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Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology

https://doi.org/10.1101/505164
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2017.0469openalex-snapshot
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases
inferredcites →https://doi.org/10.1001/jamaneurol.2018.0605openalex-snapshot
Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1002/0471142735.im1525s104openalex-snapshot
Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice
inferredcites →https://doi.org/10.1002/ana.24066openalex-snapshot
Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys
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Vagotomy and subsequent risk of P arkinson's disease
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Does vagotomy reduce the risk of Parkinson's disease?
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CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions
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Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis
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The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease
inferredcites →https://doi.org/10.1002/mds.24921openalex-snapshot
Lewy pathology and neurodegeneration in premotor Parkinson's disease
inferredcites →https://doi.org/10.1002/mds.25020openalex-snapshot
Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases
inferredcites →https://doi.org/10.1002/mds.25736openalex-snapshot
Progression of intestinal permeability changes and alpha‐synuclein expression in a mouse model of Parkinson's disease
inferredcites →https://doi.org/10.1002/mds.25779openalex-snapshot
Alpha‐synuclein in the appendiceal mucosa of neurologically intact subjects
inferredcites →https://doi.org/10.1002/mds.26077openalex-snapshot
The O nset of N onmotor S ymptoms in P arkinson's disease ( T he ONSET PD S tudy)
inferredcites →https://doi.org/10.1007/978-3-540-79850-7openalex-snapshot
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
inferredcites →https://doi.org/10.1007/s00401-014-1343-6openalex-snapshot
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
inferredcites →https://doi.org/10.1007/s00401-017-1792-9openalex-snapshot
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
inferredcites →https://doi.org/10.1007/s00401-018-1943-7openalex-snapshot
Enteric alpha-synuclein expression is increased in Crohn’s disease
inferredcites →https://doi.org/10.1007/s00415-002-1204-4openalex-snapshot
Treatment of Parkinson's disease: levodopa as the first choice
inferredcites →https://doi.org/10.1007/s00415-002-1301-4openalex-snapshot
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
inferredcites →https://doi.org/10.1007/s00441-017-2706-9openalex-snapshot
Neurodegeneration and the ordered assembly of α-synuclein
inferredcites →https://doi.org/10.1007/s00441-018-2814-1openalex-snapshot
The concept of alpha-synuclein as a prion-like protein: ten years after
inferredcites →https://doi.org/10.1007/s00702-011-0653-2openalex-snapshot
Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
inferredcites →https://doi.org/10.1007/s00702-017-1686-yopenalex-snapshot
Epidemiology of Parkinson’s disease
inferredcites →https://doi.org/10.1016/0304-3940(94)90508-8openalex-snapshot
Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients
inferredcites →https://doi.org/10.1016/j.bbamem.2008.08.027openalex-snapshot
Cytokine regulation of tight junctions
inferredcites →https://doi.org/10.1016/j.bbi.2010.12.016openalex-snapshot
LPS-induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine-dependent
inferredcites →https://doi.org/10.1016/j.bbi.2012.07.003openalex-snapshot
Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine
inferredcites →https://doi.org/10.1016/j.cell.2015.01.019openalex-snapshot
SnapShot: Genetics of Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.cell.2016.11.018openalex-snapshot
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.nbd.2012.09.007openalex-snapshot
Colonic inflammation in Parkinson's disease
inferredcites →https://doi.org/10.1016/j.nbd.2018.01.008openalex-snapshot
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
inferredcites →https://doi.org/10.1016/j.neulet.2005.11.012openalex-snapshot
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
inferredcites →https://doi.org/10.1016/j.neuroscience.2008.02.074openalex-snapshot
Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
inferredcites →https://doi.org/10.1016/j.parkreldis.2017.01.013openalex-snapshot
