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Boosting ATM Activity Promotes Longevity in Nematodes and Mice

https://doi.org/10.1101/240606
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s10072-012-1188-5openalex-snapshot
Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians
inferredcites →https://doi.org/10.1007/s10557-015-6571-zopenalex-snapshot
ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease
inferredcites →https://doi.org/10.1016/0014-5793(95)00144-xopenalex-snapshot
Alterations in the internucleosomal DNA helical twist in chromatin of human erythroleukemia cells in vivo influences the chromatin higher‐order folding
inferredcites →https://doi.org/10.1016/j.arr.2012.02.001openalex-snapshot
The role of DNA damage and repair in aging through the prism of Koch-like criteria
inferredcites →https://doi.org/10.1016/j.arr.2016.05.002openalex-snapshot
Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing
inferredcites →https://doi.org/10.1016/j.bbagen.2009.03.020openalex-snapshot
Genome instability, cancer and aging
inferredcites →https://doi.org/10.1016/j.cbpa.2005.08.010openalex-snapshot
The Sir2 family of protein deacetylases
inferredcites →https://doi.org/10.1016/j.cell.2005.01.028openalex-snapshot
DNA Repair, Genome Stability, and Aging
inferredcites →https://doi.org/10.1016/j.cell.2005.11.044openalex-snapshot
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
inferredcites →https://doi.org/10.1016/j.cell.2009.12.041openalex-snapshot
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
inferredcites →https://doi.org/10.1016/j.cell.2012.10.047openalex-snapshot
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot
The Hallmarks of Aging
inferredcites →https://doi.org/10.1016/j.cell.2016.07.031openalex-snapshot
Metabolic Control of Longevity
inferredcites →https://doi.org/10.1016/j.celrep.2015.04.014openalex-snapshot
ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence
inferredcites →https://doi.org/10.1016/j.celrep.2015.10.006openalex-snapshot
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair
inferredcites →https://doi.org/10.1016/j.chroma.2007.02.034openalex-snapshot
Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography–mass spectrometry
inferredcites →https://doi.org/10.1016/j.cmet.2006.10.002openalex-snapshot
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
inferredcites →https://doi.org/10.1016/j.cmet.2014.10.008openalex-snapshot
DNA Damage Response and Metabolic Disease
inferredcites →https://doi.org/10.1016/j.cmet.2016.09.004openalex-snapshot
NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
inferredcites →https://doi.org/10.1016/j.cmet.2016.09.013openalex-snapshot
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
inferredcites →https://doi.org/10.1016/j.dnarep.2015.12.009openalex-snapshot
ATM kinase: Much more than a DNA damage responsive protein
inferredcites →https://doi.org/10.1016/j.exger.2012.02.010openalex-snapshot
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2011.10.437openalex-snapshot
Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells
inferredcites →https://doi.org/10.1016/j.gde.2014.04.002openalex-snapshot
Somatic mutations, genome mosaicism, cancer and aging
inferredcites →https://doi.org/10.1016/j.mad.2004.09.036openalex-snapshot
The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice
inferredcites →https://doi.org/10.1016/j.mad.2010.08.009openalex-snapshot
A functional single nucleotide polymorphism in promoter of ATM is associated with longevity
inferredcites →https://doi.org/10.1016/j.molcel.2005.07.019openalex-snapshot
Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway
inferredcites →https://doi.org/10.1016/j.molcel.2007.11.015openalex-snapshot
The DNA Damage Response: Ten Years After
inferredcites →https://doi.org/10.1016/j.molcel.2011.08.038openalex-snapshot
ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress
inferredcites →https://doi.org/10.1016/j.molcel.2016.08.004openalex-snapshot
Do DNA Double-Strand Breaks Drive Aging?
