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Targeted lipid A modification of Shigella vaccine strains reduced endotoxicity without compromising immunogenicity or invasiveness

https://doi.org/10.1101/2023.08.24.554604

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship

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Characterization of WRSs2 and WRSs3, new second-generation virG(icsA)-based Shigella sonnei vaccine candidates with the potential for reduced reactogenicity

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Shigella sonnei vaccine candidates WRSs2 and WRSs3 are as immunogenic as WRSS1, a clinically tested vaccine candidate, in a primate model of infection

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Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: A new combination of gene deletions for 2nd generation live attenuated vaccine candidates

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

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Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

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Lipid A Structural Determination from a Single Colony

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Human Toll-like receptor 4 recognizes host-specific LPS modifications

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LPS, TLR4 and infectious disease diversity

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Lipopolysaccharide Engineering in Neisseria meningitidis

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Modulation of Endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

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3-O-Deacylation of Lipid A by PagL, a PhoP/PhoQ-regulated Deacylase of Salmonella typhimurium, Modulates Signaling through Toll-like Receptor 4

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Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

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Construction of a Stable Attenuated Shigella sonnei ΔvirG Vaccine Strain, WRSS1, and Protective Efficacy and Immunogenicity in the Guinea Pig Keratoconjunctivitis Model

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A Brief History of Shigella

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Vaccination against Shigellosis with Attenuated Shigella flexneri 2a Strain SC602

inferredcites →https://doi.org/10.1128/iai.70.4.2016-2021.2002openalex-snapshot

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Community-Based Safety, Immunogenicity, and Transmissibility Study of the Shigella sonnei WRSS1 Vaccine in Israeli Volunteers

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Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

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Lipid A Modification Systems in Gram-Negative Bacteria

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The RAST Server: Rapid Annotations using Subsystems Technology

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Bacterial lipids: powerful modifiers of the innate immune response

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mMass as a Software Tool for the Annotation of Cyclic Peptide Tandem Mass Spectra

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