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The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies

https://doi.org/10.1101/234815
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Inferring the direction of causation in cross‐sectional twin data: Theoretical and empirical considerations
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Correlation and Causation in the Study of Personality
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Conditions for the validity of SNP-based heritability estimation
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Five Years of GWAS Discovery
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Improved Heritability Estimation from Genome-wide SNPs
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A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait
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Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits
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Uncovering the Genetic Architectures of Quantitative Traits
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Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank
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Molecular genetic contributions to socioeconomic status and intelligence
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Causality
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The causal meaning of Fisher's average effect
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The Minnesota Center for Twin and Family Research Genome-Wide Association Study
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Genome-wide association study identifies 74 loci associated with educational attainment
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3390openalex-snapshot
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
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An atlas of genetic correlations across human diseases and traits
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Genome-wide analysis identifies 12 loci influencing human reproductive behavior
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Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot
Principal components analysis corrects for stratification in genome-wide association studies
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Family-based designs in the age of large-scale gene-association studies
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Mixed-model association for biobank-scale datasets
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The quantitative genetic theory of parental effects
inferredcites →https://doi.org/10.1101/211821openalex-snapshot
Equivalence of LD-Score Regression and Individual-Level-Data Methods
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Genomic Control for Association Studies
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Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspring
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AVERAGE EXCESS AND AVERAGE EFFECT OF A GENE SUBSTITUTION
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Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring
inferredcites →https://doi.org/10.1126/science.aan6877openalex-snapshot
The nature of nurture: Effects of parental genotypes
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Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis
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How Large are the Effects from Changes in Family Environment? A Study of Korean American Adoptees
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Second-generation PLINK: rising to the challenge of larger and richer datasets
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The Importance of Synthetic Associations Will Only Be Resolved Empirically
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Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits
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Genomic Heritability: What Is It?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Relationship Between Chronic Pain and Breast Cancer: Insight From Genetic Correlation Analyses and 2-Sample Mendelian Randomization
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Dissecting the association between psychiatric disorders and neurological proteins: a genetic correlation and two-sample bidirectional Mendelian randomization study
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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
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Expectation of the intercept from bivariate LD score regression in the presence of population stratification
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An atlas of genetic correlations between psychiatric disorders and human blood plasma proteome
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The Emerging Landscape of Epidemiological Research Based on Biobanks Linked to Electronic Health Records: Existing Resources, Analytic Challenges and Potential Opportunities
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A Genetic Correlation Scan Identifies Blood Proteins Associated With Bone Mineral Density
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