16openalex-snapshot

Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding

inferredcites →https://doi.org/10.1530/joe-19-0364openalex-snapshot

Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism

inferredcites →https://doi.org/10.2337/db11-0390openalex-snapshot

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

inferredcites →https://doi.org/10.2337/db12-1605openalex-snapshot

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

inferredcites →https://doi.org/10.2337/db13-1495openalex-snapshot

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

inferredcites →https://doi.org/10.4049/jimmunol.0901518openalex-snapshot

TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain

inferredcites →https://doi.org/10.4049/jimmunol.1302392openalex-snapshot

TRIL Is Involved in Cytokine Production in the Brain following Escherichia coli Infection

inferredcites →https://doi.org/10.7554/elife.09800openalex-snapshot

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.51847/n1hvob1ansopenalex-snapshot

Hypothalamic neuroinflammation induced by obesity and the effect of Liraglutide

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