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Transcriptomics effects of per- and polyfluorinated alkyl substances in differentiated neuronal cells

https://doi.org/10.1101/2024.01.26.577438

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Occupational exposure and serum levels of per‐ and polyfluoroalkyl substances (PFAS): A review

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Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

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Perfluorooctane Sulfonate (PFOS) Negatively Impacts Prey Capture Capabilities in Larval Zebrafish

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Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

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Identification and classification of commercially relevant per- and poly-fluoroalkyl substances (PFAS)

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Untargeted Lipidomics Highlight the Depletion of Deoxyceramides during Therapy‐Induced Senescence

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Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

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Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells

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Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders

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Carbohydrate and amino acid metabolism during acute hypoxia in rats: blood and heart metabolites

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Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line

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Derivatization method for sensitive determination of fluorotelomer alcohols in sediment by liquid chromatography–electrospray tandem mass spectrometry

inferredcites →https://doi.org/10.1016/j.cppeds.2020.100760openalex-snapshot

Exposures to per-and polyfluoroalkyl substances (PFAS): Potential risks to reproductive and children's health

inferredcites →https://doi.org/10.1016/j.envint.2013.06.004openalex-snapshot

Accumulation of perfluoroalkyl substances in human tissues

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Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals

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Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden

inferredcites →https://doi.org/10.1016/j.envint.2023.107779openalex-snapshot

Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study

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Role of bioavailability and protein binding of four anionic perfluoroalkyl substances in cell-based bioassays for quantitative in vitro to in vivo extrapolations

inferredcites →https://doi.org/10.1016/j.envpol.2019.113429openalex-snapshot

Perfluorooctane sulfonate disrupts the blood brain barrier through the crosstalk between endothelial cells and astrocytes in mice

inferredcites →https://doi.org/10.1016/j.envpol.2022.119684openalex-snapshot

Pre-differentiation exposure of PFOA induced persistent changes in DNA methylation and mitochondrial morphology in human dopaminergic-like neurons

inferredcites →https://doi.org/10.1016/j.envres.2021.110825openalex-snapshot

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and neurobehavior in US children through 8 years of age: The HOME study

inferredcites →https://doi.org/10.1016/j.envres.2021.111775openalex-snapshot

Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in human livers with liver cancer

inferredcites →https://doi.org/10.1016/j.etap.2007.04.003openalex-snapshot

Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans

inferredcites →https://doi.org/10.1016/j.gene.2019.144223openalex-snapshot

The roles and regulation of TBX3 in development and disease

inferredcites →https://doi.org/10.1016/j.hazl.2022.100070openalex-snapshot

Henry’s Law constants of 15 per- and polyfluoroalkyl substances determined by static headspace analysis

inferredcites →https://doi.org/10.1016/j.molmed.2019.05.011openalex-snapshot

tRNA Deregulation and Its Consequences in Cancer

inferredcites →https://doi.org/10.1016/j.scitotenv.2018.04.380openalex-snapshot

A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)

inferredcites →https://doi.org/10.1016/j.tox.2022.153281openalex-snapshot

Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines

inferredcites →https://doi.org/10.1016/j.toxlet.2018.03.029openalex-snapshot

Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro

inferredcites →https://doi.org/10.1016/j.toxrep.2019.08.009openalex-snapshot

Toxicokinetics of 8:2 fluorotelomer alcohol (8:2-FTOH) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration

inferredcites →https://doi.org/10.1021/acs.chemrestox.2c00072openalex-snapshot

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

inferredcites →https://doi.org/10.1021/acs.chemrestox.2c00116openalex-snapshot

Development of a Liquid Chromatography–Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances

inferredcites →https://doi.org/10.1021/acs.est.2c00201openalex-snapshot

Uncovering PFAS and Other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning

inferredcites →https://doi.org/10.1021/acs.est.4c06017openalex-snapshot

Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations

inferredcites →https://doi.org/10.1021/acs.est.7b04650openalex-snapshot

Time Trends in Per- and Polyfluoroalkyl Substances (PFASs) in California Women: Declining Serum Levels, 2011–2015

inferredcites →https://doi.org/10.1021/acs.est.8b04550openalex-snapshot

Penetration of PFASs Across the Blood Cerebrospinal Fluid Barrier and Its Determinants in Humans

inferredcites →https://doi.org/10.1021/acs.estlett.7b00042openalex-snapshot

Radiosynthesis and Biological Distribution of 18F-Labeled Perfluorinated Alkyl Substances

inferredcites →https://doi.org/10.1021/acschembio.6b00410openalex-snapshot

Specific Triacylglycerols AccumulateviaIncreased Lipogenesis During 5-FU-Induced Apoptosis

