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Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared to mice and Drosophila melanogaster

https://doi.org/10.1101/427583
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Biased Gene Conversion Skews Allele Frequencies in Human Populations, Increasing the Disease Burden of Recessive Alleles
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The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation
inferredcites →https://doi.org/10.1016/j.tig.2011.06.003openalex-snapshot
Weighing the evidence for adaptation at the molecular level
inferredcites →https://doi.org/10.1017/cbo9780511542619.012openalex-snapshot
Why k = 4Nus is silly
inferredcites →https://doi.org/10.1017/cbo9780511623486openalex-snapshot
The Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1017/s0094837300012641openalex-snapshot
Morphological complexity increase in metazoans
inferredcites →https://doi.org/10.1038/246096a0openalex-snapshot
Slightly Deleterious Mutant Substitutions in Evolution
inferredcites →https://doi.org/10.1038/287560a0openalex-snapshot
Mutagenic deamination of cytosine residues in DNA
inferredcites →https://doi.org/10.1038/351652a0openalex-snapshot
Adaptive protein evolution at the Adh locus in Drosophila
inferredcites →https://doi.org/10.1038/4151022aopenalex-snapshot
Adaptive protein evolution in Drosophila
inferredcites →https://doi.org/10.1038/4151024aopenalex-snapshot
Testing the neutral theory of molecular evolution with genomic data from Drosophila
inferredcites →https://doi.org/10.1038/nature04107openalex-snapshot
Adaptive evolution of non-coding DNA in Drosophila
inferredcites →https://doi.org/10.1038/nature04240openalex-snapshot
Natural selection on protein-coding genes in the human genome
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature12228openalex-snapshot
Great ape genetic diversity and population history
inferredcites →https://doi.org/10.1038/nature13685openalex-snapshot
Comparative population genomics in animals uncovers the determinants of genetic diversity
inferredcites →https://doi.org/10.1038/nmeth.1359openalex-snapshot
A customized and versatile high-density genotyping array for the mouse
inferredcites →https://doi.org/10.1038/s41559-019-0890-6openalex-snapshot
Exploiting selection at linked sites to infer the rate and strength of adaptation
inferredcites →https://doi.org/10.1073/pnas.0708078105openalex-snapshot
Estimating the size of the human interactome
inferredcites →https://doi.org/10.1073/pnas.1106877109openalex-snapshot
Extensive X-linked adaptive evolution in central chimpanzees
inferredcites →https://doi.org/10.1073/pnas.1220835110openalex-snapshot
Frequent adaptation and the McDonald–Kreitman test
inferredcites →https://doi.org/10.1073/pnas.1605660114openalex-snapshot
Evidence that the rate of strong selective sweeps increases with population size in the great apes
inferredcites →https://doi.org/10.1073/pnas.1619434114openalex-snapshot
Estimating the parameters of background selection and selective sweeps in Drosophila in the presence of gene conversion
inferredcites →https://doi.org/10.1073/pnas.1619508114openalex-snapshot
Determining the factors driving selective effects of new nonsynonymous mutations
inferredcites →https://doi.org/10.1073/pnas.87.12.4692openalex-snapshot
The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model.
inferredcites →https://doi.org/10.1086/318206openalex-snapshot
Genomic Divergences between Humans and Other Hominoids and the Effective Population Size of the Common Ancestor of Humans and Chimpanzees
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/gbe/evq086openalex-snapshot
Effective Population Size and the Efficacy of Selection on the X Chromosomes of Two Closely Related Drosophila Species
inferredcites →https://doi.org/10.1093/gbe/evs027openalex-snapshot
The Effect of Variation in the Effective Population Size on the Rate of Adaptive Molecular Evolution in Eukaryotes
inferredcites →https://doi.org/10.1093/gbe/evx213openalex-snapshot
Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species
inferredcites →https://doi.org/10.1093/genetics/132.4.1161openalex-snapshot
Population genetics of polymorphism and divergence.
