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Mapping genetic effects on cellular phenotypes with “cell villages”
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/978-1-4939-8967-6_10openalex-snapshot
Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines
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Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes
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Interpreting DNA mixtures with the presence of relatives
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Estimating the number of contributors to a DNA profile
inferredcites →https://doi.org/10.1016/0092-8674(95)90460-3openalex-snapshot
Identification and characterization of a spinal muscular atrophy-determining gene
inferredcites →https://doi.org/10.1016/j.ajhg.2008.01.014openalex-snapshot
Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice
inferredcites →https://doi.org/10.1016/j.cell.2014.05.010openalex-snapshot
Development and Applications of CRISPR-Cas9 for Genome Engineering
inferredcites →https://doi.org/10.1016/j.cell.2017.05.038openalex-snapshot
An Expanded View of Complex Traits: From Polygenic to Omnigenic
inferredcites →https://doi.org/10.1016/j.cell.2018.11.029openalex-snapshot
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
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Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
inferredcites →https://doi.org/10.1016/j.neuron.2013.05.029openalex-snapshot
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2008.09.017openalex-snapshot
Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation
inferredcites →https://doi.org/10.1016/j.stem.2013.07.001openalex-snapshot
Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application
inferredcites →https://doi.org/10.1016/j.stem.2016.06.019openalex-snapshot
Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity
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Likelihood-based inference for genetic correlation coefficients
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Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study
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Analysis and interpretation of mixed forensic stains using DNA STR profiling
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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)
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Genetic analysis of genome-wide variation in human gene expression
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Mapping determinants of human gene expression by regional and genome-wide association
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Understanding mechanisms underlying human gene expression variation with RNA sequencing
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Biological insights from 108 schizophrenia-associated genetic loci
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
inferredcites →https://doi.org/10.1038/nature22403openalex-snapshot
Common genetic variation drives molecular heterogeneity in human iPSCs
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
inferredcites →https://doi.org/10.1038/nbt.3749openalex-snapshot
Influence of donor age on induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nchembio.1837openalex-snapshot
SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
inferredcites →https://doi.org/10.1038/ng.3200openalex-snapshot
Large multiallelic copy number variations in humans
inferredcites →https://doi.org/10.1038/ng.768openalex-snapshot
Discovery and genotyping of genome structural polymorphism by sequencing on a population scale
inferredcites →https://doi.org/10.1038/ng2142openalex-snapshot
Population genomics of human gene expression
inferredcites →https://doi.org/10.1038/nprot.2013.132openalex-snapshot
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
inferredcites →https://doi.org/10.1038/nrm3584openalex-snapshot
Origins and implications of pluripotent stem cell variability and heterogeneity
inferredcites →https://doi.org/10.1038/nrneurol.2018.4openalex-snapshot
Advances in therapy for spinal muscular atrophy: promises and challenges
inferredcites →https://doi.org/10.1038/s41467-020-17440-wopenalex-snapshot
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
inferredcites →https://doi.org/10.1038/s41586-018-0321-xopenalex-snapshot
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations
inferredcites →https://doi.org/10.1038/s41588-018-0183-zopenalex-snapshot
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
inferredcites →https://doi.org/10.1038/s41588-019-0512-xopenalex-snapshot
Comparative genetic architectures of schizophrenia in East Asian and European populations
inferredcites →https://doi.org/10.1038/s41592-018-0225-6openalex-snapshot
CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data
inferredcites →https://doi.org/10.1073/pnas.96.11.6307openalex-snapshot
A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
inferredcites →https://doi.org/10.1080/14656566.2019.1704732openalex-snapshot
New treatments in spinal muscular atrophy: an overview of currently available data
inferredcites →https://doi.org/10.1093/hmg/8.7.1177openalex-snapshot
A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2
inferredcites →https://doi.org/10.1093/hmg/ddn382openalex-snapshot
Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation
inferredcites →https://doi.org/10.1101/gad.1941310openalex-snapshot
Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model
inferredcites →https://doi.org/10.1126/science.1136678openalex-snapshot
Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes
inferredcites →https://doi.org/10.1126/science.1246981openalex-snapshot
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
inferredcites →https://doi.org/10.1126/science.1247005openalex-snapshot
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
inferredcites →https://doi.org/10.1126/science.6451928openalex-snapshot
Cross-Contamination of Cells in Culture
inferredcites →https://doi.org/10.1128/mcb.01262-08openalex-snapshot
Regulation of SMN Protein Stability
inferredcites →https://doi.org/10.1212/01.wnl.0000201929.56928.13openalex-snapshot
SMN mRNA and protein levels in peripheral blood
inferredcites →https://doi.org/10.1371/journal.pgen.1004432openalex-snapshot
Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1371/journal.pone.0220211openalex-snapshot
The frequency of SMN gene variants lacking exon 7 and 8 is highly population dependent
inferredcites →https://doi.org/10.3390/ijms21093297openalex-snapshot
New and Developing Therapies in Spinal Muscular Atrophy: From Genotype to Phenotype to Treatment and Where Do We Stand?
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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NAIP Gene Deletion and SMN2 Copy Number as Molecular Tools in Predicting the Severity of Spinal Muscular Atrophy
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A reference human induced pluripotent stem cell line for large-scale collaborative studies
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Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
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Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection
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Biomanufacturing in low Earth orbit for regenerative medicine
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Functional genomics and the future of iPSCs in disease modeling
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Somatic mutations alter the differentiation outcomes of iPSC-derived neurons
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Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation
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Sibling chimerism among microglia in marmosets
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Sibling chimerism among microglia in marmosets
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Sibling chimerism among microglia in marmosets
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