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Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Rapid and reliable protein extraction from yeast

inferredcites →https://doi.org/10.1002/1873-3468.12707openalex-snapshot

Chromatin accessibility and guide sequence secondary structure affect CRISPR ‐Cas9 gene editing efficiency

inferredcites →https://doi.org/10.1002/j.1460-2075.1986.tb04551.xopenalex-snapshot

Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast.

inferredcites →https://doi.org/10.1002/j.1460-2075.1986.tb04552.xopenalex-snapshot

Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.

inferredcites →https://doi.org/10.1002/j.1460-2075.1990.tb08158.xopenalex-snapshot

Intermediates of recombination during mating type switching in Saccharomyces cerevisiae.

inferredcites →https://doi.org/10.1016/0076-6879(91)94004-vopenalex-snapshot

Getting started with yeast

inferredcites →https://doi.org/10.1016/0076-6879(91)94022-5openalex-snapshot

[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast

inferredcites →https://doi.org/10.1016/0307-4412(91)90039-bopenalex-snapshot

Methods in Yeast Genetics — A Laboratory Course Manual

inferredcites →https://doi.org/10.1016/j.cell.2009.02.043openalex-snapshot

Mechanisms that Specify Promoter Nucleosome Location and Identity

inferredcites →https://doi.org/10.1016/j.cell.2014.05.010openalex-snapshot

Development and Applications of CRISPR-Cas9 for Genome Engineering

inferredcites →https://doi.org/10.1016/j.cell.2016.10.044openalex-snapshot

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

inferredcites →https://doi.org/10.1016/j.molcel.2005.02.017openalex-snapshot

Distinction and Relationship between Elongation Rate and Processivity of RNA Polymerase II In Vivo

inferredcites →https://doi.org/10.1016/j.molcel.2011.03.028openalex-snapshot

Multiple Sequence-Specific Factors Generate the Nucleosome-Depleted Region on CLN2 Promoter

inferredcites →https://doi.org/10.1016/j.molcel.2015.10.002openalex-snapshot

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

inferredcites →https://doi.org/10.1016/j.molcel.2018.06.017openalex-snapshot

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

inferredcites →https://doi.org/10.1016/j.omtn.2017.08.005openalex-snapshot

The Chromatin Structure Differentially Impacts High-Specificity CRISPR-Cas9 Nuclease Strategies

inferredcites →https://doi.org/10.1016/j.tibs.2013.06.009openalex-snapshot

Dancing the cell cycle two-step: regulation of yeast G1-cell-cycle genes by chromatin structure

inferredcites →https://doi.org/10.1016/j.ymeth.2017.04.003openalex-snapshot

Genome editing via delivery of Cas9 ribonucleoprotein

inferredcites →https://doi.org/10.1016/s1046-2023(05)80158-6openalex-snapshot

Overview of manual and automated DNA sequencing by the dideoxy chain termination method

inferredcites →https://doi.org/10.1016/s1097-2765(02)00459-8openalex-snapshot

Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4

inferredcites →https://doi.org/10.1021/acs.biochem.5b01108openalex-snapshot

Nucleosomes Inhibit Cas9 Endonuclease Activity in Vitro

inferredcites →https://doi.org/10.1021/acssynbio.5b00299openalex-snapshot

The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells

inferredcites →https://doi.org/10.1021/ja983267vopenalex-snapshot

Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach

inferredcites →https://doi.org/10.1038/38444openalex-snapshot

Crystal structure of the nucleosome core particle at 2.8 Å resolution

inferredcites →https://doi.org/10.1038/90837openalex-snapshot

In vivo site-directed mutagenesis using oligonucleotides

inferredcites →https://doi.org/10.1038/nature13579openalex-snapshot

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

inferredcites →https://doi.org/10.1038/nature17946openalex-snapshot

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

inferredcites →https://doi.org/10.1038/nature24644openalex-snapshot

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

inferredcites →https://doi.org/10.1038/nbt.3437openalex-snapshot

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

inferredcites →https://doi.org/10.1038/sj.emboj.7601859openalex-snapshot

Forkhead proteins control the outcome of transcription factor binding by antiactivation

