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High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

https://doi.org/10.1371/journal.pone.0005045

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inferred← citeshttps://doi.org/10.1016/j.mcn.2016.07.003openalex-snapshot

Orexin A attenuates palmitic acid-induced hypothalamic cell death

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inferred← citeshttps://doi.org/10.1016/j.metabol.2020.154694openalex-snapshot

LKB1 up-regulation inhibits hypothalamic inflammation and attenuates diet-induced obesity in mice

inferred← citeshttps://doi.org/10.1016/j.molmet.2012.07.001openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.molmet.2012.10.001openalex-snapshot

Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity

inferred← citeshttps://doi.org/10.1016/j.neuint.2018.08.010openalex-snapshot

Palmitate treated-astrocyte conditioned medium contains increased glutathione and interferes in hypothalamic synaptic network in vitro

inferred← citeshttps://doi.org/10.1016/j.neulet.2012.07.002openalex-snapshot

Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model

inferred← citeshttps://doi.org/10.1016/j.neulet.2021.136261openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.108983openalex-snapshot

The timeline of neuronal and glial alterations in experimental obesity

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2010.08.013openalex-snapshot

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.02.044openalex-snapshot

Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.11.009openalex-snapshot

Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2018.12.037openalex-snapshot

High-fat Diet and Physical Exercise Differentially Modulate Adult Neurogenesis in the Mouse Hypothalamus

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.09.031openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.10.012openalex-snapshot

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AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet

inferred← citeshttps://doi.org/10.1016/j.nut.2017.10.019openalex-snapshot

Resveratrol promotes the arcuate nucleus architecture remodeling to produce more anorexigenic neurons in high-fat-diet–fed mice

inferred← citeshttps://doi.org/10.1016/j.nutres.2016.11.002openalex-snapshot

The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.obmed.2021.100375openalex-snapshot

Female obesity: Association with endocrine disruption and reproductive dysfunction

inferred← citeshttps://doi.org/10.1016/j.orcp.2015.10.012openalex-snapshot

Metaflammatory responses during obesity: Pathomechanism and treatment

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2025.12.006openalex-snapshot

Unraveling cerebral ultrastructural alterations in TLR4-mediated neuroinflammation via transmission electron microscopy: a systematic preclinical review

inferred← citeshttps://doi.org/10.1016/j.peptides.2021.170546openalex-snapshot

Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats

inferred← citeshttps://doi.org/10.1016/j.physbeh.2015.04.029openalex-snapshot

Sex differences in motivational responses to dietary fat in Syrian hamsters

inferred← citeshttps://doi.org/10.1016/j.physbeh.2015.07.023openalex-snapshot

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

inferred← citeshttps://doi.org/10.1016/j.physbeh.2025.114917openalex-snapshot

Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity

inferred← citeshttps://doi.org/10.1016/j.physbeh.2025.115119openalex-snapshot

Molecular mechanisms underlying obesity-induced memory dysfunction: a comprehensive narrative review

inferred← citeshttps://doi.org/10.1016/j.plefa.2012.11.009openalex-snapshot

Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules

inferred← citeshttps://doi.org/10.1016/j.plefa.2015.10.003openalex-snapshot

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2016.03.001openalex-snapshot

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2019.104418openalex-snapshot

Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis

inferred← citeshttps://doi.org/10.1016/j.taap.2014.08.028openalex-snapshot

Genistein modulation of streptozotocin diabetes in male B6C3F1 mice can be induced by diet

inferred← citeshttps://doi.org/10.1016/j.tem.2012.11.003openalex-snapshot

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

inferred← citeshttps://doi.org/10.1016/j.tem.2013.10.005openalex-snapshot

Role of hypothalamic neurogenesis in feeding regulation

inferred← citeshttps://doi.org/10.1016/j.tem.2020.01.002openalex-snapshot

Hypothalamic IRX3: A New Player in the Development of Obesity

inferred← citeshttps://doi.org/10.1016/j.tics.2017.03.004openalex-snapshot

DRD2: Bridging the Genome and Ingestive Behavior

inferred← citeshttps://doi.org/10.1016/j.tifs.2021.03.042openalex-snapshot

Fatty acids role on obesity induced hypothalamus inflammation: From problem to solution – A review

inferred← citeshttps://doi.org/10.1016/j.tins.2012.12.008openalex-snapshot

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

inferred← citeshttps://doi.org/10.1016/j.yexcr.2020.111848openalex-snapshot

Unveiling the transcriptome alteration of POMC neuron in diet-induced obesity

inferred← citeshttps://doi.org/10.1016/j.yfrne.2014.09.001openalex-snapshot

Delineating the regulation of energy homeostasis using hypothalamic cell models

inferred← citeshttps://doi.org/10.1016/j.yfrne.2019.02.003openalex-snapshot

Giving a good start to a new life via maternal brain allostatic adaptations in pregnancy

