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Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

https://doi.org/10.1101/2023.08.23.554476

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

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Targeting senescence as an anticancer therapy

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Imaging the mitochondrial permeability transition pore in intact cells

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Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control

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Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

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Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

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Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

inferredcites →https://doi.org/10.1016/j.ebiom.2018.09.015openalex-snapshot

Fisetin is a senotherapeutic that extends health and lifespan

inferredcites →https://doi.org/10.1016/j.ebiom.2019.01.056openalex-snapshot

Senolytics and senostatics as adjuvant tumour therapy

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Current overview on the clinical update of Bcl-2 anti-apoptotic inhibitors for cancer therapy

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.06.005openalex-snapshot

Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2008.09.031openalex-snapshot

Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

inferredcites →https://doi.org/10.1016/j.ijrobp.2017.02.216openalex-snapshot

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

inferredcites →https://doi.org/10.1016/j.mad.2005.11.004openalex-snapshot

Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging

inferredcites →https://doi.org/10.1016/j.mad.2019.03.006openalex-snapshot

Sublethal whole-body irradiation causes progressive premature frailty in mice

inferredcites →https://doi.org/10.1016/j.molcel.2014.10.028openalex-snapshot

Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis

inferredcites →https://doi.org/10.1016/j.molcel.2015.01.018openalex-snapshot

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

inferredcites →https://doi.org/10.1016/j.molmet.2013.11.005openalex-snapshot

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

inferredcites →https://doi.org/10.1016/j.molmet.2021.101222openalex-snapshot

Exploring the therapeutic potential of mitochondrial uncouplers in cancer

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2007.08.002openalex-snapshot

Control of OXPHOS efficiency by complex I in brain mitochondria

inferredcites →https://doi.org/10.1016/j.phrs.2022.106356openalex-snapshot

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

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Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

inferredcites →https://doi.org/10.1016/j.semcancer.2020.09.012openalex-snapshot

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

inferredcites →https://doi.org/10.1016/j.tips.2012.03.010openalex-snapshot

Mitochondrial pharmacology

inferredcites →https://doi.org/10.1016/s0021-9258(19)50355-6openalex-snapshot

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

inferredcites →https://doi.org/10.1016/s1470-2045(10)70261-8openalex-snapshot

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

inferredcites →https://doi.org/10.1021/acs.jmedchem.7b01182openalex-snapshot

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

inferredcites →https://doi.org/10.1023/a:1022945107762openalex-snapshot

The mitochondrial membrane potential (Δψm) in apoptosis; an update

inferredcites →https://doi.org/10.1023/a:1026331226241openalex-snapshot

Effect of Metabolic Inhibitors on Membrane Potential and Ion Conductance of Rat Astrocytes

inferredcites →https://doi.org/10.1038/228562a0openalex-snapshot

Unexpected Features of the Action of Dinitrophenol on Cortical Neurones

inferredcites →https://doi.org/10.1038/cdd.2017.179openalex-snapshot

MOMP, cell suicide as a BCL-2 family business

inferredcites →https://doi.org/10.1038/msb.2010.5openalex-snapshot

Feedback between p21 and reactive oxygen production is necessary for cell senescence

inferredcites →https://doi.org/10.1038/ncomms4837openalex-snapshot

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

inferredcites →https://doi.org/10.1038/nm.4010openalex-snapshot

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

inferredcites →https://doi.org/10.1038/s41418-018-0118-3openalex-snapshot

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

inferredcites →https://doi.org/10.1038/s41419-020-03074-9openalex-snapshot

Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche

inferredcites →https://doi.org/10.1038/s41467-020-16298-2openalex-snapshot

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

inferredcites →https://doi.org/10.1038/s41467-020-18714-zopenalex-snapshot

Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds

inferredcites →https://doi.org/10.1038/s41467-022-29824-1openalex-snapshot

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

inferredcites →https://doi.org/10.1038/s41467-022-35657-9openalex-snapshot

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression

inferredcites →https://doi.org/10.1038/s41586-018-0543-yopenalex-snapshot

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

inferredcites →https://doi.org/10.1038/s41591-022-01923-yopenalex-snapshot

Cellular senescence and senolytics: the path to the clinic

inferredcites →https://doi.org/10.1038/sj.cdd.4402091openalex-snapshot

Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts

inferredcites →https://doi.org/10.1042/bcj20210608openalex-snapshot

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

inferredcites →https://doi.org/10.1042/bj20040095openalex-snapshot

Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts

inferredcites →https://doi.org/10.1046/j.1474-9728.2003.00040.xopenalex-snapshot

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

inferredcites →https://doi.org/10.1073/pnas.92.20.9363openalex-snapshot

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

inferredcites →https://doi.org/10.1074/jbc.m404003200openalex-snapshot

Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis

inferredcites →https://doi.org/10.1080/10428194.2020.1845332openalex-snapshot

Safety and efficacy of navitoclax, a BCL-2 and BCL-X L inhibitor, in patients with relapsed or refractory lymphoid malignancies: results from a phase 2a study