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Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases

inferredcites →https://doi.org/10.1073/pnas.211195798openalex-snapshot

Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response

inferredcites →https://doi.org/10.1074/jbc.c116.758706openalex-snapshot

Nucleosomes Selectively Inhibit Cas9 Off-target Activity at a Site Located at the Nucleosome Edge

inferredcites →https://doi.org/10.1093/emboj/20.17.4944openalex-snapshot

Increasing the rate of chromatin remodeling and gene activation—a novel role for the histone acetyltransferase Gcn5

inferredcites →https://doi.org/10.1093/genetics/123.4.725openalex-snapshot

The genetic control of direct-repeat recombination in Saccharomyces: the effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene.

inferredcites →https://doi.org/10.1093/nar/gku784openalex-snapshot

The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin

inferredcites →https://doi.org/10.1093/nar/gkw524openalex-snapshot

Probing the impact of chromatin conformation on genome editing tools

inferredcites →https://doi.org/10.1101/gad.824700openalex-snapshot

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

inferredcites →https://doi.org/10.1101/gad.921601openalex-snapshot

The Swi5 activator recruits the Mediator complex to theHOpromoter without RNA polymerase II

inferredcites →https://doi.org/10.1126/science.1258096openalex-snapshot

The new frontier of genome engineering with CRISPR-Cas9

inferredcites →https://doi.org/10.1126/science.aaf8729openalex-snapshot

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

inferredcites →https://doi.org/10.1126/scitranslmed.aaf9336openalex-snapshot

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

inferredcites →https://doi.org/10.1128/mcb.12.2.563openalex-snapshot

Characterization of Double-Strand Break-Induced Recombination: Homology Requirements and Single-Stranded DNA Formation

inferredcites →https://doi.org/10.1128/mcb.17.5.2669openalex-snapshot

Long-Range Interactions at the HO Promoter

inferredcites →https://doi.org/10.1128/mcb.24.14.6419-6429.2004openalex-snapshot

TATA-Binding Protein Mutants That Are Lethal in the Absence of the Nhp6 High-Mobility-Group Protein

inferredcites →https://doi.org/10.1146/annurev-biochem-060713-035418openalex-snapshot

Genome Engineering with Targetable Nucleases

inferredcites →https://doi.org/10.1186/s13059-016-0900-9openalex-snapshot

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design

inferredcites →https://doi.org/10.1534/genetics.105.052829openalex-snapshot

Efficient Gene Targeting in Drosophila With Zinc-Finger Nucleases

inferredcites →https://doi.org/10.1534/genetics.115.183715openalex-snapshot

Nucleosomes Are Essential for Proper Regulation of a Multigated Promoter inSaccharomyces cerevisiae

inferredcites →https://doi.org/10.7554/elife.12677openalex-snapshot

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

inferredcites →https://doi.org/10.7554/elife.13450openalex-snapshot

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

inferredcites →https://doi.org/10.7554/elife.14846openalex-snapshot

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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CRISPR-Cas9 Expressed in Stably Transduced Cell Lines Promotes Recombination and Selects for Herpes Simplex Virus Recombinants between Co-Transfected DNAs

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Reading the chromatinized genome

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Chromatin context-dependent regulation and epigenetic manipulation of prime editing

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Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis

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CRISPR-Cas9 expressed in stably transduced cell lines promotes recombination and selects for herpes simplex virus recombinants

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Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease

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Construction of wild-type Yarrowia lipolytica IMUFRJ 50682 auxotrophic mutants using dual CRISPR/Cas9 strategy for novel biotechnological approaches

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Development and expansion of the CRISPR/Cas9 toolboxes for powerful genome engineering in yeast

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Marker-free CRISPR-Cas9 based genetic engineering of the phytopathogenic fungus, Penicillium expansum

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Efficient BoPDS Gene Editing in Cabbage by the CRISPR/Cas9 System

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The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells

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Genome oligopaint via local denaturation fluorescence in situ hybridization

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TALEN outperforms Cas9 in editing heterochromatin target sites

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Profile of Dana Carroll

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CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects

