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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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F2RL3 methylation, lung cancer incidence and mortality

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Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans

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Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and Replication

inferredcites →https://doi.org/10.1016/j.drugalcdep.2016.04.020openalex-snapshot

Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture

inferredcites →https://doi.org/10.1016/j.ehb.2013.12.002openalex-snapshot

Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates

inferredcites →https://doi.org/10.1016/j.thromres.2017.12.014openalex-snapshot

Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects

inferredcites →https://doi.org/10.1016/s0140-6736(12)60404-8openalex-snapshot

What makes UK Biobank special?

inferredcites →https://doi.org/10.1016/s0140-6736(17)30751-1openalex-snapshot

Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial

inferredcites →https://doi.org/10.1038/nature11896openalex-snapshot

Molecular signatures of G-protein-coupled receptors

inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot

The Genotype-Tissue Expression (GTEx) project

inferredcites →https://doi.org/10.1038/ng.2756openalex-snapshot

Systematic identification of trans eQTLs as putative drivers of known disease associations

inferredcites →https://doi.org/10.1038/ng.3396openalex-snapshot

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

inferredcites →https://doi.org/10.1038/sj.onc.1204891openalex-snapshot

Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression

inferredcites →https://doi.org/10.1038/sj.onc.1205699openalex-snapshot

5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

inferredcites →https://doi.org/10.1038/srep39945openalex-snapshot

Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

inferredcites →https://doi.org/10.1055/s-0031-1278255openalex-snapshot

Inflammation and platelet activation in peripheral arterial occlusive disease

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An Important Step for Thrombocardiology

inferredcites →https://doi.org/10.1056/nejmoa1112277openalex-snapshot

Rivaroxaban in Patients with a Recent Acute Coronary Syndrome

inferredcites →https://doi.org/10.1056/nejmoa1700518openalex-snapshot

Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism

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Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

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Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

inferredcites →https://doi.org/10.1093/aje/kwx181openalex-snapshot

Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study

inferredcites →https://doi.org/10.1093/eurheartj/ehv443openalex-snapshot

Long-term dual antiplatelet therapy for secondary prevention of cardiovascular events in the subgroup of patients with previous myocardial infarction: a collaborative meta-analysis of randomized trials

inferredcites →https://doi.org/10.1093/hmg/dds135openalex-snapshot

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome

inferredcites →https://doi.org/10.1093/hmg/ddw288openalex-snapshot

A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking

inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

inferredcites →https://doi.org/10.1093/ije/dyr233openalex-snapshot

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

inferredcites →https://doi.org/10.1093/ije/dys064openalex-snapshot

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

inferredcites →https://doi.org/10.1093/ije/dyu006openalex-snapshot

F2RL3methylation in blood DNA is a strong predictor of mortality

inferredcites →https://doi.org/10.1093/ije/dyv072openalex-snapshot

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)

inferredcites →https://doi.org/10.1093/ije/dyx034openalex-snapshot

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

inferredcites →https://doi.org/10.1101/078972openalex-snapshot

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

inferredcites →https://doi.org/10.1101/166298openalex-snapshot

Genome-wide genetic data on ~500,000 UK Biobank participants

inferredcites →https://doi.org/10.1101/gr.229102openalex-snapshot

The Human Genome Browser at UCSC

inferredcites →https://doi.org/10.1111/jth.13293openalex-snapshot

Inhibition of protease‐activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

inferredcites →https://doi.org/10.1113/jphysiol.2011.225417openalex-snapshot

Platelets: a critical link between inflammation and microvascular dysfunction

inferredcites →https://doi.org/10.1126/scitranslmed.aaf5294openalex-snapshot

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

inferredcites →https://doi.org/10.1136/bmj.h1551openalex-snapshot

Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium

inferredcites →https://doi.org/10.1161/01.res.0000260805.99076.22openalex-snapshot

Peroxisome Proliferator-Activated Receptor-δ Upregulates 14-3-3ε in Human Endothelial Cells via CCAAT/Enhancer Binding Protein-β

inferredcites →https://doi.org/10.1161/atvbaha.115.307102openalex-snapshot

Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking

inferredcites →https://doi.org/10.1161/atvbaha.117.310104openalex-snapshot

PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

inferredcites →https://doi.org/10.1161/circgenetics.116.001506openalex-snapshot

Epigenetic Signatures of Cigarette Smoking

inferredcites →https://doi.org/10.1161/circulationaha.105.587758openalex-snapshot

Blocking the Protease-Activated Receptor 1-4 Heterodimer in Platelet-Mediated Thrombosis

inferredcites →https://doi.org/10.1172/jci6042openalex-snapshot

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

inferredcites →https://doi.org/10.1182/blood-2014-04-572479openalex-snapshot

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

inferredcites →https://doi.org/10.1182/blood.v74.1.42.42openalex-snapshot

Growth and differentiation of a human megakaryoblastic cell line, CMK

inferredcites →https://doi.org/10.1182/bloodadvances.2017015552openalex-snapshot

A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant

inferredcites →https://doi.org/10.1186/gb-2014-15-5-r73openalex-snapshot

Contribution of genetic variation to transgenerational inheritance of DNA methylation

inferredcites →https://doi.org/10.1186/s13059-016-0926-zopenalex-snapshot

Systematic identification of genetic influences on methylation across the human life course

inferredcites →https://doi.org/10.1289/ehp.1306937openalex-snapshot

F2RL3 Methylation as a Biomarker of Current and Lifetime Smoking Exposures

inferredcites →https://doi.org/10.1371/journal.pone.0063812openalex-snapshot

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

inferredcites →https://doi.org/10.1371/journal.pone.0065528openalex-snapshot

Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets

inferredcites →https://doi.org/10.15252/msb.20156520openalex-snapshot

Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

inferredcites →https://doi.org/10.17863/cam.26250openalex-snapshot

Abstract

inferredcites →https://doi.org/10.18632/aging.101333openalex-snapshot

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936

inferredcites →https://doi.org/10.2105/ajph.84.8.1235openalex-snapshot

What determines mortality risk in male former cigarette smokers?

inferredcites →https://doi.org/10.3390/ijms19020573openalex-snapshot

Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy

inferredcites →https://doi.org/10.4161/15592294.2014.969637openalex-snapshot

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/b978-0-323-85652-2.00016-6openalex-snapshot

Epigenetic insights for wound healing mechanism

inferred← citeshttps://doi.org/10.1055/s-0040-1718400openalex-snapshot

The Role of Epigenetics in the Regulation of Hemostatic Balance

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