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Polygenic risk scores applied to a single cohort reveal pleiotropy among hundreds of human phenotypes

https://doi.org/10.1101/203257

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What this work says

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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Discovery and refinement of loci associated with lipid levels

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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An atlas of genetic correlations across human diseases and traits

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Genome-wide meta-analyses identify multiple loci associated with smoking behavior

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

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Translating genome-wide association findings into new therapeutics for psychiatry

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Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

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Personality and Psychopathology: An Application of the Five‐Factor Model

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Cardiovascular disease risk reduction by raising HDL cholesterol – current therapies and future opportunities

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Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

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Exercise and Crohn’s Disease: Speculations on Potential Benefits

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A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders

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Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

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Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients

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A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study

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Genome-wide association of sleep and circadian phenotypes

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The autosomal genetic control of sexually dimorphic traits in humans is largely the same across the sexes

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Genetic analysis for a shared biological basis between migraine and coronary artery disease

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Migraine and cardiovascular disease

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A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

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Genetic and Environmental Contributions to Weight, Height, and BMI from Birth to 19 Years of Age: An International Study of Over 12,000 Twin Pairs

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Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative Associations, Including Cadherin 13 (CDH13)

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Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms

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Health benefits of physical activity: the evidence

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Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder

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A brief review of exercise, bipolar disorder, and mechanistic pathways

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Hypothyroidism in Patients With Asthma and Major Depressive Disorder

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00439-020-02250-3openalex-snapshot

Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn’s disease

inferred← citeshttps://doi.org/10.1037/pspp0000241openalex-snapshot

Polygenic score for educational attainment captures DNA variants shared between personality traits and educational achievement.

inferred← citeshttps://doi.org/10.1038/s41386-019-0461-1openalex-snapshot

Evidence for a sex-specific contribution of polygenic load for anorexia nervosa to body weight and prefrontal brain structure in nonclinical individuals

inferred← citeshttps://doi.org/10.1038/s41398-019-0577-4openalex-snapshot

Genetic risk for Alzheimer’s dementia predicts motor deficits through multi-omic systems in older adults

inferred← citeshttps://doi.org/10.1038/s41596-020-0353-1openalex-snapshot

Tutorial: a guide to performing polygenic risk score analyses

inferred← citeshttps://doi.org/10.1038/s41598-020-68881-8openalex-snapshot

Genetic architecture of complex traits and disease risk predictors

inferred← citeshttps://doi.org/10.1101/252270openalex-snapshot

Polygenic scores for UK Biobank scale data

inferred← citeshttps://doi.org/10.1101/288555openalex-snapshot

Large-scale neuroimaging and genetic study reveals genetic architecture of brain white matter microstructure

inferred← citeshttps://doi.org/10.1101/311332openalex-snapshot

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

inferred← citeshttps://doi.org/10.1101/447797openalex-snapshot

On prs for complex polygenic trait prediction

inferred← citeshttps://doi.org/10.1186/s13059-019-1844-7openalex-snapshot

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

inferred← citeshttps://doi.org/10.48550/arxiv.1903.01301openalex-snapshot

On Genetic Correlation Estimation With Summary Statistics From Genome-Wide Association Studies

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