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Deep computational analysis of human cancer and non-cancer tissues details dysregulation of eIF4F components and their interactions in human cancers

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Competitive PCR to detect eIF4E gene amplification in head and neck cancer
inferredcites →https://doi.org/10.1002/(sici)1098-2264(199807)22:3<186::aid-gcc4>3.0.co;2-sopenalex-snapshot
Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancer
inferredcites →https://doi.org/10.1002/pmic.201400466openalex-snapshot
Studying macromolecular complex stoichiometries by peptide‐based mass spectrometry
inferredcites →https://doi.org/10.1007/bf02303778openalex-snapshot
Detection of eIF4E gene amplification in breast cancer by competitive PCR
inferredcites →https://doi.org/10.1016/0165-4608(88)90010-6openalex-snapshot
Fragile sites at 4q23 and 7q11.23 unique to bone marrow cells
inferredcites →https://doi.org/10.1016/0165-4608(92)90013-xopenalex-snapshot
Acute monocytic leukemia with (8;22)(p11;q13) translocation
inferredcites →https://doi.org/10.1016/j.ccr.2007.07.006openalex-snapshot
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
inferredcites →https://doi.org/10.1016/j.cell.2009.01.014openalex-snapshot
Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation
inferredcites →https://doi.org/10.1016/j.cell.2015.05.049openalex-snapshot
Differential Requirements for eIF4E Dose in Normal Development and Cancer
inferredcites →https://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferredcites →https://doi.org/10.1016/j.cell.2017.10.039openalex-snapshot
Cancer Evolution: No Room for Negative Selection
inferredcites →https://doi.org/10.1016/j.cell.2018.02.052openalex-snapshot
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
inferredcites →https://doi.org/10.1016/j.cell.2018.03.042openalex-snapshot
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data
inferredcites →https://doi.org/10.1016/j.cell.2020.06.013openalex-snapshot
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
inferredcites →https://doi.org/10.1016/j.cels.2018.03.003openalex-snapshot
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
inferredcites →https://doi.org/10.1016/j.cels.2018.11.003openalex-snapshot
Production of Protein-Complex Components Is Stoichiometric and Lacks General Feedback Regulation in Eukaryotes
inferredcites →https://doi.org/10.1016/j.molcel.2006.01.010openalex-snapshot
Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth
inferredcites →https://doi.org/10.1016/j.molcel.2007.10.019openalex-snapshot
A Hypoxia-Controlled Cap-Dependent to Cap-Independent Translation Switch in Breast Cancer
inferredcites →https://doi.org/10.1016/j.molcel.2016.09.020openalex-snapshot
The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation
inferredcites →https://doi.org/10.1016/j.molonc.2015.12.004openalex-snapshot
Non‐invasive detection of genome‐wide somatic copy number alterations by liquid biopsies
inferredcites →https://doi.org/10.1016/s0021-9258(19)75938-9openalex-snapshot
Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.
inferredcites →https://doi.org/10.1016/s0092-8674(00)80201-9openalex-snapshot
Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons
inferredcites →https://doi.org/10.1016/s0092-8674(03)00975-9openalex-snapshot
Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E
inferredcites →https://doi.org/10.1038/bjc.2015.450openalex-snapshot
Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma
inferredcites →https://doi.org/10.1038/nature01771openalex-snapshot
Dosage sensitivity and the evolution of gene families in yeast
inferredcites →https://doi.org/10.1038/nature10098openalex-snapshot
Global quantification of mammalian gene expression control
inferredcites →https://doi.org/10.1038/nature11055openalex-snapshot
An oxygen-regulated switch in the protein synthesis machinery
inferredcites →https://doi.org/10.1038/nature13572openalex-snapshot
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
inferredcites →https://doi.org/10.1038/nature18003openalex-snapshot
Proteogenomics connects somatic mutations to signalling in breast cancer
inferredcites →https://doi.org/10.1038/nature18954openalex-snapshot
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
inferredcites →https://doi.org/10.1038/nbt.1522openalex-snapshot
Dynamic modularity in protein interaction networks predicts breast cancer outcome
inferredcites →https://doi.org/10.1038/nbt.3772openalex-snapshot
Toil enables reproducible, open source, big biomedical data analyses
inferredcites →https://doi.org/10.1038/ncomms5790openalex-snapshot
4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation
inferredcites →https://doi.org/10.1038/ng.2760openalex-snapshot
