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CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

https://doi.org/10.1101/2022.08.12.503154
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Preparation of Hydrogel Substrates with Tunable Mechanical Properties
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Aβ Measurement by Enzyme-Linked Immunosorbent Assay
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The relation between load and penetration in the axisymmetric boussinesq problem for a punch of arbitrary profile
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Poisson's ratio of polyacrylamide (PAAm) gels
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A potential role for integrins in host cell entry by SARS-CoV-2
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Galectin-3: An open-ended story
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Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions
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The role of proteases in transforming growth factor-β activation
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Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis
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High levels of IL-6 and IL-8 characterize early-on idiopathic pulmonary fibrosis acute exacerbations
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Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
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Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
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The SLC3 and SLC7 families of amino acid transporters
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Matrix biomechanics and dynamics in pulmonary fibrosis
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Outcome of patients with idiopathic pulmonary fibrosis (IPF) ventilated in intensive care unit
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Impact of the pattern of interstitial lung disease on mortality in rheumatoid arthritis: A systematic literature review and meta-analysis
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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial
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Complementation of dominant suppression implicates CD98 in integrin activation
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Hypersensitivity pneumonia: the role of lung biopsy in diagnosis and management
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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Latent TGF-β structure and activation
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Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch
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Direct observation of individual endogenous protein complexes in situ by proximity ligation
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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
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A dynamic COVID-19 immune signature includes associations with poor prognosis
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An inflammatory cytokine signature predicts COVID-19 severity and survival
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A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis
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Tensin1 expression and function in chronic obstructive pulmonary disease
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Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins
inferredcites →https://doi.org/10.1056/nejmoa1113354openalex-snapshot
Prednisone, Azathioprine, and N -Acetylcysteine for Pulmonary Fibrosis
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A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
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Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
inferredcites →https://doi.org/10.1074/jbc.m109.033332openalex-snapshot
Association of Cell Surface Mucins with Galectin-3 Contributes to the Ocular Surface Epithelial Barrier
inferredcites →https://doi.org/10.1074/jbc.m110.143370openalex-snapshot
Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force
inferredcites →https://doi.org/10.1074/jbc.m117.802793openalex-snapshot
The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions
inferredcites →https://doi.org/10.1074/jbc.m702877200openalex-snapshot
CD98hc (SLC3A2) Interaction with the Integrin β Subunit Cytoplasmic Domain Mediates Adhesive Signaling
inferredcites →https://doi.org/10.1080/14397595.2020.1751402openalex-snapshot
Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: A Japanese population analysis of the SENSCIS trial
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The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
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Interleukin 4 is localized to and released by human mast cells.
inferredcites →https://doi.org/10.1091/mbc.01-11-0530openalex-snapshot
Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth
inferredcites →https://doi.org/10.1091/mbc.9.9.2627openalex-snapshot
Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1
inferredcites →https://doi.org/10.1093/jb/mvv127openalex-snapshot
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners
inferredcites →https://doi.org/10.1096/fasebj.2020.34.s1.02311openalex-snapshot
Translational pharmacology of TD139, an inhaled small molecule galectin‐3 (Gal‐3) inhibitor for the treatment of idiopathic pulmonary fibrosis (IPF)
inferredcites →https://doi.org/10.1099/vir.0.81749-0openalex-snapshot
Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus
inferredcites →https://doi.org/10.1111/j.1742-4658.2007.05806.xopenalex-snapshot
Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells − implication for placental cell fusion
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Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality
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Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo
inferredcites →https://doi.org/10.1128/jvi.01146-08openalex-snapshot
Kaposi's Sarcoma-Associated Herpesvirus Forms a Multimolecular Complex of Integrins (αVβ5, αVβ3, and α3β1) and CD98-xCT during Infection of Human Dermal Microvascular Endothelial Cells, and CD98-xCT Is Essential for the Postentry Stage of Infection
inferredcites →https://doi.org/10.1136/thorax-2019-btsabstracts2019.258openalex-snapshot
P115 A segmental LPS challenge study to investigate the pharmacodynamics of a TRPV4 antagonist (GSK2798745) in healthy participants
inferredcites →https://doi.org/10.1136/thx.2005.055814openalex-snapshot
Relationship between histopathological features and the course of idiopathic pulmonary fibrosis/usual interstitial pneumonia
inferredcites →https://doi.org/10.1152/ajplung.00221.2016openalex-snapshot
Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis
inferredcites →https://doi.org/10.1152/physrev.00036.2018openalex-snapshot
Cell Adhesion by Integrins
inferredcites →https://doi.org/10.1159/000329891openalex-snapshot
Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Outcome and Prognostic Factors
inferredcites →https://doi.org/10.1164/ajrccm.164.9.2103074openalex-snapshot
Histopathologic Variability in Usual and Nonspecific Interstitial Pneumonias
inferredcites →https://doi.org/10.1164/rccm.201106-0965ocopenalex-snapshot
Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3
inferredcites →https://doi.org/10.1164/rccm.201403-0566ocopenalex-snapshot
Epidemiologic Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences
inferredcites →https://doi.org/10.1164/rccm.201508-1638ocopenalex-snapshot
Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis
inferredcites →https://doi.org/10.1164/rccm.201903-0497ppopenalex-snapshot
Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?
