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GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Coordinate regulation of glycolysis by hypoxia in mammalian cells
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Kinetic Properties of NAD-Dependent Glyceraldehyde-3-phosphate Dehydrogenase from the Host Fraction of Soybean Root Nodules
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Hypoxia and Metabolism in Cancer
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Structure primaire de la paracaseine κ bovine
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
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Tumor Cell Metabolism: Cancer's Achilles' Heel
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Cancer Cell Metabolism: Warburg and Beyond
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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
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HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis
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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
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Metabolic Flux and the Regulation of Mammalian Cell Growth
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Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor
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In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
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Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling
inferredcites →https://doi.org/10.1016/j.devcel.2016.02.012openalex-snapshot
Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
inferredcites →https://doi.org/10.1016/j.ejca.2007.03.027openalex-snapshot
The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1α and GLUT-1 in non-small cell lung cancer
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Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
inferredcites →https://doi.org/10.1016/j.molcel.2017.06.002openalex-snapshot
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
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NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
inferredcites →https://doi.org/10.1016/j.molcel.2022.07.007openalex-snapshot
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells
inferredcites →https://doi.org/10.1016/j.molcel.2022.10.005openalex-snapshot
Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
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Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
inferredcites →https://doi.org/10.1016/s0021-9258(18)50152-6openalex-snapshot
The Mechanism of Triosephosphate Dehydrogenase Inactivation by Reduced Diphosphopyridine Nucleotide
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Inactivation of Muscle Triosephosphate Dehydrogenase by Reduced Diphosphopyridine Nucleotide at Physiological Concentrations
inferredcites →https://doi.org/10.1016/s0021-9258(19)85326-7openalex-snapshot
Rapid activation of GLUT-1 glucose transporter following inhibition of oxidative phosphorylation in clone 9 cells
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Hypoxia and Regulation of Messenger RNA Translation
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C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
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Proton Transfer in the Mechanism of Triosephosphate Isomerase
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inferredcites →https://doi.org/10.1038/nchembio.2143openalex-snapshot
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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
inferredcites →https://doi.org/10.1038/nprot.2013.143openalex-snapshot
Genome engineering using the CRISPR-Cas9 system
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inferredcites →https://doi.org/10.1038/nrc1478openalex-snapshot
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inferredcites →https://doi.org/10.1038/nrn2949openalex-snapshot
How does PKMζ maintain long-term memory?
inferredcites →https://doi.org/10.1038/onc.2009.250openalex-snapshot
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
inferredcites →https://doi.org/10.1038/onc.2017.36openalex-snapshot
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
inferredcites →https://doi.org/10.1038/oncsis.2015.50openalex-snapshot
Hypoxia and metabolic adaptation of cancer cells
inferredcites →https://doi.org/10.1038/s41388-018-0259-3openalex-snapshot
Intermittent hypoxia induces a metastatic phenotype in breast cancer
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Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
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Aspartate is an endogenous metabolic limitation for tumour growth
inferredcites →https://doi.org/10.1038/s41598-020-58906-7openalex-snapshot
Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer
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PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
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Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation
inferredcites →https://doi.org/10.1039/c8cc00387dopenalex-snapshot
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
inferredcites →https://doi.org/10.1042/bj1150837openalex-snapshot
Disequilibrium in the triose phosphate isomerase system in rat liver
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Control of the redox state of the nicotinamide–adenine dinucleotide couple in rat liver cytoplasm
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A study of the kinetics and mechanism of rabbit muscle l -glycerol 3-phosphate dehydrogenase
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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
inferredcites →https://doi.org/10.1073/pnas.94.13.6658openalex-snapshot