inferredcites →https://doi.org/10.1093/genetics/158.3.1227openalex-snapshot
Positive and Negative Selection on the Human Genome
inferredcites →https://doi.org/10.1093/genetics/162.4.2017openalex-snapshot
Changing Effective Population Size and the McDonald-Kreitman Test
inferredcites →https://doi.org/10.1093/genetics/47.6.713openalex-snapshot
ON THE PROBABILITY OF FIXATION OF MUTANT GENES IN A POPULATION
inferredcites →https://doi.org/10.1093/ilar/ilt048openalex-snapshot
Great Ape Genomics
inferredcites →https://doi.org/10.1093/molbev/msh083openalex-snapshot
Evidence for a Complex Demographic History of Chimpanzees
inferredcites →https://doi.org/10.1093/molbev/msn005openalex-snapshot
The McDonald-Kreitman Test and Slightly Deleterious Mutations
inferredcites →https://doi.org/10.1093/molbev/msn079openalex-snapshot
Selection on Amino Acid Substitutions in Arabidopsis
inferredcites →https://doi.org/10.1093/molbev/msn148openalex-snapshot
Estimation of Hominoid Ancestral Population Sizes under Bayesian Coalescent Models Incorporating Mutation Rate Variation and Sequencing Errors
inferredcites →https://doi.org/10.1093/molbev/msp119openalex-snapshot
Estimating the Rate of Adaptive Molecular Evolution in the Presence of Slightly Deleterious Mutations and Population Size Change
inferredcites →https://doi.org/10.1093/molbev/msq079openalex-snapshot
Genome Wide Analyses Reveal Little Evidence for Adaptive Evolution in Many Plant Species
inferredcites →https://doi.org/10.1093/molbev/msq270openalex-snapshot
Effective Population Size Is Positively Correlated with Levels of Adaptive Divergence among Annual Sunflowers
inferredcites →https://doi.org/10.1093/molbev/mss105openalex-snapshot
Adaptive Evolution and Effective Population Size in Wild House Mice
inferredcites →https://doi.org/10.1093/molbev/mst026openalex-snapshot
The Rate of Molecular Adaptation in a Changing Environment
inferredcites →https://doi.org/10.1093/molbev/mst191openalex-snapshot
The Effective Population Sizes of the Anthropoid Ancestors of the Human-Chimpanzee Lineage Provide Insights on the Historical Biogeography of the Great Apes
inferredcites →https://doi.org/10.1093/molbev/mst220openalex-snapshot
Population Genomic Analysis Reveals No Evidence for GC-Biased Gene Conversion in Drosophila melanogaster
inferredcites →https://doi.org/10.1093/molbev/msu166openalex-snapshot
Evidence for Increased Levels of Positive and Negative Selection on the X Chromosome versus Autosomes in Humans
inferredcites →https://doi.org/10.1093/molbev/msv214openalex-snapshot
Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill–Robertson Interference, in an Avian System
inferredcites →https://doi.org/10.1093/molbev/msy188openalex-snapshot
Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome
inferredcites →https://doi.org/10.1098/rsbl.2018.0055openalex-snapshot
Overestimation of the adaptive substitution rate in fluctuating populations
inferredcites →https://doi.org/10.1101/gr.107524.110openalex-snapshot
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
inferredcites →https://doi.org/10.1101/gr.111120.110openalex-snapshot
Stampy: A statistical algorithm for sensitive and fast mapping of Illumina sequence reads
inferredcites →https://doi.org/10.1101/gr.141689.112openalex-snapshot
A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence
inferredcites →https://doi.org/10.1101/gr.164822.113openalex-snapshot
Genome-wide signals of positive selection in human evolution
inferredcites →https://doi.org/10.1101/gr.204255.116openalex-snapshot
The population genomics of rhesus macaques ( Macaca mulatta ) based on whole-genome sequences
inferredcites →https://doi.org/10.1111/evo.12673openalex-snapshot
The distribution of fitness effects in an uncertain world
inferredcites →https://doi.org/10.1111/j.1558-5646.1998.tb01823.xopenalex-snapshot
THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION
inferredcites →https://doi.org/10.1126/science.1140462openalex-snapshot
Demographic Histories and Patterns of Linkage Disequilibrium in Chinese and Indian Rhesus Macaques
inferredcites →https://doi.org/10.1146/annurev-genom-082908-150001openalex-snapshot
Biased Gene Conversion and the Evolution of Mammalian Genomic Landscapes
inferredcites →https://doi.org/10.1146/annurev.ecolsys.23.1.263openalex-snapshot
The Nearly Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1371/journal.pbio.1002112openalex-snapshot
Natural Selection Constrains Neutral Diversity across A Wide Range of Species
inferredcites →https://doi.org/10.1371/journal.pgen.0030007openalex-snapshot
Genomic Relationships and Speciation Times of Human, Chimpanzee, and Gorilla Inferred from a Coalescent Hidden Markov Model
inferredcites →https://doi.org/10.1371/journal.pgen.1000083openalex-snapshot
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
inferredcites →https://doi.org/10.1371/journal.pgen.1000471openalex-snapshot
Widespread Genomic Signatures of Natural Selection in Hominid Evolution
inferredcites →https://doi.org/10.1371/journal.pgen.1000495openalex-snapshot
Pervasive Natural Selection in the Drosophila Genome?