Occurrence of Crohn's disease with Parkinson’s disease
inferredcites →https://doi.org/10.1016/j.tins.2018.09.007openalex-snapshot
Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
inferredcites →https://doi.org/10.1016/s0197-4580(02)00065-9openalex-snapshot
Staging of brain pathology related to sporadic Parkinson’s disease
inferredcites →https://doi.org/10.1016/s1474-4422(14)70287-xopenalex-snapshot
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study
inferredcites →https://doi.org/10.1038/42166openalex-snapshot
α-Synuclein in Lewy bodies
inferredcites →https://doi.org/10.1038/mi.2013.103openalex-snapshot
IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis
inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot
NIH Image to ImageJ: 25 years of image analysis
inferredcites →https://doi.org/10.1038/nn.2432openalex-snapshot
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
inferredcites →https://doi.org/10.1038/nn.4030openalex-snapshot
Host microbiota constantly control maturation and function of microglia in the CNS
inferredcites →https://doi.org/10.1038/s41531-016-0002-0openalex-snapshot
The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
inferredcites →https://doi.org/10.1038/s41531-019-0076-6openalex-snapshot
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
inferredcites →https://doi.org/10.1038/s41586-018-0023-4openalex-snapshot
Innate immune memory in the brain shapes neurological disease hallmarks
inferredcites →https://doi.org/10.1038/s41598-017-09362-3openalex-snapshot
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages
inferredcites →https://doi.org/10.1038/srep00898openalex-snapshot
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
inferredcites →https://doi.org/10.1038/srep34477openalex-snapshot
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
inferredcites →https://doi.org/10.1073/pnas.0903691106openalex-snapshot
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
inferredcites →https://doi.org/10.1073/pnas.1321785111openalex-snapshot
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
inferredcites →https://doi.org/10.1084/jem.20160368openalex-snapshot
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
inferredcites →https://doi.org/10.1093/hmg/ddq038openalex-snapshot
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
inferredcites →https://doi.org/10.1093/jnen/nlw103openalex-snapshot
The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease
inferredcites →https://doi.org/10.1097/mib.0000000000000735openalex-snapshot
Association Between Parkinsonʼs Disease and Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1111/j.1468-1331.2012.03798.xopenalex-snapshot
The PRIPS study: screening battery for subjects at risk for P arkinson's disease
inferredcites →https://doi.org/10.1111/jnc.14139openalex-snapshot
‘Prion‐like’ propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
inferredcites →https://doi.org/10.1111/jnc.14656openalex-snapshot
Acute inflammation down‐regulates alpha‐synuclein expression in enteric neurons
inferredcites →https://doi.org/10.1126/science.1227157openalex-snapshot
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
inferredcites →https://doi.org/10.1126/science.276.5321.2045openalex-snapshot
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
inferredcites →https://doi.org/10.1126/scitranslmed.aan8162openalex-snapshot
An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis
inferredcites →https://doi.org/10.1126/scitranslmed.aar5280openalex-snapshot
The vermiform appendix impacts the risk of developing Parkinson’s disease
inferredcites →https://doi.org/10.1128/jvi.01399-16openalex-snapshot
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation
inferredcites →https://doi.org/10.1128/mcb.20.11.4106-4114.2000openalex-snapshot
Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
inferredcites →https://doi.org/10.1136/gutjnl-2017-315666openalex-snapshot
Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014
inferredcites →https://doi.org/10.1136/gutjnl-2018-317103openalex-snapshot
Older patients with IBD might have higher risk of Parkinson’s disease
inferredcites →https://doi.org/10.1159/000477990openalex-snapshot
A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity
inferredcites →https://doi.org/10.1159/000479653openalex-snapshot
Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection
inferredcites →https://doi.org/10.1172/jci15777openalex-snapshot
Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
inferredcites →https://doi.org/10.1172/jci30602openalex-snapshot
