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Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
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Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
1 of the 39 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1126/science.1192049 (notice 2019-04-11).
Dataset join, best-effort; this page does not check the publisher record. Retraction Watch data via Crossref Labs, used with credit; OpenCitations Index (CC0) and Meta (CC BY 4.0); dataset doi:10.7910/DVN/WT8VOA (CC BY 4.0).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-4652(199907)180:1<123::aid-jcp14>3.0.co;2-wopenalex-snapshot
Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)
inferredcites →https://doi.org/10.1006/exmp.2000.2346openalex-snapshot
Tubular Cell Senescence and Expression of TGF-β1 and p21WAF1/CIP1 in Tubulointerstitial Fibrosis of Aging Rats
inferredcites →https://doi.org/10.1016/0921-8734(89)90019-2openalex-snapshot
Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes
inferredcites →https://doi.org/10.1016/0921-8734(90)90018-mopenalex-snapshot
DNA damage and rpair with age in individual human lymphocytes
inferredcites →https://doi.org/10.1016/j.cell.2008.10.052openalex-snapshot
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
inferredcites →https://doi.org/10.1016/j.cub.2006.08.058openalex-snapshot
Age-Dependent Usage of Double-Strand-Break Repair Pathways
inferredcites →https://doi.org/10.1016/j.dnarep.2007.06.010openalex-snapshot
Changes in the level and distribution of Ku proteins during cellular senescence
inferredcites →https://doi.org/10.1016/j.dnarep.2008.01.012openalex-snapshot
Tissue-specific differences in the accumulation of sequence rearrangements with age
inferredcites →https://doi.org/10.1016/j.dnarep.2008.06.018openalex-snapshot
Comparison of nonhomologous end joining and homologous recombination in human cells
inferredcites →https://doi.org/10.1016/j.fertnstert.2003.04.002openalex-snapshot
Effects of age on DNA double-strand breaks and apoptosis in human sperm
inferredcites →https://doi.org/10.1016/j.mad.2006.11.008openalex-snapshot
Accumulation of senescent cells in mitotic tissue of aging primates
inferredcites →https://doi.org/10.1016/s0027-5107(01)00115-4openalex-snapshot
Homologous recombinational repair of DNA ensures mammalian chromosome stability
inferredcites →https://doi.org/10.1016/s0047-6374(02)00028-3openalex-snapshot
Large genome rearrangements as a primary cause of aging
inferredcites →https://doi.org/10.1016/s0090-4295(00)00538-0openalex-snapshot
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
inferredcites →https://doi.org/10.1023/a:1013262327193openalex-snapshot
DNA double-strand breaks in mouse kidney cells with age
inferredcites →https://doi.org/10.1038/nature06261openalex-snapshot
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
inferredcites →https://doi.org/10.1038/nature06337openalex-snapshot
Human CtIP promotes DNA end resection
inferredcites →https://doi.org/10.1038/nature10815openalex-snapshot
The sirtuin SIRT6 regulates lifespan in male mice
inferredcites →https://doi.org/10.1038/nrm2008openalex-snapshot
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
inferredcites →https://doi.org/10.1053/hupa.2001.22747openalex-snapshot
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
inferredcites →https://doi.org/10.1073/pnas.0400726101openalex-snapshot
DNA end joining becomes less efficient and more error-prone during cellular senescence
inferredcites →https://doi.org/10.1073/pnas.0702410104openalex-snapshot
TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination
inferredcites →https://doi.org/10.1073/pnas.92.20.9363openalex-snapshot
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
inferredcites →https://doi.org/10.1074/jbc.r700039200openalex-snapshot
The Mechanism of Human Nonhomologous DNA End Joining
inferredcites →https://doi.org/10.1093/embo-reports/kve201openalex-snapshot
Visualization of recombination intermediates produced by RAD52‐mediated single‐strand annealing
inferredcites →https://doi.org/10.1093/emboj/19.13.3398openalex-snapshot
Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells
inferredcites →https://doi.org/10.1093/genetics/154.3.1291openalex-snapshot
