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Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

https://doi.org/10.1101/2022.01.03.474779
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2020.6019openalex-snapshot
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
inferredcites →https://doi.org/10.1002/rmv.722openalex-snapshot
Phosphorylation events during viral infections provide potential therapeutic targets
inferredcites →https://doi.org/10.1007/s00018-009-9150-2openalex-snapshot
Protein Kinase CK2 in Health and Disease
inferredcites →https://doi.org/10.1016/j.bmcl.2020.127284openalex-snapshot
Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines
inferredcites →https://doi.org/10.1016/j.bmcl.2021.128407openalex-snapshot
Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)
inferredcites →https://doi.org/10.1016/j.cell.2020.06.034openalex-snapshot
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
inferredcites →https://doi.org/10.1016/j.celrep.2020.107940openalex-snapshot
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
inferredcites →https://doi.org/10.1016/j.celrep.2021.109364openalex-snapshot
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
inferredcites →https://doi.org/10.1016/j.chembiol.2017.10.010openalex-snapshot
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
inferredcites →https://doi.org/10.1016/j.chembiol.2020.12.013openalex-snapshot
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
inferredcites →https://doi.org/10.1016/j.jbc.2021.100306openalex-snapshot
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00302openalex-snapshot
Kinase Inhibitors as Underexplored Antiviral Agents
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b01213openalex-snapshot
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00136openalex-snapshot
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
inferredcites →https://doi.org/10.1021/acschembio.1c00036openalex-snapshot
The Promise and Peril of Chemical Probe Negative Controls
inferredcites →https://doi.org/10.1021/acsmedchemlett.9b00399openalex-snapshot
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K
inferredcites →https://doi.org/10.1021/cb3002478openalex-snapshot
Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
inferredcites →https://doi.org/10.1038/nature12005openalex-snapshot
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
inferredcites →https://doi.org/10.1038/nchembio.1867openalex-snapshot
The promise and peril of chemical probes
inferredcites →https://doi.org/10.1038/nrd.2016.244openalex-snapshot
Applications of chemogenomic library screening in drug discovery
inferredcites →https://doi.org/10.1038/s41579-020-00468-6openalex-snapshot
Coronavirus biology and replication: implications for SARS-CoV-2
inferredcites →https://doi.org/10.1038/s41580-021-00418-xopenalex-snapshot
Mechanisms of SARS-CoV-2 entry into cells
inferredcites →https://doi.org/10.1038/s41586-020-2180-5openalex-snapshot
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
inferredcites →https://doi.org/10.1038/s41586-020-2286-9openalex-snapshot
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
inferredcites →https://doi.org/10.1042/bj20021469openalex-snapshot
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death
inferredcites →https://doi.org/10.1093/ve/vew014openalex-snapshot
Antiviral drug resistance as an adaptive process
inferredcites →https://doi.org/10.1096/fj.02-0473revopenalex-snapshot
One‐thousand‐and‐one substrates of protein kinase CK2?
inferredcites →https://doi.org/10.1126/science.abe8499openalex-snapshot
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
inferredcites →https://doi.org/10.1126/science.abe9403openalex-snapshot
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
inferredcites →https://doi.org/10.1126/science.abi4708openalex-snapshot
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
inferredcites →https://doi.org/10.1126/scitranslmed.aal3653openalex-snapshot
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
inferredcites →https://doi.org/10.1128/cmr.00168-19openalex-snapshot
Host-Directed Antiviral Therapy
inferredcites →https://doi.org/10.1146/annurev-virology-110615-042301openalex-snapshot
Structure, Function, and Evolution of Coronavirus Spike Proteins
inferredcites →https://doi.org/10.1172/jci89857openalex-snapshot
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
inferredcites →https://doi.org/10.1186/s12967-020-02476-9openalex-snapshot
A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals
inferredcites →https://doi.org/10.1186/s12967-020-02480-zopenalex-snapshot
The current landscape of coronavirus-host protein–protein interactions
inferredcites →https://doi.org/10.1371/journal.ppat.1004502openalex-snapshot
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
inferredcites →https://doi.org/10.1371/journal.ppat.1007788openalex-snapshot
Activity of CK2α protein kinase is required for efficient replication of some HPV types
inferredcites →https://doi.org/10.1371/journal.ppat.1008392openalex-snapshot
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry
inferredcites →https://doi.org/10.3390/ijms22020566openalex-snapshot
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
inferredcites →https://doi.org/10.3390/v12080880openalex-snapshot
Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00697openalex-snapshot
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses
inferred← citeshttps://doi.org/10.1021/acsomega.2c02794openalex-snapshot
Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice
inferred← citeshttps://doi.org/10.3390/v14030552openalex-snapshot
Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
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