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Genome-wide Marginal Epistatic Association Mapping in Case-Control Studies

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Sequence Kernel Association Test for Quantitative Traits in Family Samples

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CD200 Immunoadhesin Suppresses Collagen-Induced Arthritis in Mice

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The investigation of linkage between a quantitative trait and a marker locus

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BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies

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Estimating Missing Heritability for Disease from Genome-wide Association Studies

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Five Years of GWAS Discovery

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Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

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Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

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Mixed Model Association with Family-Biased Case-Control Ascertainment

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Common Genetic Mechanisms of Blood Pressure Elevation in Two Independent Rodent Models of Human Essential Hypertension

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Etiology of Type 1 Diabetes

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Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

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Global burden of hypertension: analysis of worldwide data

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Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

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Bayesian Analysis of Case-Control Studies

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Another explanation for apparent epistasis

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Common SNPs explain a large proportion of the heritability for human height

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Quantitative trait loci mapped to single-nucleotide resolution in yeast

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Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

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Distributions of epistasis in microbes fit predictions from a fitness landscape model

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Bayesian inference of epistatic interactions in case-control studies

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Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

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Efficient multivariate linear mixed model algorithms for genome-wide association studies

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A tutorial on statistical methods for population association studies

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Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis

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Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study

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Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins

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The mystery of missing heritability: Genetic interactions create phantom heritability

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Approximate Inference in Generalized Linear Mixed Models

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Bias Correction in Generalized Linear Mixed Models With Multiple Components of Dispersion

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Bayesian Approximate Kernel Regression With Variable Selection

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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

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TEAM: efficient two-locus epistasis tests in human genome-wide association study

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EpiGPU: exhaustive pairwise epistasis scans parallelized on consumer level graphics cards

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A rapid epistatic mixed-model association analysis by linear retransformations of genomic estimated values

inferredcites →https://doi.org/10.1093/bioinformatics/bty154openalex-snapshot

SMMB: a stochastic Markov blanket framework strategy for epistasis detection in GWAS

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Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies

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Bias Correction in Generalised Linear Mixed Models with a Single Component of Dispersion

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Variance component testing in generalised linear models with random effects

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Miscellanea. Saddlepoint approximations for distributions of quadratic forms in normal variables

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Defining the Assumptions Underlying Modeling of Epistatic QTL Using Variance Component Methods

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Differential expression analysis for RNAseq using Poisson mixed models

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inferredcites →https://doi.org/10.1093/rheumatology/keu362openalex-snapshot

Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis

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Genetic architecture of quantitative traits in mice, flies, and humans

inferredcites →https://doi.org/10.1101/gr.137885.112openalex-snapshot

Ultrafast genome-wide scan for SNP–SNP interactions in common complex disease

inferredcites →https://doi.org/10.1105/tpc.108.058131openalex-snapshot

Biochemical Networks and Epistasis Shape the Arabidopsis thaliana Metabolome

inferredcites →https://doi.org/10.1109/34.735807openalex-snapshot

Bayesian classification with Gaussian processes

inferredcites →https://doi.org/10.1111/j.0006-341x.1999.00997.xopenalex-snapshot

Genomic Control for Association Studies

inferredcites →https://doi.org/10.1111/j.1420-9101.2004.00702.xopenalex-snapshot

Epistasis affecting litter size in mice

inferredcites →https://doi.org/10.1111/sji.12329openalex-snapshot

Clinical Role of Human Leukocyte Antigen in Health and Disease

inferredcites →https://doi.org/10.1126/science.1091317openalex-snapshot

Global Mapping of the Yeast Genetic Interaction Network

inferredcites →https://doi.org/10.1126/science.1166426openalex-snapshot

Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast

inferredcites →https://doi.org/10.1126/science.1180823openalex-snapshot

The Genetic Landscape of a Cell

inferredcites →https://doi.org/10.1155/2012/948218openalex-snapshot

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

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Virus-like infection induces human β cell dedifferentiation

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Marginal maximum likelihood estimation of variance components in Poisson mixed models using Laplacian integration

