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A Novel Mechanobiological Model of Bone Metastasis Reveals that Mechanical Stimulation Inhibits the Pro-Osteoclastogenic Effects of Breast Cancer Cells

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Molecular mechanisms of osteolytic bone metastases
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Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma
inferredcites →https://doi.org/10.1002/adfm.202206992openalex-snapshot
Bioinspired Silk Fibroin Mineralization for Advanced In Vitro Bone Remodeling Models
inferredcites →https://doi.org/10.1002/bdrc.20110openalex-snapshot
Cellular mechanobiology and cancer metastasis
inferredcites →https://doi.org/10.1002/jbm.b.33772openalex-snapshot
In vitro cyclic compressive loads potentiate early osteogenic events in engineered bone tissue
inferredcites →https://doi.org/10.1002/jbmr.1966openalex-snapshot
In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model
inferredcites →https://doi.org/10.1002/jbmr.5650050905openalex-snapshot
Cellular responses to mechanical loading in vitro
inferredcites →https://doi.org/10.1002/jcb.26745openalex-snapshot
Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling
inferredcites →https://doi.org/10.1002/jcp.25708openalex-snapshot
A Human 3D In Vitro Model to Assess the Relationship Between Osteoporosis and Dissemination to Bone of Breast Cancer Tumor Cells
inferredcites →https://doi.org/10.1002/jor.20179openalex-snapshot
Release of nitric oxide, but not prostaglandin E 2 , by bone cells depends on fluid flow frequency
inferredcites →https://doi.org/10.1007/s00018-002-8524-5openalex-snapshot
Genes involved in breast cancer metastasis to bone
inferredcites →https://doi.org/10.1007/s00223-008-9174-xopenalex-snapshot
Bone Volume Fraction Explains the Variation in Strength and Stiffness of Cancellous Bone Affected by Metastatic Cancer and Osteoporosis
inferredcites →https://doi.org/10.1007/s10237-014-0599-zopenalex-snapshot
Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
inferredcites →https://doi.org/10.1007/s10585-007-9127-1openalex-snapshot
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
inferredcites →https://doi.org/10.1007/s10659-016-9619-9openalex-snapshot
Solid Tumors Are Poroelastic Solids with a Chemo-mechanical Feedback on Growth
inferredcites →https://doi.org/10.1007/s10911-004-1404-xopenalex-snapshot
The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
inferredcites →https://doi.org/10.1016/0021-9290(94)90021-3openalex-snapshot
Stress-dependent finite growth in soft elastic tissues
inferredcites →https://doi.org/10.1016/0046-8177(92)90034-zopenalex-snapshot
Integrins and their accessory adhesion molecules in mammary carcinomas: Loss of polarization in poorly differentiated tumors
inferredcites →https://doi.org/10.1016/j.actbio.2007.04.002openalex-snapshot
Biomechanics and biophysics of cancer cells☆
inferredcites →https://doi.org/10.1016/j.bbrc.2004.01.138openalex-snapshot
Nitric oxide production by bone cells is fluid shear stress rate dependent
inferredcites →https://doi.org/10.1016/j.bbrc.2020.12.016openalex-snapshot
Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism
inferredcites →https://doi.org/10.1016/j.biomaterials.2015.06.026openalex-snapshot
Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II
inferredcites →https://doi.org/10.1016/j.biomaterials.2020.120624openalex-snapshot
In vitro bone metastasis dwelling in a 3D bioengineered niche
inferredcites →https://doi.org/10.1016/j.bone.2007.04.191openalex-snapshot
Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro
inferredcites →https://doi.org/10.1016/j.bone.2007.07.019openalex-snapshot
Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption
inferredcites →https://doi.org/10.1016/j.bone.2007.09.047openalex-snapshot
Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading
inferredcites →https://doi.org/10.1016/j.bone.2008.12.027openalex-snapshot
Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds
inferredcites →https://doi.org/10.1016/j.bone.2021.116100openalex-snapshot
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer
inferredcites →https://doi.org/10.1016/j.cam.2016.12.026openalex-snapshot
Bone metastasis modeling based on the interactions between the BMU and tumor cells
inferredcites →https://doi.org/10.1016/j.ccell.2014.11.017openalex-snapshot
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells
inferredcites →https://doi.org/10.1016/j.ccr.2005.08.010openalex-snapshot