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Monitoring the Land and Sea: Enhancing Efficiency Through CRISPR-Cas Driven Depletion and Enrichment of Environmental DNA

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Benchmarking deep learning methods for predicting CRISPR/Cas9 sgRNA on- and off-target activities

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CEDA: integrating gene expression data with CRISPR-pooled screen data identifies essential genes with higher expression

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Limitations of transcriptome-based prediction of pathogenicity genes in the plant pathogen Leptosphaeria maculans

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How to use CRISPR/Cas9 in plants: from target site selection to DNA repair

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Systematic in vitro profiling of off-target affinity, cleavage and efficiency for CRISPR enzymes

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Efficient DNA double-strand break formation at single or multiple defined sites in the Saccharomyces cerevisiae genome

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crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays

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INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

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Small-molecule inhibitors of histone deacetylase improve CRISPR-based adenine base editing

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Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR–Cas9 variants

inferred← citeshttps://doi.org/10.1093/nar/gkad021openalex-snapshot

The impact of nucleosome structure on CRISPR/Cas9 fidelity

inferred← citeshttps://doi.org/10.1093/nar/gkad1076openalex-snapshot

Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells

inferred← citeshttps://doi.org/10.1093/nar/gkad736openalex-snapshot

Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering

inferred← citeshttps://doi.org/10.1093/nar/gkae570openalex-snapshot

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

inferred← citeshttps://doi.org/10.1093/nar/gkag548openalex-snapshot

Empirical evaluation of all unique Cas9 protospacers in E. coli reveal widespread functionality and rules for gRNA design

inferred← citeshttps://doi.org/10.1093/nar/gkz1136openalex-snapshot

Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

inferred← citeshttps://doi.org/10.1093/nar/gkz1214openalex-snapshot

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene

inferred← citeshttps://doi.org/10.1093/nar/gkz750openalex-snapshot

Training-free measures based on algorithmic probability identify high nucleosome occupancy in DNA sequences

inferred← citeshttps://doi.org/10.1093/narmme/ugae013openalex-snapshot

Cas9 nickase-mediated contractions of CAG/CTG repeats are transcription-dependent and replication-independent

inferred← citeshttps://doi.org/10.1093/plphys/kiac285openalex-snapshot

Epigenetic features drastically impact CRISPR–Cas9 efficacy in plants

inferred← citeshttps://doi.org/10.1093/plphys/kiac431openalex-snapshot

Insights into the molecular mechanisms of CRISPR/Cas9-mediated gene targeting at multiple loci in Arabidopsis

inferred← citeshttps://doi.org/10.1101/2020.05.12.091991openalex-snapshot

High-throughput in vitro specificity profiling of natural and high-fidelity CRISPR-Cas9 variants

inferred← citeshttps://doi.org/10.1101/2020.07.09.196253openalex-snapshot

2-Locus Cleave and Rescue selfish elements harness a recombination rate-dependent generational clock for self limiting gene drive

inferred← citeshttps://doi.org/10.1101/2021.10.25.465699openalex-snapshot

Alternative strategy to induce CRISPR-mediated genetic changes in hematopoietic cells

inferred← citeshttps://doi.org/10.1101/2025.05.23.651106openalex-snapshot

When good guides go bad: empirical evaluation of all unique Cas9 protospacers in E. coli reveal widespread functionality and rules for gRNA design

inferred← citeshttps://doi.org/10.1101/2025.10.08.681228openalex-snapshot

DeepEmbCas9: Cas9 coevolution and sgRNA structural information for CRISPR-Cas9 cleavage activity prediction

inferred← citeshttps://doi.org/10.1101/480145openalex-snapshot

Base editing generates substantial off-target single nucleotide variants

inferred← citeshttps://doi.org/10.1101/657791openalex-snapshot

Pervasive off-target and double-stranded DNA nicking by CRISPR-Cas12a

inferred← citeshttps://doi.org/10.1101/797746openalex-snapshot

In Vivo Study of Key Transcription Factors in Muscle Satellite Cells by CRISPR/Cas9/AAV9-sgRNA Mediated Genome Editing

inferred← citeshttps://doi.org/10.1111/1751-7915.13780openalex-snapshot

A plasmid toolset for CRISPR‐mediated genome editing and CRISPRi gene regulation in Escherichia coli

