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Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

https://doi.org/10.1126/scitranslmed.abb0203

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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inferred← citeshttps://doi.org/10.1093/gerona/glaf042openalex-snapshot

Ferroptosis Activation Contributes to Kidney Aging in Mice by Promoting Tubular Cell Senescence

inferred← citeshttps://doi.org/10.1093/jb/mvae015openalex-snapshot

Therapeutic strategies targeting cellular senescence for cancer and other diseases

inferred← citeshttps://doi.org/10.1093/ndt/gfae177openalex-snapshot

Biology of the proximal tubule in body homeostasis and kidney disease

inferred← citeshttps://doi.org/10.1096/fj.202402558ropenalex-snapshot

Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells

inferred← citeshttps://doi.org/10.1096/fj.202403361ropenalex-snapshot

A Novel Role of Adipokine ‘Intelectin‐1’: Ameliorating Renal Fibrosis Through Inhibition of Renal Tubular Epithelial Cell Senescence

inferred← citeshttps://doi.org/10.1096/fj.202503532ropenalex-snapshot

Cellular Senescence in Kidney Diseases: From Bench to Clinic

inferred← citeshttps://doi.org/10.1096/fj.202504960ropenalex-snapshot

Revealing the Heterogeneity of Renal Tubular Epithelial Cell Senescence and Its Impact on Renal Fibrosis via Single‐Cell Sequencing and Spatial Omics Technologies

inferred← citeshttps://doi.org/10.1097/cm9.0000000000003698openalex-snapshot

Cellular senescence in renal ischemia-reperfusion injury

inferred← citeshttps://doi.org/10.1097/cm9.0000000000003746openalex-snapshot

Cellular senescence in kidney diseases

inferred← citeshttps://doi.org/10.1097/mnh.0000000000000782openalex-snapshot

Ageing, cellular senescence and chronic kidney disease: experimental evidence

inferred← citeshttps://doi.org/10.1097/mnh.0000000000000893openalex-snapshot

Proximal tubule responses to injury: interrogation by single-cell transcriptomics

inferred← citeshttps://doi.org/10.1097/tp.0000000000005291openalex-snapshot

Senotherapy: Implications for Transplantation

inferred← citeshttps://doi.org/10.1101/2023.08.10.552883openalex-snapshot

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal aging

inferred← citeshttps://doi.org/10.1101/2023.08.23.554476openalex-snapshot

Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

inferred← citeshttps://doi.org/10.1101/2024.03.17.24304404openalex-snapshot

Recapitulation of Cellular Senescence, Inflammation, and Fibrosis in Human Kidney-Derived Tubuloids by Repeated Cisplatin Treatment: A Novel Pathophysiological Model for Sensing Nephrotoxicity and Drug Screening

inferred← citeshttps://doi.org/10.1101/2025.01.06.631437openalex-snapshot

NNMT promotes tubular senescence and fibrosis in chronic kidney disease

inferred← citeshttps://doi.org/10.1101/2025.09.15.676236openalex-snapshot

DynPerturb:Dynamic Perturbation Modeling for Spatiotemporal Single-Cell Systems

inferred← citeshttps://doi.org/10.1101/2025.11.25.690611openalex-snapshot

Progranulin deficiency aggravates aging-induced vascular injury

inferred← citeshttps://doi.org/10.1111/acel.13574openalex-snapshot

Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis

inferred← citeshttps://doi.org/10.1111/acel.13948openalex-snapshot

Strategies for senolytic drug discovery

inferred← citeshttps://doi.org/10.1111/acel.14445openalex-snapshot

Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice

inferred← citeshttps://doi.org/10.1111/acel.70698openalex-snapshot

Insights Into the Interplay Between the Senescent Cells and Immune Cells

inferred← citeshttps://doi.org/10.1111/ajt.17102openalex-snapshot

Induction of ferroptosis selectively eliminates senescent tubular cells

inferred← citeshttps://doi.org/10.1111/ajt.17154openalex-snapshot

Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation

inferred← citeshttps://doi.org/10.1111/apha.70189openalex-snapshot

Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan

inferred← citeshttps://doi.org/10.1111/dme.15408openalex-snapshot

Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management

inferred← citeshttps://doi.org/10.1111/febs.16573openalex-snapshot

Context‐dependent roles of cellular senescence in normal, aged, and disease states