Tensional homeostasis and the malignant phenotype
inferredcites →https://doi.org/10.1016/j.ejca.2010.02.026openalex-snapshot
Interleukin-6 in bone metastasis and cancer progression
inferredcites →https://doi.org/10.1016/j.gene.2005.10.028openalex-snapshot
Molecular pathways mediating mechanical signaling in bone
inferredcites →https://doi.org/10.1016/j.jbiomech.2003.08.010openalex-snapshot
Mechanical properties, density and quantitative CT scan data of trabecular bone with and without metastases
inferredcites →https://doi.org/10.1016/j.jbiomech.2009.10.016openalex-snapshot
In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds
inferredcites →https://doi.org/10.1016/j.jmbbm.2014.11.001openalex-snapshot
The role of integrin αVβ3 in osteocyte mechanotransduction
inferredcites →https://doi.org/10.1016/j.urology.2007.01.093openalex-snapshot
Heterogeneous Activation of MMP-9 Due to Prostate Cancer-Bone Interaction
inferredcites →https://doi.org/10.1016/s0026-2862(03)00057-8openalex-snapshot
Solid stress generated by spheroid growth estimated using a linear poroelasticity model☆
inferredcites →https://doi.org/10.1023/b:clin.0000024763.69809.64openalex-snapshot
A small molecule antagonist of the α v β3 integrin suppresses MDA-MB-435 skeletal metastasis
inferredcites →https://doi.org/10.1038/nm.2489openalex-snapshot
Suppression of bone formation by osteoclastic expression of semaphorin 4D
inferredcites →https://doi.org/10.1038/nrm1490openalex-snapshot
Integrin signalling during tumour progression
inferredcites →https://doi.org/10.1038/s41413-020-0083-6openalex-snapshot
Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion
inferredcites →https://doi.org/10.1038/sj.onc.1208790openalex-snapshot
Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer
inferredcites →https://doi.org/10.1038/srep05512openalex-snapshot
Macroscopic Stiffness of Breast Tumors Predicts Metastasis
inferredcites →https://doi.org/10.1038/srep29384openalex-snapshot
Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer
inferredcites →https://doi.org/10.1073/pnas.0604460103openalex-snapshot
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
inferredcites →https://doi.org/10.1073/pnas.1213353109openalex-snapshot
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
inferredcites →https://doi.org/10.1074/jbc.m607999200openalex-snapshot
Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways
inferredcites →https://doi.org/10.1074/jbc.m701419200openalex-snapshot
Short-term Treatment of RAW264.7 Macrophages with Adiponectin Increases Tumor Necrosis Factor-α (TNF-α) Expression via ERK1/2 Activation and Egr-1 Expression
inferredcites →https://doi.org/10.1080/07853890310016333openalex-snapshot
Mechanobiology and diseases of mechanotransduction
inferredcites →https://doi.org/10.1084/jem.20011681openalex-snapshot
A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation
inferredcites →https://doi.org/10.1088/0031-9155/45/6/314openalex-snapshot
Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography
inferredcites →https://doi.org/10.1088/1758-5090/abefeaopenalex-snapshot
Engineering the early bone metastatic niche through human vascularized immuno bone minitissues
inferredcites →https://doi.org/10.1089/ten.tea.2011.0198openalex-snapshot
Temporal and Spatial Changes in Cartilage-Matrix-Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression
inferredcites →https://doi.org/10.1089/ten.tea.2014.0249openalex-snapshot
An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation
inferredcites →https://doi.org/10.1089/ten.tea.2019.0085openalex-snapshot
Three-Dimensional Co-culture of Primary Human Osteocytes and Mature Human Osteoclasts in Collagen Gels
inferredcites →https://doi.org/10.1089/ten.tec.2015.0362openalex-snapshot
Single-Step RNA Extraction from Different Hydrogel-Embedded Mesenchymal Stem Cells for Quantitative Reverse Transcription–Polymerase Chain Reaction Analysis
inferredcites →https://doi.org/10.1097/00007611-200405000-00018openalex-snapshot
Osteoprotegerin-Receptor Activator of Nuclear Factor-κB Ligand Ratio: A New Approach to Osteoporosis Treatment?
inferredcites →https://doi.org/10.1098/rsif.2020.0568openalex-snapshot
Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture
inferredcites →https://doi.org/10.1101/2022.06.29.498001openalex-snapshot
Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer
inferredcites →https://doi.org/10.1111/j.1745-7254.2008.00889.xopenalex-snapshot
Tumor necrosis factor and cancer, buddies or foes?
