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Autoimmunity to hypocretin and molecular mimicry to flu antigens in Type 1 narcolepsy

https://doi.org/10.1101/378109
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Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

1 of the 74 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1126/scitranslmed.3007762 (notice 2014-07-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2013.2831openalex-snapshot
Hypothalamic Immunopathology in Anti-Ma–Associated Diencephalitis With Narcolepsy-Cataplexy
inferredcites →https://doi.org/10.1002/ana.22587openalex-snapshot
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china
inferredcites →https://doi.org/10.1002/ana.23799openalex-snapshot
Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic
inferredcites →https://doi.org/10.1016/0304-4017(87)90129-4openalex-snapshot
The effect of the host's age on the pathology of Eimeria stiedai infection in rabbits
inferredcites →https://doi.org/10.1016/j.ajhg.2014.12.010openalex-snapshot
HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy
inferredcites →https://doi.org/10.1016/j.bbi.2014.11.004openalex-snapshot
Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development
inferredcites →https://doi.org/10.1016/j.jaut.2013.02.003openalex-snapshot
Genetic association, seasonal infections and autoimmune basis of narcolepsy
inferredcites →https://doi.org/10.1016/j.jaut.2014.01.031openalex-snapshot
A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009–2010
inferredcites →https://doi.org/10.1016/j.jneuroim.2015.04.008openalex-snapshot
Immunohistochemical screening for antibodies in recent onset type 1 narcolepsy and after H1N1 vaccination
inferredcites →https://doi.org/10.1016/j.jneuroim.2017.05.001openalex-snapshot
Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot
inferredcites →https://doi.org/10.1016/j.prrv.2016.12.005openalex-snapshot
Epidemiology and Pathophysiology of Childhood Narcolepsy
inferredcites →https://doi.org/10.1016/j.sleep.2013.12.012openalex-snapshot
Symptoms and occurrences of narcolepsy: a retrospective study of 162 patients during a 10-year period in Eastern China
inferredcites →https://doi.org/10.1016/j.vaccine.2011.11.081openalex-snapshot
An additional oligosaccharide moiety in the HA of a pandemic influenza H1N1 candidate vaccine virus confers increased antigen yield in eggs
inferredcites →https://doi.org/10.1016/s0022-2836(05)80360-2openalex-snapshot
Basic Local Alignment Search Tool
inferredcites →https://doi.org/10.1016/s0092-8674(00)80949-6openalex-snapshot
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
inferredcites →https://doi.org/10.1016/s0140-6736(99)05582-8openalex-snapshot
Hypocretin (orexin) deficiency in human narcolepsy
inferredcites →https://doi.org/10.1016/s0896-6273(00)00058-1openalex-snapshot
Reduced Number of Hypocretin Neurons in Human Narcolepsy
inferredcites →https://doi.org/10.1016/s1046-2023(02)00350-xopenalex-snapshot
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes
inferredcites →https://doi.org/10.1038/79690openalex-snapshot
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
inferredcites →https://doi.org/10.1038/nature22976openalex-snapshot
Identifying specificity groups in the T cell receptor repertoire
inferredcites →https://doi.org/10.1038/nbt.2938openalex-snapshot
Linking T-cell receptor sequence to functional phenotype at the single-cell level
inferredcites →https://doi.org/10.1038/ng.3625openalex-snapshot
Genetic variation in MHC proteins is associated with T cell receptor expression biases
inferredcites →https://doi.org/10.1038/ng.372openalex-snapshot
Narcolepsy is strongly associated with the T-cell receptor alpha locus
inferredcites →https://doi.org/10.1038/ng.647openalex-snapshot
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
inferredcites →https://doi.org/10.1038/ng.734openalex-snapshot
Common variants in P2RY11 are associated with narcolepsy
inferredcites →https://doi.org/10.1038/ni1187openalex-snapshot
Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor
inferredcites →https://doi.org/10.1038/nmeth.1344openalex-snapshot
Simultaneous detection of many T-cell specificities using combinatorial tetramer staining
inferredcites →https://doi.org/10.1038/nri.2017.143openalex-snapshot