inferred← citeshttps://doi.org/10.1111/nph.18212openalex-snapshot

DNA methylation can alter CRISPR/Cas9 editing frequency and DNA repair outcome in a target‐specific manner

inferred← citeshttps://doi.org/10.1111/nyas.14675openalex-snapshot

Plant genome engineering from lab to field—a Keystone Symposia report

inferred← citeshttps://doi.org/10.1111/pbi.13169openalex-snapshot

Efficient TALEN ‐mediated gene editing in wheat

inferred← citeshttps://doi.org/10.1111/pbi.14188openalex-snapshot

Prime editing: Mechanism insight and recent applications in plants

inferred← citeshttps://doi.org/10.1111/sji.12862openalex-snapshot

A simple and efficient workflow for generation of knock‐in mutations in Jurkat T cells using CRISPR/Cas9

inferred← citeshttps://doi.org/10.1126/sciadv.aaw9807openalex-snapshot

The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation

inferred← citeshttps://doi.org/10.1126/sciadv.abd6030openalex-snapshot

Inhibition of CRISPR-Cas12a DNA targeting by nucleosomes and chromatin

inferred← citeshttps://doi.org/10.1126/science.aav9023openalex-snapshot

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

inferred← citeshttps://doi.org/10.1134/s0026893320010069openalex-snapshot

Design of Guide RNA for CRISPR/Cas Plant Genome Editing

inferred← citeshttps://doi.org/10.1134/s0026893322060164openalex-snapshot

A Test System for Assessment of the Activity of Mutant Cas9 Variants in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1146/annurev-bioeng-122019-121602openalex-snapshot

Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science

inferred← citeshttps://doi.org/10.1177/10430342261442511openalex-snapshot

AAV-Mediated Base Editing for Correction of RSPH4A Mutations in Primary Ciliary Dyskinesia: A Proof-of-Concept Study

inferred← citeshttps://doi.org/10.1186/s12859-019-3151-4openalex-snapshot

Prediction of sgRNA on-target activity in bacteria by deep learning

inferred← citeshttps://doi.org/10.1186/s12864-025-11775-8openalex-snapshot

CRISPRware: a software package for contextual gRNA library design

inferred← citeshttps://doi.org/10.1186/s12915-024-01810-7openalex-snapshot

Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis

inferred← citeshttps://doi.org/10.1186/s12929-025-01197-9openalex-snapshot

Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin

inferred← citeshttps://doi.org/10.1186/s13059-019-1762-8openalex-snapshot

Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo

inferred← citeshttps://doi.org/10.1186/s13059-024-03215-9openalex-snapshot

Eukaryotic-driven directed evolution of Cas9 nucleases

inferred← citeshttps://doi.org/10.1186/s13059-025-03640-4openalex-snapshot

Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation

inferred← citeshttps://doi.org/10.1186/s13072-019-0275-8openalex-snapshot

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

inferred← citeshttps://doi.org/10.1186/s13072-025-00573-xopenalex-snapshot

Impact of chromatin on HIV-1 latency: a multi-dimensional perspective

inferred← citeshttps://doi.org/10.1186/s13104-019-4207-2openalex-snapshot

Mutagenesis of seed storage protein genes in Soybean using CRISPR/Cas9

inferred← citeshttps://doi.org/10.1186/s40694-018-0064-3openalex-snapshot

The CRISPR revolution in fungal biology and biotechnology, and beyond

inferred← citeshttps://doi.org/10.1371/journal.pbio.2005595openalex-snapshot

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

inferred← citeshttps://doi.org/10.1371/journal.pbio.3001478openalex-snapshot

Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline

inferred← citeshttps://doi.org/10.1371/journal.pgen.1009385openalex-snapshot

Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive

inferred← citeshttps://doi.org/10.1371/journal.pone.0216515openalex-snapshot

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove

inferred← citeshttps://doi.org/10.1371/journal.pone.0262299openalex-snapshot

In silico analysis of potential off-target sites to gene editing for Mucopolysaccharidosis type I using the CRISPR/Cas9 system: Implications for population-specific treatments

