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Analysis of Polygenic Score Usage and Performance in Diverse Human Populations

https://doi.org/10.1101/398396
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gepi.21906openalex-snapshot
Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction
inferredcites →https://doi.org/10.1002/gepi.22166openalex-snapshot
Generalizing polygenic risk scores from Europeans to Hispanics/Latinos
inferredcites →https://doi.org/10.1016/0040-5809(73)90005-1openalex-snapshot
Models for cultural inheritance I. Group mean and within group variation
inferredcites →https://doi.org/10.1016/j.ajhg.2015.09.001openalex-snapshot
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1016/j.ajhg.2016.05.001openalex-snapshot
Transethnic Genetic-Correlation Estimates from Summary Statistics
inferredcites →https://doi.org/10.1016/j.ajhg.2017.03.004openalex-snapshot
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.11.034openalex-snapshot
Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)
inferredcites →https://doi.org/10.1016/j.ebiom.2015.10.002openalex-snapshot
Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed
inferredcites →https://doi.org/10.1016/s0140-6736(09)60327-5openalex-snapshot
Cystic fibrosis
inferredcites →https://doi.org/10.1016/s0140-6736(10)61029-xopenalex-snapshot
Sickle-cell disease
inferredcites →https://doi.org/10.1037/a0036320openalex-snapshot
Mind the gap: Why many geneticists and psychological scientists have discrepant views about gene–environment interaction (G×E) research.
inferredcites →https://doi.org/10.1038/475163aopenalex-snapshot
Genomics for the world
inferredcites →https://doi.org/10.1038/538161aopenalex-snapshot
Genomics is failing on diversity
inferredcites →https://doi.org/10.1038/mp.2017.77openalex-snapshot
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
inferredcites →https://doi.org/10.1038/nature08185openalex-snapshot
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
inferredcites →https://doi.org/10.1038/nature09534openalex-snapshot
A map of human genome variation from population-scale sequencing
inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot
Biological insights from 108 schizophrenia-associated genetic loci
inferredcites →https://doi.org/10.1038/nature14659openalex-snapshot
Sparse whole-genome sequencing identifies two loci for major depressive disorder
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/ng.3359openalex-snapshot
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
inferredcites →https://doi.org/10.1038/ng.3401openalex-snapshot
Population genetic differentiation of height and body mass index across Europe
inferredcites →https://doi.org/10.1038/ng.3603openalex-snapshot
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
inferredcites →https://doi.org/10.1038/ng.3667openalex-snapshot
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
inferredcites →https://doi.org/10.1038/ng.3715openalex-snapshot
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
inferredcites →https://doi.org/10.1038/ng.381openalex-snapshot
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
inferredcites →https://doi.org/10.1038/nrg3457openalex-snapshot
Pitfalls of predicting complex traits from SNPs
inferredcites →https://doi.org/10.1038/s41467-018-04191-yopenalex-snapshot
Global genetic differentiation of complex traits shaped by natural selection in humans
inferredcites →https://doi.org/10.1038/s41576-018-0018-xopenalex-snapshot
The personal and clinical utility of polygenic risk scores
inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/s41598-017-13056-1openalex-snapshot
A machine-learning heuristic to improve gene score prediction of polygenic traits
inferredcites →https://doi.org/10.1073/pnas.1620732114openalex-snapshot
Cultural evolutionary theory: How culture evolves and why it matters
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/hmg/ddu583openalex-snapshot
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
inferredcites →https://doi.org/10.1097/ypg.0000000000000206openalex-snapshot
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia
inferredcites →https://doi.org/10.1101/106062openalex-snapshot
Heterogeneity in polygenic scores for common human traits
inferredcites →https://doi.org/10.1101/166298openalex-snapshot
Genome-wide genetic data on ~500,000 UK Biobank participants
inferredcites →https://doi.org/10.1101/188094openalex-snapshot
The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex Traits
inferredcites →https://doi.org/10.1101/gr.6665407openalex-snapshot
Prediction of individual genetic risk to disease from genome-wide association studies
inferredcites →https://doi.org/10.1111/j.1467-9280.2007.01984.xopenalex-snapshot
Cognitive Costs of Exposure to Racial Prejudice
inferredcites →https://doi.org/10.1126/science.aag0776openalex-snapshot
Detection of human adaptation during the past 2000 years
inferredcites →https://doi.org/10.1126/science.aau2571openalex-snapshot
