On the public citation graph

Disassembly of the Escherichia coli AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts

https://doi.org/10.1101/2025.02.18.638599
0 signed · 51 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcc.20084openalex-snapshot
UCSF Chimera—A visualization system for exploratory research and analysis
inferredcites →https://doi.org/10.1002/pro.3330openalex-snapshot
MolProbity: More and better reference data for improved all‐atom structure validation
inferredcites →https://doi.org/10.1002/pro.3943openalex-snapshot
UCSF ChimeraX : Structure visualization for researchers, educators, and developers
inferredcites →https://doi.org/10.1016/j.bbagen.2017.07.014openalex-snapshot
Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt
inferredcites →https://doi.org/10.1016/j.bbapap.2008.11.005openalex-snapshot
Outer membrane permeability and antibiotic resistance
inferredcites →https://doi.org/10.1016/j.bmcl.2018.10.032openalex-snapshot
A hit deconstruction approach for the discovery of fetal hemoglobin inducers
inferredcites →https://doi.org/10.1016/j.chembiol.2011.02.011openalex-snapshot
Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC
inferredcites →https://doi.org/10.1016/j.jmb.2004.07.088openalex-snapshot
Structure of the Ligand-blocked Periplasmic Entrance of the Bacterial Multidrug Efflux Protein TolC
inferredcites →https://doi.org/10.1016/j.str.2015.12.007openalex-snapshot
Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC
inferredcites →https://doi.org/10.1021/acs.chemrev.1c00055openalex-snapshot
Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b00487openalex-snapshot
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00453openalex-snapshot
Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli
inferredcites →https://doi.org/10.1021/acsinfecdis.6b00167openalex-snapshot
Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump
inferredcites →https://doi.org/10.1038/35016007openalex-snapshot
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
inferredcites →https://doi.org/10.1038/msb4100050openalex-snapshot
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
inferredcites →https://doi.org/10.1038/nature12300openalex-snapshot
Structural basis for the inhibition of bacterial multidrug exporters
inferredcites →https://doi.org/10.1038/ncomms10731openalex-snapshot
Tripartite assembly of RND multidrug efflux pumps
inferredcites →https://doi.org/10.1038/nmeth.2727openalex-snapshot
Quantifying the local resolution of cryo-EM density maps
inferredcites →https://doi.org/10.1038/nmeth.4169openalex-snapshot
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
inferredcites →https://doi.org/10.1038/nrd.2018.168openalex-snapshot
Drug repurposing: progress, challenges and recommendations
inferredcites →https://doi.org/10.1038/s41467-021-27146-2openalex-snapshot
Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
inferredcites →https://doi.org/10.1038/s41467-021-27726-2openalex-snapshot
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
inferredcites →https://doi.org/10.1038/s41467-023-39615-xopenalex-snapshot
Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein
inferredcites →https://doi.org/10.1038/s41579-018-0048-6openalex-snapshot
Multidrug efflux pumps: structure, function and regulation
inferredcites →https://doi.org/10.1073/pnas.1602472113openalex-snapshot
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
inferredcites →https://doi.org/10.1093/jac/dki445openalex-snapshot
Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
inferredcites →https://doi.org/10.1093/jac/dkq079openalex-snapshot
Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria
inferredcites →https://doi.org/10.1093/jac/dkq169openalex-snapshot
A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli
inferredcites →https://doi.org/10.1093/jac/dks321openalex-snapshot
Molecular mechanisms of higher MICs of antibiotics and quaternary ammonium compounds for Escherichia coli isolated from bacteraemia
inferredcites →https://doi.org/10.1093/nar/gky949openalex-snapshot
Protein Data Bank: the single global archive for 3D macromolecular structure data
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1107/s2059798318002425openalex-snapshot
ISOLDE : a physically realistic environment for model building into low-resolution electron-density maps
inferredcites →https://doi.org/10.1107/s2059798321008998openalex-snapshot
eSPC: an online data-analysis platform for molecular biophysics
inferredcites →https://doi.org/10.1107/s2059798323004862openalex-snapshot
Raynals , an online tool for the analysis of dynamic light scattering
inferredcites →https://doi.org/10.1111/nyas.14239openalex-snapshot
AcrB: a mean, keen, drug efflux machine
inferredcites →https://doi.org/10.1128/aac.45.1.105-116.2001openalex-snapshot
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
inferredcites →https://doi.org/10.1128/mbio.00465-20openalex-snapshot
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
inferredcites →https://doi.org/10.1186/s13058-016-0694-4openalex-snapshot
The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells
inferredcites →https://doi.org/10.1371/journal.pbio.0050007openalex-snapshot
Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
inferredcites →https://doi.org/10.1371/journal.pone.0100881openalex-snapshot
Interaction Mediated by the Putative Tip Regions of MdsA and MdsC in the Formation of a Salmonella-Specific Tripartite Efflux Pump
inferredcites →https://doi.org/10.2165/11317030-000000000-00000openalex-snapshot
Efflux-Mediated Drug Resistance in Bacteria
inferredcites →https://doi.org/10.3389/fmicb.2015.00377openalex-snapshot
RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition
inferredcites →https://doi.org/10.3390/antibiotics12010180openalex-snapshot
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria
inferredcites →https://doi.org/10.3390/biom13061000openalex-snapshot
Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators
inferredcites →https://doi.org/10.7554/elife.24905openalex-snapshot
An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
inferredcites →https://doi.org/10.7554/elife.34085openalex-snapshot
The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution
inferredcites →https://doi.org/10.7554/elife.73297openalex-snapshot
Colicin E1 opens its hinge to plug TolC

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3389/fphar.2026.1895729openalex-snapshot
Targeting the AcrAB-TolC efflux pump by small molecules selectively addressing the outer membrane factor TolC
inferred← citeshttps://doi.org/10.7554/elife.109684openalex-snapshot
Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system
inferred← citeshttps://doi.org/10.7554/elife.109684.1openalex-snapshot
Structural mechanisms of pump assembly and drug transport in the AcrAB-TolC efflux system
inferred← citeshttps://doi.org/10.7554/elife.109684.3openalex-snapshot
Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.