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Systems genetics identifies modifiers of Alzheimer’s disease risk and resilience

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2015.1424openalex-snapshot

Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation inPSEN1With Familial Alzheimer Disease Among Caribbean Hispanics

inferredcites →https://doi.org/10.1002/ana.10507openalex-snapshot

PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease

inferredcites →https://doi.org/10.1007/s00210-005-1052-8openalex-snapshot

Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels

inferredcites →https://doi.org/10.1007/s00401-016-1533-5openalex-snapshot

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

inferredcites →https://doi.org/10.1016/j.bbr.2014.12.018openalex-snapshot

TRPC3 channels critically regulate hippocampal excitability and contextual fear memory

inferredcites →https://doi.org/10.1016/j.bbr.2016.05.007openalex-snapshot

Transcriptional signatures of brain aging and Alzheimer’s disease: What are our rodent models telling us?

inferredcites →https://doi.org/10.1016/j.biopsych.2014.05.006openalex-snapshot

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

inferredcites →https://doi.org/10.1016/j.brainresbull.2015.12.003openalex-snapshot

Toward more predictive genetic mouse models of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.cell.2013.03.030openalex-snapshot

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/j.jalz.2015.10.010openalex-snapshot

Unraveling the mechanistic complexity of Alzheimer's disease through systems biology

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2007.02.017openalex-snapshot

Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2014.10.004openalex-snapshot

Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice

inferredcites →https://doi.org/10.1016/s0959-4388(99)80027-0openalex-snapshot

Hippocampus and context in classical conditioning

inferredcites →https://doi.org/10.1037//0735-7044.98.2.269openalex-snapshot

Opiate modulation of the active and inactive components of the postshock reaction: Parallels between naloxone pretreatment and shock intensity.

inferredcites →https://doi.org/10.1038/nature10413openalex-snapshot

Mouse genomic variation and its effect on phenotypes and gene regulation

inferredcites →https://doi.org/10.1038/ncomms9382openalex-snapshot

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

inferredcites →https://doi.org/10.1038/ncomms9876openalex-snapshot

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

inferredcites →https://doi.org/10.1038/ng.2802openalex-snapshot

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

inferredcites →https://doi.org/10.1038/nn.3786openalex-snapshot

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

inferredcites →https://doi.org/10.1038/nrg2664openalex-snapshot

The genetics of inbreeding depression

inferredcites →https://doi.org/10.1038/nrn960openalex-snapshot

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

inferredcites →https://doi.org/10.1038/nrneurol.2012.263openalex-snapshot

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

inferredcites →https://doi.org/10.1038/sj.cdd.4401803openalex-snapshot

FGF-2 overexpression opposes the beta amyloid toxic injuries to the vascular endothelium

