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Base editing generates substantial off-target single nucleotide variants

https://doi.org/10.1101/480145
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1 of the 44 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/nmeth.4293 (notice 2018-03-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamacardio.2017.1713openalex-snapshot
The Hope and Hype of CRISPR-Cas9 Genome Editing
inferredcites →https://doi.org/10.1016/j.ydbio.2009.06.012openalex-snapshot
Nucleosome positioning: How is it established, and why does it matter?
inferredcites →https://doi.org/10.1016/s0167-4781(00)00219-0openalex-snapshot
RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA
inferredcites →https://doi.org/10.1038/cr.2017.58openalex-snapshot
CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development
inferredcites →https://doi.org/10.1038/cr.2017.81openalex-snapshot
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
inferredcites →https://doi.org/10.1038/nbt.2514openalex-snapshot
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
inferredcites →https://doi.org/10.1038/nbt.3101openalex-snapshot
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
inferredcites →https://doi.org/10.1038/nbt.3117openalex-snapshot
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
inferredcites →https://doi.org/10.1038/nbt.4192openalex-snapshot
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
inferredcites →https://doi.org/10.1038/nbt0918-899copenalex-snapshot
Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
inferredcites →https://doi.org/10.1038/ncomms15464openalex-snapshot
CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome
inferredcites →https://doi.org/10.1038/ni.1864openalex-snapshot
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
inferredcites →https://doi.org/10.1038/ni0510-367openalex-snapshot
AIMing 2 defend against intracellular pathogens
inferredcites →https://doi.org/10.1038/nm.4313openalex-snapshot
Refining strategies to translate genome editing to the clinic
inferredcites →https://doi.org/10.1038/nmeth.3408openalex-snapshot
Off-target mutations are rare in Cas9-modified mice
inferredcites →https://doi.org/10.1038/nmeth.4278openalex-snapshot
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
inferredcites →https://doi.org/10.1038/nmeth.4293openalex-snapshot
Unexpected mutations after CRISPR–Cas9 editing in vivo
inferredcites →https://doi.org/10.1038/nmeth.4541openalex-snapshot
Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
inferredcites →https://doi.org/10.1038/nmeth.4553openalex-snapshot
Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
inferredcites →https://doi.org/10.1038/nmeth.4554openalex-snapshot
Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
inferredcites →https://doi.org/10.1038/nmeth.4559openalex-snapshot
Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
inferredcites →https://doi.org/10.1038/nn.2467openalex-snapshot
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
inferredcites →https://doi.org/10.1038/nprot.2016.150openalex-snapshot
Indel variant analysis of short-read sequencing data with Scalpel
inferredcites →https://doi.org/10.1038/nrd.2016.238openalex-snapshot
Cornerstones of CRISPR–Cas in drug discovery and therapy
inferredcites →https://doi.org/10.1038/nrg.2016.28openalex-snapshot
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
inferredcites →https://doi.org/10.1038/s41576-018-0059-1openalex-snapshot
Base editing: precision chemistry on the genome and transcriptome of living cells
inferredcites →https://doi.org/10.1038/s41576-018-0068-0openalex-snapshot
Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells
inferredcites →https://doi.org/10.1038/s41586-018-0500-9openalex-snapshot
In vivo CRISPR editing with no detectable genome-wide off-target mutations
inferredcites →https://doi.org/10.1038/s41591-018-0215-3openalex-snapshot
Towards therapeutic base editing
inferredcites →https://doi.org/10.1038/s41592-018-0148-2openalex-snapshot
Mutation frequency is not increased in CRISPR–Cas9-edited mice
inferredcites →https://doi.org/10.1073/pnas.1810062115openalex-snapshot
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
inferredcites →https://doi.org/10.1093/bfgp/elw032openalex-snapshot
Therapeutic applications of CRISPR RNA-guided genome editing
inferredcites →https://doi.org/10.1093/bioinformatics/bts271openalex-snapshot
Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs
inferredcites →https://doi.org/10.1093/bioinformatics/btu048openalex-snapshot
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
inferredcites →https://doi.org/10.1093/genetics/148.4.1667openalex-snapshot
Rates of Spontaneous Mutation
inferredcites →https://doi.org/10.1093/hmg/ddp036openalex-snapshot
Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component
inferredcites →https://doi.org/10.1093/nar/gkq603openalex-snapshot
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
inferredcites →https://doi.org/10.1093/nar/gks918openalex-snapshot
LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets
inferredcites →https://doi.org/10.1093/nar/gkw983openalex-snapshot
Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse
inferredcites →https://doi.org/10.1111/j.1558-5646.1993.tb01204.xopenalex-snapshot
OUTCROSSING RATE AND INBREEDING DEPRESSION IN TWO ANNUAL MONOECIOUS HERBS,BEGONIA HIRSUTAANDB. SEMIOVATA
inferredcites →https://doi.org/10.1126/science.8511591openalex-snapshot
Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein
inferredcites →https://doi.org/10.1126/science.aan4672openalex-snapshot
Gene therapy comes of age
inferredcites →https://doi.org/10.1186/1756-8935-7-33openalex-snapshot
Chromatin accessibility: a window into the genome
inferredcites →https://doi.org/10.1186/s13059-016-1012-2openalex-snapshot
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-1-0716-0687-2_1openalex-snapshot
Cloud-Based Design of Short Guide RNA (sgRNA) Libraries for CRISPR Experiments
inferred← citeshttps://doi.org/10.1007/s00335-018-9791-2openalex-snapshot
Fearful old world? A commentary on the Second International Summit on human genome editing
inferred← citeshttps://doi.org/10.1007/s11427-019-1611-1openalex-snapshot
Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes
inferred← citeshttps://doi.org/10.1038/s41392-019-0044-yopenalex-snapshot
Off-Targeting of Base Editors: BE3 but not ABE induces substantial off-target single nucleotide variants
inferred← citeshttps://doi.org/10.1038/s41467-019-10748-2openalex-snapshot
Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos
inferred← citeshttps://doi.org/10.1038/s41592-018-0307-5openalex-snapshot
A rocky road for the maturation of embryo-editing methods
inferred← citeshttps://doi.org/10.1042/etls20180144openalex-snapshot
Emerging CRISPR/Cas9 applications for T-cell gene editing
inferred← citeshttps://doi.org/10.1096/fj.201900476rropenalex-snapshot
Improved base editor for efficient editing in GC contexts in rabbits with an optimized AID‐Cas9 fusion
inferred← citeshttps://doi.org/10.1101/2020.02.07.939074openalex-snapshot
High-fidelity base editor with no detectable genome-wide off-target effects
inferred← citeshttps://doi.org/10.1111/bjh.15851openalex-snapshot
Therapeutic gene editing in haematological disorders with CRISPR /Cas9
inferred← citeshttps://doi.org/10.1186/s13059-020-02000-8openalex-snapshot
Inference of single-cell phylogenies from lineage tracing data using Cassiopeia
inferred← citeshttps://doi.org/10.3390/genes10050387openalex-snapshot
Gene and Base Editing as a Therapeutic Option for Cystic Fibrosis—Learning from Other Diseases
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