inferredcites →https://doi.org/10.1164/rccm.202007-2794ocopenalex-snapshot
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study
inferredcites →https://doi.org/10.1165/rcmb.2009-0210stopenalex-snapshot
An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals
inferredcites →https://doi.org/10.1165/rcmb.2018-0182ocopenalex-snapshot
LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin
inferredcites →https://doi.org/10.1172/jci.insight.90558openalex-snapshot
Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1172/jci27183openalex-snapshot
Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury
inferredcites →https://doi.org/10.1172/jci44631openalex-snapshot
CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
inferredcites →https://doi.org/10.1172/jci75331openalex-snapshot
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice
inferredcites →https://doi.org/10.1183/09031936.00106011openalex-snapshot
Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study
inferredcites →https://doi.org/10.1183/09059180.00000713openalex-snapshot
The role of infection in the pathogenesis of idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1183/09059180.00003214openalex-snapshot
Cellular interactions in the pathogenesis of interstitial lung diseases
inferredcites →https://doi.org/10.1186/s12890-019-0969-5openalex-snapshot
Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: a retrospective single-center study
inferredcites →https://doi.org/10.1242/jcs.151159openalex-snapshot
The galectin lattice at a glance
inferredcites →https://doi.org/10.1371/journal.pone.0051830openalex-snapshot
CD98 Positive Eosinophils Contribute to T Helper 1 Pattern Inflammation
inferredcites →https://doi.org/10.1371/journal.pone.0116775openalex-snapshot
Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
inferredcites →https://doi.org/10.1371/journal.pone.0164438openalex-snapshot
Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype
inferredcites →https://doi.org/10.1371/journal.ppat.1009128openalex-snapshot
SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
inferredcites →https://doi.org/10.1378/chest.125.2.522openalex-snapshot
Prognostic Implications of Histologic Patterns in Multiple Surgical Lung Biopsies From Patients With Idiopathic Interstitial Pneumonias
inferredcites →https://doi.org/10.1513/annalsats.201410-448mgopenalex-snapshot
Mechanisms of Alveolar Epithelial Injury, Repair, and Fibrosis
inferredcites →https://doi.org/10.2144/000113719openalex-snapshot
Detection of Antigen Interactions Ex Vivo by Proximity Ligation Assay: Endogenous Dopamine D2-Adenosine A2A Receptor Complexes in the Striatum
inferredcites →https://doi.org/10.3389/fimmu.2020.602395openalex-snapshot
Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
inferredcites →https://doi.org/10.3390/ijms19020392openalex-snapshot
Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
inferredcites →https://doi.org/10.4049/jimmunol.1100002openalex-snapshot
Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity
inferredcites →https://doi.org/10.4049/jimmunol.180.4.2650openalex-snapshot
Regulation of Alternative Macrophage Activation by Galectin-3

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107300openalex-snapshot
Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis
inferred← citeshttps://doi.org/10.3390/pharmaceutics17091127openalex-snapshot
Therapeutic Effect of Membrane Vesicle Drug Delivery Systems in Inflammatory Bowel Disease
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