Mutation Frequency and Specificity With Age in Liver, Bladder and Brain of lacI Transgenic Mice
inferredcites →https://doi.org/10.1093/nar/gkh703openalex-snapshot
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00354.xopenalex-snapshot
Delayed kinetics of DNA double‐strand break processing in normal and pathological aging
inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00544.xopenalex-snapshot
SIRT6 protects against pathological damage caused by diet‐induced obesity
inferredcites →https://doi.org/10.1126/science.1122446openalex-snapshot
Cellular Senescence in Aging Primates
inferredcites →https://doi.org/10.1126/science.1192049openalex-snapshot
RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
inferredcites →https://doi.org/10.1126/science.1202723openalex-snapshot
SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
inferredcites →https://doi.org/10.1186/1752-0509-3-31openalex-snapshot
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
inferredcites →https://doi.org/10.1371/journal.pgen.1002153openalex-snapshot
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
inferredcites →https://doi.org/10.18632/aging.100389openalex-snapshot
Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
inferredcites →https://doi.org/10.4161/cc.10.18.17435openalex-snapshot
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
inferredcites →https://doi.org/10.4161/cc.7.18.6679openalex-snapshot
DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Changes in DNA Double-Strand Break Repair during Aging Correlate with An Increased Rate of Genomic Mutations
inferred← citeshttps://doi.org/10.1002/jcp.30791openalex-snapshot
SIRT6 mediates multidimensional modulation to maintain organism homeostasis
inferred← citeshttps://doi.org/10.1002/lsm.22135openalex-snapshot
Minimally Invasive Bipolar Fractional Radiofrequency Treatment Upregulates Anti‐ S enescence Pathways
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Emerging roles of SIRT6 in human diseases and its modulators
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Proteomics of Long‐Lived Mammals
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SIRT6: A Promising Target for Cancer Prevention and Therapy
inferred← citeshttps://doi.org/10.1007/978-3-319-14151-0_6openalex-snapshot
Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity
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Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila
inferred← citeshttps://doi.org/10.1007/978-3-319-43157-4_12openalex-snapshot
Sirtuins and Stress Response in Skin Cancer, Aging, and Barrier Function
inferred← citeshttps://doi.org/10.1007/978-3-319-44870-1_79-1openalex-snapshot
Cellular Senescence and Tumor Promotion
inferred← citeshttps://doi.org/10.1007/978-3-319-56820-1_8openalex-snapshot
Glioma Stem-Like Cells in Tumor Growth and Therapy Resistance of Glioblastoma
inferred← citeshttps://doi.org/10.1007/978-3-319-57415-8_79openalex-snapshot
Cellular Senescence and Tumor Promotion
inferred← citeshttps://doi.org/10.1007/978-94-017-9421-3_5openalex-snapshot
Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1007/978-94-024-0962-8_7openalex-snapshot
Diverse Roles for SIRT6 in Mammalian Healthspan and Longevity
inferred← citeshttps://doi.org/10.1007/978-981-16-0301-3_5openalex-snapshot
Genomic Instability in Stem Cells: The Basic Issues
inferred← citeshttps://doi.org/10.1007/s00018-021-04061-9openalex-snapshot
Roles of SIRT6 in kidney disease: a novel therapeutic target
inferred← citeshttps://doi.org/10.1007/s10522-013-9478-8openalex-snapshot
SIRT6, a protein with many faces
inferred← citeshttps://doi.org/10.1007/s10522-014-9529-9openalex-snapshot
Senescent cells: SASPected drivers of age-related pathologies
inferred← citeshttps://doi.org/10.1007/s10522-017-9685-9openalex-snapshot
Sirtuins, a promising target in slowing down the ageing process
inferred← citeshttps://doi.org/10.1007/s10522-017-9713-9openalex-snapshot
Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans
inferred← citeshttps://doi.org/10.1007/s10522-019-09842-1openalex-snapshot
The role of DNA repair genes in radiation-induced adaptive response in Drosophila melanogaster is differential and conditional
inferred← citeshttps://doi.org/10.1007/s10571-025-01650-1openalex-snapshot
The Role of c-Abl in Alzheimer’s Disease: Guilty or not Guilty?