Pan-cancer patterns of somatic copy number alteration
inferredcites →https://doi.org/10.1038/nm1042openalex-snapshot
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
inferredcites →https://doi.org/10.1038/nrc3063openalex-snapshot
Human cancers express mutator phenotypes: origin, consequences and targeting
inferredcites →https://doi.org/10.1038/nrd4505openalex-snapshot
Targeting the translation machinery in cancer
inferredcites →https://doi.org/10.1038/nrg2223openalex-snapshot
Coupling and coordination in gene expression processes: a systems biology view
inferredcites →https://doi.org/10.1038/nrm2838openalex-snapshot
The mechanism of eukaryotic translation initiation and principles of its regulation
inferredcites →https://doi.org/10.1038/nrmicro2655openalex-snapshot
Viral subversion of the host protein synthesis machinery
inferredcites →https://doi.org/10.1038/onc.2015.515openalex-snapshot
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis
inferredcites →https://doi.org/10.1038/s41598-018-25798-7openalex-snapshot
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis
inferredcites →https://doi.org/10.1038/s41598-019-46594-xopenalex-snapshot
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait
inferredcites →https://doi.org/10.1038/sj.onc.1202563openalex-snapshot
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis
inferredcites →https://doi.org/10.1073/pnas.1203853109openalex-snapshot
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs
inferredcites →https://doi.org/10.1073/pnas.1512118112openalex-snapshot
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1
inferredcites →https://doi.org/10.1073/pnas.95.20.11715openalex-snapshot
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
inferredcites →https://doi.org/10.1073/pnas.95.25.14863openalex-snapshot
Cluster analysis and display of genome-wide expression patterns
inferredcites →https://doi.org/10.1074/jbc.272.35.21677openalex-snapshot
eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure
inferredcites →https://doi.org/10.1074/jbc.272.51.32061openalex-snapshot
Alternative Translation of the Proto-oncogene c-mycby an Internal Ribosome Entry Site
inferredcites →https://doi.org/10.1074/jbc.273.23.14484openalex-snapshot
Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
inferredcites →https://doi.org/10.1074/jbc.m006345200openalex-snapshot
Characterization of the Two eIF4A-binding Sites on Human eIF4G-1
inferredcites →https://doi.org/10.1074/jbc.m113.471466openalex-snapshot
Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions
inferredcites →https://doi.org/10.1074/jbc.r115.675280openalex-snapshot
eIF4F: A Retrospective
inferredcites →https://doi.org/10.1074/jbc.ra119.008512openalex-snapshot
Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)
inferredcites →https://doi.org/10.1093/emboj/16.8.1909openalex-snapshot
Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
inferredcites →https://doi.org/10.1093/emboj/18.1.270openalex-snapshot
Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
inferredcites →https://doi.org/10.1093/emboj/cdf345openalex-snapshot
The exon junction complex is detected on CBP80‐bound but not eIF4E‐bound mRNA in mammalian cells: dynamics of mRNP remodeling
inferredcites →https://doi.org/10.1093/nar/gkq1206openalex-snapshot
Synergistic activation of eIF4A by eIF4B and eIF4G
inferredcites →https://doi.org/10.1101/326470openalex-snapshot
The UCSC Xena platform for public and private cancer genomics data visualization and interpretation
inferredcites →https://doi.org/10.1101/566505openalex-snapshot
The Tangent copy-number inference pipeline for cancer genome analyses
inferredcites →https://doi.org/10.1101/cshperspect.a011528openalex-snapshot
Principles of Translational Control: An Overview
inferredcites →https://doi.org/10.1101/cshperspect.a012336openalex-snapshot
Translational Control in Cancer Etiology
inferredcites →https://doi.org/10.1101/cshperspect.a032672openalex-snapshot
Noncanonical Translation Initiation in Eukaryotes
inferredcites →https://doi.org/10.1101/gad.13.11.1422openalex-snapshot
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
inferredcites →https://doi.org/10.1101/gad.889201openalex-snapshot
Suppression of cap-dependent translation in mitosis
inferredcites →https://doi.org/10.1101/gad.912401openalex-snapshot
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
inferredcites →https://doi.org/10.1101/sqb.1951.016.01.004openalex-snapshot
CHROMOSOME ORGANIZATION AND GENIC EXPRESSION
inferredcites →https://doi.org/10.1111/j.1365-2141.1994.tb04848.xopenalex-snapshot
An atypical myeloproliferative disorder with t(8;13) (p11;q12): a third case
inferredcites →https://doi.org/10.1126/sciadv.aax8978openalex-snapshot