inferred← citeshttps://doi.org/10.1371/journal.pone.0318295openalex-snapshot

A universal method for the purification of C2H2 zinc finger arrays

inferred← citeshttps://doi.org/10.1523/eneuro.0419-19.2020openalex-snapshot

Genetically Engineering the Nervous System with CRISPR-Cas

inferred← citeshttps://doi.org/10.15252/embr.201949431openalex-snapshot

The microRNA/TET3/REST axis is required for olfactory globose basal cell proliferation and male behavior

inferred← citeshttps://doi.org/10.1534/g3.120.401526openalex-snapshot

Precise Replacement of Saccharomyces cerevisiae Proteasome Genes with Human Orthologs by an Integrative Targeting Method

inferred← citeshttps://doi.org/10.17912/micropub.biology.000241openalex-snapshot

The mir-35-42 binding site in the nhl-2 3’UTR is dispensable for development and fecundity

inferred← citeshttps://doi.org/10.17912/micropub.biology.000622openalex-snapshot

A simple strategy for addition of degron tags to endogenous genes harboring prior insertions of fluorescent protein.

inferred← citeshttps://doi.org/10.2174/1574893616666210708150439openalex-snapshot

CRISPR/ Cas9 Off-targets: Computational Analysis of Causes, Prediction, Detection, and Overcoming Strategies

inferred← citeshttps://doi.org/10.21769/bioprotoc.3748openalex-snapshot

Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus

inferred← citeshttps://doi.org/10.24108/preprints-3113548openalex-snapshot

ЦИАНОКОБАЛАМИН-СВЯЗЫВАЮЩИЙ БЕЛОК ТЕРМОФИЛЬНОГО МИКРООРГАНИЗМА

inferred← citeshttps://doi.org/10.31857/s0026898420010061openalex-snapshot

Дизайн РНК-гидов для CRISPR/Cas редактирования геномов растений

inferred← citeshttps://doi.org/10.32942/x2gp7hopenalex-snapshot

Enhancing biodiversity monitoring efficiency through CRISPR-driven depletion and enrichment of aquatic environmental DNA

inferred← citeshttps://doi.org/10.33612/diss.183126910openalex-snapshot

Modulating the activity of CRISPR/Cas9 genome editing by small molecules

inferred← citeshttps://doi.org/10.3389/fbioe.2022.924914openalex-snapshot

Tips, Tricks, and Potential Pitfalls of CRISPR Genome Editing in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.3389/fbioe.2024.1327172openalex-snapshot

HyCas9-12aGEP: an efficient genome editing platform for Corynebacterium glutamicum

inferred← citeshttps://doi.org/10.3389/fcell.2021.718466openalex-snapshot

The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing

inferred← citeshttps://doi.org/10.3389/fgeed.2023.1265103openalex-snapshot

Diversity of transgene integration and gene-editing events in wheat (Triticum aestivum L.) transgenic plants generated using Agrobacterium-mediated transformation

inferred← citeshttps://doi.org/10.3389/fgeed.2026.1759382openalex-snapshot

Evaluating high-fidelity CRISPR-Cas nucleases in nucleosomal contexts using a quantitative framework

inferred← citeshttps://doi.org/10.3389/fgene.2023.1222112openalex-snapshot

Chromatin structure and context-dependent sequence features control prime editing efficiency

inferred← citeshttps://doi.org/10.3389/fmolb.2020.595474openalex-snapshot

Homology-Directed Repair in Zebrafish: Witchcraft and Wizardry?

