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2-Locus Cleave and Rescue selfish elements harness a recombination rate-dependent generational clock for self limiting gene drive

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The dawn of active genetics
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Engineered Underdominance Allows Efficient and Economical Introgression of Traits into Pest Populations
inferredcites →https://doi.org/10.1007/1-4020-4051-2openalex-snapshot
Sterile Insect Technique
inferredcites →https://doi.org/10.1007/978-1-4939-6750-6_2openalex-snapshot
Quantification and Sequencing of Crossover Recombinant Molecules from Arabidopsis Pollen DNA
inferredcites →https://doi.org/10.1007/978-1-61779-129-1_15openalex-snapshot
Isolation of Meiotic Recombinants from Mouse Sperm
inferredcites →https://doi.org/10.1007/978-3-030-27264-7openalex-snapshot
Synthetic Biology 2020: Frontiers in Risk Analysis and Governance
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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
inferredcites →https://doi.org/10.1016/j.cub.2013.02.059openalex-snapshot
A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations
inferredcites →https://doi.org/10.1016/j.jtbi.2009.01.031openalex-snapshot
The effect of gene drive on containment of transgenic mosquitoes
inferredcites →https://doi.org/10.1016/j.jtbi.2010.08.004openalex-snapshot
Using underdominance to bi-stably transform local populations
inferredcites →https://doi.org/10.1016/j.jtbi.2011.10.032openalex-snapshot
Confinement of gene drive systems to local populations: A comparative analysis
inferredcites →https://doi.org/10.1016/j.tpb.2015.11.005openalex-snapshot
Gene drive through a landscape: Reaction–diffusion models of population suppression and elimination by a sex ratio distorter
inferredcites →https://doi.org/10.1021/acssynbio.7b00451openalex-snapshot
Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila
inferredcites →https://doi.org/10.1021/acssynbio.9b00452openalex-snapshot
Population Dynamics of Underdominance Gene Drive Systems in Continuous Space
inferredcites →https://doi.org/10.1021/sb300079hopenalex-snapshot
Novel SyntheticMedeaSelfish Genetic Elements Drive Population Replacement inDrosophila; a Theoretical Exploration ofMedea-Dependent Population Suppression
inferredcites →https://doi.org/10.1038/nbt.3437openalex-snapshot
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
inferredcites →https://doi.org/10.1038/nbt.4245openalex-snapshot
A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
inferredcites →https://doi.org/10.1038/s41467-019-12209-2openalex-snapshot
Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination
inferredcites →https://doi.org/10.1038/s41467-019-13977-7openalex-snapshot
A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment
inferredcites →https://doi.org/10.1038/s41467-020-14960-3openalex-snapshot
A toxin-antidote CRISPR gene drive system for regional population modification
inferredcites →https://doi.org/10.1038/s41587-020-0508-1openalex-snapshot
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
inferredcites →https://doi.org/10.1073/pnas.1405500111openalex-snapshot
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila
inferredcites →https://doi.org/10.1073/pnas.1713825115openalex-snapshot
Consequences of resistance evolution in a Cas9-based sex conversion-suppression gene drive for insect pest management
inferredcites →https://doi.org/10.1073/pnas.1716358116openalex-snapshot
Daisy-chain gene drives for the alteration of local populations
inferredcites →https://doi.org/10.1073/pnas.1720354115openalex-snapshot
Reducing resistance allele formation in CRISPR gene drive
inferredcites →https://doi.org/10.1073/pnas.1805278115openalex-snapshot
Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs
inferredcites →https://doi.org/10.1073/pnas.1810062115openalex-snapshot
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
inferredcites →https://doi.org/10.1073/pnas.1816928116openalex-snapshot
Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive
inferredcites →https://doi.org/10.1073/pnas.1921698117openalex-snapshot
Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements
inferredcites →https://doi.org/10.1073/pnas.2004373117openalex-snapshot
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population
inferredcites →https://doi.org/10.1080/23299460.2017.1419413openalex-snapshot
‘Mapping research and governance needs for gene drives’
inferredcites →https://doi.org/10.1093/biosci/biz098openalex-snapshot
Threshold-Dependent Gene Drives in the Wild: Spread, Controllability, and Ecological Uncertainty
inferredcites →https://doi.org/10.1093/genetics/138.4.1309openalex-snapshot
The population dynamics of maternal-effect selfish genes.
