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Tracking the opening of spike crowns on the surface of coronaviruses

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition
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UCSF Chimera—A visualization system for exploratory research and analysis
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Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles
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Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain
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An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope
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Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants
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Elucidation of interactions regulating conformational stability and dynamics of SARS-CoV-2 S-protein
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
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Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding
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A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
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Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike
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Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition
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Structure of SARS-CoV-2 spike protein
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Antigenic evolution of SARS coronavirus 2
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VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
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The mechanisms of immune response and evasion by the main SARS-CoV-2 variants
inferredcites →https://doi.org/10.1016/j.isci.2023.107085openalex-snapshot
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
inferredcites →https://doi.org/10.1016/j.isci.2023.107882openalex-snapshot
ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface
inferredcites →https://doi.org/10.1016/j.molcel.2022.03.028openalex-snapshot
Structural Diversity of the SARS-CoV-2 Omicron Spike
inferredcites →https://doi.org/10.1016/j.str.2021.04.006openalex-snapshot
Conformational flexibility and structural variability of SARS-CoV2 S protein
inferredcites →https://doi.org/10.1016/j.xcrm.2024.101553openalex-snapshot
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity
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Free Energy Simulations of Receptor-Binding Domain Opening of the SARS-CoV-2 Spike Indicate a Barrierless Transition with Slow Conformational Motions
inferredcites →https://doi.org/10.1021/acscentsci.0c01056openalex-snapshot
Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein
inferredcites →https://doi.org/10.1021/acscentsci.3c00810openalex-snapshot
Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open States in SARS-CoV-2 Variants of Concern
inferredcites →https://doi.org/10.1021/jacs.1c00556openalex-snapshot
Free Energy Landscapes from SARS-CoV-2 Spike Glycoprotein Simulations Suggest that RBD Opening Can Be Modulated via Interactions in an Allosteric Pocket
inferredcites →https://doi.org/10.1021/jacs.1c07965openalex-snapshot
Predicting Mutational Effects on Receptor Binding of the Spike Protein of SARS-CoV-2 Variants
inferredcites →https://doi.org/10.1038/nature02145openalex-snapshot
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
inferredcites →https://doi.org/10.1038/nature12711openalex-snapshot
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
inferredcites →https://doi.org/10.1038/s41421-022-00449-4openalex-snapshot
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages
inferredcites →https://doi.org/10.1038/s41467-020-20321-xopenalex-snapshot
Stabilizing the closed SARS-CoV-2 spike trimer
inferredcites →https://doi.org/10.1038/s41467-021-21968-wopenalex-snapshot
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
inferredcites →https://doi.org/10.1038/s41467-021-24435-8openalex-snapshot
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
inferredcites →https://doi.org/10.1038/s41467-021-27350-0openalex-snapshot
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM
inferredcites →https://doi.org/10.1038/s41467-023-36745-0openalex-snapshot
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein
inferredcites →https://doi.org/10.1038/s41467-023-37786-1openalex-snapshot
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
inferredcites →https://doi.org/10.1038/s41467-024-50976-9openalex-snapshot
Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens
inferredcites →https://doi.org/10.1038/s41557-021-00707-0openalex-snapshot
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome
inferredcites →https://doi.org/10.1038/s41557-021-00758-3openalex-snapshot
A glycan gate controls opening of the SARS-CoV-2 spike protein
inferredcites →https://doi.org/10.1038/s41564-020-0695-zopenalex-snapshot
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
inferredcites →https://doi.org/10.1038/s41564-021-00972-2openalex-snapshot
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
inferredcites →https://doi.org/10.1038/s41565-025-01908-1openalex-snapshot
Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection
inferredcites →https://doi.org/10.1038/s41579-021-00573-0openalex-snapshot
SARS-CoV-2 variants, spike mutations and immune escape
inferredcites →https://doi.org/10.1038/s41580-021-00418-xopenalex-snapshot
Mechanisms of SARS-CoV-2 entry into cells
inferredcites →https://doi.org/10.1038/s41586-020-2012-7openalex-snapshot
A pneumonia outbreak associated with a new coronavirus of probable bat origin
inferredcites →https://doi.org/10.1038/s41586-020-2179-yopenalex-snapshot
Structural basis of receptor recognition by SARS-CoV-2