HLA variation and disease
inferredcites →https://doi.org/10.1038/nsmb.3383openalex-snapshot
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope
inferredcites →https://doi.org/10.1038/s41467-017-02763-yopenalex-snapshot
T cells specific for post-translational modifications escape intrathymic tolerance induction
inferredcites →https://doi.org/10.1038/s41577-018-0007-5openalex-snapshot
Understanding the drivers of MHC restriction of T cell receptors
inferredcites →https://doi.org/10.1038/srep16178openalex-snapshot
Emergence of Hemagglutinin Mutations During the Course of Influenza Infection
inferredcites →https://doi.org/10.1073/pnas.0913939107openalex-snapshot
High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets
inferredcites →https://doi.org/10.1073/pnas.1420936111openalex-snapshot
Molecular architecture of the αβ T cell receptor–CD3 complex
inferredcites →https://doi.org/10.1073/pnas.1603325113openalex-snapshot
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice
inferredcites →https://doi.org/10.1086/318799openalex-snapshot
Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups
inferredcites →https://doi.org/10.1093/bioinformatics/btr507openalex-snapshot
FLASH: fast length adjustment of short reads to improve genome assemblies
inferredcites →https://doi.org/10.1093/hmg/ddu480openalex-snapshot
New susceptibility variants to narcolepsy identified in HLA class II region
inferredcites →https://doi.org/10.1093/nar/gks438openalex-snapshot
Immune epitope database analysis resource
inferredcites →https://doi.org/10.1093/sleep/29.5.633openalex-snapshot
Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy
inferredcites →https://doi.org/10.1093/sleep/32.12.1548openalex-snapshot
Narcolepsy and Streptococcal Infections
inferredcites →https://doi.org/10.1093/sleep/32.8.979openalex-snapshot
Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset
inferredcites →https://doi.org/10.1093/sleep/zsw056openalex-snapshot
Antibodies Against Hypocretin Receptor 2 Are Rare in Narcolepsy
inferredcites →https://doi.org/10.1093/sleep/zsw070openalex-snapshot
CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1
inferredcites →https://doi.org/10.1101/373555openalex-snapshot
Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire
inferredcites →https://doi.org/10.1101/gad.207654.112openalex-snapshot
Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation
inferredcites →https://doi.org/10.1111/j.1349-7006.2008.00852.xopenalex-snapshot
Epstein–Barr virus nuclear antigen 1‐specific CD4+ T cells directly kill Epstein–Barr virus‐carrying natural killer and T cells
inferredcites →https://doi.org/10.1111/j.1365-2567.2005.02308.xopenalex-snapshot
Cytotoxic herpes simplex type 2‐specific, DQ0602‐restricted CD4+ T‐cell clones show alloreactivity to DQ0601
inferredcites →https://doi.org/10.1111/j.1399-0039.2012.01948.xopenalex-snapshot
HLA ‐ DQ association and allele competition in Chinese narcolepsy
inferredcites →https://doi.org/10.1111/joim.12355openalex-snapshot
Increased β‐haemolytic group A streptococcal M6 serotype and streptodornase B‐specific cellular immune responses in Swedish narcolepsy cases
inferredcites →https://doi.org/10.1111/joim.12391openalex-snapshot
A coordinated cross‐disciplinary research initiative to address an increased incidence of narcolepsy following the 2009–2010 Pandemrix vaccination programme in Sweden
inferredcites →https://doi.org/10.1126/science.1260668openalex-snapshot
Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
inferredcites →https://doi.org/10.1126/scitranslmed.3007762openalex-snapshot
CD4 + T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy
inferredcites →https://doi.org/10.1126/scitranslmed.3009995openalex-snapshot
Retraction of the Research Article: "CD4 + T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy"
inferredcites →https://doi.org/10.1126/scitranslmed.aab2354openalex-snapshot
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
inferredcites →https://doi.org/10.1128/jvi.75.18.8649-8659.2001openalex-snapshot
Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+T-Helper 1 Responses
inferredcites →https://doi.org/10.1172/jci10209openalex-snapshot
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
inferredcites →https://doi.org/10.1172/jci18509openalex-snapshot