inferredcites →https://doi.org/10.1093/jhered/esr019openalex-snapshot
Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis
inferredcites →https://doi.org/10.1098/rspb.2002.2319openalex-snapshot
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
inferredcites →https://doi.org/10.1098/rspb.2008.0846openalex-snapshot
A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs
inferredcites →https://doi.org/10.1098/rspb.2019.2994openalex-snapshot
Development and testing of a novel killer–rescue self-limiting gene drive system in Drosophila melanogaster
inferredcites →https://doi.org/10.1098/rstb.2016.0455openalex-snapshot
Variation in recombination frequency and distribution across eukaryotes: patterns and processes
inferredcites →https://doi.org/10.1111/eva.12583openalex-snapshot
Invasion and migration of spatially self‐limiting gene drives: A comparative analysis
inferredcites →https://doi.org/10.1111/eva.12827openalex-snapshot
Tethered homing gene drives: A new design for spatially restricted population replacement and suppression
inferredcites →https://doi.org/10.1111/eva.13180openalex-snapshot
Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives
inferredcites →https://doi.org/10.1111/j.1558-5646.2010.01186.xopenalex-snapshot
MEDEA SELFISH GENETIC ELEMENTS AS TOOLS FOR ALTERING TRAITS OF WILD POPULATIONS: A THEORETICAL ANALYSIS
inferredcites →https://doi.org/10.1111/j.1558-5646.2012.01582.xopenalex-snapshot
GENERAL PRINCIPLES OF SINGLE‐CONSTRUCT CHROMOSOMAL GENE DRIVE
inferredcites →https://doi.org/10.1111/j.1752-4571.2010.00153.xopenalex-snapshot
Gene‐drive into insect populations with age and spatial structure: a theoretical assessment
inferredcites →https://doi.org/10.1126/science.1134426openalex-snapshot
P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. melanogaster
inferredcites →https://doi.org/10.1126/science.1138595openalex-snapshot
A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila
inferredcites →https://doi.org/10.1146/annurev.ento.49.061802.123344openalex-snapshot
P OPULATION G ENETICS OF A UTOCIDAL C ONTROL AND S TRAIN R EPLACEMENT
inferredcites →https://doi.org/10.1186/1471-2148-14-98openalex-snapshot
Dynamics of a combined medea-underdominant population transformation system
inferredcites →https://doi.org/10.1186/s12915-017-0420-4openalex-snapshot
How driving endonuclease genes can be used to combat pests and disease vectors
inferredcites →https://doi.org/10.1186/s12915-020-0759-9openalex-snapshot
Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations
inferredcites →https://doi.org/10.1186/s12915-020-0761-2openalex-snapshot
Performance analysis of novel toxin-antidote CRISPR gene drive systems
inferredcites →https://doi.org/10.1201/9781003035572openalex-snapshot
Sterile Insect Technique
inferredcites →https://doi.org/10.1371/journal.pcbi.1002260openalex-snapshot
Stability Properties of Underdominance in Finite Subdivided Populations
inferredcites →https://doi.org/10.1371/journal.pcbi.1006059openalex-snapshot
Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors
inferredcites →https://doi.org/10.1371/journal.pgen.1006796openalex-snapshot
Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations
inferredcites →https://doi.org/10.1371/journal.pgen.1008440openalex-snapshot
Experimental population modification of the malaria vector mosquito, Anopheles stephensi
inferredcites →https://doi.org/10.1371/journal.pone.0097557openalex-snapshot
First Steps towards Underdominant Genetic Transformation of Insect Populations
inferredcites →https://doi.org/10.1371/journal.pone.0102694openalex-snapshot
Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations
inferredcites →https://doi.org/10.1534/g3.119.400985openalex-snapshot
Assessment of a Split Homing Based Gene Drive for Efficient Knockout of Multiple Genes
inferredcites →https://doi.org/10.1534/genetics.110.124479openalex-snapshot
Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations
inferredcites →https://doi.org/10.1534/genetics.116.197632openalex-snapshot
Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing
inferredcites →https://doi.org/10.1534/genetics.117.300081openalex-snapshot
Female Meiosis: Synapsis, Recombination, and Segregation in Drosophila melanogaster
inferredcites →https://doi.org/10.7554/elife.51701openalex-snapshot
Development of a confinable gene drive system in the human disease vector Aedes aegypti
inferredcites →https://doi.org/10.7554/elife.58791openalex-snapshot
Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41467-020-19426-0openalex-snapshot
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
inferred← citeshttps://doi.org/10.1038/s41467-022-34739-yopenalex-snapshot
A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias
inferred← citeshttps://doi.org/10.1101/2020.08.21.261610openalex-snapshot
A home and rescue gene drive efficiently spreads and persists in populations
inferred← citeshttps://doi.org/10.1101/2020.08.27.270611openalex-snapshot
Evading resistance to gene drives
inferred← citeshttps://doi.org/10.1146/annurev-ento-020117-043154openalex-snapshot
Engineering the Composition and Fate of Wild Populations with Gene Drive
inferred← citeshttps://doi.org/10.1146/annurev-genet-031623-105059openalex-snapshot
Manipulating the Destiny of Wild Populations Using CRISPR
inferred← citeshttps://doi.org/10.2903/j.efsa.2020.6297openalex-snapshot
Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post‐market environmental monitoring of genetically modified insects containing engineered gene drives
inferred← citeshttps://doi.org/10.32614/cran.package.mgdriveopenalex-snapshot
MGDrivE: Mosquito Gene Drive Explorer
inferred← citeshttps://doi.org/10.7554/elife.65939openalex-snapshot
A confinable home-and-rescue gene drive for population modification
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