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
inferredcites →https://doi.org/10.1073/pnas.95.20.11715openalex-snapshot
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
inferredcites →https://doi.org/10.1074/jbc.272.30.18808openalex-snapshot
Cellular Respiration during Hypoxia
inferredcites →https://doi.org/10.1074/jbc.m109.084194openalex-snapshot
Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization
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The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase
inferredcites →https://doi.org/10.1074/jbc.m604628200openalex-snapshot
The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases
inferredcites →https://doi.org/10.1074/jbc.m608337200openalex-snapshot
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
inferredcites →https://doi.org/10.1074/jbc.m610415200openalex-snapshot
Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
inferredcites →https://doi.org/10.1074/jbc.tm117.000239openalex-snapshot
The redox requirements of proliferating mammalian cells
inferredcites →https://doi.org/10.1089/ars.2017.7216openalex-snapshot
NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
inferredcites →https://doi.org/10.1093/emboj/cdg392openalex-snapshot
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
inferredcites →https://doi.org/10.1093/jnci/93.17.1337openalex-snapshot
Transcriptional Response to Hypoxia in Human Tumors
inferredcites →https://doi.org/10.1093/nar/gkp425openalex-snapshot
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
inferredcites →https://doi.org/10.1111/cpr.12363openalex-snapshot
Metabolic reprogramming by HIF ‐1 activation enhances survivability of human adipose‐derived stem cells in ischaemic microenvironments
inferredcites →https://doi.org/10.1111/j.1582-4934.2009.00944.xopenalex-snapshot
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis
inferredcites →https://doi.org/10.1111/j.1742-4658.2008.06454.xopenalex-snapshot
Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
inferredcites →https://doi.org/10.1126/sciadv.1600200openalex-snapshot
Fundamentals of cancer metabolism
inferredcites →https://doi.org/10.1126/science.1059817openalex-snapshot
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
inferredcites →https://doi.org/10.1126/science.1066373openalex-snapshot
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
inferredcites →https://doi.org/10.1126/science.aad4017openalex-snapshot
Complementation of mitochondrial electron transport chain by manipulation of the NAD + /NADH ratio
inferredcites →https://doi.org/10.1126/science.aan4665openalex-snapshot
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
inferredcites →https://doi.org/10.1128/mcb.01927-06openalex-snapshot
Cell-Permeating α -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells
inferredcites →https://doi.org/10.1128/mcb.21.10.3436-3444.2001openalex-snapshot
Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells
inferredcites →https://doi.org/10.1152/ajpcell.00485.2010openalex-snapshot
Hypoxia. 2. Hypoxia regulates cellular metabolism
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Regulation of glyceraldehyde-3-phosphate dehydrogenase by a cytosolic protein
inferredcites →https://doi.org/10.1152/ajpheart.1990.258.3.h689openalex-snapshot
Energetic response of coronary endothelial cells to hypoxia
inferredcites →https://doi.org/10.1152/ajpheart.1999.277.2.h551openalex-snapshot
Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats
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Oxygen sensing and molecular adaptation to hypoxia
inferredcites →https://doi.org/10.1158/0008-5472.can-03-0947openalex-snapshot
Tumor-dependent Kinetics of Partial Pressure of Oxygen Fluctuations during Air and Oxygen Breathing
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-1049openalex-snapshot
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
inferredcites →https://doi.org/10.1158/1541-7786.mcr-11-0053openalex-snapshot
Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1α and 2α
inferredcites →https://doi.org/10.1172/jci109977openalex-snapshot
Regulation of glycolytic enzyme activity during chronic hypoxia by changes in rate-limiting enzyme content. Use of monoclonal antibodies to quantitate changes in pyruvate kinase content.
inferredcites →https://doi.org/10.1172/jci67230openalex-snapshot
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
inferredcites →https://doi.org/10.1186/bcr1852openalex-snapshot
Sugar and fat – that's where it's at: metabolic changes in tumors
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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1242/jcs.194480openalex-snapshot
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
inferredcites →https://doi.org/10.1259/0007-1285-52-620-650openalex-snapshot
Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
inferredcites →https://doi.org/10.1371/journal.pone.0030905openalex-snapshot
Intermittent Hypoxia Regulates Stem-like Characteristics and Differentiation of Neuroblastoma Cells
inferredcites →https://doi.org/10.1371/journal.pone.0120958openalex-snapshot
Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance
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Fluctuations inpO2in Irradiated Human Melanoma Xenografts
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Energy Status and Radiobiological Hypoxia at Specified Oxygen Concentrations
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RColorBrewer: ColorBrewer Palettes
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Metabolic Plasiticy in Cancers—Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
inferredcites →https://doi.org/10.3389/fphar.2011.00049openalex-snapshot
Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
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