inferred← citeshttps://doi.org/10.1126/sciadv.ado1463openalex-snapshot

Ketogenic diet induces p53-dependent cellular senescence in multiple organs

inferred← citeshttps://doi.org/10.1126/scitranslmed.adm6783openalex-snapshot

Spatial genomics: Mapping the landscape of fibrosis

inferred← citeshttps://doi.org/10.1126/scitranslmed.adv4071openalex-snapshot

Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease

inferred← citeshttps://doi.org/10.1152/ajpheart.00012.2026openalex-snapshot

Progranulin deficiency induces premature vascular senescence and dysfunction

inferred← citeshttps://doi.org/10.1152/ajprenal.00138.2025openalex-snapshot

Inhibition of methylthioadenosine phosphorylase protects from experimental acute kidney injury

inferred← citeshttps://doi.org/10.1152/ajprenal.00143.2024openalex-snapshot

Establishment and characterization of a mouse model for studying kidney repair in diabetes

inferred← citeshttps://doi.org/10.1152/ajprenal.00261.2023openalex-snapshot

Podocyte injury at young age causes premature senescence and worsens glomerular aging

inferred← citeshttps://doi.org/10.1152/ajprenal.00287.2024openalex-snapshot

Endothelial dysfunction in the aging kidney

inferred← citeshttps://doi.org/10.1152/physiol.00003.2023openalex-snapshot

Recent Advances in Senolysis for Age-Related Diseases

inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-2219openalex-snapshot

A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment

inferred← citeshttps://doi.org/10.1159/000544694openalex-snapshot

DOT1L Regulates Cellular Senescence during the Progression from Acute Kidney Injury to Chronic Kidney Disease via the microRNA-222-5p/WNT9B Signaling Pathway

inferred← citeshttps://doi.org/10.1161/jaha.125.045304openalex-snapshot

High‐Salt Diet–Induced Endothelial Dysfunction Is Mediated by Cellular Senescence

inferred← citeshttps://doi.org/10.1172/jci.insight.154124openalex-snapshot

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

inferred← citeshttps://doi.org/10.1172/jci.insight.166643openalex-snapshot

Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity

inferred← citeshttps://doi.org/10.1172/jci.insight.188658openalex-snapshot

A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes

inferred← citeshttps://doi.org/10.1172/jci199854openalex-snapshot

LSD1-mediated demethylation of the DNA damage response factor ATM promotes senescence and organ aging

inferred← citeshttps://doi.org/10.1186/s12964-023-01245-7openalex-snapshot

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

inferred← citeshttps://doi.org/10.1186/s12967-023-04554-0openalex-snapshot

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

inferred← citeshttps://doi.org/10.1186/s12967-024-04972-8openalex-snapshot

Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization

inferred← citeshttps://doi.org/10.1186/s12967-025-06204-zopenalex-snapshot

Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury

inferred← citeshttps://doi.org/10.1186/s40001-026-04642-zopenalex-snapshot

ATF4-mediated endoplasmic reticulum stress drives tubular epithelial cell senescence in rhabdomyolysis-induced acute kidney injury

inferred← citeshttps://doi.org/10.1186/s43556-026-00462-zopenalex-snapshot

Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions

inferred← citeshttps://doi.org/10.1186/s44505-026-00002-0openalex-snapshot

BMP7 in kidney development and disease: a multilayer regulatory network integrating inflammation, fibrosis, and regeneration

inferred← citeshttps://doi.org/10.12968/jokc.2021.6.4.196openalex-snapshot

Study reveals new way to repair damaged kidneys

inferred← citeshttps://doi.org/10.14336/ad.202.0513openalex-snapshot

Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology

inferred← citeshttps://doi.org/10.14336/ad.202.0565openalex-snapshot

Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques

inferred← citeshttps://doi.org/10.1681/asn.0000000000000057openalex-snapshot

Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury

inferred← citeshttps://doi.org/10.1681/asn.0000000659openalex-snapshot

Toward Noninvasive Biomarkers of Renal Senescence

inferred← citeshttps://doi.org/10.1681/asn.0000000771openalex-snapshot

Telomere Dysfunction in Renal Tubular Epithelial Cells Leads to Kidney Fibrosis

inferred← citeshttps://doi.org/10.18632/aging.206394openalex-snapshot

Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b

inferred← citeshttps://doi.org/10.21203/rs.3.rs-5575296/v1openalex-snapshot

Systemic Senolysis in Naturally Aged Mice Using a FAST-PLV Gene Therapy Approach

inferred← citeshttps://doi.org/10.25259/warm_15_2026openalex-snapshot

Acute kidney injury-to-chronic kidney disease transition: Maladaptive senescence, epigenetic reprogramming, and the translational frontier

inferred← citeshttps://doi.org/10.33540/1996openalex-snapshot

Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis

inferred← citeshttps://doi.org/10.3389/fcell.2024.1368711openalex-snapshot

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

inferred← citeshttps://doi.org/10.3389/fcell.2025.1597230openalex-snapshot

Mechanisms of natural killer cell-mediated clearance of senescent renal tubular epithelial cells

