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crisprQTL mapping as a genome-wide association framework for cellular genetic screens

https://doi.org/10.1101/314344
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ajhg.2012.03.014openalex-snapshot
Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids
inferredcites →https://doi.org/10.1016/j.ajhg.2017.06.010openalex-snapshot
CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions
inferredcites →https://doi.org/10.1016/j.cell.2013.12.001openalex-snapshot
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
inferredcites →https://doi.org/10.1016/j.cell.2014.11.021openalex-snapshot
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
inferredcites →https://doi.org/10.1016/j.febslet.2007.10.046openalex-snapshot
Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide
inferredcites →https://doi.org/10.1016/j.molcel.2017.03.007openalex-snapshot
Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells
inferredcites →https://doi.org/10.1016/j.neuron.2011.09.032openalex-snapshot
Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
inferredcites →https://doi.org/10.1016/j.tig.2013.05.010openalex-snapshot
Human housekeeping genes, revisited
inferredcites →https://doi.org/10.1038/nature01434openalex-snapshot
Genetics of gene expression surveyed in maize, mouse and man
inferredcites →https://doi.org/10.1038/nature02797openalex-snapshot
Genetic analysis of genome-wide variation in human gene expression
inferredcites →https://doi.org/10.1038/nature11247openalex-snapshot
An integrated encyclopedia of DNA elements in the human genome
inferredcites →https://doi.org/10.1038/nature15521openalex-snapshot
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
inferredcites →https://doi.org/10.1038/nature23469openalex-snapshot
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
inferredcites →https://doi.org/10.1038/nature23676openalex-snapshot
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation
inferredcites →https://doi.org/10.1038/nature24029openalex-snapshot
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
inferredcites →https://doi.org/10.1038/nbt.2450openalex-snapshot
Differential analysis of gene regulation at transcript resolution with RNA-seq
inferredcites →https://doi.org/10.1038/nbt.3450openalex-snapshot
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
inferredcites →https://doi.org/10.1038/nbt.3468openalex-snapshot
High-throughput mapping of regulatory DNA
inferredcites →https://doi.org/10.1038/nbt.3853openalex-snapshot
CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
inferredcites →https://doi.org/10.1038/nbt0816-888dopenalex-snapshot
Erratum: Near-optimal probabilistic RNA-seq quantification
inferredcites →https://doi.org/10.1038/nmeth.3630openalex-snapshot
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
inferredcites →https://doi.org/10.1038/nmeth.4150openalex-snapshot
Single-cell mRNA quantification and differential analysis with Census
inferredcites →https://doi.org/10.1038/nmeth.4177openalex-snapshot
Pooled CRISPR screening with single-cell transcriptome readout
inferredcites →https://doi.org/10.1038/nmeth.4264openalex-snapshot
A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells
inferredcites →https://doi.org/10.1038/nmeth.4324openalex-snapshot
Differential analysis of RNA-seq incorporating quantification uncertainty
inferredcites →https://doi.org/10.1038/nmeth.4604openalex-snapshot
On the design of CRISPR-based single-cell molecular screens
inferredcites →https://doi.org/10.1038/s41559-017-0167openalex-snapshot
Dietary adaptation of FADS genes in Europe varied across time and geography
inferredcites →https://doi.org/10.1038/s41598-017-11630-1openalex-snapshot
Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice
inferredcites →https://doi.org/10.1093/nar/gkt111openalex-snapshot
Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods
inferredcites →https://doi.org/10.1101/gr.197152.115openalex-snapshot
A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening
inferredcites →https://doi.org/10.1126/science.273.5281.1516openalex-snapshot
The Future of Genetic Studies of Complex Human Diseases
inferredcites →https://doi.org/10.1126/science.aab2319openalex-snapshot
Greenlandic Inuit show genetic signatures of diet and climate adaptation
inferredcites →https://doi.org/10.1126/science.aac7041openalex-snapshot
Identification and characterization of essential genes in the human genome
inferredcites →https://doi.org/10.1126/science.aaf7613openalex-snapshot
High-resolution interrogation of functional elements in the noncoding genome
inferredcites →https://doi.org/10.1126/science.aag2445openalex-snapshot
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
inferredcites →https://doi.org/10.1126/science.aam8940openalex-snapshot
Comprehensive single-cell transcriptional profiling of a multicellular organism
inferredcites →https://doi.org/10.1182/blood-2009-09-242131openalex-snapshot
The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis
inferredcites →https://doi.org/10.1186/1471-2105-6-126openalex-snapshot
Comparative analysis of chromatin landscape in regulatory regions of human housekeeping and tissue specific genes
inferredcites →https://doi.org/10.1186/s12915-018-0545-0openalex-snapshot
FlashFry: a fast and flexible tool for large-scale CRISPR target design
inferredcites →https://doi.org/10.1371/journal.pgen.1002639openalex-snapshot
Patterns of Cis Regulatory Variation in Diverse Human Populations
inferredcites →https://doi.org/10.1371/journal.pone.0013984openalex-snapshot
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
inferredcites →https://doi.org/10.7554/elife.19760openalex-snapshot
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.01.012openalex-snapshot
Enhancer Domains Predict Gene Pathogenicity and Inform Gene Discovery in Complex Disease
inferred← citeshttps://doi.org/10.1016/j.tig.2020.01.009openalex-snapshot
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine
inferred← citeshttps://doi.org/10.1146/annurev-genom-121119-083418openalex-snapshot
Progress, Challenges, and Surprises in Annotating the Human Genome
inferred← citeshttps://doi.org/10.3389/fgene.2019.00304openalex-snapshot
Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC
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