inferredcites →https://doi.org/10.1016/j.tem.2016.10.002openalex-snapshot
SIRT6: Novel Mechanisms and Links to Aging and Disease
inferredcites →https://doi.org/10.1016/s0005-2728(00)00177-8openalex-snapshot
Mitochondrial bioenergetics in aging
inferredcites →https://doi.org/10.1016/s0092-8674(00)00046-5openalex-snapshot
Cellular Senescence
inferredcites →https://doi.org/10.1016/s0092-8674(00)80086-0openalex-snapshot
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
inferredcites →https://doi.org/10.1038/366461a0openalex-snapshot
A C. elegans mutant that lives twice as long as wild type
inferredcites →https://doi.org/10.1038/aps.2013.5openalex-snapshot
Application and interpretation of current autophagy inhibitors and activators
inferredcites →https://doi.org/10.1038/cdd.2016.65openalex-snapshot
Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans
inferredcites →https://doi.org/10.1038/ejhg.2013.299openalex-snapshot
Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis
inferredcites →https://doi.org/10.1038/emboj.2010.330openalex-snapshot
ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair
inferredcites →https://doi.org/10.1038/nature01368openalex-snapshot
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
inferredcites →https://doi.org/10.1038/nature01629openalex-snapshot
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
inferredcites →https://doi.org/10.1038/nature04019openalex-snapshot
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
inferredcites →https://doi.org/10.1038/nature08197openalex-snapshot
Recent progress in the biology and physiology of sirtuins
inferredcites →https://doi.org/10.1038/nature10815openalex-snapshot
The sirtuin SIRT6 regulates lifespan in male mice
inferredcites →https://doi.org/10.1038/ncb1024openalex-snapshot
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
inferredcites →https://doi.org/10.1038/ncb1108-1241openalex-snapshot
DNA damage and ageing: new-age ideas for an age-old problem
inferredcites →https://doi.org/10.1038/ncb1599openalex-snapshot
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
inferredcites →https://doi.org/10.1038/ncomms2885openalex-snapshot
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
inferredcites →https://doi.org/10.1038/ng871openalex-snapshot
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice
inferredcites →https://doi.org/10.1038/nm.4222openalex-snapshot
Cardioprotection and lifespan extension by the natural polyamine spermidine
inferredcites →https://doi.org/10.1038/nm0202-94openalex-snapshot
Edible vaccines: not quite ready for prime time
inferredcites →https://doi.org/10.1038/nm1266openalex-snapshot
Genomic instability in laminopathy-based premature aging
inferredcites →https://doi.org/10.1038/nprot.2013.143openalex-snapshot
Genome engineering using the CRISPR-Cas9 system
inferredcites →https://doi.org/10.1038/nrm4007openalex-snapshot
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
inferredcites →https://doi.org/10.1038/sj.bjp.0705776openalex-snapshot
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
inferredcites →https://doi.org/10.1046/j.1474-9728.2003.00062.xopenalex-snapshot
Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
inferredcites →https://doi.org/10.1056/nejm197805252982103openalex-snapshot
Extreme Insulin Resistance in Ataxia Telangiectasia
inferredcites →https://doi.org/10.1056/nejmra0804615openalex-snapshot
DNA Damage, Aging, and Cancer
inferredcites →https://doi.org/10.1073/pnas.1102789108openalex-snapshot
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
inferredcites →https://doi.org/10.1073/pnas.1200583109openalex-snapshot
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
inferredcites →https://doi.org/10.1073/pnas.94.7.3064openalex-snapshot
Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
inferredcites →https://doi.org/10.1074/jbc.274.53.37795openalex-snapshot
The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I
inferredcites →https://doi.org/10.1074/jbc.c000289200openalex-snapshot
Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing
inferredcites →https://doi.org/10.1074/jbc.c100466200openalex-snapshot
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
inferredcites →https://doi.org/10.1074/jbc.m301877200openalex-snapshot
DNA Damage-mediated Apoptosis Induced by Selenium Compounds
inferredcites →https://doi.org/10.1091/mbc.10.8.2655openalex-snapshot
The Werner Syndrome Protein Is Involved in RNA Polymerase II Transcription
inferredcites →https://doi.org/10.1101/gad.14.8.907openalex-snapshot
Ku complex interacts with and stimulates the Werner protein
inferredcites →https://doi.org/10.1111/acel.12035openalex-snapshot
Defective ATM ‐Kap‐1‐mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model
inferredcites →https://doi.org/10.1126/science.1084125openalex-snapshot
Lamin A Truncation in Hutchinson-Gilford Progeria
inferredcites →https://doi.org/10.1126/science.aaf2693openalex-snapshot
NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
inferredcites →https://doi.org/10.1126/scisignal.2001959openalex-snapshot
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism
inferredcites →https://doi.org/10.1126/scisignal.2005076openalex-snapshot
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
inferredcites →https://doi.org/10.1128/mcb.25.13.5363-5379.2005openalex-snapshot
ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1
inferredcites →https://doi.org/10.1139/cjpp-77-2-118openalex-snapshot
Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent
inferredcites →https://doi.org/10.1146/annurev-biochem-060614-034335openalex-snapshot
Mechanisms of ATM Activation
inferredcites →https://doi.org/10.1158/0008-5472.can-03-0846openalex-snapshot
The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2727openalex-snapshot
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2464openalex-snapshot
Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy
inferredcites →https://doi.org/10.1159/000368856openalex-snapshot
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei
inferredcites →https://doi.org/10.1194/jlr.m003681openalex-snapshot
p53 is required for chloroquine-induced atheroprotection but not insulin sensitization
inferredcites →https://doi.org/10.18632/aging.100866openalex-snapshot
DNA repair in species with extreme lifespan differences
inferredcites →https://doi.org/10.18632/oncotarget.7645openalex-snapshot
Reprogramming of energy metabolism as a driver of aging
inferredcites →https://doi.org/10.4161/cc.5.17.3191openalex-snapshot
Constitutive Histone H2AX Phosphorylation and ATM Activation, the Reporters of DNA Damage by Endogenous Oxidants
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