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
inferredcites →https://doi.org/10.1172/jci41366openalex-snapshot
Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients
inferredcites →https://doi.org/10.1172/jci98819openalex-snapshot
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
inferredcites →https://doi.org/10.1371/journal.pgen.1003270openalex-snapshot
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
inferredcites →https://doi.org/10.1371/journal.pgen.1003880openalex-snapshot
Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic
inferredcites →https://doi.org/10.1371/journal.pone.0108489openalex-snapshot
Risk of Narcolepsy Associated with Inactivated Adjuvanted (AS03) A/H1N1 (2009) Pandemic Influenza Vaccine in Quebec
inferredcites →https://doi.org/10.1371/journal.pone.0114361openalex-snapshot
Antigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines: Implications for Pandemrix-Associated Narcolepsy Risk
inferredcites →https://doi.org/10.1371/journal.pone.0187305openalex-snapshot
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases
inferredcites →https://doi.org/10.1371/journal.pone.0190561openalex-snapshot
Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype
inferredcites →https://doi.org/10.1371/journal.ppat.1000918openalex-snapshot
Global Migration Dynamics Underlie Evolution and Persistence of Human Influenza A (H3N2)
inferredcites →https://doi.org/10.1371/journal.ppat.1005892openalex-snapshot
Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals
inferredcites →https://doi.org/10.14740/jocmr2569wopenalex-snapshot
Comorbidity of Narcolepsy Type 1 With Autoimmune Diseases and Other Immunopathological Disorders: A Case-Control Study
inferredcites →https://doi.org/10.4049/jimmunol.160.5.2365openalex-snapshot
A Peptide Binding Motif for HLA-DQA1*0102/DQB1*0602, the Class II MHC Molecule Associated with Dominant Protection in Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.4049/jimmunol.164.8.4244openalex-snapshot
HLA-DQ Tetramers Identify Epitope-Specific T Cells in Peripheral Blood of Herpes Simplex Virus Type 2-Infected Individuals: Direct Detection of Immunodominant Antigen-Responsive Cells
inferredcites →https://doi.org/10.4049/jimmunol.167.8.4196openalex-snapshot
Purification of Ag-Specific T Lymphocytes After Direct Peripheral Blood Mononuclear Cell Stimulation Followed by CD25 Selection. I. Application to CD4+ or CD8+ Cytomegalovirus Phosphoprotein pp65 Epitope Determination
inferredcites →https://doi.org/10.5665/sleep.3300openalex-snapshot
DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe
inferredcites →https://doi.org/10.5665/sleep.4342openalex-snapshot
HLA-DQ Allele Competition in Narcolepsy: A Comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s10309-018-0239-1openalex-snapshot
Narkolepsie – mit Beachtung der Kataplexie als Differenzialdiagnose epileptischer Anfälle
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2019.04.019openalex-snapshot
Response to “H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls”
inferred← citeshttps://doi.org/10.1016/j.smrv.2018.09.006openalex-snapshot
Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy
inferred← citeshttps://doi.org/10.1038/d41586-018-06666-wopenalex-snapshot
Put to sleep by immune cells
inferred← citeshttps://doi.org/10.1038/d41586-018-06866-4openalex-snapshot
From the archive
inferred← citeshttps://doi.org/10.1038/s41467-019-08774-1openalex-snapshot
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
inferred← citeshttps://doi.org/10.1038/s41583-018-0097-xopenalex-snapshot
The neurobiological basis of narcolepsy
inferred← citeshttps://doi.org/10.1051/jbio/2019026openalex-snapshot
Narcolepsie : une maladie auto-immune affectant un peptide de l’éveil liée à un mimétisme moléculaire avec des épitopes du virus de la grippe
inferred← citeshttps://doi.org/10.1080/14728222.2021.1969361openalex-snapshot
Emerging therapeutic targets for narcolepsy
inferred← citeshttps://doi.org/10.1111/ene.14888openalex-snapshot
European guideline and expert statements on the management of narcolepsy in adults and children
inferred← citeshttps://doi.org/10.1111/jsr.13387openalex-snapshot
European guideline and expert statements on the management of narcolepsy in adults and children
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