Beyond mass spectrometry, the next step in proteomics
inferredcites →https://doi.org/10.1126/science.8235596openalex-snapshot
Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma
inferredcites →https://doi.org/10.1128/mcb.00306-18openalex-snapshot
Ribosomal RACK1:Protein Kinase C β II Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding
inferredcites →https://doi.org/10.1128/mcb.01046-13openalex-snapshot
Mitotic Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1232 by Cdk1:Cyclin B Inhibits eIF4A Helicase Complex Binding with RNA
inferredcites →https://doi.org/10.1128/mcb.01187-08openalex-snapshot
Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap
inferredcites →https://doi.org/10.1128/mcb.16.9.4754openalex-snapshot
An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc
inferredcites →https://doi.org/10.1128/mcb.20.2.468-477.2000openalex-snapshot
Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region
inferredcites →https://doi.org/10.1146/annurev-biochem-013118-111042openalex-snapshot
The Organizing Principles of Eukaryotic Ribosome Recruitment
inferredcites →https://doi.org/10.1146/annurev-biochem-060713-035802openalex-snapshot
The Scanning Mechanism of Eukaryotic Translation Initiation
inferredcites →https://doi.org/10.1158/0008-5472.can-07-5635openalex-snapshot
Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy
inferredcites →https://doi.org/10.1158/0008-5472.can-07-5876openalex-snapshot
c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3472openalex-snapshot
eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2395openalex-snapshot
eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
inferredcites →https://doi.org/10.1158/0008-5472.can-16-1298openalex-snapshot
Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-2082openalex-snapshot
Reactive Oxygen Species: A Breath of Life or Death?
inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-0986openalex-snapshot
Overexpression of Phospho-eIF4E Is Associated with Survival through AKT Pathway in Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-0433openalex-snapshot
Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer
inferredcites →https://doi.org/10.1158/1541-7786.mcr-05-0128openalex-snapshot
Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
inferredcites →https://doi.org/10.1158/1541-7786.mcr-12-0095openalex-snapshot
Contribution of HIF-1α in 4E-BP1 Gene Expression
inferredcites →https://doi.org/10.1182/blood.v83.7.1757.1757openalex-snapshot
Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma
inferredcites →https://doi.org/10.1186/gb-2005-6-3-r22openalex-snapshot
A DNA microarray survey of gene expression in normal human tissues
inferredcites →https://doi.org/10.1186/gb-2011-12-4-r41openalex-snapshot
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
inferredcites →https://doi.org/10.1186/gm62openalex-snapshot
Copy number variations and cancer
inferredcites →https://doi.org/10.1186/s12885-019-5667-4openalex-snapshot
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer
inferredcites →https://doi.org/10.1186/s13000-019-0856-7openalex-snapshot
Prognostic impact of diffuse large B-cell lymphoma with extra copies of MYC, BCL2 and/or BCL6: comparison with double/triple hit lymphoma and double expressor lymphoma
inferredcites →https://doi.org/10.1261/rna.029322.111openalex-snapshot
Alternative ferritin mRNA translation via internal initiation
inferredcites →https://doi.org/10.1261/rna.033209.112openalex-snapshot
A cellular response linking eIF4AI activity to eIF4AII transcription
inferredcites →https://doi.org/10.1371/journal.pone.0003094openalex-snapshot
A Translation Initiation Element Specific to mRNAs with Very Short 5′UTR that Also Regulates Transcription
inferredcites →https://doi.org/10.1371/journal.pone.0009474openalex-snapshot
Dosage Sensitivity Shapes the Evolution of Copy-Number Varied Regions
inferredcites →https://doi.org/10.1371/journal.pone.0012791openalex-snapshot
Comparative Structural Analysis of Human DEAD-Box RNA Helicases
inferredcites →https://doi.org/10.4046/trd.2017.80.2.179openalex-snapshot
Keratinization of Lung Squamous Cell Carcinoma Is Associated with Poor Clinical Outcome

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41420-022-00963-0openalex-snapshot
EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma
inferred← citeshttps://doi.org/10.1038/s41420-023-01380-7openalex-snapshot
The long non-coding RNA PVT1 promotes tumorigenesis of cutaneous squamous cell carcinoma via interaction with 4EBP1
inferred← citeshttps://doi.org/10.1101/2022.09.16.508318openalex-snapshot
Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer models
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