inferredcites →https://doi.org/10.1038/s41586-020-2180-5openalex-snapshot
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
inferredcites →https://doi.org/10.1038/s41586-020-2665-2openalex-snapshot
Structures and distributions of SARS-CoV-2 spike proteins on intact virions
inferredcites →https://doi.org/10.1038/s41586-024-07636-1openalex-snapshot
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
inferredcites →https://doi.org/10.1038/s41594-020-0478-5openalex-snapshot
A thermostable, closed SARS-CoV-2 spike protein trimer
inferredcites →https://doi.org/10.1038/s41594-020-0479-4openalex-snapshot
Controlling the SARS-CoV-2 spike glycoprotein conformation
inferredcites →https://doi.org/10.1038/s41594-020-0483-8openalex-snapshot
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
inferredcites →https://doi.org/10.1038/s41594-022-00735-5openalex-snapshot
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes
inferredcites →https://doi.org/10.1038/s41594-023-01023-6openalex-snapshot
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein
inferredcites →https://doi.org/10.1038/s42003-022-04138-6openalex-snapshot
SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact
inferredcites →https://doi.org/10.1056/nejmoa2001017openalex-snapshot
A Novel Coronavirus from Patients with Pneumonia in China, 2019
inferredcites →https://doi.org/10.1056/nejmoa2035002openalex-snapshot
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
inferredcites →https://doi.org/10.1073/pnas.2112703118openalex-snapshot
Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein
inferredcites →https://doi.org/10.1073/pnas.2205412119openalex-snapshot
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes
inferredcites →https://doi.org/10.1080/14760584.2023.2211153openalex-snapshot
Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines
inferredcites →https://doi.org/10.1126/sciadv.abf3671openalex-snapshot
The SARS-CoV-2 Spike variant D614G favors an open conformational state
inferredcites →https://doi.org/10.1126/science.abb2507openalex-snapshot
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
inferredcites →https://doi.org/10.1126/science.abb9983openalex-snapshot
Site-specific glycan analysis of the SARS-CoV-2 spike
inferredcites →https://doi.org/10.1126/science.abc5881openalex-snapshot
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
inferredcites →https://doi.org/10.1126/science.abd0826openalex-snapshot
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
inferredcites →https://doi.org/10.1126/science.abd0831openalex-snapshot
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
inferredcites →https://doi.org/10.1126/science.abd5223openalex-snapshot
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
inferredcites →https://doi.org/10.1126/science.abd9909openalex-snapshot
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
inferredcites →https://doi.org/10.1126/science.abe1502openalex-snapshot
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
inferredcites →https://doi.org/10.1126/science.abe3255openalex-snapshot
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
inferredcites →https://doi.org/10.1126/science.abe6230openalex-snapshot
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
inferredcites →https://doi.org/10.1126/science.abf2303openalex-snapshot
Structural impact on SARS-CoV-2 spike protein by D614G substitution
inferredcites →https://doi.org/10.1126/science.abi6226openalex-snapshot
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
inferredcites →https://doi.org/10.1126/science.abq3773openalex-snapshot
Broadly neutralizing antibodies target the coronavirus fusion peptide
inferredcites →https://doi.org/10.1126/science.adn5658openalex-snapshot
Structure and inhibition of SARS-CoV-2 spike refolding in membranes
inferredcites →https://doi.org/10.1126/scitranslmed.abn1252openalex-snapshot
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice
inferredcites →https://doi.org/10.1128/mbio.00464-25openalex-snapshot
Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants
inferredcites →https://doi.org/10.1128/mbio.02030-21openalex-snapshot
Structural Dynamics and Molecular Evolution of the SARS-CoV-2 Spike Protein
inferredcites →https://doi.org/10.1128/mbio.03227-21openalex-snapshot
SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy
inferredcites →https://doi.org/10.1172/jci178880openalex-snapshot
Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV
inferredcites →https://doi.org/10.1371/journal.ppat.1009704openalex-snapshot
Structure-guided antibody cocktail for prevention and treatment of COVID-19
inferredcites →https://doi.org/10.1371/journal.ppat.1010260openalex-snapshot
Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants
inferredcites →https://doi.org/10.1371/journal.ppat.1010951openalex-snapshot
Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains
inferredcites →https://doi.org/10.1371/journal.ppat.1010994openalex-snapshot
A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
inferredcites →https://doi.org/10.1371/journal.ppat.1013034openalex-snapshot
Structural basis and mode of action for two broadly neutralizing nanobodies targeting the highly conserved spike stem-helix of sarbecoviruses including SARS-CoV-2 and its variants
inferredcites →https://doi.org/10.3390/v13020332openalex-snapshot
Single-Molecule FRET Imaging of Virus Spike–Host Interactions
inferredcites →https://doi.org/10.3390/v15030639openalex-snapshot
SARS-CoV-2 Spike-Mediated Entry and Its Regulation by Host Innate Immunity
inferredcites →https://doi.org/10.7554/elife.75720openalex-snapshot
The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein
inferredcites →https://doi.org/10.7554/elife.83442openalex-snapshot
The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution
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