inferred← citeshttps://doi.org/10.3389/fmolb.2022.1070489openalex-snapshot

Nucleosomes and their complexes in the cryoEM era: Trends and limitations

inferred← citeshttps://doi.org/10.3389/fpls.2025.1549136openalex-snapshot

Unlocking male sterility in horticultural crops through gene editing technology for precision breeding applications: presentation of a case study in tomato

inferred← citeshttps://doi.org/10.3390/cells10061299openalex-snapshot

Genome Editing to Generate Sake Yeast Strains with Eight Mutations That Confer Excellent Brewing Characteristics

inferred← citeshttps://doi.org/10.3390/cells9051288openalex-snapshot

Computational Tools and Resources Supporting CRISPR-Cas Experiments

inferred← citeshttps://doi.org/10.3390/epigenomes5030017openalex-snapshot

Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering

inferred← citeshttps://doi.org/10.3390/ijms22157817openalex-snapshot

TSA Promotes CRISPR/Cas9 Editing Efficiency and Expression of Cell Division-Related Genes from Plant Protoplasts

inferred← citeshttps://doi.org/10.3390/ijms24054416openalex-snapshot

Application of Nicotinamide to Culture Medium Improves the Efficiency of Genome Editing in Hexaploid Wheat

inferred← citeshttps://doi.org/10.3390/ijms25010444openalex-snapshot

Increasing the Activity of the High-Fidelity SpyCas9 Form in Yeast by Directed Mutagenesis of the PAM-Interacting Domain

inferred← citeshttps://doi.org/10.3390/ijms262311391openalex-snapshot

The Potential of NGTs to Overcome Constraints in Plant Breeding and Their Regulatory Implications

inferred← citeshttps://doi.org/10.3390/ijms27188104openalex-snapshot

3D Genome Engineering Using CRISPR/dCas Systems

inferred← citeshttps://doi.org/10.3390/microorganisms11041040openalex-snapshot

Overcoming the Limitations of CRISPR-Cas9 Systems in Saccharomyces cerevisiae: Off-Target Effects, Epigenome, and Mitochondrial Editing

inferred← citeshttps://doi.org/10.3390/v15112171openalex-snapshot

HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing

inferred← citeshttps://doi.org/10.3390/v18030354openalex-snapshot

Breaking into HIV-1’s Epigenetic Vault: Cure Strategies to Eliminate the Viral Reservoir

inferred← citeshttps://doi.org/10.3410/f.737033315.793579898openalex-snapshot

Faculty Opinions recommendation of Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing.

inferred← citeshttps://doi.org/10.4236/jbm.2020.811018openalex-snapshot

Development of Genetic Engineering Tools for p75ngfr Methylation and Expression Modulation

inferred← citeshttps://doi.org/10.47743/pesd2023171019openalex-snapshot

Modeling the Impact of Citizens' Social Responsibility on Sustainable Development Based on the Modifying Role of the COVID-19 Pandemic

inferred← citeshttps://doi.org/10.4995/thesis/10251/181891openalex-snapshot

Investigación de la Leucemia Mieloide Aguda mediante el desarrollo de modelos in vitro e in vivo

inferred← citeshttps://doi.org/10.6084/m9.figshare.25017788openalex-snapshot

Additional file 1 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis

inferred← citeshttps://doi.org/10.6084/m9.figshare.25017975openalex-snapshot

Additional file 2 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis

inferred← citeshttps://doi.org/10.6084/m9.figshare.26668953openalex-snapshot

Additional file 3 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis

inferred← citeshttps://doi.org/10.6084/m9.figshare.26668956openalex-snapshot

Additional file 4 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis

inferred← citeshttps://doi.org/10.6084/m9.figshare.26697428openalex-snapshot

Additional file 1 of Eukaryotic-driven directed evolution of Cas9 nucleases

inferred← citeshttps://doi.org/10.6084/m9.figshare.26697431openalex-snapshot

Additional file 2 of Eukaryotic-driven directed evolution of Cas9 nucleases

inferred← citeshttps://doi.org/10.6084/m9.figshare.26697434openalex-snapshot

Additional file 3 of Eukaryotic-driven directed evolution of Cas9 nucleases

inferred← citeshttps://doi.org/10.64898/2026.02.06.703857openalex-snapshot

Regenerative base editing enables deep lineage recording

inferred← citeshttps://doi.org/10.70675/de2db5b0zc42az4172z99d6zcd2c4e2c37b1openalex-snapshot

Etude sur le changement de type sexuel et les cassures chromosomiques chez Candida glabrata

inferred← citeshttps://doi.org/10.7150/ijbs.37152openalex-snapshot

Evaluation of the effects of sequence length and microsatellite instability on single-guide RNA activity and specificity

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