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WNT4 and WNT3A activate cell autonomous Wnt signaling independent of PORCN or secretion

https://doi.org/10.1101/333906
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/excr.1999.4535openalex-snapshot
p38 Mitogen-Activated Protein Kinase Functionally Contributes to Chondrogenesis Induced by Growth/Differentiation Factor-5 in ATDC5 Cells
inferredcites →https://doi.org/10.1007/s00198-010-1296-0openalex-snapshot
Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
inferredcites →https://doi.org/10.1007/s00198-015-3457-7openalex-snapshot
Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families
inferredcites →https://doi.org/10.1007/s10815-015-0523-1openalex-snapshot
Association of WNT4 polymorphisms with endometriosis in infertile patients
inferredcites →https://doi.org/10.1016/j.biocel.2006.06.007openalex-snapshot
Wnt4 action in gonadal development and sex determination
inferredcites →https://doi.org/10.1016/j.cell.2006.02.049openalex-snapshot
Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells
inferredcites →https://doi.org/10.1016/j.cell.2015.09.033openalex-snapshot
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
inferredcites →https://doi.org/10.1016/j.cell.2017.05.016openalex-snapshot
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
inferredcites →https://doi.org/10.1016/j.devcel.2006.10.003openalex-snapshot
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
inferredcites →https://doi.org/10.1016/j.devcel.2016.08.011openalex-snapshot
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
inferredcites →https://doi.org/10.1016/j.diff.2012.06.004openalex-snapshot
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities
inferredcites →https://doi.org/10.1016/j.febslet.2014.11.016openalex-snapshot
Identification of the WNT1 residues required for palmitoylation by Porcupine
inferredcites →https://doi.org/10.1016/j.immuni.2008.04.023openalex-snapshot
The Signaling Protein Wnt4 Enhances Thymopoiesis and Expands Multipotent Hematopoietic Progenitors through β-Catenin-Independent Signaling
inferredcites →https://doi.org/10.1016/j.ydbio.2006.02.019openalex-snapshot
Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney
inferredcites →https://doi.org/10.1016/j.ydbio.2015.08.017openalex-snapshot
Wnt4 is essential to normal mammalian lung development
inferredcites →https://doi.org/10.1016/j.ydbio.2018.04.025openalex-snapshot
Direct visualization of the Wntless-induced redistribution of WNT1 in developing chick embryos
inferredcites →https://doi.org/10.1016/j.yexcr.2004.04.036openalex-snapshot
Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/β-catenin activity in kidney epithelial cells
inferredcites →https://doi.org/10.1016/j.yexcr.2016.07.028openalex-snapshot
Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling
inferredcites →https://doi.org/10.1038/17068openalex-snapshot
Female development in mammals is regulated by Wnt-4 signalling
inferredcites →https://doi.org/10.1038/nature09091openalex-snapshot
Progesterone induces adult mammary stem cell expansion
inferredcites →https://doi.org/10.1038/ng.3185openalex-snapshot
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
inferredcites →https://doi.org/10.1038/nm.3586openalex-snapshot
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB
inferredcites →https://doi.org/10.1038/onc.2015.280openalex-snapshot
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
inferredcites →https://doi.org/10.1042/bc20070072openalex-snapshot
Wnt4 inhibits β‐catenin/TCF signalling by redirecting β‐catenin to the cell membrane
inferredcites →https://doi.org/10.1042/bj20061476openalex-snapshot
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
inferredcites →https://doi.org/10.1056/nejmoa1612665openalex-snapshot
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
inferredcites →https://doi.org/10.1073/pnas.1314239110openalex-snapshot
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
inferredcites →https://doi.org/10.1073/pnas.1834480100openalex-snapshot
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy
inferredcites →https://doi.org/10.1074/jbc.m112.381970openalex-snapshot
Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling
inferredcites →https://doi.org/10.1074/jbc.m702391200openalex-snapshot
Noncanonical Wnt-4 Signaling Enhances Bone Regeneration of Mesenchymal Stem Cells in Craniofacial Defects through Activation of p38 MAPK
inferredcites →https://doi.org/10.1074/jbc.m802059200openalex-snapshot
Lipid-independent Secretion of a Drosophila Wnt Protein
inferredcites →https://doi.org/10.1083/jcb.201704081openalex-snapshot
The signal hypothesis matures with age
inferredcites →https://doi.org/10.1093/hmg/ddn036openalex-snapshot
