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Islet Gene View - a tool to facilitate islet research
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/978-0-387-21706-2openalex-snapshot
Modern Applied Statistics with S
inferredcites →https://doi.org/10.1007/s00125-010-2012-5openalex-snapshot
Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors
inferredcites →https://doi.org/10.1007/s00125-012-2612-3openalex-snapshot
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
inferredcites →https://doi.org/10.1007/s00125-014-3451-1openalex-snapshot
GLUT2, glucose sensing and glucose homeostasis
inferredcites →https://doi.org/10.1007/s00125-017-4500-3openalex-snapshot
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
inferredcites →https://doi.org/10.1007/s00125-018-4759-zopenalex-snapshot
A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes
inferredcites →https://doi.org/10.1016/j.bbadis.2017.10.037openalex-snapshot
Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1
inferredcites →https://doi.org/10.1016/j.celrep.2014.11.010openalex-snapshot
RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells
inferredcites →https://doi.org/10.1016/j.cmet.2012.06.006openalex-snapshot
A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.020openalex-snapshot
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.mce.2017.11.019openalex-snapshot
The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets
inferredcites →https://doi.org/10.1016/s1470-2045(18)30537-0openalex-snapshot
Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report from the Childhood Cancer Survivor Study cohort
inferredcites →https://doi.org/10.1016/s2213-8587(18)30051-2openalex-snapshot
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
inferredcites →https://doi.org/10.1038/nbt1295openalex-snapshot
A human phenome-interactome network of protein complexes implicated in genetic disorders
inferredcites →https://doi.org/10.1038/ng.2274openalex-snapshot
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot
The Genotype-Tissue Expression (GTEx) project
inferredcites →https://doi.org/10.1038/ng.3632openalex-snapshot
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
inferredcites →https://doi.org/10.1038/nprot.2009.97openalex-snapshot
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
inferredcites →https://doi.org/10.1038/s41419-020-2589-7openalex-snapshot
BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells
inferredcites →https://doi.org/10.1038/s41467-020-18581-8openalex-snapshot
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
inferredcites →https://doi.org/10.1038/s41588-018-0241-6openalex-snapshot
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
inferredcites →https://doi.org/10.1038/s41592-018-0039-6openalex-snapshot
GeNets: a unified web platform for network-based genomic analyses
inferredcites →https://doi.org/10.1053/j.gastro.2011.05.051openalex-snapshot
Interferon Regulatory Factor-2 Regulates Exocytosis Mechanisms Mediated by SNAREs in Pancreatic Acinar Cells
inferredcites →https://doi.org/10.1056/nejmoa0801869openalex-snapshot
Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes
inferredcites →https://doi.org/10.1073/pnas.1214312110openalex-snapshot
Intraislet SLIT–ROBO signaling is required for beta-cell survival and potentiates insulin secretion
inferredcites →https://doi.org/10.1073/pnas.1402665111openalex-snapshot
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
inferredcites →https://doi.org/10.1073/pnas.1621192114openalex-snapshot
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
inferredcites →https://doi.org/10.1074/jbc.275.11.8240openalex-snapshot
Role of SNAP23 in Insulin-induced Translocation of GLUT4 in 3T3-L1 Adipocytes
inferredcites →https://doi.org/10.1074/jbc.m502927200openalex-snapshot
Accelerated Glucose Intolerance, Nephropathy, and Atherosclerosis in Prostaglandin D2 Synthase Knock-out Mice
inferredcites →https://doi.org/10.1074/jbc.m507426200openalex-snapshot
WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells
inferredcites →https://doi.org/10.1083/jcb.201604030openalex-snapshot
Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
inferredcites →https://doi.org/10.1093/bioinformatics/bts034openalex-snapshot
The sva package for removing batch effects and other unwanted variation in high-throughput experiments
inferredcites →https://doi.org/10.1093/bioinformatics/btt656openalex-snapshot
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
inferredcites →https://doi.org/10.1093/hmg/ddu610openalex-snapshot
Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia
inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot
limma powers differential expression analyses for RNA-sequencing and microarray studies
