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Delayed Anxiolytic-Like Effects of Psilocybin in Male Mice Are Supported by Acute Glucocorticoid Release

https://doi.org/10.1101/2020.08.12.248229

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

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Psychedelics as Medicines: An Emerging New Paradigm

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Phenomenology, Structure, and Dynamic of Psychedelic States

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Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose?effect study

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Characterization of the head-twitch response induced by hallucinogens in mice

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Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

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Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning

inferredcites →https://doi.org/10.1007/s00702-019-02084-yopenalex-snapshot

Animal models of major depression: drawbacks and challenges

inferredcites →https://doi.org/10.1016/j.bbr.2016.03.003openalex-snapshot

Brief anesthesia by isoflurane alters plasma corticosterone levels distinctly in male and female rats: Implications for tissue collection methods

inferredcites →https://doi.org/10.1016/j.biopsych.2012.04.008openalex-snapshot

Glucocorticoids Protect Against the Delayed Behavioral and Cellular Effects of Acute Stress on the Amygdala

inferredcites →https://doi.org/10.1016/j.celrep.2018.05.022openalex-snapshot

Psychedelics Promote Structural and Functional Neural Plasticity

inferredcites →https://doi.org/10.1016/j.ejphar.2009.09.022openalex-snapshot

Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation

inferredcites →https://doi.org/10.1016/j.neubiorev.2015.11.008openalex-snapshot

Rethinking psychopharmacotherapy: The role of treatment context and brain plasticity in antidepressant and antipsychotic interventions

inferredcites →https://doi.org/10.1016/j.neubiorev.2019.12.001openalex-snapshot

Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms

inferredcites →https://doi.org/10.1016/j.pharmthera.2018.11.010openalex-snapshot

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

inferredcites →https://doi.org/10.1016/j.pnpbp.2017.04.008openalex-snapshot

The recent progress in animal models of depression

inferredcites →https://doi.org/10.1016/j.ynstr.2019.100168openalex-snapshot

Interventions after acute stress prevent its delayed effects on the amygdala

inferredcites →https://doi.org/10.1016/s0028-3908(01)00166-6openalex-snapshot

Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)2 receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT2A receptor mediation of the HPA axis

inferredcites →https://doi.org/10.1016/s1566-2772(03)00086-0openalex-snapshot

Stress models of depression

inferredcites →https://doi.org/10.1017/neu.2019.15openalex-snapshot

Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat

inferredcites →https://doi.org/10.1021/acschemneuro.8b00134openalex-snapshot

Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression

inferredcites →https://doi.org/10.1021/acschemneuro.8b00692openalex-snapshot

Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

inferredcites →https://doi.org/10.1021/acschemneuro.9b00493openalex-snapshot

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression

inferredcites →https://doi.org/10.1021/acsptsci.0c00065openalex-snapshot

Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth

inferredcites →https://doi.org/10.1037/cap0000166openalex-snapshot

Mice are people too: Increasing evidence for cognitive, emotional and social capabilities in laboratory rodents.

inferredcites →https://doi.org/10.1038/s41386-020-00796-4openalex-snapshot

“Corting” stress: post-stress corticosterone administration prevents delayed-onset biobehavioral consequences

inferredcites →https://doi.org/10.1038/s41386-020-0694-zopenalex-snapshot

Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse

inferredcites →https://doi.org/10.1038/s41386-020-0758-0openalex-snapshot

Corticosterone after acute stress prevents the delayed effects on the amygdala

inferredcites →https://doi.org/10.1038/s41598-017-13282-7openalex-snapshot

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

inferredcites →https://doi.org/10.1038/s41598-019-49913-4openalex-snapshot

Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo

inferredcites →https://doi.org/10.1055/s-0032-1312592openalex-snapshot

Sex, Stress, and Mood Disorders: At the Intersection of Adrenal and Gonadal Hormones

