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Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

https://doi.org/10.1101/236182
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.282.16.1523openalex-snapshot
The Disease Burden Associated With Overweight and Obesity
inferredcites →https://doi.org/10.1001/jamacardio.2016.5804openalex-snapshot
Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank
inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1007/s10654-016-0147-5openalex-snapshot
High body mass index and cancer risk—a Mendelian randomisation study
inferredcites →https://doi.org/10.1016/j.ajhg.2011.11.029openalex-snapshot
Five Years of GWAS Discovery
inferredcites →https://doi.org/10.1016/j.csda.2010.04.005openalex-snapshot
Avoiding bias due to perfect prediction in multiple imputation of incomplete categorical variables
inferredcites →https://doi.org/10.1016/j.hlpt.2012.07.003openalex-snapshot
UK Biobank: Current status and what it means for epidemiology
inferredcites →https://doi.org/10.1016/j.jpsychores.2011.03.004openalex-snapshot
Associations of mood and anxiety disorders with obesity: Comparisons by ethnicity
inferredcites →https://doi.org/10.1016/s0140-6736(08)60269-xopenalex-snapshot
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
inferredcites →https://doi.org/10.1016/s0140-6736(12)61179-9openalex-snapshot
The UK Biobank and selection bias
inferredcites →https://doi.org/10.1016/s0140-6736(16)32245-0openalex-snapshot
Body-mass index and cardiometabolic disease: a Mendelian randomisation study of UK Biobank participants
inferredcites →https://doi.org/10.1017/s0033291714001226openalex-snapshot
Do genetic risk scores for body mass index predict risk of phobic anxiety? Evidence for a shared genetic risk factor
inferredcites →https://doi.org/10.1038/ijo.2008.268openalex-snapshot
Depression and anxiety among US adults: associations with body mass index
inferredcites →https://doi.org/10.1038/ijo.2008.82openalex-snapshot
Does obesity shorten life? The importance of well-defined interventions to answer causal questions
inferredcites →https://doi.org/10.1038/ijo.2009.252openalex-snapshot
The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/nrg.2017.72openalex-snapshot
Convergence between biological, behavioural and genetic determinants of obesity
inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/srep16645openalex-snapshot
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization
inferredcites →https://doi.org/10.1073/pnas.1718206115openalex-snapshot
Neurobehavioral correlates of obesity are largely heritable
inferredcites →https://doi.org/10.1093/aje/kwm280openalex-snapshot
Association of Adult Body Mass Index and Height with Anxiety, Depression, and Suicide in the General Population: The HUNT Study
inferredcites →https://doi.org/10.1093/aje/kwn299openalex-snapshot
Instrumental Variable Analysis for Estimation of Treatment Effects With Dichotomous Outcomes
inferredcites →https://doi.org/10.1093/aje/kwx246openalex-snapshot
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
inferredcites →https://doi.org/10.1093/eurheartj/ehn252openalex-snapshot
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study
inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
inferredcites →https://doi.org/10.1093/ije/28.1.30openalex-snapshot
Alcohol consumption as a major risk factor for the rise in liver cancer mortality rates in Japanese men
inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
inferredcites →https://doi.org/10.1093/ije/dyp162openalex-snapshot
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/ije/dyw220openalex-snapshot
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
inferredcites →https://doi.org/10.1093/ije/dyx102openalex-snapshot
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1093/ije/dyx204openalex-snapshot
Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank
inferredcites →https://doi.org/10.1093/ije/dyx206openalex-snapshot
Collider scope: when selection bias can substantially influence observed associations
inferredcites →https://doi.org/10.1093/ndt/gfr418openalex-snapshot
The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population
inferredcites →https://doi.org/10.1097/ede.0000000000000972openalex-snapshot
Selection Bias When Estimating Average Treatment Effects Using One-sample Instrumental Variable Analysis
inferredcites →https://doi.org/10.1101/079707openalex-snapshot
Collider Scope: When selection bias can substantially influence observed associations
inferredcites →https://doi.org/10.1101/166298openalex-snapshot
Genome-wide genetic data on ~500,000 UK Biobank participants
inferredcites →https://doi.org/10.1101/cshperspect.a009621openalex-snapshot
Functional Neuroanatomy of the Basal Ganglia
inferredcites →https://doi.org/10.1111/all.13242openalex-snapshot
Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.1141634openalex-snapshot
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
inferredcites →https://doi.org/10.1136/bmj.322.7280.226openalex-snapshot
Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods
inferredcites →https://doi.org/10.1136/bmj.i582openalex-snapshot
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
inferredcites →https://doi.org/10.1136/jech-2017-210000openalex-snapshot
Causal associations between body mass index and mental health: a Mendelian randomisation study
inferredcites →https://doi.org/10.1146/annurev-genom-090314-024956openalex-snapshot
Phenome-Wide Association Studies as a Tool to Advance Precision Medicine
inferredcites →https://doi.org/10.1146/annurev.publhealth.22.1.355openalex-snapshot
The Public Health Impact of Obesity
inferredcites →https://doi.org/10.1155/2011/180729openalex-snapshot
Mendelian Randomisation Study of Childhood BMI and Early Menarche
inferredcites →https://doi.org/10.1161/circgenetics.116.001643openalex-snapshot
Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor
inferredcites →https://doi.org/10.1161/hypertensionaha.109.130005openalex-snapshot
Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?
inferredcites →https://doi.org/10.1176/appi.ps.59.12.1383openalex-snapshot
Depression and Anxiety in the United States: Findings From the 2006 Behavioral Risk Factor Surveillance System
inferredcites →https://doi.org/10.1210/jc.2009-1064openalex-snapshot
Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach
inferredcites →https://doi.org/10.1359/jbmr.081109openalex-snapshot
How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach
inferredcites →https://doi.org/10.1371/journal.pmed.1001212openalex-snapshot
The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach
inferredcites →https://doi.org/10.1371/journal.pmed.1001618openalex-snapshot
Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis
inferredcites →https://doi.org/10.1371/journal.pmed.1001765openalex-snapshot
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.1371/journal.pmed.1002314openalex-snapshot
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
inferredcites →https://doi.org/10.1371/journal.pone.0131708openalex-snapshot
Association of Body Mass Index with Depression, Anxiety and Suicide—An Instrumental Variable Analysis of the HUNT Study
inferredcites →https://doi.org/10.2337/db07-1466openalex-snapshot
Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
inferredcites →https://doi.org/10.2337/db16-0418openalex-snapshot
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization
inferredcites →https://doi.org/10.3389/fgene.2014.00250openalex-snapshot
Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-3-030-00353-1_28openalex-snapshot
Automatic Calculation of Body Mass Index Using Digital Image Processing
inferred← citeshttps://doi.org/10.1093/ije/dyy223openalex-snapshot
Using genetics to understand the causal influence of higher BMI on depression
inferred← citeshttps://doi.org/10.1101/304741openalex-snapshot
Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008405openalex-snapshot
Causal relationships between obesity and the leading causes of death in women and men
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