inferred← citeshttps://doi.org/10.1007/s11064-016-2110-yopenalex-snapshot
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.1007/s11357-014-9744-yopenalex-snapshot
Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner
inferred← citeshttps://doi.org/10.1007/s13238-015-0149-1openalex-snapshot
SIRTain regulators of premature senescence and accelerated aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-799958-6.00014-7openalex-snapshot
Epigenetics of physiological and premature aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-803690-7.00008-9openalex-snapshot
Sirtuin Modulation as Novel Neuroprotective Strategy for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-814118-2.00002-1openalex-snapshot
Sirtuins in the biology of aging
inferred← citeshttps://doi.org/10.1016/b978-0-443-45380-9.00007-9openalex-snapshot
DNA repair and genome maintenance via sirtuin pathways
inferred← citeshttps://doi.org/10.1016/bs.adgen.2025.11.001openalex-snapshot
Transposable elements in aging: From biomarkers to effectors
inferred← citeshttps://doi.org/10.1016/j.advms.2015.09.003openalex-snapshot
The role of sirtuins in aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.arr.2013.06.003openalex-snapshot
The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101154openalex-snapshot
Fight to the bitter end: DNA repair and aging
inferred← citeshttps://doi.org/10.1016/j.bbcan.2016.01.007openalex-snapshot
Cellular senescence and tumor promotion: Is aging the key?
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.01.143openalex-snapshot
Sirt6 deacetylase activity regulates circadian rhythms via Per2
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149713openalex-snapshot
Podocyte Ercc1 is indispensable for glomerular integrity
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.07.004openalex-snapshot
Overview of the mammalian ADP-ribosyl-transferases clostridia toxin-like (ARTCs) family
inferred← citeshttps://doi.org/10.1016/j.cell.2021.09.034openalex-snapshot
Cytoplasmic DNA: sources, sensing, and role in aging and disease
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.11.026openalex-snapshot
Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!
inferred← citeshttps://doi.org/10.1016/j.celrep.2015.10.006openalex-snapshot
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.02.082openalex-snapshot
Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.07.082openalex-snapshot
Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109917openalex-snapshot
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.04.022openalex-snapshot
Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.02.014openalex-snapshot
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
inferred← citeshttps://doi.org/10.1016/j.dnarep.2019.06.009openalex-snapshot
Current role of mammalian sirtuins in DNA repair
inferred← citeshttps://doi.org/10.1016/j.dnarep.2024.103752openalex-snapshot
From rest to repair: Safeguarding genomic integrity in quiescent cells
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.116191openalex-snapshot
Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.10.525openalex-snapshot
Seven sirtuins for seven deadly diseases ofaging
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2013.03.015openalex-snapshot
Redox regulation of SIRT1 in inflammation and cellular senescence
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.02.042openalex-snapshot
Optimization of oxidative stress for mesenchymal stromal/stem cell engraftment, function and longevity
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.108532openalex-snapshot
DNA stimulates the deacetylase SIRT6 to mono-ADP-ribosylate proteins with histidine repeats
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2020.04.005openalex-snapshot
SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167798openalex-snapshot
Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations
inferred← citeshttps://doi.org/10.1016/j.joca.2015.03.024openalex-snapshot
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
inferred← citeshttps://doi.org/10.1016/j.molcel.2016.08.004openalex-snapshot
Do DNA Double-Strand Breaks Drive Aging?