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Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

inferredcites →https://doi.org/10.1021/es4026722openalex-snapshot

Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein

inferredcites →https://doi.org/10.1021/es404008gopenalex-snapshot

Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models

inferredcites →https://doi.org/10.1021/es404390xopenalex-snapshot

Protein Binding Associated with Exposure to Fluorotelomer Alcohols (FTOHs) and Polyfluoroalkyl Phosphate Esters (PAPs) in Rats

inferredcites →https://doi.org/10.1021/es802985eopenalex-snapshot

Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group

inferredcites →https://doi.org/10.1021/es9003894openalex-snapshot

Perfluoroalkyl Contaminants in an Arctic Marine Food Web: Trophic Magnification and Wildlife Exposure

inferredcites →https://doi.org/10.1021/tx400317popenalex-snapshot

Cellular Toxicity Associated with Exposure to Perfluorinated Carboxylates (PFCAs) and Their Metabolic Precursors

inferredcites →https://doi.org/10.1038/nrm3902openalex-snapshot

Extracellular matrix assembly: a multiscale deconstruction

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Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

inferredcites →https://doi.org/10.1038/s41587-019-0201-4openalex-snapshot

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

inferredcites →https://doi.org/10.1038/s41598-021-03442-1openalex-snapshot

Optimised techniques for high-throughput screening of differentiated SH-SY5Y cells and application for neurite outgrowth assays

inferredcites →https://doi.org/10.1038/s41598-022-05103-3openalex-snapshot

Five hypoxia and immunity related genes as potential biomarkers for the prognosis of osteosarcoma

inferredcites →https://doi.org/10.1039/d1em00228gopenalex-snapshot

Absorption, distribution, and toxicity of per- and polyfluoroalkyl substances (PFAS) in the brain: a review

inferredcites →https://doi.org/10.1074/jbc.m110.146738openalex-snapshot

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

inferredcites →https://doi.org/10.1074/jbc.ra119.009827openalex-snapshot

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI

inferredcites →https://doi.org/10.1093/bioinformatics/btt656openalex-snapshot

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

inferredcites →https://doi.org/10.1093/bioinformatics/btw354openalex-snapshot

MultiQC: summarize analysis results for multiple tools and samples in a single report

inferredcites →https://doi.org/10.1093/eurpub/ckx066openalex-snapshot

Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy

inferredcites →https://doi.org/10.1111/cas.14614openalex-snapshot

Hypoxia‐inducible hexokinase‐2 enhances anti‐apoptotic function via activating autophagy in multiple myeloma

inferredcites →https://doi.org/10.1111/cns.12721openalex-snapshot

Thioredoxin‐interacting protein induced α‐synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease

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Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

inferredcites →https://doi.org/10.1128/mcb.16.1.211openalex-snapshot

Induction of Apoptosis by c-Fos Protein

inferredcites →https://doi.org/10.1155/2012/574180openalex-snapshot

PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma

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Egr1 Transcription Factor: Multiple Roles in Prostate Tumor Cell Growth and Survival

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Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

inferredcites →https://doi.org/10.1182/blood-2011-01-332890openalex-snapshot

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche

inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

inferredcites →https://doi.org/10.1261/rna.053959.115openalex-snapshot

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

inferredcites →https://doi.org/10.12688/f1000research.15931.1openalex-snapshot

FastQ Screen: A tool for multi-genome mapping and quality control

inferredcites →https://doi.org/10.1289/ehp10092openalex-snapshot

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis

inferredcites →https://doi.org/10.1289/ehp5337openalex-snapshot

Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program

inferredcites →https://doi.org/10.1289/ehp7853openalex-snapshot

Breaking It Down: Estimating Short-Chain PFAS Half-Lives in a Human Population

inferredcites →https://doi.org/10.1371/journal.pone.0209255openalex-snapshot

Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study

inferredcites →https://doi.org/10.3389/fbioe.2020.602040openalex-snapshot

Challenges and Current Status of the Biological Treatment of PFAS-Contaminated Soils

inferredcites →https://doi.org/10.3389/fcell.2020.603837openalex-snapshot

Metabolism of Amino Acids in Cancer

inferredcites →https://doi.org/10.3389/fcell.2022.867003openalex-snapshot

NIBAN1, Exploring its Roles in Cell Survival Under Stress Context

inferredcites →https://doi.org/10.3389/fneur.2020.577312openalex-snapshot

Peripheral Blood and Salivary Biomarkers of Blood–Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts

inferredcites →https://doi.org/10.3389/fonc.2018.00106openalex-snapshot

DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

inferredcites →https://doi.org/10.3390/cancers14122919openalex-snapshot

Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer

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Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012

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A Glimpse of Molecular Biomarkers in Huntington’s Disease

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.envres.2026.123901openalex-snapshot

Early-childhood exposure to per- and polyfluoroalkyl substances (PFAS) and neurobehavioral development in children

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