TREM-1–expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
inferredcites →https://doi.org/10.1172/jci43366openalex-snapshot
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
inferredcites →https://doi.org/10.1172/jci59150openalex-snapshot
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
inferredcites →https://doi.org/10.1186/s13024-018-0257-5openalex-snapshot
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
inferredcites →https://doi.org/10.1186/s40478-014-0179-6openalex-snapshot
IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis
inferredcites →https://doi.org/10.1186/s40478-015-0198-yopenalex-snapshot
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
inferredcites →https://doi.org/10.1186/s40478-016-0305-8openalex-snapshot
Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies
inferredcites →https://doi.org/10.1189/jlb.1109768openalex-snapshot
Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice
inferredcites →https://doi.org/10.1212/wnl.0000000000001364openalex-snapshot
Parkinson risk in idiopathic REM sleep behavior disorder
inferredcites →https://doi.org/10.1212/wnl.0000000000004146openalex-snapshot
A new potential biomarker for dementia with Lewy bodies
inferredcites →https://doi.org/10.1212/wnl.0b013e3181c34af5openalex-snapshot
Medical records documentation of constipation preceding Parkinson disease
inferredcites →https://doi.org/10.1212/wnl.57.3.456openalex-snapshot
Frequency of bowel movements and the future risk of Parkinson’s disease
inferredcites →https://doi.org/10.1371/journal.pone.0012728openalex-snapshot
Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms
inferredcites →https://doi.org/10.1371/journal.pone.0028032openalex-snapshot
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
inferredcites →https://doi.org/10.1371/journal.pone.0035919openalex-snapshot
Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells
inferredcites →https://doi.org/10.1371/journal.pone.0039465openalex-snapshot
Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
inferredcites →https://doi.org/10.1523/jneurosci.20-17-06365.2000openalex-snapshot
Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain
inferredcites →https://doi.org/10.1523/jneurosci.2868-05.2005openalex-snapshot
Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease
inferredcites →https://doi.org/10.3233/jpd-150685openalex-snapshot
The Concept of Prodromal Parkinson’s Disease
inferredcites →https://doi.org/10.3791/1652openalex-snapshot
Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
inferredcites →https://doi.org/10.4049/jimmunol.1000548openalex-snapshot
LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens
inferredcites →https://doi.org/10.4049/jimmunol.1102084openalex-snapshot
Intestinal Epithelial Cell-Derived Semaphorin 7A Negatively Regulates Development of Colitis via αvβ1 Integrin
inferredcites →https://doi.org/10.4049/jimmunol.178.7.4641openalex-snapshot
IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Gut Dysbiosis and Neurological Disorders—An Eclectic Perspective
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2019.06.002openalex-snapshot
Can infections trigger alpha-synucleinopathies?
inferred← citeshttps://doi.org/10.1016/j.chom.2020.06.008openalex-snapshot
The Microbiome as a Modifier of Neurodegenerative Disease Risk
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105654openalex-snapshot
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
inferred← citeshttps://doi.org/10.1038/s41467-021-25474-xopenalex-snapshot
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
inferred← citeshttps://doi.org/10.1055/s-0043-1771459openalex-snapshot
Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.1101/2020.09.26.279851openalex-snapshot
Gut microbiome dysbiosis is associated with elevated toxic bile acids in Parkinson’s disease
inferred← citeshttps://doi.org/10.14336/ad.2021.0418openalex-snapshot
Intestinal Inflammation and Parkinson’s Disease
inferred← citeshttps://doi.org/10.3233/jpd-191703openalex-snapshot
The Appendix in Parkinson’s Disease: From Vestigial Remnant to Vital Organ?
inferred← citeshttps://doi.org/10.3233/jpd-191729openalex-snapshot
Inflammatory Bowel Diseases and Parkinson’s Disease
inferred← citeshttps://doi.org/10.3389/fnbeh.2022.791128openalex-snapshot
Fecal Implants From AppNL–G–F and AppNL–G–F/E4 Donor Mice Sufficient to Induce Behavioral Phenotypes in Germ-Free Mice
inferred← citeshttps://doi.org/10.3390/ijms23126626openalex-snapshot
PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases
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