inferred← citeshttps://doi.org/10.1016/s0083-6729(10)82007-2openalex-snapshot

Hypothalamic Inflammation and Obesity

inferred← citeshttps://doi.org/10.1016/s1474-4422(17)30084-4openalex-snapshot

Neurological consequences of obesity

inferred← citeshttps://doi.org/10.1017/s000711451200579xopenalex-snapshot

Relationships between dietary macronutrients and adult neurogenesis in the regulation of energy metabolism

inferred← citeshttps://doi.org/10.1017/s0007114518000429openalex-snapshot

n-3 PUFA and obesity: from peripheral tissues to the central nervous system

inferred← citeshttps://doi.org/10.1017/s002966511200078xopenalex-snapshot

Hypothalamic dysfunction in obesity

inferred← citeshttps://doi.org/10.1017/s204017442000094xopenalex-snapshot

Maternal resistance to diet-induced obesity partially protects newborn and post-weaning male mice offspring from metabolic disturbances

inferred← citeshttps://doi.org/10.1021/jf303795bopenalex-snapshot

Impact of Dietary Dairy Polar Lipids on Lipid Metabolism of Mice Fed a High-Fat Diet

inferred← citeshttps://doi.org/10.1038/emboj.2013.25openalex-snapshot

pRb is an obesity suppressor in hypothalamus and high‐fat diet inhibits pRb in this location

inferred← citeshttps://doi.org/10.1038/ijo.2011.56openalex-snapshot

Altered hypothalamic function in diet-induced obesity

inferred← citeshttps://doi.org/10.1038/ijo.2016.183openalex-snapshot

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

inferred← citeshttps://doi.org/10.1038/nrendo.2015.48openalex-snapshot

Hypothalamic innate immune reaction in obesity

inferred← citeshttps://doi.org/10.1038/nrendo.2016.107openalex-snapshot

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

inferred← citeshttps://doi.org/10.1038/nrendo.2017.78openalex-snapshot

FGF1 — a new weapon to control type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1038/s41366-019-0399-8openalex-snapshot

Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41366-019-0451-8openalex-snapshot

Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity

inferred← citeshttps://doi.org/10.1038/s41380-021-01169-zopenalex-snapshot

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity

inferred← citeshttps://doi.org/10.1038/s41467-024-46589-xopenalex-snapshot

Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

inferred← citeshttps://doi.org/10.1038/s41467-024-47877-2openalex-snapshot

Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity

inferred← citeshttps://doi.org/10.1038/s41467-024-52898-yopenalex-snapshot

Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy

inferred← citeshttps://doi.org/10.1038/s41598-018-30714-0openalex-snapshot

MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway

inferred← citeshttps://doi.org/10.1038/s41598-018-32553-5openalex-snapshot

Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor

inferred← citeshttps://doi.org/10.1038/s41598-019-53578-4openalex-snapshot

Higher body mass index is linked to altered hypothalamic microstructure

inferred← citeshttps://doi.org/10.1038/s41598-020-68110-2openalex-snapshot

Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms

inferred← citeshttps://doi.org/10.1038/s41598-021-01059-yopenalex-snapshot

Short high fat diet triggers reversible and region specific effects in DCX+ hippocampal immature neurons of adolescent male mice

inferred← citeshttps://doi.org/10.1038/s41598-021-97291-7openalex-snapshot

TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation

inferred← citeshttps://doi.org/10.1038/s41598-025-27087-6openalex-snapshot

The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity

inferred← citeshttps://doi.org/10.1038/s42255-023-00877-wopenalex-snapshot

Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA

inferred← citeshttps://doi.org/10.1038/s42255-024-01079-8openalex-snapshot

Obesity-induced inflammation: connecting the periphery to the brain

inferred← citeshttps://doi.org/10.1038/s44319-023-00016-2openalex-snapshot

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis

inferred← citeshttps://doi.org/10.1038/s44319-024-00321-4openalex-snapshot

Interplay between the brain and adipose tissue: a metabolic conversation

inferred← citeshttps://doi.org/10.1038/s44324-024-00026-1openalex-snapshot

Hypothalamic neuronal-glial crosstalk in metabolic disease

inferred← citeshttps://doi.org/10.1038/srep29290openalex-snapshot

Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity

inferred← citeshttps://doi.org/10.1042/cs20256728openalex-snapshot

The transition from preclinical to clinical obesity: the importance of a borderline stage

inferred← citeshttps://doi.org/10.1053/j.gastro.2013.10.053openalex-snapshot

MicroRNA 375 Mediates Palmitate-Induced Enteric Neuronal Damage and High-Fat Diet-Induced Delayed Intestinal Transit in Mice

inferred← citeshttps://doi.org/10.1055/s-0041-111699openalex-snapshot

STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?

