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Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer’s disease across model systems

https://doi.org/10.1101/2025.06.17.660179

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/alz.046129openalex-snapshot

Agora: An open platform for exploration of Alzheimer’s disease evidence

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Errors in translation act as a “tipping point” leading to the onset of neurodegenerative disease

inferredcites →https://doi.org/10.1002/cpz1.90openalex-snapshot

Gene Set Knowledge Discovery with Enrichr

inferredcites →https://doi.org/10.1007/s00401-016-1663-9openalex-snapshot

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

inferredcites →https://doi.org/10.1007/s00401-021-02301-7openalex-snapshot

Tau strains shape disease

inferredcites →https://doi.org/10.1007/s00401-023-02600-1openalex-snapshot

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

inferredcites →https://doi.org/10.1007/s00401-024-02775-1openalex-snapshot

Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease

inferredcites →https://doi.org/10.1016/j.arr.2016.05.004openalex-snapshot

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

inferredcites →https://doi.org/10.1016/j.cell.2021.12.041openalex-snapshot

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

inferredcites →https://doi.org/10.1016/j.cell.2025.04.006openalex-snapshot

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

inferredcites →https://doi.org/10.1016/j.celrep.2016.04.045openalex-snapshot

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

inferredcites →https://doi.org/10.1016/j.celrep.2016.09.063openalex-snapshot

Loss of Bin1 Promotes the Propagation of Tau Pathology

inferredcites →https://doi.org/10.1016/j.celrep.2020.02.026openalex-snapshot

Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

inferredcites →https://doi.org/10.1016/j.celrep.2020.107807openalex-snapshot

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia

inferredcites →https://doi.org/10.1016/j.cels.2016.11.006openalex-snapshot

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/j.jalz.2017.09.012openalex-snapshot

Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

inferredcites →https://doi.org/10.1016/j.jmb.2004.04.008openalex-snapshot

Surface-decoration of Microtubules by Human Tau

inferredcites →https://doi.org/10.1016/j.jmb.2019.04.026openalex-snapshot

Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2010.11.022openalex-snapshot

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2013.03.015openalex-snapshot

Tau phosphorylation affects its axonal transport and degradation

inferredcites →https://doi.org/10.1016/j.neuron.2006.07.019openalex-snapshot

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration

inferredcites →https://doi.org/10.1016/j.neuron.2007.03.022openalex-snapshot

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

inferredcites →https://doi.org/10.1016/j.neuron.2011.04.009openalex-snapshot

The Many Faces of Tau

inferredcites →https://doi.org/10.1016/j.neuron.2014.04.047openalex-snapshot

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

inferredcites →https://doi.org/10.1016/j.neuron.2016.09.055openalex-snapshot

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

inferredcites →https://doi.org/10.1016/j.neuron.2018.01.022openalex-snapshot

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

inferredcites →https://doi.org/10.1016/j.neuron.2018.12.031openalex-snapshot

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/j.neuron.2020.12.016openalex-snapshot

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

inferredcites →https://doi.org/10.1016/j.xpro.2024.103185openalex-snapshot

Protocol for the isolation and proteomic analysis of pathological tau-seeds

inferredcites →https://doi.org/10.1021/acs.jproteome.0c00137openalex-snapshot

Physiological Tau Interactome in Brain and Its Link to Tauopathies

inferredcites →https://doi.org/10.1038/ncomms15295openalex-snapshot

Tau association with synaptic vesicles causes presynaptic dysfunction

inferredcites →https://doi.org/10.1038/ncomms5998openalex-snapshot

PICALM modulates autophagy activity and tau accumulation

inferredcites →https://doi.org/10.1038/ncomms9490openalex-snapshot

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

inferredcites →https://doi.org/10.1038/nn.4328openalex-snapshot

Neuronal activity enhances tau propagation and tau pathology in vivo

inferredcites →https://doi.org/10.1038/s41467-026-68864-9openalex-snapshot

Integrative epigenomic landscape of Alzheimer’s Disease brains reveals oligodendrocyte molecular perturbations associated with tau

