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Fluidity and Predictability of Epistasis on an Intragenic Fitness Landscape
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Outgoing claims: the papers this work cites, builds on, or argues with.
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The imprint of codons on protein structure
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How mutational epistasis impairs predictability in protein evolution and design
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From genes to phenotype: dynamical systems and evolvability
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Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers
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Systems-Level Response to Point Mutations in a Core Metabolic Enzyme Modulates Genotype-Phenotype Relationship
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Genotype-Phenotype Mapping Meets Single Cell Biology
inferredcites →https://doi.org/10.1016/j.cels.2024.03.002openalex-snapshot
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors
inferredcites →https://doi.org/10.1016/j.jmb.2019.03.020openalex-snapshot
Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase
inferredcites →https://doi.org/10.1016/j.jmb.2024.168487openalex-snapshot
Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements
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Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding
inferredcites →https://doi.org/10.1016/j.molcel.2016.01.008openalex-snapshot
Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations
inferredcites →https://doi.org/10.1016/j.tig.2014.04.006openalex-snapshot
Exposing synonymous mutations
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Epistasis between deleterious mutations and the evolution of recombination
inferredcites →https://doi.org/10.1016/s0022-5193(87)80029-2openalex-snapshot
Towards a general theory of adaptive walks on rugged landscapes
inferredcites →https://doi.org/10.1017/s0016672300011459openalex-snapshot
Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles
inferredcites →https://doi.org/10.1038/225563a0openalex-snapshot
Natural Selection and the Concept of a Protein Space
inferredcites →https://doi.org/10.1038/345086a0openalex-snapshot
Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing
inferredcites →https://doi.org/10.1038/celldisc.2015.1openalex-snapshot
Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner
inferredcites →https://doi.org/10.1038/nature13410openalex-snapshot
Historical contingency and its biophysical basis in glucocorticoid receptor evolution
inferredcites →https://doi.org/10.1038/nature17995openalex-snapshot
Local fitness landscape of the green fluorescent protein
inferredcites →https://doi.org/10.1038/ng.1034openalex-snapshot
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
inferredcites →https://doi.org/10.1038/nrg2452openalex-snapshot
Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems
inferredcites →https://doi.org/10.1038/nrg3051openalex-snapshot
Understanding the contribution of synonymous mutations to human disease
inferredcites →https://doi.org/10.1038/nrg3744openalex-snapshot
Empirical fitness landscapes and the predictability of evolution
inferredcites →https://doi.org/10.1038/s41467-019-10489-2openalex-snapshot
A pan-cancer analysis of synonymous mutations
inferredcites →https://doi.org/10.1038/s41467-023-39321-8openalex-snapshot
Evolvability-enhancing mutations in the fitness landscapes of an RNA and a protein
inferredcites →https://doi.org/10.1038/s41467-023-44333-5openalex-snapshot
Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
inferredcites →https://doi.org/10.1038/s41467-024-48387-xopenalex-snapshot
Environment modulates protein heterogeneity through transcriptional and translational stop codon readthrough
inferredcites →https://doi.org/10.1038/s41467-024-51895-5openalex-snapshot
The simplicity of protein sequence-function relationships
inferredcites →https://doi.org/10.1038/s41557-022-01091-zopenalex-snapshot
How synonymous mutations alter enzyme structure and function over long timescales
inferredcites →https://doi.org/10.1038/s41559-016-0061openalex-snapshot
Diminishing-returns epistasis decreases adaptability along an evolutionary trajectory
inferredcites →https://doi.org/10.1038/s41559-022-01867-zopenalex-snapshot
The structure of genotype-phenotype maps makes fitness landscapes navigable
inferredcites →https://doi.org/10.1038/s41576-018-0069-zopenalex-snapshot
The causes of evolvability and their evolution
inferredcites →https://doi.org/10.1038/s41586-022-04464-zopenalex-snapshot
ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
inferredcites →https://doi.org/10.1073/pnas.0906192106openalex-snapshot
Adaptive landscapes and protein evolution
inferredcites →https://doi.org/10.1073/pnas.1013529108openalex-snapshot
The noisy edge of traveling waves
inferredcites →https://doi.org/10.1073/pnas.1016024108openalex-snapshot
Experimental illumination of a fitness landscape
inferredcites →https://doi.org/10.1073/pnas.1119910109openalex-snapshot
Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations
inferredcites →https://doi.org/10.1073/pnas.1507916112openalex-snapshot
Measuring ruggedness in fitness landscapes
inferredcites →https://doi.org/10.1073/pnas.1711927114openalex-snapshot
Molecular ensembles make evolution unpredictable
inferredcites →https://doi.org/10.1073/pnas.1718133115openalex-snapshot
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
inferredcites →https://doi.org/10.1073/pnas.1907126117openalex-snapshot
Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness
inferredcites →https://doi.org/10.1073/pnas.1910456117openalex-snapshot
Premature termination codons in the DMD gene cause reduced local mRNA synthesis
inferredcites →https://doi.org/10.1073/pnas.2010612118openalex-snapshot
Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity
inferredcites →https://doi.org/10.1073/pnas.84.14.4890openalex-snapshot
Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.
