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Atomic-level characterization of conformational transition and substrate binding of xCT transporter

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter

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Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system x c -

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Ligand docking and binding site analysis with PyMOL and Autodock/Vina

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Targeted molecular dynamics: A new approach for searching pathways of conformational transitions

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VMD: Visual molecular dynamics

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A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

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Decreased mRNA expression for the two subunits of system xc−, SLC3A2 and SLC7A11, in WBC in patients with schizophrenia: Evidence in support of the hypo-glutamatergic hypothesis of schizophrenia

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Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress

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Computational characterization of structural dynamics underlying function in active membrane transporters

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GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers

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Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

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Exchange of cystine and glutamate across plasma membrane of human fibroblasts.

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Contrasts in transport systems for anionic amino acids in hepatocytes and a hepatoma cell line HTC.

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Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

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PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

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Chemoinformatics Analysis Identifies Cytotoxic Compounds Susceptible to Chemoresistance Mediated by Glutathione and Cystine/Glutamate Transport System xc-

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A General Theory of Membrane Transport From Studies of Bacteria

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Simple Allosteric Model for Membrane Pumps

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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

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The mechanism of sodium and substrate release from the binding pocket of vSGLT

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Structure and mechanism of a glutamate–GABA antiporter

inferredcites →https://doi.org/10.1038/ncomms15074openalex-snapshot

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

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Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK

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Atomic-level characterization of transport cycle thermodynamics in the glycerol-3-phosphate:phosphate antiporter

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Mechanistic diversity in ATP-binding cassette (ABC) transporters

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xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

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Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis

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Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines

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The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

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Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: a new action for an old drug

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Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

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Stochastic steps in secondary active sugar transport

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Membrane Topology of System Xc- Light Subunit Reveals a Re-entrant Loop with Substrate-restricted Accessibility

inferredcites →https://doi.org/10.1074/jbc.m506439200openalex-snapshot

Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice

inferredcites →https://doi.org/10.1089/ars.2000.2.4-665openalex-snapshot

Molecular Cloning and Expression of Human xCT, the Light Chain of Amino Acid Transport System x c ¯

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Transport activity–dependent intracellular sorting of the yeast general amino acid permease

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System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

inferredcites →https://doi.org/10.1093/emboj/cdf500openalex-snapshot

The light subunit of system bo,+ is fully functional in the absence of the heavy subunit

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OPM database and PPM web server: resources for positioning of proteins in membranes

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CCTOP: a Consensus Constrained TOPology prediction web server

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Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats

inferredcites →https://doi.org/10.1107/s0909049510032449openalex-snapshot

The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1

inferredcites →https://doi.org/10.1111/j.1471-4159.1990.tb05800.xopenalex-snapshot

Uptake of Glutamate and Cystine in C‐6 Glioma Cells and in Cultured Astrocytes

inferredcites →https://doi.org/10.1111/j.1471-4159.2009.06347.xopenalex-snapshot

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

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Kaposi's Sarcoma-Associated Herpesvirus Fusion-Entry Receptor: Cystine Transporter xCT

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Structure and Mechanism of a Na + -Independent Amino Acid Transporter

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Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

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Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells

inferredcites →https://doi.org/10.1128/mcb.00221-14openalex-snapshot

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

inferredcites →https://doi.org/10.1146/annurev-biochem-060815-014520openalex-snapshot

Shared Molecular Mechanisms of Membrane Transporters

inferredcites →https://doi.org/10.1146/annurev-biophys-042910-155245openalex-snapshot

Biomolecular Simulation: A Computational Microscope for Molecular Biology

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Structural Biology of the Major Facilitator Superfamily Transporters

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P-Type ATPases

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Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

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Significance of Lipid Composition in a Blood-Brain Barrier–Mimetic PAMPA Assay

inferredcites →https://doi.org/10.1186/1742-2094-8-63openalex-snapshot

Increased expression of cystine/glutamate antiporter in multiple sclerosis

inferredcites →https://doi.org/10.1186/s40880-018-0288-xopenalex-snapshot

Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

inferredcites →https://doi.org/10.1200/jco.2005.02.7110openalex-snapshot

Role of the Glutathione Metabolic Pathway in Lung Cancer Treatment and Prognosis: A Review

inferredcites →https://doi.org/10.1371/journal.pcbi.1003879openalex-snapshot

Complete Mapping of Substrate Translocation Highlights the Role of LeuT N-terminal Segment in Regulating Transport Cycle

inferredcites →https://doi.org/10.1371/journal.pone.0030465openalex-snapshot

The Conformational Transition Pathways of ATP-Binding Cassette Transporter BtuCD Revealed by Targeted Molecular Dynamics Simulation

inferredcites →https://doi.org/10.1371/journal.pone.0125361openalex-snapshot

Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1

inferredcites →https://doi.org/10.1371/journal.ppat.1000742openalex-snapshot

Upregulation of xCT by KSHV-Encoded microRNAs Facilitates KSHV Dissemination and Persistence in an Environment of Oxidative Stress

inferredcites →https://doi.org/10.1529/biophysj.107.118778openalex-snapshot

End-Point Targeted Molecular Dynamics: Large-Scale Conformational Changes in Potassium Channels

inferredcites →https://doi.org/10.18632/oncotarget.8651openalex-snapshot

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

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Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight

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Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

inferredcites →https://doi.org/10.3389/fmicb.2015.00120openalex-snapshot

xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases

inferredcites →https://doi.org/10.4049/jimmunol.178.10.6549openalex-snapshot

System xc− and Glutamate Transporter Inhibition Mediates Microglial Toxicity to Oligodendrocytes

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3390/membranes11080602openalex-snapshot

Rush Hour of LATs towards Their Transport Cycle

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