‘It’s a toxic place.’ How the online world of white nationalists distorts population genetics
inferredcites →https://doi.org/10.1186/s12864-017-4262-9openalex-snapshot
Population differentiation in allele frequencies of obesity-associated SNPs
inferredcites →https://doi.org/10.1186/s13059-016-1016-yopenalex-snapshot
Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine
inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot
Second-generation PLINK: rising to the challenge of larger and richer datasets
inferredcites →https://doi.org/10.1371/journal.pgen.1003348openalex-snapshot
Power and Predictive Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1371/journal.pgen.1004412openalex-snapshot
A Population Genetic Signal of Polygenic Adaptation
inferredcites →https://doi.org/10.1371/journal.pgen.1004754openalex-snapshot
Regularized Machine Learning in the Genetic Prediction of Complex Traits
inferredcites →https://doi.org/10.1371/journal.pgen.1006288openalex-snapshot
Using Genetic Distance to Infer the Accuracy of Genomic Prediction
inferredcites →https://doi.org/10.1371/journal.pmed.1002546openalex-snapshot
Cardiovascular disease: The rise of the genetic risk score
inferredcites →https://doi.org/10.1534/genetics.117.300489openalex-snapshot
Detecting Polygenic Adaptation in Admixture Graphs
inferredcites →https://doi.org/10.2337/db16-1150openalex-snapshot
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
inferredcites →https://doi.org/10.7554/elife.39702openalex-snapshot
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
inferredcites →https://doi.org/10.7554/elife.39725openalex-snapshot
Reduced signal for polygenic adaptation of height in UK Biobank

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00439-019-02014-8openalex-snapshot
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
inferred← citeshttps://doi.org/10.1016/j.biopsych.2018.12.015openalex-snapshot
Predicting Polygenic Risk of Psychiatric Disorders
inferred← citeshttps://doi.org/10.1038/s41380-019-0517-yopenalex-snapshot
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
inferred← citeshttps://doi.org/10.1038/s41380-019-0614-yopenalex-snapshot
Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease
inferred← citeshttps://doi.org/10.1038/s41539-020-0060-2openalex-snapshot
Genetic associations with mathematics tracking and persistence in secondary school
inferred← citeshttps://doi.org/10.1038/s41539-022-00137-8openalex-snapshot
Socioeconomic and genomic roots of verbal ability from current evidence
inferred← citeshttps://doi.org/10.1038/s41596-020-0353-1openalex-snapshot
Tutorial: a guide to performing polygenic risk score analyses
inferred← citeshttps://doi.org/10.1080/19485565.2019.1681257openalex-snapshot
Genetic nature or genetic nurture? Introducing social genetic parameters to quantify bias in polygenic score analyses
inferred← citeshttps://doi.org/10.1093/gigascience/giz082openalex-snapshot
PRSice-2: Polygenic Risk Score software for biobank-scale data
inferred← citeshttps://doi.org/10.1093/ije/dyab046openalex-snapshot
Genetic risk scores for cardiometabolic traits in sub-Saharan African populations
inferred← citeshttps://doi.org/10.1101/481036openalex-snapshot
The transcriptional landscape of cortical interneurons underlies in-vivo brain function and schizophrenia risk
inferred← citeshttps://doi.org/10.1101/512541openalex-snapshot
Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery disease
inferred← citeshttps://doi.org/10.1101/524850openalex-snapshot
Genetic Nature or Genetic Nurture? Quantifying Bias in Analyses Using Polygenic Scores
inferred← citeshttps://doi.org/10.1101/544411openalex-snapshot
Socioeconomic and Genomic Roots of Verbal Ability
inferred← citeshttps://doi.org/10.1136/jmedgenet-2019-106763openalex-snapshot
Understanding polygenic models, their development and the potential application of polygenic scores in healthcare
inferred← citeshttps://doi.org/10.1176/appi.ajp.2019.18091085openalex-snapshot
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems
inferred← citeshttps://doi.org/10.1177/2332858418810516openalex-snapshot
Genetics and Education: Recent Developments in the Context of an Ugly History and an Uncertain Future
inferred← citeshttps://doi.org/10.1210/clinem/dgz326openalex-snapshot
A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies
inferred← citeshttps://doi.org/10.1371/journal.pbio.3001072openalex-snapshot
The evolution of group differences in changing environments
inferred← citeshttps://doi.org/10.3389/fsoc.2019.00053openalex-snapshot
The Genome-Wide Study of Human Social Behavior and Its Application in Sociology
inferred← citeshttps://doi.org/10.3390/psych1010034openalex-snapshot
Global Ancestry and Cognitive Ability
inferred← citeshttps://doi.org/10.7554/elife.48376openalex-snapshot
Variable prediction accuracy of polygenic scores within an ancestry group
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