inferredcites →https://doi.org/10.1073/pnas.86.16.6191openalex-snapshot
Protein evolution on rugged landscapes.
inferredcites →https://doi.org/10.1073/pnas.96.17.9716openalex-snapshot
Neutral evolution of mutational robustness
inferredcites →https://doi.org/10.1086/599081openalex-snapshot
Exploring the Effect of Sex on Empirical Fitness Landscapes
inferredcites →https://doi.org/10.1093/gbe/evab141openalex-snapshot
Effects of Synonymous Mutations beyond Codon Bias: The Evidence for Adaptive Synonymous Substitutions from Microbial Evolution Experiments
inferredcites →https://doi.org/10.1093/genetics/152.2.485openalex-snapshot
Mutators, Population Size, Adaptive Landscape and the Adaptation of Asexual Populations of Bacteria
inferredcites →https://doi.org/10.1093/jhered/esq007openalex-snapshot
Fitness Epistasis among 6 Biosynthetic Loci in the Budding Yeast Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1093/molbev/msae086openalex-snapshot
Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli
inferredcites →https://doi.org/10.1093/molbev/mss273openalex-snapshot
Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme
inferredcites →https://doi.org/10.1093/molbev/mst096openalex-snapshot
Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene
inferredcites →https://doi.org/10.1093/molbev/msz086openalex-snapshot
High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection
inferredcites →https://doi.org/10.1093/nar/gkac681openalex-snapshot
SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo
inferredcites →https://doi.org/10.1098/rsbl.2018.0881openalex-snapshot
The distribution of epistasis on simple fitness landscapes
inferredcites →https://doi.org/10.1098/rsif.2017.0275openalex-snapshot
Structural properties of genotype–phenotype maps
inferredcites →https://doi.org/10.1098/rspb.2011.0870openalex-snapshot
Impact of epistasis and pleiotropy on evolutionary adaptation
inferredcites →https://doi.org/10.1098/rstb.2009.0154openalex-snapshot
Evolution: like any other science it is predictable
inferredcites →https://doi.org/10.1098/rstb.2009.0241openalex-snapshot
Genotype–phenotype mapping and the end of the ‘genes as blueprint’ metaphor
inferredcites →https://doi.org/10.1098/rstb.2022.0053openalex-snapshot
Global epistasis on fitness landscapes
inferredcites →https://doi.org/10.1103/physreve.80.041903openalex-snapshot
Evolutionary dynamics on rugged fitness landscapes: Exact dynamics and information theoretical aspects
inferredcites →https://doi.org/10.1111/j.1558-5646.1997.tb01473.xopenalex-snapshot
TEST OF INTERACTION BETWEEN GENETIC MARKERS THAT AFFECT FITNESS INASPERGILLUS NIGER
inferredcites →https://doi.org/10.1111/mmi.12476openalex-snapshot
A silent mutation in mabA confers isoniazid resistance on M ycobacterium tuberculosis
inferredcites →https://doi.org/10.1126/science.1123539openalex-snapshot
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
inferredcites →https://doi.org/10.1126/science.1170160openalex-snapshot
Coding-Sequence Determinants of Gene Expression in Escherichia coli
inferredcites →https://doi.org/10.1126/science.1180823openalex-snapshot
The Genetic Landscape of a Cell
inferredcites →https://doi.org/10.1126/science.1203801openalex-snapshot
Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population
inferredcites →https://doi.org/10.1126/science.1241934openalex-snapshot
Causes and Effects of N-Terminal Codon Bias in Bacterial Genes
inferredcites →https://doi.org/10.1126/science.1250939openalex-snapshot
Global epistasis makes adaptation predictable despite sequence-level stochasticity
inferredcites →https://doi.org/10.1126/science.17920openalex-snapshot
Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate
inferredcites →https://doi.org/10.1126/science.3125607openalex-snapshot
Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase
inferredcites →https://doi.org/10.1126/science.aae0568openalex-snapshot
The fitness landscape of a tRNA gene
inferredcites →https://doi.org/10.1126/science.aay4199openalex-snapshot