inferredcites →https://doi.org/10.1089/ars.2011.3969openalex-snapshot

Mitochondria-Targeted Small Molecule Therapeutics and Probes

inferredcites →https://doi.org/10.1093/bioinformatics/btw230openalex-snapshot

Combenefit: an interactive platform for the analysis and visualization of drug combinations

inferredcites →https://doi.org/10.1093/gerona/glt136openalex-snapshot

A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans

inferredcites →https://doi.org/10.1093/jnci/djq364openalex-snapshot

Therapy-Induced Senescence in Cancer

inferredcites →https://doi.org/10.1093/lifemedi/lnac030openalex-snapshot

Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging

inferredcites →https://doi.org/10.1093/toxsci/kfm052openalex-snapshot

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

inferredcites →https://doi.org/10.1098/rsfs.2016.0109openalex-snapshot

Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms

inferredcites →https://doi.org/10.1111/acel.12344openalex-snapshot

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

inferredcites →https://doi.org/10.1111/acel.12445openalex-snapshot

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

inferredcites →https://doi.org/10.1111/acel.12945openalex-snapshot

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

inferredcites →https://doi.org/10.1111/acel.13188openalex-snapshot

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice

inferredcites →https://doi.org/10.1111/acel.13817openalex-snapshot

Effect of peripheral cellular senescence on brain aging and cognitive decline

inferredcites →https://doi.org/10.1111/hepr.13879openalex-snapshot

Navitoclax improves acute‐on‐chronic liver failure by eliminating senescent cells in mice

inferredcites →https://doi.org/10.1111/j.1469-7793.1998.819ba.xopenalex-snapshot

Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells

inferredcites →https://doi.org/10.1111/joim.13141openalex-snapshot

Senolytic drugs: from discovery to translation

inferredcites →https://doi.org/10.1126/scitranslmed.abb0203openalex-snapshot

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

inferredcites →https://doi.org/10.1128/mcb.01868-08openalex-snapshot

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

inferredcites →https://doi.org/10.1158/0008-5472.can-07-5836openalex-snapshot

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

inferredcites →https://doi.org/10.1161/circulationaha.122.058794openalex-snapshot

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

inferredcites →https://doi.org/10.1172/jci158447openalex-snapshot

Mitochondrial dysfunction in cell senescence and aging

inferredcites →https://doi.org/10.1172/jci162519openalex-snapshot

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

inferredcites →https://doi.org/10.1182/blood-2011-04-347849openalex-snapshot

Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

inferredcites →https://doi.org/10.1186/2046-2395-1-3openalex-snapshot

Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction

inferredcites →https://doi.org/10.1242/jcs.059246openalex-snapshot

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

inferredcites →https://doi.org/10.12688/f1000research.9629.1openalex-snapshot

Mitochondrial apoptosis and BH3 mimetics

inferredcites →https://doi.org/10.1371/journal.pbio.0050110openalex-snapshot

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

inferredcites →https://doi.org/10.1371/journal.pcbi.1003728openalex-snapshot

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

inferredcites →https://doi.org/10.15252/embj.201592862openalex-snapshot

Mitochondria are required for pro‐ageing features of the senescent phenotype

inferredcites →https://doi.org/10.15252/emmm.202012088openalex-snapshot

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

inferredcites →https://doi.org/10.18632/aging.100196openalex-snapshot

Adult-onset, short-term dietary restriction reduces cell senescence in mice

inferredcites →https://doi.org/10.18632/aging.101202openalex-snapshot

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

inferredcites →https://doi.org/10.3389/fcell.2020.00354openalex-snapshot

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

inferredcites →https://doi.org/10.3390/cancers12040822openalex-snapshot

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

inferredcites →https://doi.org/10.3892/ijo.26.4.1069openalex-snapshot

Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells

inferredcites →https://doi.org/10.4103/0976-0105.177703openalex-snapshot

A simple practice guide for dose conversion between animals and human

inferredcites →https://doi.org/10.7554/elife.75492openalex-snapshot

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102558openalex-snapshot

Oxidative stress and cell senescence as drivers of ageing: Chicken and egg

inferred← citeshttps://doi.org/10.1016/j.mad.2023.111888openalex-snapshot

Current senolytics: Mode of action, efficacy and limitations, and their future

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