inferred← citeshttps://doi.org/10.1055/s-006-30936openalex-snapshot

inferred← citeshttps://doi.org/10.1074/jbc.m109.030874openalex-snapshot

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

inferred← citeshttps://doi.org/10.1080/01913123.2023.2195484openalex-snapshot

Could vitamin D protect against high fat diet induced damage in the arcuate nucleus in the rat: histological, immunohistochemical and ultrastructural study

inferred← citeshttps://doi.org/10.1080/09291016.2026.2702484openalex-snapshot

Blind C3H substrains differ in anxiety-like behavior, weight gain, and circadian period but not in responses to constant light

inferred← citeshttps://doi.org/10.1080/1028415x.2017.1388557openalex-snapshot

Western-style diet induces object recognition deficits and alters complexity of dendritic arborization in the hippocampus and entorhinal cortex of male rats

inferred← citeshttps://doi.org/10.1080/1028415x.2020.1821519openalex-snapshot

Maternal hypercaloric diet affects factors involved in lipid metabolism and the endogenous cannabinoid systems in the hypothalamus of adult offspring: sex-specific response of astrocytes to palmitic acid and anandamide

inferred← citeshttps://doi.org/10.1080/10408398.2020.1747046openalex-snapshot

High-fat or high-sugar diets as trigger inflammation in the microbiota-gut-brain axis

inferred← citeshttps://doi.org/10.1080/19768354.2018.1497707openalex-snapshot

High-fat-diet impaired mitochondrial function of cumulus cells but improved the efficiency of parthenogenetic embryonic quality in mice

inferred← citeshttps://doi.org/10.1080/23328940.2017.1327003openalex-snapshot

The role of leptin in health and disease

inferred← citeshttps://doi.org/10.1080/87559129.2020.1762639openalex-snapshot

Biopeptides with Neuroprotective Effect in the Treatment of Neuroinflammation Induced by Adiposity-based Chronic Disease

inferred← citeshttps://doi.org/10.1089/ars.2010.3330openalex-snapshot

Jejunum Inflammation in Obese and Diabetic Mice Impairs Enteric Glucose Detection and Modifies Nitric Oxide Release in the Hypothalamus

inferred← citeshttps://doi.org/10.1093/advances/nmaa072openalex-snapshot

Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases

inferred← citeshttps://doi.org/10.1093/nutrit/nuz056openalex-snapshot

Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity

inferred← citeshttps://doi.org/10.1096/fj.202002740ropenalex-snapshot

Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting‐ and ghrelin‐mediated food intake

inferred← citeshttps://doi.org/10.1097/med.0000000000000182openalex-snapshot

Hypothalamic inflammation and gliosis in obesity

inferred← citeshttps://doi.org/10.1098/rsos.250681openalex-snapshot

The long-term impact of obesity in pregnancy on offspring hypothalamic feeding pathways

inferred← citeshttps://doi.org/10.1101/2020.06.25.172379openalex-snapshot

POMC-specific knockdown of Tril reduces body adiposity and increases hypothalamic leptin responsiveness

inferred← citeshttps://doi.org/10.1101/2025.03.30.645467openalex-snapshot

Milk-derived extracellular vesicles mitigate NF-κB pathway and NLRP3 inflammasome formation in Long Evans neonates

inferred← citeshttps://doi.org/10.1101/593004openalex-snapshot

Altered hypothalamic microstructure in human obesity

inferred← citeshttps://doi.org/10.1101/cshperspect.a026591openalex-snapshot

Effects of Maternal Obesity on Fetal Programming: Molecular Approaches

inferred← citeshttps://doi.org/10.1111/ijpo.12486openalex-snapshot

Initial evidence for hypothalamic gliosis in children with obesity by quantitative T2 MRI and implications for blood oxygen‐level dependent response to glucose ingestion

inferred← citeshttps://doi.org/10.1111/j.1365-2826.2009.01916.xopenalex-snapshot

Physiological Models of Leptin Resistance

inferred← citeshttps://doi.org/10.1111/j.1365-2826.2010.02105.xopenalex-snapshot

Hyperphagia and Leptin Resistance in Tissue Inhibitor of Metalloproteinase-2 Deficient Mice

inferred← citeshttps://doi.org/10.1111/j.1460-9568.2011.07650.xopenalex-snapshot

Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions

inferred← citeshttps://doi.org/10.1111/j.1467-789x.2010.00727.xopenalex-snapshot

Expanding the definition of hypothalamic obesity

inferred← citeshttps://doi.org/10.1111/j.1467-789x.2012.01004.xopenalex-snapshot

Hypothalamic obesity in children

inferred← citeshttps://doi.org/10.1111/j.1749-6632.2010.05799.xopenalex-snapshot

CNS leptin and insulin action in the control of energy homeostasis

inferred← citeshttps://doi.org/10.1111/j.1749-6632.2011.06388.xopenalex-snapshot

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

inferred← citeshttps://doi.org/10.1111/jnc.13057openalex-snapshot

Possible involvement of 15‐deoxy‐Δ12,14‐prostaglandin J2 in the development of leptin resistance

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