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2016.02.004openalex-snapshot
DNA double strand break repair, aging and the chromatin connection
inferred← citeshttps://doi.org/10.1016/j.neuro.2014.10.008openalex-snapshot
Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.09.009openalex-snapshot
Expanding functions of ADP-ribosylation in the maintenance of genome integrity
inferred← citeshttps://doi.org/10.1016/j.tcb.2021.06.009openalex-snapshot
Sirtuin 6: linking longevity with genome and epigenome stability
inferred← citeshttps://doi.org/10.1016/j.tem.2017.07.004openalex-snapshot
Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2020.01.002openalex-snapshot
Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00306openalex-snapshot
An NAD + -Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM
inferred← citeshttps://doi.org/10.1038/cdd.2016.65openalex-snapshot
Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans
inferred← citeshttps://doi.org/10.1038/ncomms6011openalex-snapshot
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
inferred← citeshttps://doi.org/10.1038/nrm.2017.68openalex-snapshot
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
inferred← citeshttps://doi.org/10.1038/onc.2013.120openalex-snapshot
Sorting out functions of sirtuins in cancer
inferred← citeshttps://doi.org/10.1038/onc.2013.344openalex-snapshot
Sirtuins in stress response: guardians of the genome
inferred← citeshttps://doi.org/10.1038/onc.2016.77openalex-snapshot
Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence
inferred← citeshttps://doi.org/10.1038/onc.2017.289openalex-snapshot
Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics
inferred← citeshttps://doi.org/10.1038/s41388-023-02935-9openalex-snapshot
TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41419-018-0300-zopenalex-snapshot
Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
inferred← citeshttps://doi.org/10.1038/s41420-024-02201-1openalex-snapshot
Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair
inferred← citeshttps://doi.org/10.1038/s41467-025-57334-3openalex-snapshot
ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation
inferred← citeshttps://doi.org/10.1038/s41577-022-00751-yopenalex-snapshot
DNA damage and repair in age-related inflammation
inferred← citeshttps://doi.org/10.1038/s41598-021-00836-zopenalex-snapshot
Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells
inferred← citeshttps://doi.org/10.1038/s41598-025-24018-3openalex-snapshot
The association of the SIRT6 rs117385980 variant with frailty and longevity: an exploratory study
inferred← citeshttps://doi.org/10.1038/s42003-022-04369-7openalex-snapshot
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
inferred← citeshttps://doi.org/10.1038/s42255-021-00483-8openalex-snapshot
The metabolic roots of senescence: mechanisms and opportunities for intervention
inferred← citeshttps://doi.org/10.1038/s43018-023-00535-wopenalex-snapshot
Loss of the receptors ER, PR and HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s44319-024-00176-9openalex-snapshot
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence
inferred← citeshttps://doi.org/10.1038/srep03022openalex-snapshot
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
inferred← citeshttps://doi.org/10.1038/srep15299openalex-snapshot
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes
inferred← citeshttps://doi.org/10.1071/rd13178openalex-snapshot
Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age
inferred← citeshttps://doi.org/10.1073/pnas.2420502122openalex-snapshot
Age-dependent cytokine surge in blood precedes cancer diagnosis
inferred← citeshttps://doi.org/10.1080/15384047.2015.1078021openalex-snapshot
Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells
inferred← citeshttps://doi.org/10.1080/19491034.2016.1264552openalex-snapshot
Sirtuins and DNA damage repair: SIRT7 comes to play
inferred← citeshttps://doi.org/10.1089/dna.2016.3280openalex-snapshot
Role of Sirtuins in Maintenance of Genomic Stability: Relevance to Cancer and Healthy Aging
inferred← citeshttps://doi.org/10.1093/eurheartj/ehv290openalex-snapshot
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
inferred← citeshttps://doi.org/10.1093/eurheartj/ehz712openalex-snapshot
Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood–brain barrier integrity: a translational study
inferred← citeshttps://doi.org/10.1093/humupd/dmy040openalex-snapshot
DNA damage and repair in the female germline: contributions to ART
inferred← citeshttps://doi.org/10.1093/nar/gkw922openalex-snapshot
The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair
inferred← citeshttps://doi.org/10.1093/procel/pwac001openalex-snapshot
IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways
inferred← citeshttps://doi.org/10.1096/fj.202301012ropenalex-snapshot