inferredcites →https://doi.org/10.1097/tp.0b013e31820ae48eopenalex-snapshot
Quantification of the Islet Product: Presentation of a Standardized Current Good Manufacturing Practices Compliant System With Minimal Variability
inferredcites →https://doi.org/10.1101/245506openalex-snapshot
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
inferredcites →https://doi.org/10.1111/j.1463-1326.2009.01121.xopenalex-snapshot
Pdx1 and other factors that regulate pancreatic β‐cell survival
inferredcites →https://doi.org/10.1111/j.1742-4658.2010.07565.xopenalex-snapshot
Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2in vivo
inferredcites →https://doi.org/10.1111/j.2040-1124.2011.00178.xopenalex-snapshot
KCNQ1, a susceptibility gene for type 2 diabetes
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1128/mcb.23.17.6049-6062.2003openalex-snapshot
Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells
inferredcites →https://doi.org/10.1128/mcb.23.23.8773-8785.2003openalex-snapshot
The Murine G+C-Rich Promoter Binding Protein mGPBP Is Required for Promoter-Specific Transcription
inferredcites →https://doi.org/10.1172/jci109665openalex-snapshot
Dependency of cyclic AMP-induced insulin release on intra- and extracellular calcium in rat islets of Langerhans.
inferredcites →https://doi.org/10.1172/jci58447openalex-snapshot
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
inferredcites →https://doi.org/10.1182/blood-2011-10-387464openalex-snapshot
Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology
inferredcites →https://doi.org/10.1186/1471-2105-12-323openalex-snapshot
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
inferredcites →https://doi.org/10.1186/1752-0509-4-78openalex-snapshot
Network properties of human disease genes with pleiotropic effects
inferredcites →https://doi.org/10.1186/gb-2014-15-2-r29openalex-snapshot
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
inferredcites →https://doi.org/10.1196/annals.1372.039openalex-snapshot
Inflammatory Process in Type 2 Diabetes
inferredcites →https://doi.org/10.1371/journal.pgen.1004235openalex-snapshot
A Central Role for GRB10 in Regulation of Islet Function in Man
inferredcites →https://doi.org/10.1371/journal.pgen.1005694openalex-snapshot
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
inferredcites →https://doi.org/10.1371/journal.pone.0182932openalex-snapshot
Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk
inferredcites →https://doi.org/10.2337/db15-1272openalex-snapshot
A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db16-0996openalex-snapshot
Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
inferredcites →https://doi.org/10.2337/db16-1253openalex-snapshot
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
inferredcites →https://doi.org/10.2337/db16-1452openalex-snapshot
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
inferredcites →https://doi.org/10.2337/db16-1516openalex-snapshot
Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
inferredcites →https://doi.org/10.2337/db17-0311openalex-snapshot
Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia
inferredcites →https://doi.org/10.3109/03009734.2016.1164769openalex-snapshot
Pancreatic islet blood flow and its measurement
inferredcites →https://doi.org/10.3390/genes6010087openalex-snapshot
Genetics of Type 2 Diabetes—Pitfalls and Possibilities
inferredcites →https://doi.org/10.3892/mmr.2017.6874openalex-snapshot
miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2
inferredcites →https://doi.org/10.7554/elife.15082openalex-snapshot
Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/s00125-019-4908-zopenalex-snapshot
Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
inferred← citeshttps://doi.org/10.1007/s00125-020-05159-8openalex-snapshot
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes
inferred← citeshttps://doi.org/10.1007/s00125-022-05699-1openalex-snapshot
Lessons from single-cell RNA sequencing of human islets
inferred← citeshttps://doi.org/10.1007/s13340-022-00580-3openalex-snapshot
Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.mce.2020.111107openalex-snapshot
SCRT1 is a novel beta cell transcription factor with insulin regulatory properties
inferred← citeshttps://doi.org/10.1038/s41467-022-34069-zopenalex-snapshot
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
inferred← citeshttps://doi.org/10.1038/s42255-022-00607-8openalex-snapshot
Every islet matters: improving the impact of human islet research
inferred← citeshttps://doi.org/10.1111/apha.13857openalex-snapshot
The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion
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