inferredcites →https://doi.org/10.1115/1.2746375openalex-snapshot
Cyclic Mechanical Compression Increases Mineralization of Cell-Seeded Polymer Scaffolds In Vivo
inferredcites →https://doi.org/10.1126/sciadv.abg2564openalex-snapshot
In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer
inferredcites →https://doi.org/10.1146/annurev-bioeng-071813-105259openalex-snapshot
The Role of Mechanical Forces in Tumor Growth and Therapy
inferredcites →https://doi.org/10.1152/ajprenal.00260.2018openalex-snapshot
Macrophage-secreted TGF-β 1 contributes to fibroblast activation and ureteral stricture after ablation injury
inferredcites →https://doi.org/10.1158/0008-5472.can-08-4859openalex-snapshot
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2652openalex-snapshot
An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-1590openalex-snapshot
Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness
inferredcites →https://doi.org/10.1159/000465455openalex-snapshot
IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro
inferredcites →https://doi.org/10.1159/000489184openalex-snapshot
Molecular Regulation of Bone Metastasis Pathogenesis
inferredcites →https://doi.org/10.1172/jci.insight.125543openalex-snapshot
Sclerostin inhibition alleviates breast cancer–induced bone metastases and muscle weakness
inferredcites →https://doi.org/10.1177/016173469802000403openalex-snapshot
Elastic Moduli of Breast and Prostate Tissues under Compression
inferredcites →https://doi.org/10.1186/ar2165openalex-snapshot
Biology of RANK, RANKL, and osteoprotegerin
inferredcites →https://doi.org/10.1186/s12967-018-1611-7openalex-snapshot
Unleashing endogenous TNF-alpha as a cancer immunotherapeutic
inferredcites →https://doi.org/10.1196/annals.1402.071openalex-snapshot
The Role of NFAT in Osteoclast Formation
inferredcites →https://doi.org/10.1242/dmm.014076openalex-snapshot
A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone
inferredcites →https://doi.org/10.1242/jcs.079509openalex-snapshot
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues
inferredcites →https://doi.org/10.1359/jbmr.2001.16.8.1486openalex-snapshot
A Bone-Seeking Clone Exhibits Different Biological Properties from the MDA-MB-231 Parental Human Breast Cancer Cells and a Brain-Seeking Clone In Vivo and In Vitro
inferredcites →https://doi.org/10.1371/journal.pone.0006361openalex-snapshot
Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism
inferredcites →https://doi.org/10.1371/journal.pone.0041679openalex-snapshot
Osteomimicry of Mammary Adenocarcinoma Cells In Vitro; Increased Expression of Bone Matrix Proteins and Proliferation within a 3D Collagen Environment
inferredcites →https://doi.org/10.18632/oncotarget.12763openalex-snapshot
An in vitro 3D bone metastasis model by using a human bone tissue culture and human sex-related cancer cells
inferredcites →https://doi.org/10.2174/1389450117666161226121650openalex-snapshot
Bone: A Fertile Soil for Cancer Metastasis
inferredcites →https://doi.org/10.2217/nnm-2015-0021openalex-snapshot
A 3D Vascularized Bone Remodeling Model Combining Osteoblasts and Osteoclasts in a CaP Nanoparticle-Enriched Matrix
inferredcites →https://doi.org/10.22203/ecm.v020a05openalex-snapshot
Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cells
inferredcites →https://doi.org/10.2741/s110openalex-snapshot
Osteomimicry how tumor cells try to deceive the bone
inferredcites →https://doi.org/10.3389/fbioe.2020.00601openalex-snapshot
A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency
inferredcites →https://doi.org/10.3390/cancers10090292openalex-snapshot
Three-Dimensional In Vitro Hydro- and Cryogel-Based Cell-Culture Models for the Study of Breast-Cancer Metastasis to Bone
inferredcites →https://doi.org/10.3390/cancers13122906openalex-snapshot
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
inferredcites →https://doi.org/10.3390/ijms19103028openalex-snapshot
Role of Extracellular Matrix in Development and Cancer Progression
inferredcites →https://doi.org/10.3390/ijms20081998openalex-snapshot
In Vitro Co-Culture Model of Primary Human Osteoblasts and Osteocytes in Collagen Gels
inferredcites →https://doi.org/10.3390/ijms20133143openalex-snapshot
Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression
inferredcites →https://doi.org/10.3390/ijms22147316openalex-snapshot
Triple Culture of Primary Human Osteoblasts, Osteoclasts and Osteocytes as an In Vitro Bone Model
inferredcites →https://doi.org/10.3390/toxins11120731openalex-snapshot
The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells
inferredcites →https://doi.org/10.3892/ijmm_00000090openalex-snapshot
Differential sensitivity of breast cancer and melanoma cells to proteasome inhibitor Velcade
inferredcites →https://doi.org/10.4049/jimmunol.145.10.3297openalex-snapshot
IL-6 is produced by osteoblasts and induces bone resorption.

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s12195-025-00866-xopenalex-snapshot
Strain Promotes Triple Negative Breast Cancer Proliferation and Migration Via VEGFR-2
inferred← citeshttps://doi.org/10.1016/j.actbio.2024.02.046openalex-snapshot
Printing of 3D biomimetic structures for the study of bone metastasis: A review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.