Higher-fitness yeast genotypes are less robust to deleterious mutations
inferredcites →https://doi.org/10.1126/science.abn6895openalex-snapshot
Epistatic drift causes gradual decay of predictability in protein evolution
inferredcites →https://doi.org/10.1126/science.adh3860openalex-snapshot
A rugged yet easily navigable fitness landscape
inferredcites →https://doi.org/10.1126/science.adn0753openalex-snapshot
Environment-independent distribution of mutational effects emerges from microscopic epistasis
inferredcites →https://doi.org/10.1126/science.ado5719openalex-snapshot
Compensatory mutations potentiate constructive neutral evolution by gene duplication
inferredcites →https://doi.org/10.1128/jb.00262-16openalex-snapshot
A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate
inferredcites →https://doi.org/10.1146/annurev-ecolsys-102320-112153openalex-snapshot
Epistasis and Adaptation on Fitness Landscapes
inferredcites →https://doi.org/10.1146/annurev.biophys.33.110502.133613openalex-snapshot
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
inferredcites →https://doi.org/10.1186/1471-2148-11-158openalex-snapshot
Mutator dynamics in sexual and asexual experimental populations of yeast
inferredcites →https://doi.org/10.1186/s12915-023-01585-3openalex-snapshot
Epistasis and evolution: recent advances and an outlook for prediction
inferredcites →https://doi.org/10.1371/journal.pcbi.1002134openalex-snapshot
Evolutionary Accessibility of Mutational Pathways
inferredcites →https://doi.org/10.1371/journal.pcbi.1010524openalex-snapshot
On the incongruence of genotype-phenotype and fitness landscapes
inferredcites →https://doi.org/10.1371/journal.pgen.1007615openalex-snapshot
Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme
inferredcites →https://doi.org/10.1371/journal.pgen.1008079openalex-snapshot
An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape
inferredcites →https://doi.org/10.1371/journal.pone.0000096openalex-snapshot
Experimental Rugged Fitness Landscape in Protein Sequence Space
inferredcites →https://doi.org/10.1371/journal.pone.0174345openalex-snapshot
Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation
inferredcites →https://doi.org/10.1534/genetics.114.167668openalex-snapshot
Adaptation in Tunably Rugged Fitness Landscapes: The Rough Mount Fuji Model
inferredcites →https://doi.org/10.1534/genetics.114.170233openalex-snapshot
Deleterious Passengers in Adapting Populations
inferredcites →https://doi.org/10.1534/genetics.114.172460openalex-snapshot
The Impact of Macroscopic Epistasis on Long-Term Evolutionary Dynamics
inferredcites →https://doi.org/10.1534/genetics.115.182691openalex-snapshot
Epistasis and the Structure of Fitness Landscapes: Are Experimental Fitness Landscapes Compatible with Fisher’s Geometric Model?
inferredcites →https://doi.org/10.1534/genetics.117.300519openalex-snapshot
Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments
inferredcites →https://doi.org/10.1554/04-272openalex-snapshot
PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
inferredcites →https://doi.org/10.7554/elife.16965openalex-snapshot
Adaptation in protein fitness landscapes is facilitated by indirect paths
inferredcites →https://doi.org/10.7554/elife.33292openalex-snapshot
Nonsense mRNA suppression via nonstop decay
inferredcites →https://doi.org/10.7554/elife.45952openalex-snapshot
The distribution of fitness effects among synonymous mutations in a gene under directional selection
inferredcites →https://doi.org/10.7554/elife.53810openalex-snapshot
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
inferredcites →https://doi.org/10.7554/elife.76491openalex-snapshot
Mutational robustness changes during long-term adaptation in laboratory budding yeast populations
inferredcites →https://doi.org/10.7554/elife.77433openalex-snapshot
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
inferredcites →https://doi.org/10.7554/elife.93971openalex-snapshot
Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters
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