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HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.200800022openalex-snapshot

Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

inferredcites →https://doi.org/10.1002/gepi.20546openalex-snapshot

Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients

inferredcites →https://doi.org/10.1002/sim.7221openalex-snapshot

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

inferredcites →https://doi.org/10.1007/s00439-017-1854-zopenalex-snapshot

The ubiquity of pleiotropy in human disease

inferredcites →https://doi.org/10.1016/j.ajhg.2011.10.004openalex-snapshot

Abundant Pleiotropy in Human Complex Diseases and Traits

inferredcites →https://doi.org/10.1016/j.cell.2017.05.038openalex-snapshot

An Expanded View of Complex Traits: From Polygenic to Omnigenic

inferredcites →https://doi.org/10.1016/j.cell.2019.04.014openalex-snapshot

Trans Effects on Gene Expression Can Drive Omnigenic Inheritance

inferredcites →https://doi.org/10.1016/j.jaac.2010.06.008openalex-snapshot

Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder

inferredcites →https://doi.org/10.1016/j.jacc.2012.09.017openalex-snapshot

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

inferredcites →https://doi.org/10.1016/j.tig.2012.10.010openalex-snapshot

The many faces of pleiotropy

inferredcites →https://doi.org/10.1016/s0140-6736(12)62129-1openalex-snapshot

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

inferredcites →https://doi.org/10.1038/mp.2012.21openalex-snapshot

A mega-analysis of genome-wide association studies for major depressive disorder

inferredcites →https://doi.org/10.1038/nature10405openalex-snapshot

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

inferredcites →https://doi.org/10.1038/nature11677openalex-snapshot

Seventy-five genetic loci influencing the human red blood cell

inferredcites →https://doi.org/10.1038/nature12873openalex-snapshot

Genetics of rheumatoid arthritis contributes to biology and drug discovery

inferredcites →https://doi.org/10.1038/nature13545openalex-snapshot

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot

Biological insights from 108 schizophrenia-associated genetic loci

inferredcites →https://doi.org/10.1038/nature14101openalex-snapshot

Common genetic variants influence human subcortical brain structures

inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot

New genetic loci link adipose and insulin biology to body fat distribution

inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot

Genetic studies of body mass index yield new insights for obesity biology

inferredcites →https://doi.org/10.1038/nature17671openalex-snapshot

Genome-wide association study identifies 74 loci associated with educational attainment

inferredcites →https://doi.org/10.1038/nature19356openalex-snapshot

High-throughput discovery of novel developmental phenotypes

inferredcites →https://doi.org/10.1038/nature19806openalex-snapshot

Genome-wide associations for birth weight and correlations with adult disease

inferredcites →https://doi.org/10.1038/nature24277openalex-snapshot

Genetic effects on gene expression across human tissues

inferredcites →https://doi.org/10.1038/nbt1010-1045openalex-snapshot

The NIH Roadmap Epigenomics Mapping Consortium

inferredcites →https://doi.org/10.1038/ncomms10023openalex-snapshot

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

inferredcites →https://doi.org/10.1038/ng.1051openalex-snapshot

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

inferredcites →https://doi.org/10.1038/ng.2238openalex-snapshot

Common variants at 12q15 and 12q24 are associated with infant head circumference

inferredcites →https://doi.org/10.1038/ng.2247openalex-snapshot

A genome-wide association meta-analysis identifies new childhood obesity loci

inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

inferredcites →https://doi.org/10.1038/ng.2385openalex-snapshot

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

inferredcites →https://doi.org/10.1038/ng.2500openalex-snapshot

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

inferredcites →https://doi.org/10.1038/ng.2795openalex-snapshot

Common variants associated with plasma triglycerides and risk for coronary artery disease

inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot

Discovery and refinement of loci associated with lipid levels

inferredcites →https://doi.org/10.1038/ng.2802openalex-snapshot

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

inferredcites →https://doi.org/10.1038/ng.2982openalex-snapshot

An atlas of genetic influences on human blood metabolites

inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot

Defining the role of common variation in the genomic and biological architecture of adult human height

inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

inferredcites →https://doi.org/10.1038/ng.3359openalex-snapshot

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

inferredcites →https://doi.org/10.1038/ng.3396openalex-snapshot

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

inferredcites →https://doi.org/10.1038/ng.3570openalex-snapshot

Detection and interpretation of shared genetic influences on 42 human traits

inferredcites →https://doi.org/10.1038/ng.520openalex-snapshot

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

inferredcites →https://doi.org/10.1038/ng.571openalex-snapshot

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

inferredcites →https://doi.org/10.1038/ng.943openalex-snapshot

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

inferredcites →https://doi.org/10.1038/nrg.2016.142openalex-snapshot

Dissecting the genetics of complex traits using summary association statistics

inferredcites →https://doi.org/10.1038/nrg3461openalex-snapshot

Pleiotropy in complex traits: challenges and strategies

inferredcites →https://doi.org/10.1038/s41588-018-0047-6openalex-snapshot

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

inferredcites →https://doi.org/10.1038/s41588-018-0099-7openalex-snapshot

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

inferredcites →https://doi.org/10.1038/s41588-018-0184-yopenalex-snapshot

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

inferredcites →https://doi.org/10.1073/pnas.1004666107openalex-snapshot

Genomic patterns of pleiotropy and the evolution of complexity

inferredcites →https://doi.org/10.1093/hmg/ddt104openalex-snapshot

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

inferredcites →https://doi.org/10.1093/hmg/ddu150openalex-snapshot

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

inferredcites →https://doi.org/10.1093/hmg/ddu510openalex-snapshot

A novel common variant in DCST2 is associated with length in early life and height in adulthood

inferredcites →https://doi.org/10.1093/hmg/ddv472openalex-snapshot

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

inferredcites →https://doi.org/10.1093/ije/dyq151openalex-snapshot

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

inferredcites →https://doi.org/10.1093/nar/gkh113openalex-snapshot

SCMD: Saccharomyces cerevisiae Morphological Database

inferredcites →https://doi.org/10.1093/nar/gkn923openalex-snapshot

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

inferredcites →https://doi.org/10.1098/rspb.1990.0110openalex-snapshot

Variation maintained in quantitative traits with mutation–selection balance: pleiotropic side-effects on fitness traits

inferredcites →https://doi.org/10.1101/203257openalex-snapshot

Polygenic risk scores applied to a single cohort reveal pleiotropy among hundreds of human phenotypes

inferredcites →https://doi.org/10.1161/circulationaha.110.948570openalex-snapshot

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

inferredcites →https://doi.org/10.1186/s13059-016-0974-4openalex-snapshot

The Ensembl Variant Effect Predictor

inferredcites →https://doi.org/10.1371/journal.pgen.1002607openalex-snapshot

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

inferredcites →https://doi.org/10.1371/journal.pgen.1004235openalex-snapshot

A Central Role for GRB10 in Regulation of Islet Function in Man

inferredcites →https://doi.org/10.1371/journal.pone.0108891openalex-snapshot

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

inferredcites →https://doi.org/10.5281/zenodo.3462162openalex-snapshot

rondolab/HOPS: PublicationPaper

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41467-020-17668-6openalex-snapshot

Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

inferred← citeshttps://doi.org/10.1038/s41598-020-58040-4openalex-snapshot

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits

inferred← citeshttps://doi.org/10.1101/833210openalex-snapshot

PhenomeXcan: Mapping the genome to the phenome through the transcriptome

inferred← citeshttps://doi.org/10.1186/s12874-020-01170-0openalex-snapshot

Overlapping-sample Mendelian randomisation with multiple exposures: a Bayesian approach

inferred← citeshttps://doi.org/10.1534/genetics.120.303096openalex-snapshot

Detecting Shared Genetic Architecture Among Multiple Phenotypes by Hierarchical Clustering of Gene-Level Association Statistics

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