inferredcites →https://doi.org/10.1042/bj20051246openalex-snapshot

Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy

inferredcites →https://doi.org/10.1073/pnas.051632698openalex-snapshot

Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain

inferredcites →https://doi.org/10.1073/pnas.0808793106openalex-snapshot

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

inferredcites →https://doi.org/10.1093/bioinformatics/btg112openalex-snapshot

R/qtl: QTL mapping in experimental crosses

inferredcites →https://doi.org/10.1093/brain/aws234openalex-snapshot

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies

inferredcites →https://doi.org/10.1093/brain/aww330openalex-snapshot

Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer’s disease mice

inferredcites →https://doi.org/10.1093/gerona/52a.2.m117openalex-snapshot

Heritability for Alzheimer's Disease: The Study of Dementia in Swedish Twins

inferredcites →https://doi.org/10.1093/hmg/ddl157openalex-snapshot

Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice

inferredcites →https://doi.org/10.1101/024588openalex-snapshot

Genomic analysis of allele-specific expression in the mouse liver

inferredcites →https://doi.org/10.1111/bpa.12365openalex-snapshot

The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts

inferredcites →https://doi.org/10.1126/science.1566067openalex-snapshot

Alzheimer's Disease: The Amyloid Cascade Hypothesis

inferredcites →https://doi.org/10.1126/science.aad8373openalex-snapshot

Complement and microglia mediate early synapse loss in Alzheimer mouse models

inferredcites →https://doi.org/10.1126/scitranslmed.aaf2362openalex-snapshot

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

inferredcites →https://doi.org/10.1161/strokeaha.110.595082openalex-snapshot

Microinfarct Pathology, Dementia, and Cognitive Systems

inferredcites →https://doi.org/10.1161/strokeaha.111.623462openalex-snapshot

Cerebrovascular Disease Pathology and Parkinsonian Signs in Old Age

inferredcites →https://doi.org/10.1186/1471-2105-9-559openalex-snapshot

WGCNA: an R package for weighted correlation network analysis

inferredcites →https://doi.org/10.1186/1471-2156-5-7openalex-snapshot

A new set of BXD recombinant inbred lines from advanced intercross populations in mice

inferredcites →https://doi.org/10.1186/1750-1326-10-1openalex-snapshot

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

inferredcites →https://doi.org/10.1186/s13059-016-0974-4openalex-snapshot

The Ensembl Variant Effect Predictor

inferredcites →https://doi.org/10.1212/01.wnl.0000219668.47116.e6openalex-snapshot

Neuropathology of older persons without cognitive impairment from two community-based studies

inferredcites →https://doi.org/10.1212/01.wnl.0000271090.28148.24openalex-snapshot

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

inferredcites →https://doi.org/10.1212/wnl.0000000000000596openalex-snapshot

Symptom onset in autosomal dominant Alzheimer disease

inferredcites →https://doi.org/10.1212/wnl.0000000000002175openalex-snapshot

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

inferredcites →https://doi.org/10.1212/wnl.41.4.479openalex-snapshot

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

inferredcites →https://doi.org/10.1371/journal.pone.0050976openalex-snapshot

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

inferredcites →https://doi.org/10.1371/journal.pone.0079771openalex-snapshot

Alzheimer’s Disease: Analyzing the Missing Heritability

inferredcites →https://doi.org/10.1371/journal.pone.0125897openalex-snapshot

DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease

inferredcites →https://doi.org/10.1371/journal.pone.0144052openalex-snapshot

Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer’s Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease

inferredcites →https://doi.org/10.1523/jneurosci.0033-12.2012openalex-snapshot

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent Aβ Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

inferredcites →https://doi.org/10.1523/jneurosci.1202-06.2006openalex-snapshot

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

inferredcites →https://doi.org/10.2174/156720512801322573openalex-snapshot

Overview and Findings from the Religious Orders Study

inferredcites →https://doi.org/10.2174/156720512801322663openalex-snapshot

Overview and Findings from the Rush Memory and Aging Project

inferredcites →https://doi.org/10.2353/ajpath.2010.100346openalex-snapshot

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

inferredcites →https://doi.org/10.3389/fgene.2014.00088openalex-snapshot

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.bcp.2020.113945openalex-snapshot

Alzheimer’s disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105558openalex-snapshot

Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models

inferred← citeshttps://doi.org/10.1016/j.nlm.2019.107069openalex-snapshot

Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer’s disease, and genetic diversity

inferred← citeshttps://doi.org/10.1038/s41598-021-93085-zopenalex-snapshot

Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1101/2024.01.09.574219openalex-snapshot

Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population

inferred← citeshttps://doi.org/10.1101/746222openalex-snapshot

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1101/lm.051839.120openalex-snapshot

Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice

inferred← citeshttps://doi.org/10.1111/gbb.12538openalex-snapshot

Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age

inferred← citeshttps://doi.org/10.1186/s13024-020-00412-5openalex-snapshot

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13064-026-00236-xopenalex-snapshot

Modifier gene identification reveals therapeutic pathways for adult and childhood dementias

inferred← citeshttps://doi.org/10.1371/journal.pgen.1009406openalex-snapshot

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease

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