R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
inferredcites →https://doi.org/10.1093/hmg/ddu516openalex-snapshot
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci
inferredcites →https://doi.org/10.1093/hmg/ddv621openalex-snapshot
Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract
inferredcites →https://doi.org/10.1093/humrep/del360openalex-snapshot
WNT4 deficiency—a clinical phenotype distinct from the classic Mayer–Rokitansky–Kuster–Hauser syndrome: A Case Report
inferredcites →https://doi.org/10.1101/378463openalex-snapshot
Targeting Wnt Signaling To Overcome PARP Inhibitor Resistance
inferredcites →https://doi.org/10.1101/cshperspect.a007864openalex-snapshot
Wnt Proteins
inferredcites →https://doi.org/10.1101/cshperspect.a007914openalex-snapshot
Alternative Wnt Pathways and Receptors
inferredcites →https://doi.org/10.1101/cshperspect.a008037openalex-snapshot
Wnt Signaling in Mammary Glands: Plastic Cell Fates and Combinatorial Signaling
inferredcites →https://doi.org/10.1101/gad.14.6.650openalex-snapshot
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2258openalex-snapshot
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2779openalex-snapshot
Invasive Lobular Carcinoma Cell Lines Are Characterized by Unique Estrogen-Mediated Gene Expression Patterns and Altered Tamoxifen Response
inferredcites →https://doi.org/10.1172/jci41695openalex-snapshot
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance
inferredcites →https://doi.org/10.1182/blood-2016-05-714089openalex-snapshot
Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI
inferredcites →https://doi.org/10.1186/1471-213x-9-55openalex-snapshot
Wnt4 is not sufficient to induce lobuloalveolar mammary development
inferredcites →https://doi.org/10.1186/bcr3419openalex-snapshot
Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium
inferredcites →https://doi.org/10.1186/s13058-016-0748-7openalex-snapshot
WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines
inferredcites →https://doi.org/10.1210/en.2012-1585openalex-snapshot
WNT4 Acts Downstream of BMP2 and Functions via β-Catenin Signaling Pathway to Regulate Human Endometrial Stromal Cell Differentiation
inferredcites →https://doi.org/10.1210/en.2015-1392openalex-snapshot
Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis
inferredcites →https://doi.org/10.1210/jc.2007-2023openalex-snapshot
Identification and Functional Analysis of a New WNT4 Gene Mutation among 28 Adolescent Girls with Primary Amenorrhea and Mullerian Duct Abnormalities: A French Collaborative Study
inferredcites →https://doi.org/10.1242/dev.125.21.4225openalex-snapshot
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
inferredcites →https://doi.org/10.1242/jcs.072132openalex-snapshot
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
inferredcites →https://doi.org/10.1242/jcs.098368openalex-snapshot
Deficiency of Porcupine, an O-acyltransferase gene, impairs convergent extension during gastrulation in zebrafish embryos and does not affect equivalently the trafficking of different Wnt proteins.
inferredcites →https://doi.org/10.1242/jcs.126052openalex-snapshot
Apicobasal secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by distinct mechanisms
inferredcites →https://doi.org/10.1359/jbmr.2003.18.10.1842openalex-snapshot
BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
inferredcites →https://doi.org/10.1371/journal.pone.0029976openalex-snapshot
Wnt4 Participates in the Formation of Vertebrate Neuromuscular Junction
inferredcites →https://doi.org/10.1371/journal.pone.0092159openalex-snapshot
Porcupine Is Not Required for the Production of the Majority of Wnts from Primary Human Astrocytes and CD8+ T Cells
inferredcites →https://doi.org/10.15252/embj.201490434openalex-snapshot
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
inferredcites →https://doi.org/10.15252/embj.201797311openalex-snapshot
ERAD‐dependent control of the Wnt secretory factor Evi
inferredcites →https://doi.org/10.17605/osf.io/7x8ngopenalex-snapshot
ILC-CORE (Collaboration, Openness, REproducibility)
inferredcites →https://doi.org/10.18632/oncotarget.19432openalex-snapshot
Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma
inferredcites →https://doi.org/10.2739/kurumemedj.ms652008openalex-snapshot
A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/mc.23064openalex-snapshot
Activation of Wnt signaling promotes olaparib resistant ovarian cancer
inferred← citeshttps://doi.org/10.3389/fcell.2020.00025openalex-snapshot
Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence
inferred← citeshttps://doi.org/10.3390/cancers11070908openalex-snapshot
Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer
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