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Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL pro and M pro in in vitro studies
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cber.19240570703openalex-snapshot
Über selenhaltige aromatische Verbindungen (VI)
inferredcites →https://doi.org/10.1002/chem.200801258openalex-snapshot
Antioxidant Activity of the Anti‐Inflammatory Compound Ebselen: A Reversible Cyclization Pathway via Selenenic and Seleninic Acid Intermediates
inferredcites →https://doi.org/10.1002/jcb.25457openalex-snapshot
Antiviral Action of Diphenyl Diselenide on Herpes Simplex Virus 2 Infection in Female BALB/c Mice
inferredcites →https://doi.org/10.1002/jlac.1993199301201openalex-snapshot
Aromatic and Azaaromatic Diselenides, Benzisoselenazolones and Related Compounds as Immunomodulators Active in Humans: Synthesis and Properties
inferredcites →https://doi.org/10.1007/s00210-020-01901-6openalex-snapshot
A comprehensive review on drug repositioning against coronavirus disease 2019 (COVID19)
inferredcites →https://doi.org/10.1007/s00213-016-4319-5openalex-snapshot
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing
inferredcites →https://doi.org/10.1007/s11033-014-3417-xopenalex-snapshot
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
inferredcites →https://doi.org/10.1016/j.jmb.2006.11.073openalex-snapshot
Production of Authentic SARS-CoV Mpro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction
inferredcites →https://doi.org/10.1016/j.lfs.2020.117592openalex-snapshot
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
inferredcites →https://doi.org/10.1016/j.lfs.2020.117627openalex-snapshot
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
inferredcites →https://doi.org/10.1016/j.micpath.2020.104241openalex-snapshot
Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19)
inferredcites →https://doi.org/10.1016/j.tet.2011.09.141openalex-snapshot
Copper catalyzed/mediated synthetic methodology for ebselen and related isoselenazolones
inferredcites →https://doi.org/10.1016/j.tet.2018.05.027openalex-snapshot
Key steps and intermediates in the catalytic mechanism for the reduction of peroxides by the antioxidant ebselen
inferredcites →https://doi.org/10.1016/s0140-6736(20)30185-9openalex-snapshot
A novel coronavirus outbreak of global health concern
inferredcites →https://doi.org/10.1016/s1473-3099(20)30120-1openalex-snapshot
An interactive web-based dashboard to track COVID-19 in real time
inferredcites →https://doi.org/10.1021/acs.jmedchem.5b01183openalex-snapshot
Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity
inferredcites →https://doi.org/10.1021/acscombsci.0c00058openalex-snapshot
Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
inferredcites →https://doi.org/10.1021/acsinfecdis.0c00168openalex-snapshot
Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease
inferredcites →https://doi.org/10.1021/cb500512zopenalex-snapshot
Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication
inferredcites →https://doi.org/10.1021/cr000426wopenalex-snapshot
Chemistry of Biologically Important Synthetic Organoselenium Compounds
inferredcites →https://doi.org/10.1021/ic201603vopenalex-snapshot
Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen
inferredcites →https://doi.org/10.1021/ol102027jopenalex-snapshot
Cu-Catalyzed Efficient Synthetic Methodology for Ebselen and Related Se−N Heterocycles
inferredcites →https://doi.org/10.1038/nrd.2015.37openalex-snapshot
Coronaviruses — drug discovery and therapeutic options
inferredcites →https://doi.org/10.1038/s41586-020-2008-3openalex-snapshot
A new coronavirus associated with human respiratory disease in China
inferredcites →https://doi.org/10.1038/s41586-020-2223-yopenalex-snapshot
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
inferredcites →https://doi.org/10.1038/s41586-020-2601-5openalex-snapshot
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
inferredcites →https://doi.org/10.1038/s41591-020-0820-9openalex-snapshot
The proximal origin of SARS-CoV-2
inferredcites →https://doi.org/10.1039/c4ob00027gopenalex-snapshot
An ebselen like catalyst with enhanced GPx activity via a selenol intermediate
inferredcites →https://doi.org/10.1055/s-0028-1111106openalex-snapshot
Development of Ebselen, a Glutathione Peroxidase Mimic, for the Prevention and Treatment of Noise-Induced Hearing Loss
inferredcites →https://doi.org/10.1056/nejmoa2007764openalex-snapshot
Remdesivir for the Treatment of Covid-19 — Final Report
inferredcites →https://doi.org/10.1101/2020.03.07.981928openalex-snapshot
Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging
inferredcites →https://doi.org/10.1101/2020.04.29.068890openalex-snapshot
Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design
inferredcites →https://doi.org/10.1101/2020.05.17.100768openalex-snapshot
Ebselen as a highly active inhibitor of PL Pro CoV2
inferredcites →https://doi.org/10.1101/2020.05.20.107052openalex-snapshot
Discovery of potent inhibitors of PL pro CoV2 by screening a library of selenium-containing compounds
inferredcites →https://doi.org/10.1111/febs.12936openalex-snapshot
From SARS to MERS : crystallographic studies on coronaviral proteases enable antiviral drug design
inferredcites →https://doi.org/10.1126/science.1085658openalex-snapshot
Coronavirus Main Proteinase (3CL pro ) Structure: Basis for Design of Anti-SARS Drugs
inferredcites →https://doi.org/10.1126/science.abb3405openalex-snapshot
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
inferredcites →https://doi.org/10.1128/aac.02574-15openalex-snapshot
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
inferredcites →https://doi.org/10.1161/01.str.29.1.12openalex-snapshot
Ebselen in Acute Ischemic Stroke
inferredcites →https://doi.org/10.1371/journal.pbio.0030324openalex-snapshot
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
inferredcites →https://doi.org/10.1371/journal.pbio.0030428openalex-snapshot
Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
inferredcites →https://doi.org/10.1371/journal.ppat.1006854openalex-snapshot
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission
inferredcites →https://doi.org/10.1371/journal.ppat.1006885openalex-snapshot
When are pathogen genome sequences informative of transmission events?