SIRT6 : A potential therapeutic target for diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1101/2021.10.12.464167openalex-snapshot
The accumulation of lncRNAs in hybrid with DNA in patients with psoriasis reveals a decrease in the levels of RNase HII transcripts in the skin
inferred← citeshttps://doi.org/10.1101/2021.12.09.471907openalex-snapshot
Nuclear NAD + homeostasis is essential for naive and chemoresistant BRCA1/2 -deficient tumor survival
inferred← citeshttps://doi.org/10.1101/2023.02.27.530205openalex-snapshot
SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
inferred← citeshttps://doi.org/10.1101/2024.07.31.606047openalex-snapshot
DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats
inferred← citeshttps://doi.org/10.1101/240606openalex-snapshot
Boosting ATM Activity Promotes Longevity in Nematodes and Mice
inferred← citeshttps://doi.org/10.1101/460808openalex-snapshot
Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
inferred← citeshttps://doi.org/10.1101/615914openalex-snapshot
Cancer control is a key functionality underlying evolution of extended lifespan in mammals
inferred← citeshttps://doi.org/10.1104/pp.15.00291openalex-snapshot
Parental Age Affects Somatic Mutation Rates in the Progeny of Flowering Plants
inferred← citeshttps://doi.org/10.1111/acel.12306openalex-snapshot
Aging and radiation: bad companions
inferred← citeshttps://doi.org/10.1111/acel.12556openalex-snapshot
Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells
inferred← citeshttps://doi.org/10.1111/acel.13062openalex-snapshot
Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells
inferred← citeshttps://doi.org/10.1111/acel.13185openalex-snapshot
The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells
inferred← citeshttps://doi.org/10.1111/acel.13276openalex-snapshot
Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence
inferred← citeshttps://doi.org/10.1126/sciadv.aaq0236openalex-snapshot
Impaired cohesion and homologous recombination during replicative aging in budding yeast
inferred← citeshttps://doi.org/10.1128/mmbr.00038-18openalex-snapshot
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity
inferred← citeshttps://doi.org/10.1134/s1022795425700152openalex-snapshot
The Role of Sirtuins in Cellular Senescence and the Development of Age-Associated Diseases
inferred← citeshttps://doi.org/10.1134/s1990519x2106002xopenalex-snapshot
Reduced Efficiency of DNA Repair and Antioxidant Defense Promotes the Accumulation of DNA Damage during Cell Senescence
inferred← citeshttps://doi.org/10.1136/thoraxjnl-2014-206084openalex-snapshot
Accelerated ageing of the lung in COPD: new concepts
inferred← citeshttps://doi.org/10.1152/physrev.00030.2018openalex-snapshot
SIRT6, a Mammalian Deacylase with Multitasking Abilities
inferred← citeshttps://doi.org/10.1155/2016/1628041openalex-snapshot
Two tagSNPs rs352493 and rs3760908 withinSIRT6Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population
inferred← citeshttps://doi.org/10.1155/2016/2989076openalex-snapshot
Effects of Oxidative Stress on Mesenchymal Stem Cell Biology
inferred← citeshttps://doi.org/10.1155/2016/8270464openalex-snapshot
In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-1308openalex-snapshot
SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-2783openalex-snapshot
MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1
inferred← citeshttps://doi.org/10.1159/000368856openalex-snapshot
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei
inferred← citeshttps://doi.org/10.1161/circresaha.118.312562openalex-snapshot
Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework
inferred← citeshttps://doi.org/10.1177/1535370219876651openalex-snapshot
The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair
inferred← citeshttps://doi.org/10.1177/1947601913483767openalex-snapshot
The Diversity of Histone Versus Nonhistone Sirtuin Substrates
inferred← citeshttps://doi.org/10.1186/s12863-016-0447-5openalex-snapshot
Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations
inferred← citeshttps://doi.org/10.1186/s12964-023-01442-4openalex-snapshot
Sirtuins in kidney diseases: potential mechanism and therapeutic targets
inferred← citeshttps://doi.org/10.1186/s13578-024-01300-xopenalex-snapshot
YIPF2 regulates genome integrity
inferred← citeshttps://doi.org/10.1194/jlr.m039339openalex-snapshot
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
inferred← citeshttps://doi.org/10.1242/dmm.016287openalex-snapshot
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
inferred← citeshttps://doi.org/10.1360/n052016-00332openalex-snapshot
Research progress of Sirtuins in DNA damage repair
inferred← citeshttps://doi.org/10.1371/journal.pntd.0006180openalex-snapshot
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0063052openalex-snapshot
Increased Mammogram-Induced DNA Damage in Mammary Epithelial Cells Aged In Vitro
