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Equivalence of LD-Score Regression and Individual-Level-Data Methods

https://doi.org/10.1101/211821
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/tpbi.2001.1542openalex-snapshot
Genomic Control, a New Approach to Genetic-Based Association Studies
inferredcites →https://doi.org/10.1007/bf01066731openalex-snapshot
The investigation of linkage between a quantitative trait and a marker locus
inferredcites →https://doi.org/10.1016/0165-1765(80)90024-5openalex-snapshot
Efficient tests for normality, homoscedasticity and serial independence of regression residuals
inferredcites →https://doi.org/10.1016/j.ajhg.2008.06.005openalex-snapshot
Long-Range LD Can Confound Genome Scans in Admixed Populations
inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot
GCTA: A Tool for Genome-wide Complex Trait Analysis
inferredcites →https://doi.org/10.1016/j.ajhg.2011.05.025openalex-snapshot
Population Structure Can Inflate SNP-Based Heritability Estimates
inferredcites →https://doi.org/10.1016/j.ajhg.2012.05.024openalex-snapshot
Estimating Kinship in Admixed Populations
inferredcites →https://doi.org/10.1016/j.ajhg.2015.11.022openalex-snapshot
Model-free Estimation of Recent Genetic Relatedness
inferredcites →https://doi.org/10.1016/j.tpb.2013.08.004openalex-snapshot
Separation of the largest eigenvalues in eigenanalysis of genotype data from discrete subpopulations
inferredcites →https://doi.org/10.1038/nature09298openalex-snapshot
Integrating common and rare genetic variation in diverse human populations
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3401openalex-snapshot
Population genetic differentiation of height and body mass index across Europe
inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot
Principal components analysis corrects for stratification in genome-wide association studies
inferredcites →https://doi.org/10.1038/s41588-018-0144-6openalex-snapshot
Mixed-model association for biobank-scale datasets
inferredcites →https://doi.org/10.1073/pnas.1602743113openalex-snapshot
GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/nar/gkt1122openalex-snapshot
InvFEST, a database integrating information of polymorphic inversions in the human genome
inferredcites →https://doi.org/10.1101/018283openalex-snapshot
Relationship between LD Score and Haseman-Elston Regression
inferredcites →https://doi.org/10.1101/gr.154831.113openalex-snapshot
Estimating and interpreting F ST : The impact of rare variants
inferredcites →https://doi.org/10.1111/j.0006-341x.1999.00997.xopenalex-snapshot
Genomic Control for Association Studies
inferredcites →https://doi.org/10.1111/j.1469-1809.1949.tb02451.xopenalex-snapshot
THE GENETICAL STRUCTURE OF POPULATIONS
inferredcites →https://doi.org/10.1111/j.1558-5646.1984.tb05657.xopenalex-snapshot
ESTIMATING F -STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE
inferredcites →https://doi.org/10.1111/j.1558-5646.1986.tb00516.xopenalex-snapshot
DEFINITION AND ESTIMATION OF FIXATION INDICES
inferredcites →https://doi.org/10.1146/annurev.genet.36.050802.093940openalex-snapshot
Estimating F-Statistics
inferredcites →https://doi.org/10.1186/2047-217x-4-1openalex-snapshot
SmileFinder: a resampling-based approach to evaluate signatures of selection from genome-wide sets of matching allele frequency data in two or more diploid populations
inferredcites →https://doi.org/10.1371/journal.pgen.1006495openalex-snapshot
Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/gepi.22161openalex-snapshot
The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome‐wide association studies
inferred← citeshttps://doi.org/10.1002/gepi.22259openalex-snapshot
Summary statistic analyses can mistake confounding bias for heritability
inferred← citeshttps://doi.org/10.1038/s41467-020-18085-5openalex-snapshot
CORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses
inferred← citeshttps://doi.org/10.1038/s41562-019-0566-xopenalex-snapshot
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
inferred← citeshttps://doi.org/10.1038/s41588-018-0320-8openalex-snapshot
Multivariate genome-wide analyses of the well-being spectrum
inferred← citeshttps://doi.org/10.1038/s41588-025-02093-6openalex-snapshot
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex
inferred← citeshttps://doi.org/10.1093/g3journal/jkac261openalex-snapshot
Accurate modeling of replication rates in genome-wide association studies by accounting for Winner’s Curse and study-specific heterogeneity
inferred← citeshttps://doi.org/10.1101/2023.04.06.535886openalex-snapshot
StocSum: stochastic summary statistics for whole genome sequencing studies
inferred← citeshttps://doi.org/10.1101/234815openalex-snapshot
The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies
inferred← citeshttps://doi.org/10.1101/305029openalex-snapshot
Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
inferred← citeshttps://doi.org/10.1101/532069openalex-snapshot
Summary statistic analyses do not correct confounding bias
inferred← citeshttps://doi.org/10.15195/v7.a19openalex-snapshot
Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
inferred← citeshttps://doi.org/10.1534/genetics.120.303242openalex-snapshot
Multi-trait Genome-Wide Analyses of the Brain Imaging Phenotypes in UK Biobank
inferred← citeshttps://doi.org/10.64898/2026.05.13.724972openalex-snapshot
When can whole-genome SNP heritability be reliably estimated from summary statistics?
inferred← citeshttps://doi.org/10.64898/2026.08.04.742829openalex-snapshot
The Genome-Wide Effect of Drift and Selection over a Single Generation
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