inferredcites →https://doi.org/10.15252/embj.2020106275openalex-snapshot
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
inferredcites →https://doi.org/10.2174/2213346103666160127003506openalex-snapshot
Synthesis of Biologically Active Selenium-Containing Molecules From Greener Perspectives
inferredcites →https://doi.org/10.24820/ark.5550190.p009.797openalex-snapshot
Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties
inferredcites →https://doi.org/10.3390/molecules22060974openalex-snapshot
Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties
inferredcites →https://doi.org/10.4155/fmc-2020-0147openalex-snapshot
Tackling SARS-CoV-2: Proposed Targets and Repurposed Drugs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/s00204-021-03003-5openalex-snapshot
Toxicology and pharmacology of synthetic organoselenium compounds: an update
inferred← citeshttps://doi.org/10.1007/s11030-025-11315-2openalex-snapshot
9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease
inferred← citeshttps://doi.org/10.1007/s11696-022-02298-7openalex-snapshot
Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106830openalex-snapshot
Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease
inferred← citeshttps://doi.org/10.1016/j.drudis.2023.103832openalex-snapshot
Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113863openalex-snapshot
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.134476openalex-snapshot
Disrupting protease and deubiquitinase activities of SARS-CoV-2 papain-like protease by natural and synthetic products discovered through multiple computational and biochemical approaches
inferred← citeshttps://doi.org/10.1016/j.rechem.2021.100199openalex-snapshot
In silico investigation of phytoconstituents of medicinal herb ‘Piper Longum’ against SARS-CoV-2 by molecular docking and molecular dynamics analysis
inferred← citeshttps://doi.org/10.1016/j.str.2021.07.007openalex-snapshot
Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01005openalex-snapshot
Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure–Activity Relationship Insights and Evolution Perspectives
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01799openalex-snapshot
Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action
inferred← citeshttps://doi.org/10.1021/acsptsci.0c00130openalex-snapshot
Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV‑2 Main Protease Inhibitors
inferred← citeshttps://doi.org/10.1038/s41598-022-18676-wopenalex-snapshot
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts
inferred← citeshttps://doi.org/10.1039/bk9781839167386-00567openalex-snapshot
The Long Story of Ebselen: From about One Century of its Synthesis to Clinical Trials
inferred← citeshttps://doi.org/10.1039/d2ob00696kopenalex-snapshot
Silver-catalysed three-component reactions of alkynyl aryl ketones, element selenium, and boronic acids leading to 3-organoselenylchromones
inferred← citeshttps://doi.org/10.1039/d3nj05180copenalex-snapshot
Selenium compounds as promising antiviral agents
inferred← citeshttps://doi.org/10.1042/bcj20200514openalex-snapshot
The role of chemical biology in the fight against SARS-CoV-2
inferred← citeshttps://doi.org/10.1111/sji.13044openalex-snapshot
Interactions between SARS coronavirus 2 papain‐like protease and immune system: A potential drug target for the treatment of COVID‐19
inferred← citeshttps://doi.org/10.1128/jvi.02374-20openalex-snapshot
Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity
inferred← citeshttps://doi.org/10.1134/s0006350922060082openalex-snapshot
SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein–Protein Interactions
inferred← citeshttps://doi.org/10.13005/bpj/2908openalex-snapshot
Computational Investigation of Bioactive Phytoconstituents as SarS-Cov-2 Main Protease Inhibitors Through Molecular Docking and Interaction Fingerprint Studies
inferred← citeshttps://doi.org/10.21203/rs.3.rs-997891/v1openalex-snapshot
Evaluation of the inhibitory potential of essential oils and aromatic extracts on SARS-CoV-2 Mpro and PLpro
inferred← citeshttps://doi.org/10.29413/abs.2021-6.3.6openalex-snapshot
Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
inferred← citeshttps://doi.org/10.3389/fchem.2021.819165openalex-snapshot
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
inferred← citeshttps://doi.org/10.3389/fchem.2022.832431openalex-snapshot
Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease
inferred← citeshttps://doi.org/10.3390/app11146291openalex-snapshot
Mechanistic Insight into SARS-CoV-2 Mpro Inhibition by Organoselenides: The Ebselen Case Study
inferred← citeshttps://doi.org/10.3390/biom13091339openalex-snapshot
Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives
inferred← citeshttps://doi.org/10.3390/ijms22083957openalex-snapshot
SARS-CoV-2 Papain-Like Protease Potential Inhibitors—In Silico Quantitative Assessment
inferred← citeshttps://doi.org/10.3390/ijms22189792openalex-snapshot
The Se–S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study
inferred← citeshttps://doi.org/10.3390/ijms25158105openalex-snapshot
Breaking the Chain: Protease Inhibitors as Game Changers in Respiratory Viruses Management
inferred← citeshttps://doi.org/10.3390/ph14080742openalex-snapshot
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors–Molecular Docking and In Vitro Study
inferred← citeshttps://doi.org/10.34184/kssb.2022.10.1.1openalex-snapshot
Current understanding of SARS-CoV-2 papain-like protease inhibitors
inferred← citeshttps://doi.org/10.3897/pharmacia.68.e68432openalex-snapshot
Molecular docking of secondary metabolites from Indonesian marine and terrestrial organisms targeting SARS-CoV-2 ACE-2, M pro, and PL pro receptors
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