inferredcites →https://doi.org/10.1371/journal.pgen.1000592openalex-snapshot
Evolutionary Processes Acting on Candidate cis-Regulatory Regions in Humans Inferred from Patterns of Polymorphism and Divergence
inferredcites →https://doi.org/10.1371/journal.pgen.1000825openalex-snapshot
Evidence for Pervasive Adaptive Protein Evolution in Wild Mice
inferredcites →https://doi.org/10.1371/journal.pgen.1003995openalex-snapshot
Contributions of Protein-Coding and Regulatory Change to Adaptive Molecular Evolution in Murid Rodents
inferredcites →https://doi.org/10.1371/journal.pgen.1005774openalex-snapshot
Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis
inferredcites →https://doi.org/10.1371/journal.pgen.1006130openalex-snapshot
A Genomic Map of the Effects of Linked Selection in Drosophila
inferredcites →https://doi.org/10.1371/journal.pgen.1008668openalex-snapshot
Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals
inferredcites →https://doi.org/10.1534/g3.112.004713openalex-snapshot
Nuclear Gene Variation in Wild Brown Rats
inferredcites →https://doi.org/10.1534/g3.120.401052openalex-snapshot
Inferring Parameters of the Distribution of Fitness Effects of New Mutations When Beneficial Mutations Are Strongly Advantageous and Rare
inferredcites →https://doi.org/10.1534/genetics.111.131730openalex-snapshot
A Method for Inferring the Rate of Occurrence and Fitness Effects of Advantageous Mutations
inferredcites →https://doi.org/10.1534/genetics.115.174664openalex-snapshot
The Drosophila Genome Nexus: A Population Genomic Resource of 623 Drosophila melanogaster Genomes, Including 197 from a Single Ancestral Range Population
inferredcites →https://doi.org/10.1534/genetics.116.188102openalex-snapshot
Inferring the Frequency Spectrum of Derived Variants to Quantify Adaptive Molecular Evolution in Protein-Coding Genes of Drosophila melanogaster
inferredcites →https://doi.org/10.1534/genetics.117.300323openalex-snapshot
Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s10682-019-10026-zopenalex-snapshot
Variation of the adaptive substitution rate between species and within genomes
inferred← citeshttps://doi.org/10.1093/gbe/evz215openalex-snapshot
Impact of Mutation Rate and Selection at Linked Sites on DNA Variation across the Genomes of Humans and Other Homininae
inferred← citeshttps://doi.org/10.1093/genetics/iyac002openalex-snapshot
Haplotype-based inference of the distribution of fitness effects
inferred← citeshttps://doi.org/10.1101/452201openalex-snapshot
Impact of mutation rate and selection at linked sites on fine-scale DNA variation across the homininae genome
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008668openalex-snapshot
Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals
inferred← citeshttps://doi.org/10.1534/genetics.119.302494openalex-snapshot
Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes
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