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The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00449.xopenalex-snapshot

Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation.

inferredcites →https://doi.org/10.1016/j.ccr.2007.08.029openalex-snapshot

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

inferredcites →https://doi.org/10.1016/j.chom.2015.08.009openalex-snapshot

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

inferredcites →https://doi.org/10.1016/s0092-8674(00)00009-xopenalex-snapshot

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

inferredcites →https://doi.org/10.1021/jm401075xopenalex-snapshot

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

inferredcites →https://doi.org/10.1038/326711a0openalex-snapshot

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

inferredcites →https://doi.org/10.1038/35022514openalex-snapshot

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

inferredcites →https://doi.org/10.1038/ni.3152openalex-snapshot

HIV reservoirs as obstacles and opportunities for an HIV cure

inferredcites →https://doi.org/10.1038/nm880openalex-snapshot

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

inferredcites →https://doi.org/10.1038/nmeth.4197openalex-snapshot

Salmon provides fast and bias-aware quantification of transcript expression

inferredcites →https://doi.org/10.1038/sj.emboj.7600900openalex-snapshot

NF‐κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

inferredcites →https://doi.org/10.1074/jbc.c000533200openalex-snapshot

Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway

inferredcites →https://doi.org/10.1074/jbc.m111.222919openalex-snapshot

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

inferredcites →https://doi.org/10.1074/jbc.m112.366658openalex-snapshot

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

inferredcites →https://doi.org/10.1074/jbc.m208672200openalex-snapshot

Endogenous Association of TRAF2, TRAF3, cIAP1, and Smac with Lymphotoxin β Receptor Reveals a Novel Mechanism of Apoptosis

inferredcites →https://doi.org/10.1074/jbc.m401253200openalex-snapshot

Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells

inferredcites →https://doi.org/10.1074/jbc.m402124200openalex-snapshot

Prostratin Antagonizes HIV Latency by Activating NF-κB

inferredcites →https://doi.org/10.1074/jbc.m403286200openalex-snapshot

Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation

inferredcites →https://doi.org/10.1089/aid.2008.0191openalex-snapshot

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

inferredcites →https://doi.org/10.1093/infdis/jiv218openalex-snapshot

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

inferredcites →https://doi.org/10.1097/qad.0b013e3282fd6df4openalex-snapshot

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

inferredcites →https://doi.org/10.1101/gad.10.1.37openalex-snapshot

NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.

inferredcites →https://doi.org/10.1111/j.1600-065x.2011.01088.xopenalex-snapshot

The noncanonical NF‐κB pathway

inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

inferredcites →https://doi.org/10.1126/science.aaf6517openalex-snapshot

Latency reversal and viral clearance to cure HIV-1

inferredcites →https://doi.org/10.1128/mcb.18.5.2535openalex-snapshot

Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter

inferredcites →https://doi.org/10.1158/1535-7163.mct-15-0475openalex-snapshot

A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma

inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/0471266949.bmc281openalex-snapshot

Current Status of Approaches to Eradicate HIV Infection

inferred← citeshttps://doi.org/10.1002/med.21638openalex-snapshot

Diversity of small molecule HIV‐1 latency reversing agents identified in low‐ and high‐throughput small molecule screens

inferred← citeshttps://doi.org/10.1007/978-1-0716-1871-4_25openalex-snapshot

Latency Reversal and Clearance of Persistent HIV Infection

inferred← citeshttps://doi.org/10.1016/j.antiviral.2019.03.008openalex-snapshot

HIV “shock and kill” therapy: In need of revision

inferred← citeshttps://doi.org/10.1016/j.cell.2019.10.002openalex-snapshot

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

inferred← citeshttps://doi.org/10.1016/j.cell.2020.03.005openalex-snapshot

Curing HIV: Seeking to Target and Clear Persistent Infection

inferred← citeshttps://doi.org/10.1021/acsnano.5c15903openalex-snapshot

Customizable mRNA Lipid Nanoparticles for Transfection of Primary Human T Cells

inferred← citeshttps://doi.org/10.1084/jem.20251584openalex-snapshot

Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones

inferred← citeshttps://doi.org/10.1128/jvi.00445-22openalex-snapshot

Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations

inferred← citeshttps://doi.org/10.1128/jvi.01297-20openalex-snapshot

The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary T CM Cell Model of Latency

inferred← citeshttps://doi.org/10.1172/jci.insight.185480openalex-snapshot

HIV-1 latency reversal agent boosting is not limited by opioid use

inferred← citeshttps://doi.org/10.1172/jci157281openalex-snapshot

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo

inferred← citeshttps://doi.org/10.2174/1570162x18999200819172009openalex-snapshot

A Review of Current Strategies Towards the Elimination of Latent HIV-1 and Subsequent HIV-1 Cure

inferred← citeshttps://doi.org/10.3389/fcimb.2020.00221openalex-snapshot

Boosting the Immune System for HIV Cure: A γδ T Cell Perspective

inferred← citeshttps://doi.org/10.3389/fimmu.2020.579158openalex-snapshot

Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

inferred← citeshttps://doi.org/10.3390/v11121104openalex-snapshot

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

inferred← citeshttps://doi.org/10.3390/v14010135openalex-snapshot

So Pathogenic or So What?—A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research

inferred← citeshttps://doi.org/10.3390/v14071571openalex-snapshot

Off-Target Effect of Activation of NF-κB by HIV Latency Reversal Agents on Transposable Elements Expression

inferred← citeshttps://doi.org/10.3390/v18030347openalex-snapshot

To Kill a Macrophage: Targeted Strategies to Eliminate Macrophage Reservoirs of HIV

inferred← citeshttps://doi.org/10.64898/2026.06.01.729198openalex-snapshot

AZD5582 robustly reactivates latently infected cells and clears the majority of those reactivated from the SIV reservoir

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