inferredcites →https://doi.org/10.1038/s41593-022-01191-6openalex-snapshot

Bassoon contributes to tau-seed propagation and neurotoxicity

inferredcites →https://doi.org/10.1038/sdata.2016.89openalex-snapshot

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

inferredcites →https://doi.org/10.1038/sdata.2018.142openalex-snapshot

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

inferredcites →https://doi.org/10.1038/sdata.2018.185openalex-snapshot

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

inferredcites →https://doi.org/10.1073/pnas.1411649111openalex-snapshot

Proteopathic tau seeding predicts tauopathy in vivo

inferredcites →https://doi.org/10.1074/jbc.m115.641902openalex-snapshot

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

inferredcites →https://doi.org/10.1080/15548627.2023.2181614openalex-snapshot

Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease

inferredcites →https://doi.org/10.1091/mbc.8.10.2003openalex-snapshot

Amphiphysin Heterodimers: Potential Role in Clathrin-mediated Endocytosis

inferredcites →https://doi.org/10.1091/mbc.e17-06-0429openalex-snapshot

Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles

inferredcites →https://doi.org/10.1093/biomet/93.3.491openalex-snapshot

Adaptive linear step-up procedures that control the false discovery rate

inferredcites →https://doi.org/10.1093/brain/awac318openalex-snapshot

Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model

inferredcites →https://doi.org/10.1093/nar/gky1131openalex-snapshot

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

inferredcites →https://doi.org/10.1101/2024.06.26.600814openalex-snapshot

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

inferredcites →https://doi.org/10.1101/226977openalex-snapshot

Tau hyperphosphorylation on T217 in cerebrospinal fluid is specifically associated to amyloid-β pathology

inferredcites →https://doi.org/10.1101/gr.1239303openalex-snapshot

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

inferredcites →https://doi.org/10.1111/acel.13081openalex-snapshot

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

inferredcites →https://doi.org/10.1111/j.1600-0854.2007.00694.xopenalex-snapshot

Evidence for CALM in Directing VAMP2 Trafficking

inferredcites →https://doi.org/10.1126/science.aaz2924openalex-snapshot

Structure of V-ATPase from the mammalian brain

inferredcites →https://doi.org/10.1126/scitranslmed.abg0253openalex-snapshot

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

inferredcites →https://doi.org/10.1146/annurev.neuro.24.1.1121openalex-snapshot

Neurodegenerative Tauopathies

inferredcites →https://doi.org/10.1186/1471-2105-9-559openalex-snapshot

WGCNA: an R package for weighted correlation network analysis

inferredcites →https://doi.org/10.1186/gb-2003-4-5-p3openalex-snapshot

DAVID: Database for Annotation, Visualization, and Integrated Discovery

inferredcites →https://doi.org/10.1186/s13024-016-0109-0openalex-snapshot

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

inferredcites →https://doi.org/10.1186/s13024-016-0143-yopenalex-snapshot

The release and trans-synaptic transmission of Tau via exosomes

inferredcites →https://doi.org/10.1186/s13024-020-00387-3openalex-snapshot

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

inferredcites →https://doi.org/10.1186/s13024-023-00605-8openalex-snapshot

Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications

inferredcites →https://doi.org/10.1186/s40478-021-01199-2openalex-snapshot

Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

inferredcites →https://doi.org/10.1242/jcs.236737openalex-snapshot

AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells

inferredcites →https://doi.org/10.1371/journal.pone.0103187openalex-snapshot

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

inferredcites →https://doi.org/10.15252/emmm.202012921openalex-snapshot

Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected

inferredcites →https://doi.org/10.1534/g3.116.027060openalex-snapshot

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

inferredcites →https://doi.org/10.2174/156720508785132307openalex-snapshot

Mechanism of Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies

inferredcites →https://doi.org/10.3233/jad-150705openalex-snapshot

Predictive Value of Cerebrospinal Fluid Visinin-Like Protein-1 Levels for Alzheimer’s Disease Early Detection and Differential Diagnosis in Patients with Mild Cognitive Impairment

inferredcites →https://doi.org/10.3389/fgene.2019.00421openalex-snapshot

DiVenn: An Interactive and Integrated Web-Based Visualization Tool for Comparing Gene Lists

inferredcites →https://doi.org/10.3389/fimmu.2024.1424385openalex-snapshot

TUFM in health and disease: exploring its multifaceted roles

inferredcites →https://doi.org/10.3389/fnins.2020.00068openalex-snapshot

A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila

inferredcites →https://doi.org/10.3390/cancers16020423openalex-snapshot

Mapping the Anti-Cancer Activity of α-Connexin Carboxyl-Terminal (aCT1) Peptide in Resistant HER2+ Breast Cancer

inferredcites →https://doi.org/10.3390/ijms22179207openalex-snapshot

Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies

inferredcites →https://doi.org/10.3390/proteomes9010015openalex-snapshot

Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics

inferredcites →https://doi.org/10.7554/elife.69498openalex-snapshot

Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.64898/2026.10.05.756807openalex-snapshot

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

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