inferredcites →https://doi.org/10.1073/pnas.1525586113openalex-snapshot

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

inferredcites →https://doi.org/10.1093/cercor/bhy064openalex-snapshot

Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses

inferredcites →https://doi.org/10.1097/00000542-200106000-00021openalex-snapshot

Isoflurane Blocks Synaptic Plasticity in the Mouse Hippocampus

inferredcites →https://doi.org/10.1097/fbp.0000000000000198openalex-snapshot

Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

inferredcites →https://doi.org/10.1111/gbb.12208openalex-snapshot

Effect of chronic corticosterone application on depression‐like behavior in C57BL / 6N and C57BL / 6J mice

inferredcites →https://doi.org/10.1155/2016/4928081openalex-snapshot

Seeding Stress Resilience through Inoculation

inferredcites →https://doi.org/10.1177/0269881108093587openalex-snapshot

Human hallucinogen research: guidelines for safety

inferredcites →https://doi.org/10.1177/0269881114565144openalex-snapshot

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

inferredcites →https://doi.org/10.1177/0269881116662634openalex-snapshot

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

inferredcites →https://doi.org/10.1177/0269881116675512openalex-snapshot

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

inferredcites →https://doi.org/10.1177/0269881116675513openalex-snapshot

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

inferredcites →https://doi.org/10.1177/1179069518800508openalex-snapshot

Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics

inferredcites →https://doi.org/10.1371/journal.pone.0030800openalex-snapshot

Prediction of Psilocybin Response in Healthy Volunteers

inferredcites →https://doi.org/10.1371/journal.pone.0062226openalex-snapshot

Antidepressant Treatment Outcome Depends on the Quality of the Living Environment: A Pre-Clinical Investigation in Mice

inferredcites →https://doi.org/10.1371/journal.pone.0117503openalex-snapshot

Dynamics and Correlation of Serum Cortisol and Corticosterone under Different Physiological or Stressful Conditions in Mice

inferredcites →https://doi.org/10.1530/joe-10-0413openalex-snapshot

Corticosterone pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis activity via multiple actions that vary with time, site of action and de novo protein synthesis

inferredcites →https://doi.org/10.2174/1570159x1304150831150507openalex-snapshot

The Effects of Psychological Stress on Depression

inferredcites →https://doi.org/10.2174/1874473708666150107121331openalex-snapshot

Psilocybin-Occasioned Mystical Experiences in the Treatment of Tobacco Addiction

inferredcites →https://doi.org/10.22127/rjp.2018.58486openalex-snapshot

Alteration of Depressive-like Behaviors by Psilocybe cubensis Alkaloid Extract in Mice: the Role of Glutamate Pathway

inferredcites →https://doi.org/10.3389/fnmol.2018.00312openalex-snapshot

A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

inferredcites →https://doi.org/10.3389/fphar.2017.00974openalex-snapshot

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

inferredcites →https://doi.org/10.3389/fphar.2018.00733openalex-snapshot

Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development

inferredcites →https://doi.org/10.3389/fpsyt.2019.00974openalex-snapshot

Cortisol and Major Depressive Disorder—Translating Findings From Humans to Animal Models and Back

inferredcites →https://doi.org/10.3389/fpsyt.2020.00005openalex-snapshot

Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00213-024-06644-3openalex-snapshot

Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression

inferred← citeshttps://doi.org/10.1016/j.ijchp.2022.100349openalex-snapshot

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

inferred← citeshttps://doi.org/10.1016/j.isci.2024.109686openalex-snapshot

Psilocybin induces acute anxiety and changes in amygdalar phosphopeptides independently from the 5-HT2A receptor

inferred← citeshttps://doi.org/10.1038/s41593-025-01964-9openalex-snapshot

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

inferred← citeshttps://doi.org/10.1038/s44184-024-00095-6openalex-snapshot

A qualitative analysis of the psychedelic mushroom come-up and come-down

inferred← citeshttps://doi.org/10.1101/2022.10.31.22281688openalex-snapshot

Psilocybin induces acute and persisting alterations in immune status and the stress response in healthy volunteers

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3941205/v1openalex-snapshot

The Temporal Trajectory of the Psychedelic Mushroom Experience Mimics the Narrative Arc of the Hero’s Journey

inferred← citeshttps://doi.org/10.3389/fpsyt.2021.800072openalex-snapshot

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.