inferred← citeshttps://doi.org/10.3389/fcvm.2023.1250073openalex-snapshot

Using RNA-based therapies to target the kidney in cardiovascular disease

inferred← citeshttps://doi.org/10.3389/fcvm.2024.1374635openalex-snapshot

Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

inferred← citeshttps://doi.org/10.3389/fendo.2022.1095211openalex-snapshot

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

inferred← citeshttps://doi.org/10.3389/fendo.2023.1085605openalex-snapshot

Cellular senescence of renal tubular epithelial cells in renal fibrosis

inferred← citeshttps://doi.org/10.3389/fimmu.2021.700790openalex-snapshot

The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1222339openalex-snapshot

The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1825690openalex-snapshot

Cellular senescence in Crohn’s disease: a double-edged sword in intestinal fibrosis

inferred← citeshttps://doi.org/10.3389/fmed.2026.1772819openalex-snapshot

Stem cell therapies for biological repair in osteonecrosis: advances, challenges, and clinical insights

inferred← citeshttps://doi.org/10.3389/fnut.2026.1867121openalex-snapshot

Fisetin as a nutritional senotherapeutic: mechanisms, translational promise, and lessons from chronic kidney disease

inferred← citeshttps://doi.org/10.3389/fphar.2021.734892openalex-snapshot

Editorial: Premature Aging and Senescence in Renal Fibrosis

inferred← citeshttps://doi.org/10.3389/fphar.2025.1551423openalex-snapshot

Homotherapy for heteropathy of chronic kidney disease and oligoasthenozoospermia through regulating SIRT1/NF-κB pathway by Shenqi pills

inferred← citeshttps://doi.org/10.3389/fphar.2025.1615681openalex-snapshot

Renal aging and its consequences: navigating the challenges of an aging population

inferred← citeshttps://doi.org/10.3389/frtra.2023.1325232openalex-snapshot

The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome

inferred← citeshttps://doi.org/10.3389/fvets.2024.1369153openalex-snapshot

The potential for senotherapy as a novel approach to extend life quality in veterinary medicine

inferred← citeshttps://doi.org/10.3389/ti.2026.16347openalex-snapshot

Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool

inferred← citeshttps://doi.org/10.3390/biology12040565openalex-snapshot

Epimorphic Regeneration of Elastic Cartilage: Morphological Study into the Role of Cellular Senescence

inferred← citeshttps://doi.org/10.3390/biom16040611openalex-snapshot

Dual Roles and Therapeutic Prospects of Proximal Tubular Epithelial Cell Senescence in Acute Kidney Injury

inferred← citeshttps://doi.org/10.3390/biomedicines14092033openalex-snapshot

Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury

inferred← citeshttps://doi.org/10.3390/cells10071694openalex-snapshot

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models

inferred← citeshttps://doi.org/10.3390/cells12010021openalex-snapshot

NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

inferred← citeshttps://doi.org/10.3390/cells12232714openalex-snapshot

Innate Immunity and CKD: Is There a Significant Association?

inferred← citeshttps://doi.org/10.3390/cells13171475openalex-snapshot

Activation of Yes-Associated Protein Is Indispensable for Transformation of Kidney Fibroblasts into Myofibroblasts during Repeated Administration of Cisplatin

inferred← citeshttps://doi.org/10.3390/cells14221831openalex-snapshot

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

inferred← citeshttps://doi.org/10.3390/ijms222413562openalex-snapshot

Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells

inferred← citeshttps://doi.org/10.3390/ijms23031542openalex-snapshot

Molecular Mechanisms of Kidney Injury and Repair

inferred← citeshttps://doi.org/10.3390/ijms25126585openalex-snapshot

Kidney Aging and Chronic Kidney Disease

inferred← citeshttps://doi.org/10.3390/ijms26189159openalex-snapshot

Mechanisms and Therapeutic Perspectives of Podocyte Aging in Podocytopathies

inferred← citeshttps://doi.org/10.3390/ijms27073205openalex-snapshot

Chronic Kidney Disease and Cellular Senescence

inferred← citeshttps://doi.org/10.3390/ijms27208987openalex-snapshot

Is Aging a Failure to Resolve? Integrating Damage Responses, Regenerative Decline, and Geroscience Interventions

inferred← citeshttps://doi.org/10.3390/pharmaceutics16060695openalex-snapshot

Targeted Drug Therapy for Senescent Cells Alleviates Unilateral Ureteral Obstruction-Induced Renal Injury in Rats

inferred← citeshttps://doi.org/10.34067/kid.0000000000000284openalex-snapshot

Podocyte Senescence and Aging

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