inferred← citeshttps://doi.org/10.1371/journal.pone.0165835openalex-snapshot
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
inferred← citeshttps://doi.org/10.1371/journal.pone.0167454openalex-snapshot
Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome
inferred← citeshttps://doi.org/10.14218/jcth.2022.00079openalex-snapshot
Multifaceted Influence of Histone Deacetylases on DNA Damage Repair: Implications for Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.14336/ad.2022.0413openalex-snapshot
SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1667/rr14748.1openalex-snapshot
Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving
inferred← citeshttps://doi.org/10.1667/rr15348.1openalex-snapshot
DNA Damage Processing is Perturbed in Both Proliferative and Non-Proliferative Cells of Increased Chronological Cellular Age
inferred← citeshttps://doi.org/10.18632/aging.101038openalex-snapshot
SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation
inferred← citeshttps://doi.org/10.18632/aging.101114openalex-snapshot
Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.18632/aging.205394openalex-snapshot
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
inferred← citeshttps://doi.org/10.2147/ott.s37750openalex-snapshot
The emerging and diverse roles of sirtuins in cancer: a clinical perspective
inferred← citeshttps://doi.org/10.2174/1567205016666191023104036openalex-snapshot
Amyloid-β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation
inferred← citeshttps://doi.org/10.2741/4316openalex-snapshot
State of the art of protein mono-ADP-ribosylation biological role and therapeutic potential
inferred← citeshttps://doi.org/10.3324/haematol.2017.176248openalex-snapshot
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
inferred← citeshttps://doi.org/10.3389/fcell.2023.1250264openalex-snapshot
The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA
inferred← citeshttps://doi.org/10.3389/fgene.2018.00501openalex-snapshot
Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast
inferred← citeshttps://doi.org/10.3389/fmed.2018.00104openalex-snapshot
Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes
inferred← citeshttps://doi.org/10.3389/fonc.2024.1322438openalex-snapshot
Effects of p53 and ATRX inhibition on telomeric recombination in aging fibroblasts
inferred← citeshttps://doi.org/10.3389/fphys.2021.724506openalex-snapshot
Sirtuins at the Service of Healthy Longevity
inferred← citeshttps://doi.org/10.3390/biom12030368openalex-snapshot
Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?
inferred← citeshttps://doi.org/10.3390/cells13191644openalex-snapshot
The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases
inferred← citeshttps://doi.org/10.3390/cells4040569openalex-snapshot
Intracellular Mono-ADP-Ribosylation in Signaling and Disease
inferred← citeshttps://doi.org/10.3390/ijms241814279openalex-snapshot
Genomic Instability and Epigenetic Changes during Aging
inferred← citeshttps://doi.org/10.3390/ijms25063355openalex-snapshot
Senescence-Associated Heterochromatin Foci Suppress γ-H2AX Focus Formation Induced by Radiation Exposure
inferred← citeshttps://doi.org/10.3390/molecules27238623openalex-snapshot
FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50
inferred← citeshttps://doi.org/10.3390/ph18101503openalex-snapshot
Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice
inferred← citeshttps://doi.org/10.33915/etd.5764openalex-snapshot
The Effect of Chemotherapy on Stromal Components of the Bone Marrow
inferred← citeshttps://doi.org/10.3892/or.2017.5753openalex-snapshot
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway
inferred← citeshttps://doi.org/10.4161/15384101.2014.980641openalex-snapshot
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
inferred← citeshttps://doi.org/10.5772/63219openalex-snapshot
Rejuvenation on the Road to Pluripotency
inferred← citeshttps://doi.org/10.5772/intechopen.77030openalex-snapshot
Silent Information Regulator 2 from Trypanosoma cruzi Is a Potential Target to Infection Control
inferred← citeshttps://doi.org/10.5772/intechopen.84628openalex-snapshot
The Role of DNA Repair in Cellular Aging Process
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952292openalex-snapshot
Additional file 1 of YIPF2 regulates genome integrity
inferred← citeshttps://doi.org/10.7554/elife.32127openalex-snapshot
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
inferred← citeshttps://doi.org/10.7554/elife.51089openalex-snapshot
Pan-mammalian analysis of molecular constraints underlying extended lifespan
inferred← citeshttps://doi.org/10.7554/elife.56008openalex-snapshot
A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing
inferred← citeshttps://doi.org/10.7554/elife.63728openalex-snapshot
Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
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