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Inference for threshold models with variance components from the generalized linear mixed model perspective

inferredcites →https://doi.org/10.1186/1471-2105-10-294openalex-snapshot

Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

inferredcites →https://doi.org/10.1186/1471-2156-14-7openalex-snapshot

The complete compositional epistasis detection in genome-wide association studies

inferredcites →https://doi.org/10.1186/gb-2006-7-7-r63openalex-snapshot

A strategy for extracting and analyzing large-scale quantitative epistatic interaction data

inferredcites →https://doi.org/10.1214/11-aoas469openalex-snapshot

Block-based Bayesian epistasis association mapping with application to WTCCC type 1 diabetes data

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A unified framework for variance component estimation with summary statistics in genome-wide association studies

inferredcites →https://doi.org/10.1371/journal.pgen.0020190openalex-snapshot

Population Structure and Eigenanalysis

inferredcites →https://doi.org/10.1371/journal.pgen.0030162openalex-snapshot

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Epistatic Module Detection for Case-Control Studies: A Bayesian Model with a Gibbs Sampling Strategy

inferredcites →https://doi.org/10.1371/journal.pgen.1002180openalex-snapshot

Replication and Explorations of High-Order Epistasis Using a Large Advanced Intercross Line Pedigree

inferredcites →https://doi.org/10.1371/journal.pgen.1002625openalex-snapshot

Improved Statistics for Genome-Wide Interaction Analysis

inferredcites →https://doi.org/10.1371/journal.pgen.1003032openalex-snapshot

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

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Polygenic Modeling with Bayesian Sparse Linear Mixed Models

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An Evolutionary Perspective on Epistasis and the Missing Heritability

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inferredcites →https://doi.org/10.1371/journal.pgen.1004969openalex-snapshot

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inferredcites →https://doi.org/10.1371/journal.pgen.1005201openalex-snapshot

Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus

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A Flexible, Efficient Binomial Mixed Model for Identifying Differential DNA Methylation in Bisulfite Sequencing Data

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The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis

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Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

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More Than the Sum of Its Parts: A Complex Epistatic Network Underlies Natural Variation in Thermal Preference Behavior in Caenorhabditis elegans

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Estimation of Epistatic Variance Components and Heritability in Founder Populations and Crosses

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Unraveling Additive from Nonadditive Effects Using Genomic Relationship Matrices

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Modeling Epistasis in Genomic Selection

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RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests

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The Genetic Basis of Type 2 Diabetes.

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Algorithm AS 155: The Distribution of a Linear Combination of χ 2 Random Variables

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An Approximate Distribution of Estimates of Variance Components

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Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

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Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs

inferredcites →https://doi.org/10.3389/fgene.2011.00071openalex-snapshot

Sex-, Diet-, and Cancer-Dependent Epistatic Effects on Complex Traits in Mice

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IFNβ Accelerates Autoimmune Type 1 Diabetes in Nonobese Diabetic Mice and Breaks the Tolerance to β Cells in Nondiabetes-Prone Mice

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Regulation of Myeloid Cell Function through the CD200 Receptor

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Genetic interactions affecting human gene expression identified by variance association mapping

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Uncertainty quantification in variable selection for genetic fine-mapping using bayesian neural networks

inferred← citeshttps://doi.org/10.1038/s41588-025-02411-yopenalex-snapshot

A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects

inferred← citeshttps://doi.org/10.1093/g3journal/jkad118openalex-snapshot

Leveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies

inferred← citeshttps://doi.org/10.1093/g3journal/jkae263openalex-snapshot

Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies

inferred← citeshttps://doi.org/10.1098/rstb.2020.0508openalex-snapshot

Testing for fitness epistasis in a transplant experiment identifies a candidate adaptive locus in Timema stick insects

inferred← citeshttps://doi.org/10.1101/2020.09.24.312421openalex-snapshot

Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex Traits

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Detection of interactions between genetic marker sets and environment in a genome-wide study of hypertension

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A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis

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